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20,574 results on '"Lysosome"'

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1. CUL-6/cullin ubiquitin ligase-mediated degradation of HSP-90 by intestinal lysosomes promotes thermotolerance

2. Tau fibrils induce nanoscale membrane damage and nucleate cytosolic tau at lysosomes.

3. Mechanism and cellular function of direct membrane binding by the ESCRT and ERES-associated Ca2+-sensor ALG-2.

4. The progranulin cleavage product granulin 3 exerts a dominant negative effect on animal fitness.

5. Intracellular sphingolipid sorting drives membrane phase separation in the yeast vacuole.

6. VPS4A is the selective receptor for lipophagy in mice and humans.

7. RNA sequencing of Beauveria bassiana JEF-350-infected Thrips palmi reveals change of host defense and homeostasis.

8. CRISPR screens unveil nutrient-dependent lysosomal and mitochondrial nodes impacting intestinal tissue-resident memory CD8+ T cell formation.

9. STAT3 Inhibitor Increases α-Synuclein in PFF-Treated Astroglia Cells by Dysregulating Autophagy and Potentially Affects Exosome Biogenesis.

10. Targeting Lysosomal Thiols for Immunogenic Cancer Cell Death.

11. Elevated N‐glycosylated cathepsin L impairs oocyte function and contributes to oocyte senescence during reproductive aging.

12. Construction of lysosome‐related prognostic signature to predict the survival outcomes and selecting suitable drugs for patients with HNSCC.

13. Cysteine protease cathepsin B promotes lysosome integrity to extend the lifespan of alternative day fasting worms.

14. NKX3-2 Induces Ovarian Cancer Cell Migration by HDAC6-Mediated Repositioning of Lysosomes and Inhibition of Autophagy.

15. 27-Hydroxycholesterol Enhances Secretion of Extracellular Vesicles by ROS-Induced Dysregulation of Lysosomes.

16. Macrophages and autophagy: partners in crime.

17. Lanthanide conjugate Pr-MPO elicits anti-cancer activity by targeting lysosomal machinery and inducing zinc-dependent cataplerosis.

18. A TBK1-independent primordial function of STING in lysosomal biogenesis.

19. The Knowns and Unknowns of Membrane Features and Changes During Autophagosome–Lysosome/Vacuole Fusion.

20. Methuosis Inducer SGI‐1027 Cooperates with Everolimus to Promote Apoptosis and Pyroptosis by Triggering Lysosomal Membrane Permeability in Renal Cancer.

21. Integrative analysis reveals key lysosomal genes as potential therapeutic targets in Alzheimer's disease.

22. History and Perspective of LAMP-2 Deficiency (Danon Disease).

23. Myelin basic protein antagonizes the SARS-CoV-2 protein ORF3a-induced autophagy inhibition.

24. The Azalea Hypothesis of Alzheimer Disease: A Functional Iron Deficiency Promotes Neurodegeneration.

25. Transcription factor EB, a promising therapeutic target in cardiovascular disease.

26. Targeting PNPO to suppress tumor growth via inhibiting autophagic flux and to reverse paclitaxel resistance in ovarian cancer.

27. The novel TFEB agonist desloratadine ameliorates hepatic steatosis by activating the autophagy-lysosome pathway.

28. An initial HOPS-mediated fusion event is critical for autophagosome transport initiation from the axon terminal.

29. Empagliflozin protects the kidney by reducing toxic ALB (albumin) exposure and preventing autophagic stagnation in proximal tubules.

30. Senescence in the ageing skin: a new focus on mTORC1 and the lysosome.

31. The p53 target DRAM1 modulates calcium homeostasis and ER stress by promoting contact between lysosomes and the ER through STIM1.

32. Endolysosomal channel TMEM175 mediates antitoxin activity of DABMA.

33. Lysosomal TBK1 responds to amino acid availability to relieve Rab7-dependent mTORC1 inhibition.

34. Divergent effects of acute and chronic PPT1 inhibition in melanoma.

35. Lysosome quality control in health and neurodegenerative diseases.

36. Molecular mechanism and potential role of mitophagy in acute pancreatitis.

37. The role of lysosomal membrane proteins in autophagy and related diseases.

38. Feeding Mechanisms of Pathogenic Protozoa with a Focus on Endocytosis and the Digestive Vacuole.

39. Bafilomycin A1 Inhibits HIV-1 Infection by Disrupting Lysosomal Cholesterol Transport.

40. Post‐Transcriptional Regulation of Rab7a in Lysosomal Positioning and Drug Resistance in Nutrient‐Limited Cancer Cells.

41. Elongation of Very Long-Chain Fatty Acids (ELOVL) in Atopic Dermatitis and the Cutaneous Adverse Effect AGEP of Drugs.

42. Human fibroblasts from sporadic Alzheimer's disease (AD) patients show mitochondrial alterations and lysosome dysfunction.

43. Effects of lysosomal Fe2+ on mitochondria apoptosis and muscle tenderness in postmortem Tibetan sheep meat.

44. Lanthanide conjugate Pr-MPO elicits anti-cancer activity by targeting lysosomal machinery and inducing zinc-dependent cataplerosis

45. Searching for novel cellular targets for MASLD and HCC within the humble lysosomal cathepsins

46. Molecular mechanism and potential role of mitophagy in acute pancreatitis

47. Lysosome quality control in health and neurodegenerative diseases

48. Intermediate cystinosis: a case report of 10-year treatment with cysteamine

49. β-Elemene induced ferroptosis via TFEB-mediated GPX4 degradation in EGFR wide-type non-small cell lung cancer

50. Feeding Mechanisms of Pathogenic Protozoa with a Focus on Endocytosis and the Digestive Vacuole

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