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2. Frequency drift in MR spectroscopy at 3T.

Author

Hui, Steve CN, Mikkelsen, Mark, Zöllner, Helge J, Ahluwalia, Vishwadeep, Alcauter, Sarael, Baltusis, Laima, Barany, Deborah A, Barlow, Laura R, Becker, Robert, Berman, Jeffrey I, Berrington, Adam, Bhattacharyya, Pallab K, Blicher, Jakob Udby, Bogner, Wolfgang, Brown, Mark S, Calhoun, Vince D, Castillo, Ryan, Cecil, Kim M, Choi, Yeo Bi, Chu, Winnie CW, Clarke, William T, Craven, Alexander R, Cuypers, Koen, Dacko, Michael, de la Fuente-Sandoval, Camilo, Desmond, Patricia, Domagalik, Aleksandra, Dumont, Julien, Duncan, Niall W, Dydak, Ulrike, Dyke, Katherine, Edmondson, David A, Ende, Gabriele, Ersland, Lars, Evans, C John, Fermin, Alan SR, Ferretti, Antonio, Fillmer, Ariane, Gong, Tao, Greenhouse, Ian, Grist, James T, Gu, Meng, Harris, Ashley D, Hat, Katarzyna, Heba, Stefanie, Heckova, Eva, Hegarty, John P, Heise, Kirstin-Friederike, Honda, Shiori, Jacobson, Aaron, Jansen, Jacobus FA, Jenkins, Christopher W, Johnston, Stephen J, Juchem, Christoph, Kangarlu, Alayar, Kerr, Adam B, Landheer, Karl, Lange, Thomas, Lee, Phil, Levendovszky, Swati Rane, Limperopoulos, Catherine, Liu, Feng, Lloyd, William, Lythgoe, David J, Machizawa, Maro G, MacMillan, Erin L, Maddock, Richard J, Manzhurtsev, Andrei V, Martinez-Gudino, María L, Miller, Jack J, Mirzakhanian, Heline, Moreno-Ortega, Marta, Mullins, Paul G, Nakajima, Shinichiro, Near, Jamie, Noeske, Ralph, Nordhøy, Wibeke, Oeltzschner, Georg, Osorio-Duran, Raul, Otaduy, Maria CG, Pasaye, Erick H, Peeters, Ronald, Peltier, Scott J, Pilatus, Ulrich, Polomac, Nenad, Porges, Eric C, Pradhan, Subechhya, Prisciandaro, James Joseph, Puts, Nicolaas A, Rae, Caroline D, Reyes-Madrigal, Francisco, Roberts, Timothy PL, Robertson, Caroline E, Rosenberg, Jens T, Rotaru, Diana-Georgiana, O'Gorman Tuura, Ruth L, Saleh, Muhammad G, Sandberg, Kristian, Sangill, Ryan, and Schembri, Keith

Subjects
3T, Frequency drift, Magnetic resonance spectroscopy, Multi-site, Multi-vendor, Press, Brain, Data Analysis, Databases, Factual, Humans, Magnetic Resonance Imaging, Magnetic Resonance Spectroscopy, Clinical Research, Biomedical Imaging, Neurology & Neurosurgery, Medical and Health Sciences, Psychology and Cognitive Sciences
Abstract

PurposeHeating of gradient coils and passive shim components is a common cause of instability in the B0 field, especially when gradient intensive sequences are used. The aim of the study was to set a benchmark for typical drift encountered during MR spectroscopy (MRS) to assess the need for real-time field-frequency locking on MRI scanners by comparing field drift data from a large number of sites.MethodA standardized protocol was developed for 80 participating sites using 99 3T MR scanners from 3 major vendors. Phantom water signals were acquired before and after an EPI sequence. The protocol consisted of: minimal preparatory imaging; a short pre-fMRI PRESS; a ten-minute fMRI acquisition; and a long post-fMRI PRESS acquisition. Both pre- and post-fMRI PRESS were non-water suppressed. Real-time frequency stabilization/adjustment was switched off when appropriate. Sixty scanners repeated the protocol for a second dataset. In addition, a three-hour post-fMRI MRS acquisition was performed at one site to observe change of gradient temperature and drift rate. Spectral analysis was performed using MATLAB. Frequency drift in pre-fMRI PRESS data were compared with the first 5:20 minutes and the full 30:00 minutes of data after fMRI. Median (interquartile range) drifts were measured and showed in violin plot. Paired t-tests were performed to compare frequency drift pre- and post-fMRI. A simulated in vivo spectrum was generated using FID-A to visualize the effect of the observed frequency drifts. The simulated spectrum was convolved with the frequency trace for the most extreme cases. Impacts of frequency drifts on NAA and GABA were also simulated as a function of linear drift. Data from the repeated protocol were compared with the corresponding first dataset using Pearson's and intraclass correlation coefficients (ICC).ResultsOf the data collected from 99 scanners, 4 were excluded due to various reasons. Thus, data from 95 scanners were ultimately analyzed. For the first 5:20 min (64 transients), median (interquartile range) drift was 0.44 (1.29) Hz before fMRI and 0.83 (1.29) Hz after. This increased to 3.15 (4.02) Hz for the full 30 min (360 transients) run. Average drift rates were 0.29 Hz/min before fMRI and 0.43 Hz/min after. Paired t-tests indicated that drift increased after fMRI, as expected (p < 0.05). Simulated spectra convolved with the frequency drift showed that the intensity of the NAA singlet was reduced by up to 26%, 44 % and 18% for GE, Philips and Siemens scanners after fMRI, respectively. ICCs indicated good agreement between datasets acquired on separate days. The single site long acquisition showed drift rate was reduced to 0.03 Hz/min approximately three hours after fMRI.DiscussionThis study analyzed frequency drift data from 95 3T MRI scanners. Median levels of drift were relatively low (5-min average under 1 Hz), but the most extreme cases suffered from higher levels of drift. The extent of drift varied across scanners which both linear and nonlinear drifts were observed.

