Search

Your search keyword '"Lyons, Jennifer K."' showing total 22 results
Start Over Author "Lyons, Jennifer K."
22 results on '"Lyons, Jennifer K."'

2. MegaPro, a clinically translatable nanoparticle for in vivo tracking of stem cell implants in pig cartilage defects

Author

Suryadevara, Vidyani, primary, Hajipour, Mohammad Javad, additional, Adams, Lisa C., additional, Aissaoui, Nour Mary, additional, Rashidi, Ali, additional, Kiru, Louise, additional, Theruvath, Ashok J., additional, Huang, Ching‐Hsin, additional, Maruyama, Masahiro, additional, Tsubosaka, Masanori, additional, Lyons, Jennifer K., additional, Wu, Wei (Emma), additional, Roudi, Raheleh, additional, Goodman, Stuart B., additional, and Daldrup‐Link, Heike E., additional

Published
2023
Full Text
View/download PDF

3. Manganese-Enhanced cardiac MRI (MEMRI) tracks long-term in vivo survival and restorative benefit of transplanted human Amnion-Derived Mesenchymal Stem Cells (hAMSC) after porcine ischemia-reperfusion injury

Author

Dash Rajesh, Kim Paul J, Matsuura Yuka, Ge Xiaohu, Ikeno Fumiaki, Lyons Jennifer K, Huang Ngan F, Metzler Scott, Nguyen Patricia, Heidary Shahriar, Parent Marie-Claude, Yamamoto Tomoaki, Cooke John, Ruiz-Lozano Pilar, Robbins Robert C, Wu Joseph C, McConnell Michael V, Yeung Alan, Harnish Phillip, and Yang Phillip C

Subjects
Diseases of the circulatory (Cardiovascular) system, RC666-701
Published
2013
Full Text
View/download PDF

4. Manganese-enhanced MRI detects live human amnion-derived mesenchymal stem cells in vivo after transplantation and restoration of myocardial function in a pig ischemia-reperfusion injury model

Author

Dash Rajesh, Toma Ildiko, Ikeno Fumiaki, Lyons Jennifer K, Heidary Shahriar, Parent Marie-Claude, Wang INing E, Ge Xiaohu, Chung Jaehoon, Lam Justin, Kim Paul J, Nakagawa Kaori, Lyalina Svetlana, Do Grace, Robbins Robert C, McConnell Michael V, Yeung Alan, Harnish Phillip, and Yang Phillip C

Subjects
Diseases of the circulatory (Cardiovascular) system, RC666-701
Published
2012
Full Text
View/download PDF

7. Differences in Vascular Response between Balloon Overstretch and Stent Overexpansion in Nonatherosclerotic Porcine Coronary Arteries

Author

Mitsutake, Yoshiaki, Reifart, Jörg, Pyun, Wook Bum, Lyons, Jennifer K, Deuse, Tobias, Schrepfer, Sonja, and Ikeno, Fumiaki

Subjects
Time Factors, Sus scrofa, Swine Model, Coronary Angiography, Coronary Vessels, Plaque, Atherosclerotic, Coronary Restenosis, Disease Models, Animal, Neointima, Animals, Female, Stents, Angioplasty, Balloon, Coronary, Tomography, Optical Coherence, Ultrasonography, Interventional
Abstract

Which preclinical models are best suited for restenosis research remains uncertain. Here we compared the restenotic responses after balloon or stent overstretch injury in a porcine coronary artery. A total of 30 coronary lesions in 5 pigs were treated by balloon overdilatation or oversized stent implantation at various balloon-to-artery (B:A) ratios. Four weeks later, the lesions were examined in vivo by using coronary angiography, intravascular ultrasound, and optical coherence tomography (OCT). At follow-up, the lumen area stenosis and plaque burden at the minimal lumen area site were greater in stented sites than in balloon injury site (lumen area stenosis, 21.7 ± 8.9% compared with 32.8 ± 12.1%; plaque burden, 30.1% ± 10.1% compared with 44.7% ± 10.1%, respectively). The remodeling index was significantly smaller for the balloon-injury group than the stent group (0.86 ± 0.11 compared with 1.00 ± 0.04). Only the stent group that was dilated at a high B:A ratio resulted in increased plaque burden. In the balloon-injury sites, high B:A ratios were significantly associated with greater negative remodeling. Tissue morphology assessment by OCT revealed that the predominant pattern in balloon injury sites was homogeneous, whereas that in stented sites was a layered to heterogeneous pattern. Neointimal proliferation was significantly greater after oversized stenting than after balloon overstretch injury. Together these findings suggest that stent overexpansion of porcine coronary arteries might be appropriate for researching restenosis than is the balloon overstretch injury model.

Published
2017

8. Multimodality Molecular Imaging of Cardiac Cell Transplantation: Part II. In Vivo Imaging of Bone Marrow Stromal Cells in Swine with PET/CT and MR Imaging

Author

Parashurama, Natesh, primary, Ahn, Byeong-Cheol, additional, Ziv, Keren, additional, Ito, Ken, additional, Paulmurugan, Ramasamy, additional, