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3. Association between dietary macronutrient composition and plasma one-carbon metabolites and B-vitamin cofactors in patients with stable angina pectoris

Author

Bråtveit, Marianne, primary, Van Parys, Anthea, additional, Olsen, Thomas, additional, Strand, Elin, additional, Marienborg, Ingvild, additional, Laupsa-Borge, Johnny, additional, Haugsgjerd, Teresa Risan, additional, McCann, Adrian, additional, Dhar, Indu, additional, Ueland, Per Magne, additional, Dierkes, Jutta, additional, Dankel, Simon Nitter, additional, Nygård, Ottar Kjell, additional, and Lysne, Vegard, additional

Published
2024
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8. Time-resolved concentrations of serum amino acids, one-carbon metabolites and B-vitamin biomarkers during the postprandial and fasting state: the Postprandial Metabolism in Healthy Young Adults (PoMet) Study.

Author

Anfinsen, Åslaug Matre, Johannesen, Christina Osland, Myklebust, Vilde Haugen, Rosendahl-Riise, Hanne, McCann, Adrian, Nygård, Ottar Kjell, Dierkes, Jutta, and Lysne, Vegard

Subjects
BIOMARKERS, FASTING, CLINICAL pathology, BRANCHED chain amino acids, CARBON, FOOD consumption, BLOOD collection, BLOOD sugar, VITAMIN B complex, AMINO acids, METABOLITES
Abstract

Metabolomics has been utilised in epidemiological studies to investigate biomarkers of nutritional status and metabolism in relation to non-communicable diseases. However, little is known about the effect of prandial status on several biomarker concentrations. Therefore, the aim of this intervention study was to investigate the effect of a standardised breakfast meal followed by food abstinence for 24 h on serum concentrations of amino acids, one-carbon metabolites and B-vitamin biomarkers. Thirty-four healthy subjects (eighteen males and sixteen females) aged 20–30 years were served a breakfast meal (∼500 kcal) after which they consumed only water for 24 h. Blood samples were drawn before and at thirteen standardised timepoints after the meal. Circulating concentrations of most amino acids and metabolites linked to one-carbon metabolism peaked within the first 3 h after the meal. The branched-chain amino acids steadily increased from 6 or 8 hours after the meal, while proline decreased in the same period. Homocysteine and cysteine concentrations immediately decreased after the meal but steadily increased from 3 and 4 hours until 24 h. FMN and riboflavin fluctuated immediately after the meal but increased from 6 h, while folate increased immediately after the meal and remained elevated during the 24 h. Our findings indicate that accurate reporting of time since last meal is crucial when investigating concentrations of certain amino acids and one-carbon metabolites. Our results suggest a need for caution when interpretating studies, which utilise such biomarkers, but do not strictly control for time since the last meal. [ABSTRACT FROM AUTHOR]

Published
2024
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10. Time-Resolved Concentrations of Serum Amino Acids, One-carbon Metabolites, and B-vitamin Biomarkers during the Postprandial and Fasting State: The Postprandial Metabolism in Healthy Young Adults (PoMet) study

Author

Anfinsen, Åslaug M., primary, Johannesen, Christina O., additional, Myklebust, Vilde H., additional, Rosendahl-Riise, Hanne, additional, McCann, Adrian, additional, Nygård, Ottar, additional, Dierkes, Jutta, additional, and Lysne, Vegard, additional

Published
2023
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13. Plasma methylmalonic acid predicts risk of acute myocardial infarction and mortality in patients with coronary heart disease: A prospective 2‐cohort study

Author

Dhar, Indu, primary, Lysne, Vegard, additional, Ulvik, Arve, additional, Svingen, Gard F. T., additional, Pedersen, Eva R., additional, Bjørnestad, Espen Ø., additional, Olsen, Thomas, additional, Borsholm, Robert, additional, Laupsa‐Borge, Johnny, additional, Ueland, Per M., additional, Tell, Grethe S., additional, Berge, Rolf K., additional, Mellgren, Gunnar, additional, Bønaa, Kaare H., additional, and Nygård, Ottar K, additional

Published
2023
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14. Cystatin C proteoforms in chronic kidney disease

Author

Dahl, Helene, primary, Meyer, Klaus, additional, Sandnes, Kristina, additional, Welland, Natasha Lervaag, additional, Arnesen, Iselin, additional, Marti, Hans-Peter, additional, Dierkes, Jutta, additional, and Lysne, Vegard, additional

Published
2023
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17. The association between dairy intake and risk of cardiovascular disease and mortality in patients with stable angina pectoris