Published
2021

3. Differences in Intrinsic Gray Matter Connectivity and Their Genomic Underpinnings in Autism Spectrum Disorder

Author

Ahmad, Jumana, Ambrosino, Sara, Auyeung, Bonnie, Banaschewski, Tobias, Baron-Cohen, Simon, Baumeister, Sarah, Beckmann, Christian F., Bölte, Sven, Bourgeron, Thomas, Bours, Carsten, Brammer, Michael, Brandeis, Daniel, Brogna, Claudia, de Bruijn, Yvette, Buitelaar, Jan K., Chakrabarti, Bhismadev, Charman, Tony, Cornelissen, Ineke, Crawley, Daisy, Dell’Acqua, Flavio, Dumas, Guillaume, Durston, Sarah, Ecker, Christine, Faulkner, Jessica, Frouin, Vincent, Garcés, Pilar, Goyard, David, Ham, Lindsay, Hayward, Hannah, Hipp, Joerg, Holt, Rosemary, Johnson, Mark H., Jones, Emily J.H., Kundu, Prantik, Lai, Meng-Chuan, D’ardhuy, Xavier Liogier, Lombardo, Michael V., Loth, Eva, Lythgoe, David J., Mandl, René, Marquand, Andre, Mason, Luke, Mennes, Maarten, Meyer-Lindenberg, Andreas, Moessnang, Carolin, Bast, Nico, Murphy, Declan G.M., Oakley, Bethany, O’Dwyer, Laurence, Oldehinkel, Marianne, Oranje, Bob, Pandina, Gahan, Persico, Antonio M., Ruggeri, Barbara, Ruigrok, Amber, Sabet, Jessica, Sacco, Roberto, San José Cáceres, Antonia, Simonoff, Emily, Spooren, Will, Tillmann, Julian, Toro, Roberto, Tost, Heike, Waldman, Jack, Williams, Steve C.R., Wooldridge, Caroline, Zwiers, Marcel P., Leyhausen, Johanna, Schäfer, Tim, Gurr, Caroline, Berg, Lisa M., Seelemeyer, Hanna, Pretzsch, Charlotte M., Floris, Dorothea L., Chatham, Chris, and Murphy, Declan G.

Published
2024
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4. Autism Is Associated With Interindividual Variations of Gray and White Matter Morphology

Author

Buitelaar, Jan K., Ahmad, Jumana, Ambrosino, Sara, Auyeung, Bonnie, Banaschewski, Tobias, Baron-Cohen, Simon, Baumeister, Sarah, Beckmann, Christian F., Bölte, Sven, Bourgeron, Thomas, Bours, Carsten, Brammer, Michael, Brandeis, Daniel, Brogna, Claudia, de Bruijn, Yvette, Chakrabarti, Bhismadev, Charman, Tony, Cornelissen, Ineke, Crawley, Daisy, Dell’Acqua, Flavio, Dumas, Guillaume, Durston, Sarah, Ecker, Christine, Faulkner, Jessica, Frouin, Vincent, Garcés, Pilar, Goyard, David, Ham, Lindsay, Hayward, Hannah, Hipp, Joerg, Holt, Rosemary, Johnson, Mark H., Jones, Emily J.H., Kundu, Prantik, Lai, Meng-Chuan, Liogier d’Ardhuy, Xavier, Lombardo, Michael V., Loth, Eva, Lythgoe, David J., Mandl, René, Marquand, Andre, Mason, Luke, Mennes, Maarten, Meyer-Lindenberg, Andreas, Moessnang, Carolin, Mueller, Nico, Murphy, Declan G.M., Oakley, Bethany, O’Dwyer, Laurence, Oldehinkel, Marianne, Oranje, Bob, Pandina, Gahan, Persico, Antonio M., Rausch, Annika, Ruggeri, Barbara, Ruigrok, Amber, Sabet, Jessica, Sacco, Roberto, San José Cáceres, Antonia, Simonoff, Emily, Spooren, Will, Tillmann, Julian, Toro, Roberto, Tost, Heike, Waldman, Jack, Williams, Steve C.R., Wooldridge, Caroline, Ilioska, Iva, Mei, Ting, Zwiers, Marcel P., Forde, Natalie J., Floris, Dorothea L., Stones, Richard, Holt, Rosemary J., and Llera, Alberto

Published
2023
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6. Different whole-brain functional connectivity correlates of reactive-proactive aggression and callous-unemotional traits in children and adolescents with disruptive behaviors

Author

Werhahn, Julia E., Smigielski, Lukasz, Sacu, Seda, Mohl, Susanna, Willinger, David, Naaijen, Jilly, Mulder, Leandra M., Glennon, Jeffrey C., Hoekstra, Pieter J., Dietrich, Andrea, Deters, Renee Kleine, Aggensteiner, Pascal M., Holz, Nathalie E., Baumeister, Sarah, Banaschewski, Tobias, Saam, Melanie C., Schulze, Ulrike M.E., Lythgoe, David J., Sethi, Arjun, Craig, Michael, Mastroianni, Mathilde, Sagar-Ouriaghli, Ilyas, Santosh, Paramala J., Rosa, Mireia, Bargallo, Nuria, Castro-Fornieles, Josefina, Arango, Celso, Penzol, Maria J., Zwiers, Marcel P., Franke, Barbara, Buitelaar, Jan K., Walitza, Susanne, and Brandeis, Daniel

Published
2023
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9. Impaired verbal memory function is related to anterior cingulate glutamate levels in schizophrenia: findings from the STRATA study

Author

Griffiths, Kira, Egerton, Alice, Millgate, Edward, Anton, Adriana, Barker, Gareth J., Deakin, Bill, Drake, Richard, Eliasson, Emma, Gregory, Catherine J., Howes, Oliver D., Kravariti, Eugenia, Lawrie, Stephen M., Lewis, Shôn, Lythgoe, David J., Murphy, Anna, McGuire, Philip, Semple, Scott, Stockton-Powdrell, Charlotte, Walters, James T. R., Williams, Stephen R., and MacCabe, James H.

Published
2022
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11. A letter to the editor: The effects of alcohol use on brain glutamate in first episode psychosis

Author

King, Bridget, primary, Kempton, Matthew J., additional, Broberg, Brian V., additional, Merritt, Kate, additional, Barker, Gareth J., additional, Lythgoe, David J., additional, Perez-Iglesias, Rocio, additional, Baandrup, Lone, additional, Düring, Signe W., additional, Stone, James M., additional, Rostrup, Egill, additional, Sommer, Iris E., additional, Glenthøj, Birte, additional, Kahn, René S., additional, Dazzan, Paola, additional, McGuire, Philip K., additional, and Egerton, Alice, additional

Published
2024
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12. Frequency drift in MR spectroscopy at 3T

Author

Hui, Steve C.N., Mikkelsen, Mark, Zöllner, Helge J., Ahluwalia, Vishwadeep, Alcauter, Sarael, Baltusis, Laima, Barany, Deborah A., Barlow, Laura R., Becker, Robert, Berman, Jeffrey I., Berrington, Adam, Bhattacharyya, Pallab K., Blicher, Jakob Udby, Bogner, Wolfgang, Brown, Mark S., Calhoun, Vince D., Castillo, Ryan, Cecil, Kim M., Choi, Yeo Bi, Chu, Winnie C.W., Clarke, William T., Craven, Alexander R., Cuypers, Koen, Dacko, Michael, de la Fuente-Sandoval, Camilo, Desmond, Patricia, Domagalik, Aleksandra, Dumont, Julien, Duncan, Niall W., Dydak, Ulrike, Dyke, Katherine, Edmondson, David A., Ende, Gabriele, Ersland, Lars, Evans, C. John, Fermin, Alan S.R., Ferretti, Antonio, Fillmer, Ariane, Gong, Tao, Greenhouse, Ian, Grist, James T., Gu, Meng, Harris, Ashley D., Hat, Katarzyna, Heba, Stefanie, Heckova, Eva, Hegarty, John P., II, Heise, Kirstin-Friederike, Honda, Shiori, Jacobson, Aaron, Jansen, Jacobus F.A., Jenkins, Christopher W., Johnston, Stephen J., Juchem, Christoph, Kangarlu, Alayar, Kerr, Adam B., Landheer, Karl, Lange, Thomas, Lee, Phil, Levendovszky, Swati Rane, Limperopoulos, Catherine, Liu, Feng, Lloyd, William, Lythgoe, David J., Machizawa, Maro G., MacMillan, Erin L., Maddock, Richard J., Manzhurtsev, Andrei V., Martinez-Gudino, María L., Miller, Jack J., Mirzakhanian, Heline, Moreno-Ortega, Marta, Mullins, Paul G., Nakajima, Shinichiro, Near, Jamie, Noeske, Ralph, Nordhøy, Wibeke, Oeltzschner, Georg, Osorio-Duran, Raul, Otaduy, Maria C.G., Pasaye, Erick H., Peeters, Ronald, Peltier, Scott J., Pilatus, Ulrich, Polomac, Nenad, Porges, Eric C., Pradhan, Subechhya, Prisciandaro, James Joseph, Puts, Nicolaas A, Rae, Caroline D., Reyes-Madrigal, Francisco, Roberts, Timothy P.L., Robertson, Caroline E., Rosenberg, Jens T., Rotaru, Diana-Georgiana, O'Gorman Tuura, Ruth L, Saleh, Muhammad G., Sandberg, Kristian, Sangill, Ryan, Schembri, Keith, Schrantee, Anouk, Semenova, Natalia A., Singel, Debra, Sitnikov, Rouslan, Smith, Jolinda, Song, Yulu, Stark, Craig, Stoffers, Diederick, Swinnen, Stephan P., Tain, Rongwen, Tanase, Costin, Tapper, Sofie, Tegenthoff, Martin, Thiel, Thomas, Thioux, Marc, Truong, Peter, van Dijk, Pim, Vella, Nolan, Vidyasagar, Rishma, Vovk, Andrej, Wang, Guangbin, Westlye, Lars T., Wilbur, Timothy K., Willoughby, William R., Wilson, Martin, Wittsack, Hans-Jörg, Woods, Adam J., Wu, Yen-Chien, Xu, Junqian, Lopez, Maria Yanez, Yeung, David K.W., Zhao, Qun, Zhou, Xiaopeng, Zupan, Gasper, and Edden, Richard A.E.

Published
2021
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13. Temporal Profiles of Social Attention Are Different Across Development in Autistic and Neurotypical People

Author

Ahmad, Jumana, Ambrosino, Sara, Banaschewski, Tobias, Baron-Cohen, Simon, Baumeister, Sarah, Beckmann, Christian F., Bölte, Sven, Bourgeron, Thomas, Bours, Carsten, Brammer, Michael, Brandeis, Daniel, Brogna, Claudia, de Bruijn, Yvette, Cornelissen, Ineke, Crawley, Daisy, Dell’Acqua, Flavio, Dumas, Guillaume, Durston, Sarah, Ecker, Christine, Faulkner, Jessica, Frouin, Vincent, Garcés, Pilar, Goyard, David, Ham, Lindsay, Hipp, Joerg, Holt, Rosemary, Lai, Meng-Chuan, D’Ardhuy, Xavier Liogier, Lombardo, Michael V., Lythgoe, David J., Mandl, René, Marquand, Andre, Mennes, Maarten, Meyer-Lindenberg, Andreas, Moessnang, Carolin, Mueller, Nico, Murphy, Declan G.M., Oakley, Bethany, O’Dwyer, Laurence, Oldehinkel, Marianne, Oranje, Bob, Pandina, Gahan, Persico, Antonio M., Ruggeri, Barbara, Ruigrok, Amber, Sabet, Jessica, Sacco, Roberto, San José Cáceres, Antonia, Simonoff, Emily, Spooren, Will, Toro, Roberto, Tost, Heike, Waldman, Jack, Williams, Steve C.R., Wooldridge, Caroline, Zwiers, Marcel P., Del Bianco, Teresa, Mason, Luke, Charman, Tony, Tillman, Julian, Loth, Eva, Hayward, Hannah, Shic, Frederick, Buitelaar, Jan, Johnson, Mark H., and Jones, Emily J.H.