Author

Van Parys, Anthea, primary, Sæle, Jostein, additional, Puaschitz, Nathalie G, additional, Anfinsen, Åslaug Matre, additional, Karlsson, Therese, additional, Olsen, Thomas, additional, Haugsgjerd, Teresa R, additional, Vinknes, Kathrine J, additional, Holven, Kirsten B, additional, Dierkes, Jutta, additional, Nygård, Ottar K, additional, and Lysne, Vegard, additional

Published
2022
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18. Sixteen-week multicentre randomised controlled trial to study the effect of the consumption of an oat beta-glucan-enriched bread versus a whole-grain wheat bread on glycaemic control among persons with pre-diabetes: a study protocol of the CarbHealth study

Author

Hjorth, Therese, primary, Schadow, Alena, additional, Revheim, Ingrid, additional, Spielau, Ulrike, additional, Thomassen, Lise M, additional, Meyer, Klara, additional, Piotrowski, Katja, additional, Rosendahl-Riise, Hanne, additional, Rieder, Anne, additional, Varela, Paula, additional, Lysne, Vegard, additional, Ballance, Simon, additional, Koerner, Antje, additional, Landberg, Rikard, additional, Buyken, Anette, additional, and Dierkes, Jutta, additional

Published
2022
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19. Sixteen-week multicentre randomised controlled trial to study the effect of the consumption of an oat beta-glucan- enriched bread versus a whole-grain wheat bread on glycaemic control among persons with pre-diabetes: a study protocol of the CarbHealth study

Author

Hjorth, Therese, Schadow, Alena, Revheim, Ingrid, Spielau, Ulrike, Thomassen, Lise M, Meyer, Klara, Piotrowski, Katja, Rosendahl-Riise, Hanne, Rieder, Anne, Varela, Paula, Lysne, Vegard, Ballance, Simon, Koerner, Antje, Landberg, Rikard, Buyken, Anette, Dierkes, Jutta, Hjorth, Therese, Schadow, Alena, Revheim, Ingrid, Spielau, Ulrike, Thomassen, Lise M, Meyer, Klara, Piotrowski, Katja, Rosendahl-Riise, Hanne, Rieder, Anne, Varela, Paula, Lysne, Vegard, Ballance, Simon, Koerner, Antje, Landberg, Rikard, Buyken, Anette, and Dierkes, Jutta

Abstract

Introduction In 2012, the estimated global prevalence of pre-diabetes was 280 million, and the prevalence is expected to rise to 400 million by 2030. Oat-based foods are a good source of beta-glucans, which have been shown to lower postprandial blood glucose. Studies to evaluate the effectiveness of the long-term intake of beta-glucan- enriched bread as part of a habitual diet among individuals with pre-diabetes are needed. Therefore, we designed a multicentre intervention study in adults with pre-diabetes to investigate the effects of consumption of an oat-derived beta-glucan- enriched bread as part of a normal diet on glycated haemoglobin (HbA1c) in comparison to consumption of whole-grain wheat bread. Methods and analysis The CarbHealth trial is a multicentre double-blind randomised controlled 16-week dietary intervention trial in participants 40–70 years of age with a body mass index of ≥27 kg/m2 and HbA1c of 35–50 mmol/ mol. The study is conducted at four universities located in Norway, Sweden and Germany and uses intervention breads specifically designed for the trial by Nofima AS. The aim is to recruit 250 participants. The primary outcome is the difference in HbA1c between the intervention and the control groups. The main analysis will include intervention group, study centre and baseline HbA1c as independent variables in an analysis of covariance model. Ethics and dissemination The study protocol was approved by respective ethical authorities in participating countries. The results of the study will be communicated through publication in international scientific journals and presentations at (inter)national conferences. Trial registration number NCT04994327.

Published
2022

25. Assessment of Dietary Choline Intake, Contributing Food Items, and Associations with One-Carbon and Lipid Metabolites in Middle-Aged and Elderly Adults: The Hordaland Health Study

Author

Van Parys, Anthea, primary, Brække, Maria Sandvik, additional, Karlsson, Therese, additional, Vinknes, Kathrine J, additional, Tell, Grethe S, additional, Haugsgjerd, Teresa R, additional, Ueland, Per Magne, additional, Øyen, Jannike, additional, Dierkes, Jutta, additional, Nygård, Ottar, additional, and Lysne, Vegard, additional

Published
2022
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27. Metodehjørnet

Author

Lysne, Vegard, primary, Kværner, Ane Sørlie, additional, and Olsen, Thomas, additional

Published
2021
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30. Vitamin B12 -- a scoping review for Nordic Nutrition Recommendations 2023.