Published
2021
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14. Atypical Brain Asymmetry in Autism—A Candidate for Clinically Meaningful Stratification

Author

Ahmad, Jumana, Ambrosino, Sara, Auyeung, Bonnie, Banaschewski, Tobias, Baron-Cohen, Simon, Baumeister, Sarah, Beckmann, Christian F., Bölte, Sven, Bourgeron, Thomas, Bours, Carsten, Brammer, Michael, Brandeis, Daniel, Brogna, Claudia, de Bruijn, Yvette, Buitelaar, Jan K., Chakrabarti, Bhismadev, Charman, Tony, Cornelissen, Ineke, Crawley, Daisy, Dell’Acqua, Flavio, Dumas, Guillaume, Durston, Sarah, Ecker, Christine, Faulkner, Jessica, Frouin, Vincent, Garcés, Pilar, Goyard, David, Ham, Lindsay, Hayward, Hannah, Hipp, Joerg, Holt, Rosemary, Johnson, Mark H., Jones, Emily J.H., Kundu, Prantik, Lai, Meng-Chuan, Liogier d’Ardhuy, Xavier, Lombardo, Michael V., Loth, Eva, Lythgoe, David J., Mandl, René, Marquand, Andre, Mason, Luke, Mennes, Maarten, Meyer-Lindenberg, Andreas, Moessnang, Carolin, Mueller, Nico, Murphy, Declan G.M., Oakley, Bethany, O’Dwyer, Laurence, Oldehinkel, Marianne, Oranje, Bob, Pandina, Gahan, Persico, Antonio M., Ruggeri, Barbara, Ruigrok, Amber, Sabet, Jessica, Sacco, Roberto, San José Cáceres, Antonia, Simonoff, Emily, Spooren, Will, Tillmann, Julian, Toro, Roberto, Tost, Heike, Waldman, Jack, Williams, Steve C.R., Wooldridge, Caroline, Zwiers, Marcel P., Floris, Dorothea L., Wolfers, Thomas, Zabihi, Mariam, and Holz, Nathalie E.

Published
2021
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18. Aggression subtypes relate to distinct resting state functional connectivity in children and adolescents with disruptive behavior

Author

Werhahn, Julia E., Mohl, Susanna, Willinger, David, Smigielski, Lukasz, Roth, Alexander, Hofstetter, Christoph, Stämpfli, Philipp, Naaijen, Jilly, Mulder, Leandra M., Glennon, Jeffrey C., Hoekstra, Pieter J., Dietrich, Andrea, Kleine Deters, Renee, Aggensteiner, Pascal M., Holz, Nathalie E., Baumeister, Sarah, Banaschewski, Tobias, Saam, Melanie C., Schulze, Ulrike M. E., Lythgoe, David J., Sethi, Arjun, Craig, Michael C., Mastroianni, Mathilde, Sagar-Ouriaghli, Ilyas, Santosh, Paramala J., Rosa, Mireia, Bargallo, Nuria, Castro-Fornieles, Josefina, Arango, Celso, Penzol, Maria J., Zwiers, Marcel P., Franke, Barbara, Buitelaar, Jan K., Walitza, Susanne, and Brandeis, Daniel

Published
2021
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20. A letter to the editor:The effects of alcohol use on brain glutamate in first episode psychosis

Author

King, Bridget, Kempton, Matthew J., Broberg, Brian V., Merritt, Kate, Barker, Gareth J., Lythgoe, David J., Perez-Iglesias, Rocio, Baandrup, Lone, Düring, Signe W., Stone, James M., Rostrup, Egill, Sommer, Iris E., Glenthøj, Birte, Kahn, René S., Dazzan, Paola, McGuire, Philip K., Egerton, Alice, King, Bridget, Kempton, Matthew J., Broberg, Brian V., Merritt, Kate, Barker, Gareth J., Lythgoe, David J., Perez-Iglesias, Rocio, Baandrup, Lone, Düring, Signe W., Stone, James M., Rostrup, Egill, Sommer, Iris E., Glenthøj, Birte, Kahn, René S., Dazzan, Paola, McGuire, Philip K., and Egerton, Alice

Abstract

Alcohol use in schizophrenia is associated with poorer outcomes, such as increased suicidality and positive symptoms (Lv et al., 2023). Both alcohol use and psychosis have been independently associated with changes in brain glutamate levels. However, whether alcohol use impacts brain glutamate levels in people with psychosis is unknown. Potentially, overlapping glutamatergic pathophysiology could mean that, patients with schizophrenia are more vulnerable to the effects of alcohol.

Published
2024

21. Frontal and occipital brain glutathione levels are unchanged in autistic adults.

Author

Pereira, Andreia C., Leonard, Alison, Velthuis, Hester, Wong, Nichol M. L., Ponteduro, Francesca M., Dimitrov, Mihail, Ellis, Claire L., Kowalewski, Lukasz, Lythgoe, David J., Rotaru, Diana-Georgina, Edden, Richard A. E., Ivin, Glynis, Pretzsch, Charlotte M., Daly, Eileen, Murphy, Declan G. M., and McAlonan, Gráinne M.

Subjects
AUTISM spectrum disorders, PREFRONTAL cortex, OXIDATIVE stress, GLUTATHIONE, ADULTS
Abstract

Background: The neurobiological underpinnings of Autism Spectrum Disorder (ASD) are diverse and likely multifactorial. One possible mechanism is increased oxidative stress leading to altered neurodevelopment and brain function. However, this hypothesis has mostly been tested in post-mortem studies. So far, available in vivo studies in autistic individuals have reported no differences in glutathione (GSH) levels in frontal, occipital, and subcortical regions. However, these studies were limited by the technically challenging quantification of GSH, the main brain antioxidant molecule. This study aimed to overcome previous studies' limitations by using a GSH-tailored spectroscopy sequence and optimised quantification methodology to provide clarity on GSH levels in autistic adults. Methods: We used spectral editing proton-magnetic resonance spectroscopy (1H-MRS) combined with linear combination model fitting to quantify GSH in the dorsomedial prefrontal cortex (DMPFC) and medial occipital cortex (mOCC) of autistic and non-autistic adults (male and female). We compared GSH levels between groups. We also examined correlations between GSH and current autism symptoms, measured using the Autism Quotient (AQ). Results: Data were available from 31 adult autistic participants (24 males, 7 females) and 40 non-autistic participants (21 males, 16 females); the largest sample to date. The GSH levels did not differ between groups in either region. No correlations with AQ were observed. Conclusion: GSH levels as measured using 1H-MRS are unaltered in the DMPFC and mOCC regions of autistic adults, suggesting that oxidative stress in these cortical regions is not a marked neurobiological signature of ASD. [ABSTRACT FROM AUTHOR]

Published
2024
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24. Differences in Intrinsic Gray Matter Connectivity and Their Genomic Underpinnings in Autism Spectrum Disorder

Author

Leyhausen, Johanna, primary, Schäfer, Tim, additional, Gurr, Caroline, additional, Berg, Lisa M., additional, Seelemeyer, Hanna, additional, Pretzsch, Charlotte M., additional, Loth, Eva, additional, Oakley, Bethany, additional, Buitelaar, Jan K., additional, Beckmann, Christian F., additional, Floris, Dorothea L., additional, Charman, Tony, additional, Bourgeron, Thomas, additional, Banaschewski, Tobias, additional, Jones, Emily J.H., additional, Tillmann, Julian, additional, Chatham, Chris, additional, Murphy, Declan G., additional, Ecker, Christine, additional, Ahmad, Jumana, additional, Ambrosino, Sara, additional, Auyeung, Bonnie, additional, Baron-Cohen, Simon, additional, Baumeister, Sarah, additional, Bölte, Sven, additional, Bours, Carsten, additional, Brammer, Michael, additional, Brandeis, Daniel, additional, Brogna, Claudia, additional, de Bruijn, Yvette, additional, Chakrabarti, Bhismadev, additional, Cornelissen, Ineke, additional, Crawley, Daisy, additional, Dell’Acqua, Flavio, additional, Dumas, Guillaume, additional, Durston, Sarah, additional, Faulkner, Jessica, additional, Frouin, Vincent, additional, Garcés, Pilar, additional, Goyard, David, additional, Ham, Lindsay, additional, Hayward, Hannah, additional, Hipp, Joerg, additional, Holt, Rosemary, additional, Johnson, Mark H., additional, Kundu, Prantik, additional, Lai, Meng-Chuan, additional, D’ardhuy, Xavier Liogier, additional, Lombardo, Michael V., additional, Lythgoe, David J., additional, Mandl, René, additional, Marquand, Andre, additional, Mason, Luke, additional, Mennes, Maarten, additional, Meyer-Lindenberg, Andreas, additional, Moessnang, Carolin, additional, Bast, Nico, additional, Murphy, Declan G.M., additional, O’Dwyer, Laurence, additional, Oldehinkel, Marianne, additional, Oranje, Bob, additional, Pandina, Gahan, additional, Persico, Antonio M., additional, Ruggeri, Barbara, additional, Ruigrok, Amber, additional, Sabet, Jessica, additional, Sacco, Roberto, additional, San José Cáceres, Antonia, additional, Simonoff, Emily, additional, Spooren, Will, additional, Toro, Roberto, additional, Tost, Heike, additional, Waldman, Jack, additional, Williams, Steve C.R., additional, Wooldridge, Caroline, additional, and Zwiers, Marcel P., additional

Published
2024
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25. Distinct associations between fronto-striatal glutamate concentrations and callous-unemotional traits and proactive aggression in disruptive behavior

Author

Craig, Michael C., Mulder, Leandra M., Zwiers, Marcel P., Sethi, Arjun, Hoekstra, Pieter J., Dietrich, Andrea, Baumeister, Sarah, Aggensteiner, Pascal M., Banaschewski, Tobias, Brandeis, Daniel, Werhahn, Julia E., Walitza, Susanne, Castro-Fornieles, Josefina, Arango, Celso, Schulze, Ulrike M.E., Glennon, Jeffrey C., Franke, Barbara, Santosh, Paramala J., Mastroianni, Mathilde, van Asten, Jack J.A., Buitelaar, Jan K., Lythgoe, David J., and Naaijen, Jilly

Published
2019
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28. Neurochemical effects of oxytocin in people at clinical high risk for psychosis

Author

Davies, Cathy, Rutigliano, Grazia, De Micheli, Andrea, Stone, James M, Ramella-Cravaro, Valentina, Provenzani, Umberto, Cappucciati, Marco, Scutt, Eleanor, Paloyelis, Yannis, Oliver, Dominic, Murguia, Silvia, Zelaya, Fernando, Allen, Paul, Shergill, Sukhi, Morrison, Paul, Williams, Steve, Taylor, David, Lythgoe, David J, McGuire, Philip, and Fusar-Poli, Paolo

Published
2019
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30. Altered Connectivity Between Cerebellum, Visual, and Sensory-Motor Networks in Autism Spectrum Disorder: Results from the EU-AIMS Longitudinal European Autism Project