Author

Bjørke-Monsen, Anne-Lise and Lysne, Vegard

Subjects
*BIOMARKERS, *VITAMIN B12, *BREAST milk, *DIET, *PREGNANT women, *NEURAL development, *VITAMIN B12 deficiency
Abstract

Vitamin B12 (cobalamin) is essential for normal metabolic function, and even moderate deficiency of this vitamin has negative health effects. Vitamin B12 is found in animal foods, and as vegetarian diets are increasingly popular in Western countries, one might expect a higher prevalence of vitamin B12 deficiency in the Nordic population. Setting recommendations for vitamin B12 intake has proven to be difficult, as uptake of vitamin B12 varies substantially, the clinical deficiency symptoms are often diffuse, and there is no clear agreement on the decision limits for vitamin B12 deficiency. Vitamin B12 deficiency is reported to be particularly common among pregnant women and infants, despite the fact that less than 1% of Norwegian pregnant women have a cobalamin intake below the Nordic Nutrition Recommendations 2012-recommended level of 2.0 µg/day. In addition, the assumption that breast milk contains sufficient vitamin B12 for optimal health and neurodevelopment during the first 6 months of life does not comply with the high prevalence of insufficient vitamin B12 status in this age group. Recommended intakes of vitamin B12 vary among age groups and must be based on markers of cobalamin status, indicating an optimal intracellular biochemical status, and not merely absence of clinical signs of vitamin B12 deficiency. [ABSTRACT FROM AUTHOR]

Published
2023
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39. Disputassammendrag

Author

Ane Sørlie Kværner, Vegard Lysne Vegard Lysne, and Thomas Olsen

Published
2018

41. Metodehjørne

Author

Lysne, Vegard, primary, Olsen, Thomas, additional, and Kværner, Ane Sørlie, additional

Published
2020
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42. Intake of carbohydrates and SFA and risk of CHD in middle-age adults: the Hordaland Health Study (HUSK).

Author

Haugsgjerd, Teresa R, Egeland, Grace M, Nygård, Ottar K, Igland, Jannicke, Sulo, Gerhard, Lysne, Vegard, Vinknes, Kathrine J, Bjornevik, Kjetil, and Tell, Grethe S

Subjects
CARBOHYDRATES, FAT, PHYSICAL activity, ADULTS, RESEARCH, RESEARCH methodology, DIET, EVALUATION research, COMPARATIVE studies, QUESTIONNAIRES, DIETARY carbohydrates, DIETARY fats, LONGITUDINAL method
Abstract

Objective: Limiting SFA intake may minimise the risk of CHD. However, such reduction often leads to increased intake of carbohydrates. We aimed to evaluate associations and the interplay of carbohydrate and SFA intake on CHD risk.Design: Prospective cohort study.Setting: We followed participants in the Hordaland Health Study, Norway from 1997-1999 through 2009. Information on carbohydrate and SFA intake was obtained from a FFQ and analysed as continuous and categorical (quartiles) variables. Multivariable Cox regression estimated hazard ratios (HR) and 95 % CI. Theoretical substitution analyses modelled the substitution of carbohydrates with other nutrients. CHD was defined as fatal or non-fatal CHD (ICD9 codes 410-414 and ICD10 codes I20-I25).Participants: 2995 men and women, aged 46-49 years.Results: Adjusting for age, sex, energy intake, physical activity and smoking, SFA was associated with lower risk (HRQ4 v. Q1 0·44, 95 % CI 0·26, 0·76, Ptrend = 0·002). For carbohydrates, the opposite pattern was observed (HRQ4 v. Q1 2·10, 95 % CI 1·22, 3·63, Ptrend = 0·003). SFA from cheese was associated with lower CHD risk (HRQ4 v. Q1 0·44, 95 % CI 0·24, 0·83, Ptrend = 0·006), while there were no associations between SFA from other food items and CHD. A 5 E% substitution of carbohydrates with total fat, but not SFA, was associated with lower CHD risk (HR 0·75, 95 % CI 0·62, 0·90).Conclusions: Higher intake of predominantly high glycaemic carbohydrates and lower intake of SFA, specifically lower intake from cheese, were associated with higher CHD risk. Substituting carbohydrates with total fat, but not SFA, was associated with significantly lower risk of CHD. [ABSTRACT FROM AUTHOR]

Published
2022
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