Author

Ahmad, Jumana, Ambrosino, Sara, Auyeung, Bonnie, Banaschewski, Tobias, Baron-Cohen, Simon, Baumeister, Sarah, Beckmann, Christian F., Bölte, Sven, Bourgeron, Thomas, Bours, Carsten, Brammer, Michael, Brandeis, Daniel, Brogna, Claudia, de Bruijn, Yvette, Buitelaar, Jan K., Chakrabarti, Bhismadev, Charman, Tony, Cornelissen, Ineke, Crawley, Daisy, Dell’Acqua, Flavio, Dumas, Guillaume, Durston, Sarah, Ecker, Christine, Faulkner, Jessica, Frouin, Vincent, Garcés, Pilar, Goyard, David, Ham, Lindsay, Hayward, Hannah, Hipp, Joerg, Holt, Rosemary, Johnson, Mark H., Jones, Emily J.H., Kundu, Prantik, Lai, Meng-Chuan, Liogier D’ardhuy, Xavier, Lombardo, Michael V., Loth, Eva, Lythgoe, David J., Mandl, René, Marquand, Andre, Mason, Luke, Mennes, Maarten, Meyer-Lindenberg, Andreas, Moessnang, Carolin, Mueller, Nico, Murphy, Declan G.M., Oakley, Bethany, O’Dwyer, Laurence, Oldehinkel, Marianne, Oranje, Bob, Pandina, Gahan, Persico, Antonio M., Ruggeri, Barbara, Ruigrok, Amber, Sabet, Jessica, Sacco, Roberto, Cáceres, Antonia San José, Simonoff, Emily, Spooren, Will, Tillmann, Julian, Toro, Roberto, Tost, Heike, Waldman, Jack, Williams, Steve C.R., Wooldridge, Caroline, and Zwiers, Marcel P.

Published
2019
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32. Histamine-3 Receptor Availability and Glutamate Levels in the Brain: A PET-1H-MRS Study of Patients With Schizophrenia and Healthy Controls.

Author

Arumuham, Atheeshaan, Nour, Matthew M, Veronese, Mattia, Beck, Katherine, Onwordi, Ellis Chika, Lythgoe, David J, Jauhar, Sameer, Rabiner, Eugenii A, and Howes, Oliver D

Subjects
PROTON magnetic resonance spectroscopy, PEOPLE with schizophrenia, POSITRON emission tomography, GLUTAMATE receptors, TRANSLOCATOR proteins, CINGULATE cortex
Abstract

Background The histamine-3 receptor (H3R) may have a role in cognitive processes through its action as a presynaptic heteroreceptor inhibiting the release of glutamate in the brain. To explore this, we examined anterior cingulate cortex (ACC) and striatum H3R availability in patients with schizophrenia and characterized their relationships with glutamate levels in corresponding brain regions. Methods We employed a cross-sectional study, recruiting 12 patients with schizophrenia and 12 healthy volunteers. Participants underwent positron emission tomography using the H3R-specific radio ligand [11C]MK-8278, followed by proton magnetic resonance spectroscopy to measure glutamate levels, recorded as Glu and Glx. Based on existing literature, the ACC and striatum were selected as regions of interest. Results We found significant inverse relationships between tracer uptake and Glu (r = −0.66, P  = .02) and Glx (r = −0.62, P  = .04) levels in the ACC of patients, which were absent in healthy volunteers (Glu: r = −0.19, P  = .56, Glx: r = 0.10, P  = .75). We also found a significant difference in striatal (F1,20 = 6.00, P  = .02) and ACC (F1,19 = 4.75, P  = .04) Glx levels between groups. Conclusions These results provide evidence of a regionally specific relationship between H3Rs and glutamate levels, which builds on existing preclinical literature. Our findings add to a growing literature indicating H3Rs may be a promising treatment target in schizophrenia, particularly for cognitive impairment, which has been associated with altered glutamate signaling. [ABSTRACT FROM AUTHOR]

Published
2024
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40. Hippocampal Glutamate, Resting Perfusion and the Effects of Cannabidiol in Psychosis Risk

Author

Davies, Cathy, primary, Bossong, Matthijs G., additional, Martins, Daniel, additional, Wilson, Robin, additional, Appiah-Kusi, Elizabeth, additional, Blest-Hopley, Grace, additional, Allen, Paul, additional, Zelaya, Fernando, additional, Lythgoe, David J., additional, Brammer, Michael, additional, Perez, Jesus, additional, McGuire, Philip, additional, and Bhattacharyya, Sagnik, additional

Published
2023
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41. A comprehensive guide to mega-press for GABA measurement

Author

Peek, A.L., primary, Rebbeck, T.J., additional, Leaver, A.M., additional, Foster, S.L., additional, Refshauge, K.M., additional, Puts, N.A., additional, Oeltzschner, G., additional, Andronesi, Ovidiu C., additional, Barker, Peter B., additional, Bogner, Wolfgang, additional, Cecil, Kim M., additional, Choi, In-Young, additional, Deelchand, Dinesh K., additional, de Graaf, Robin A., additional, Dydak, Ulrike, additional, Edden, Richard AE., additional, Emir, Uzay E., additional, Harris, Ashley D., additional, Lin, Alexander P., additional, Lythgoe, David J., additional, Mikkelsen, Mark, additional, Mullins, Paul G., additional, Near, Jamie, additional, Öz, Gülin, additional, Rae, Caroline D., additional, Terpstra, Melissa, additional, Williams, Stephen R., additional, and Wilson, Martin, additional

Published
2023
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42. The effects of callous-unemotional traits and aggression subtypes on amygdala activity in response to negative faces – ERRATUM

Author

Aggensteiner, Pascal-M; https://orcid.org/0000-0002-1048-9044, Holz, Nathalie E, Böttinger, Boris W, Baumeister, Sarah, Hohmann, Sarah, Werhahn, Julia E, Naaijen, Jilly, Ilbegi, Shahrzad, Glennon, Jeffrey C, Hoekstra, Pieter J, Dietrich, Andrea, Deters, Renee Kleine, Saam, Melanie C, Schulze, Ulrike M E, Lythgoe, David J, Sethi, Arjun, Craig, Michael C, Mastroianni, Mathilde, Sagar-Ouriaghli, Ilyas, Santosh, Paramala J, Rosa, Mireia, Bargallo, Nuria, Castro-Fornieles, Josefina, Arango, Celso, Penzol, Maria J, Vidal, Jorge, Franke, Barbara, Zwiers, Marcel P, Buitelaar, Jan K, Walitza, Susanne, Banaschewski, Tobias, Brandeis, Daniel, Aggensteiner, Pascal-M; https://orcid.org/0000-0002-1048-9044, Holz, Nathalie E, Böttinger, Boris W, Baumeister, Sarah, Hohmann, Sarah, Werhahn, Julia E, Naaijen, Jilly, Ilbegi, Shahrzad, Glennon, Jeffrey C, Hoekstra, Pieter J, Dietrich, Andrea, Deters, Renee Kleine, Saam, Melanie C, Schulze, Ulrike M E, Lythgoe, David J, Sethi, Arjun, Craig, Michael C, Mastroianni, Mathilde, Sagar-Ouriaghli, Ilyas, Santosh, Paramala J, Rosa, Mireia, Bargallo, Nuria, Castro-Fornieles, Josefina, Arango, Celso, Penzol, Maria J, Vidal, Jorge, Franke, Barbara, Zwiers, Marcel P, Buitelaar, Jan K, Walitza, Susanne, Banaschewski, Tobias, and Brandeis, Daniel

Published
2023

43. Different Whole-Brain Functional Connectivity Correlates of Reactive-Proactive Aggression and Callous-Unemotional Traits in Children and Adolescents with Disruptive Behaviors

Author

Werhahn, Julia E, Smigielski, Lukasz, Sacu, Seda; https://orcid.org/0000-0003-4734-9835, Mohl, Susanna, Willinger, David, Naaijen, Jilly, Mulder, Leandra M, Glennon, Jeffrey C, Hoekstra, Pieter J, Dietrich, Andrea, Deters, Renee Kleine, Aggensteiner, Pascal M, Holz, Nathalie E, Baumeister, Sarah, Banaschewski, Tobias, Saam, Melanie C, Schulze, Ulrike M E, Lythgoe, David J, Sethi, Arjun, Craig, Michael, Mastroianni, Mathilde, Sagar-Ouriaghli, Ilyas, Santosh, Paramala J, Rosa, Mireia, Bargallo, Nuria, Castro-Fornieles, Josefina, Arango, Celso, Penzol, Maria J, Zwiers, Marcel P, Franke, Barbara, Buitelaar, Jan K, Walitza, Susanne; https://orcid.org/0000-0002-8161-8683, Brandeis, Daniel, Werhahn, Julia E, Smigielski, Lukasz, Sacu, Seda; https://orcid.org/0000-0003-4734-9835, Mohl, Susanna, Willinger, David, Naaijen, Jilly, Mulder, Leandra M, Glennon, Jeffrey C, Hoekstra, Pieter J, Dietrich, Andrea, Deters, Renee Kleine, Aggensteiner, Pascal M, Holz, Nathalie E, Baumeister, Sarah, Banaschewski, Tobias, Saam, Melanie C, Schulze, Ulrike M E, Lythgoe, David J, Sethi, Arjun, Craig, Michael, Mastroianni, Mathilde, Sagar-Ouriaghli, Ilyas, Santosh, Paramala J, Rosa, Mireia, Bargallo, Nuria, Castro-Fornieles, Josefina, Arango, Celso, Penzol, Maria J, Zwiers, Marcel P, Franke, Barbara, Buitelaar, Jan K, Walitza, Susanne; https://orcid.org/0000-0002-8161-8683, and Brandeis, Daniel

Abstract

Background: Disruptive behavior in children and adolescents can manifest as reactive aggression and proactive aggression and is modulated by callous-unemotional traits and other comorbidities. Neural correlates of these aggression dimensions or subtypes and comorbid symptoms remain largely unknown. This multi-center study investigated the relationship between resting state functional connectivity (rsFC) and aggression subtypes considering comorbidities. Methods: The large sample of children and adolescents aged 8–18 years (n = 207; mean age = 13.30 ± 2.60 years, 150 males) included 118 cases with disruptive behavior (80 with Oppositional Defiant Disorder and/or Conduct Disorder) and 89 controls. Attention-deficit/hyperactivity disorder (ADHD) and anxiety symptom scores were analyzed as covariates when assessing group differences and dimensional aggression effects on hypothesis-free global and local voxel-to-voxel whole-brain rsFC based on functional magnetic resonance imaging at 3 Tesla. Results: Compared to controls, the cases demonstrated altered rsFC in frontal areas, when anxiety but not ADHD symptoms were controlled. For cases, reactive and proactive aggression scores related to global and local rsFC in the central gyrus and precuneus, regions linked to aggression-related impairments. Callous-unemotional trait severity was correlated with ICC in the inferior and middle temporal regions implicated in empathy, emotion, and reward processing. Most observed aggression subtype-specific patterns could only be identified when ADHD and anxiety were controlled for. Conclusions: This study clarifies that hypothesis-free brain connectivity measures can disentangle distinct though overlapping dimensions of aggression in youths. Moreover, our results highlight the importance of considering comorbid symptoms to detect aggression-related rsFC alterations in youths.

Published
2023

48. Erbb4Deletion From Inhibitory Interneurons Causes Psychosis-Relevant Neuroimaging Phenotypes

Author

Kiemes, Amanda, primary, Serrano Navacerrada, Maria Elisa, additional, Kim, Eugene, additional, Randall, Karen, additional, Simmons, Camilla, additional, Rojo Gonzalez, Loreto, additional, Petrinovic, Marija-Magdalena, additional, Lythgoe, David J, additional, Rotaru, Diana, additional, Di Censo, Davide, additional, Hirschler, Lydiane, additional, Barbier, Emmanuel L, additional, Vernon, Anthony C, additional, Stone, James M, additional, Davies, Cathy, additional, Cash, Diana, additional, and Modinos, Gemma, additional

Published
2022
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49. sj-docx-1-jop-10.1177_02698811231168243 – Supplemental material for Signatures of exposure to childhood trauma in young adults in the structure and neurochemistry of the superior temporal gyrus

Author

Hepsomali, Piril, Machon, Sandra, Barker, Holly, Lythgoe, David J, Hugdahl, Kenneth, Gudbrandsen, Maria, and Allen, Paul

Subjects
FOS: Psychology, FOS: Clinical medicine, 170199 Psychology not elsewhere classified, 110319 Psychiatry (incl. Psychotherapy), 111599 Pharmacology and Pharmaceutical Sciences not elsewhere classified, 110904 Neurology and Neuromuscular Diseases
Abstract

Supplemental material, sj-docx-1-jop-10.1177_02698811231168243 for Signatures of exposure to childhood trauma in young adults in the structure and neurochemistry of the superior temporal gyrus by Piril Hepsomali, Sandra Machon, Holly Barker, David J Lythgoe, Kenneth Hugdahl, Maria Gudbrandsen and Paul Allen in Journal of Psychopharmacology

Published
2023
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50. Reliability of multi-site UK Biobank MRI brain phenotypes for the assessment of neuropsychiatric complications of SARS-CoV-2 infection: The COVID-CNS travelling heads study

Author

Duff, Eugene, Zelaya, Fernando, Almagro, Fidel Alfaro, Miller, Karla L, Martin, Naomi, Nichols, Thomas E, Taschler, Bernd, Griffanti, Ludovica, Arthofer, Christoph, Douaud, Gwenaëlle, Wang, Chaoyue, Okell, Thomas W, Bethlehem, Richard AI, Eickel, Klaus, Günther, Matthias, Menon, David K, Williams, Guy, Facer, Bethany, Lythgoe, David J, Dell'Acqua, Flavio, Wood, Greta K, Williams, Steven CR, Houston, Gavin, Keller, Simon S, Holden, Catherine, Hartmann, Monika, George, Lily, Breen, Gerome, Michael, Benedict D, Jezzard, Peter, Smith, Stephen M, Bullmore, Edward T, COVID-CNS Consortium, Duff, Eugene [0000-0001-8795-5472], Taschler, Bernd [0000-0001-6574-4789], Arthofer, Christoph [0000-0003-1474-9963], Okell, Thomas W [0000-0001-8258-0659], Bethlehem, Richard AI [0000-0002-0714-0685], Eickel, Klaus [0000-0002-5700-2029], Williams, Guy [0000-0001-5223-6654], Facer, Bethany [0000-0001-9214-8229], Jezzard, Peter [0000-0001-7912-2251], and Apollo - University of Cambridge Repository

Subjects
Medicine and health sciences, Research and analysis methods, Phenotype, Biology and life sciences, SARS-CoV-2, Humans, Brain, COVID-19, Reproducibility of Results, Magnetic Resonance Imaging, United Kingdom, Biological Specimen Banks, Research Article
Abstract

Acknowledgements: We thank the volunteers who participated in the travelling heads study and the radiography staff who collected data at all four sites. We thank Fraunhofer MEVIS, Bremen, Germany, for provision of the Siemens 3D-GRASE ASL sequence., Funder: National Institute for Health Research; funder-id: http://dx.doi.org/10.13039/501100000272, Funder: Addenbrooke’s Charitable Trust, Cambridge University Hospitals; funder-id: http://dx.doi.org/10.13039/501100002927, Funder: NIHR Oxford Biomedical Research Centre; funder-id: http://dx.doi.org/10.13039/501100013373, INTRODUCTION: Magnetic resonance imaging (MRI) of the brain could be a key diagnostic and research tool for understanding the neuropsychiatric complications of COVID-19. For maximum impact, multi-modal MRI protocols will be needed to measure the effects of SARS-CoV-2 infection on the brain by diverse potentially pathogenic mechanisms, and with high reliability across multiple sites and scanner manufacturers. Here we describe the development of such a protocol, based upon the UK Biobank, and its validation with a travelling heads study. A multi-modal brain MRI protocol comprising sequences for T1-weighted MRI, T2-FLAIR, diffusion MRI (dMRI), resting-state functional MRI (fMRI), susceptibility-weighted imaging (swMRI), and arterial spin labelling (ASL), was defined in close approximation to prior UK Biobank (UKB) and C-MORE protocols for Siemens 3T systems. We iteratively defined a comparable set of sequences for General Electric (GE) 3T systems. To assess multi-site feasibility and between-site variability of this protocol, N = 8 healthy participants were each scanned at 4 UK sites: 3 using Siemens PRISMA scanners (Cambridge, Liverpool, Oxford) and 1 using a GE scanner (King's College London). Over 2,000 Imaging Derived Phenotypes (IDPs), measuring both data quality and regional image properties of interest, were automatically estimated by customised UKB image processing pipelines (S2 File). Components of variance and intra-class correlations (ICCs) were estimated for each IDP by linear mixed effects models and benchmarked by comparison to repeated measurements of the same IDPs from UKB participants. Intra-class correlations for many IDPs indicated good-to-excellent between-site reliability. Considering only data from the Siemens sites, between-site reliability generally matched the high levels of test-retest reliability of the same IDPs estimated in repeated, within-site, within-subject scans from UK Biobank. Inclusion of the GE site resulted in good-to-excellent reliability for many IDPs, although there were significant between-site differences in mean and scaling, and reduced ICCs, for some classes of IDP, especially T1 contrast and some dMRI-derived measures. We also identified high reliability of quantitative susceptibility mapping (QSM) IDPs derived from swMRI images, multi-network ICA-based IDPs from resting-state fMRI, and olfactory bulb structure IDPs from T1, T2-FLAIR and dMRI data. CONCLUSION: These results give confidence that large, multi-site MRI datasets can be collected reliably at different sites across the diverse range of MRI modalities and IDPs that could be mechanistically informative in COVID brain research. We discuss limitations of the study and strategies for further harmonisation of data collected from sites using scanners supplied by different manufacturers. These acquisition and analysis protocols are now in use for MRI assessments of post-COVID patients (N = 700) as part of the ongoing COVID-CNS study.

Published
2022
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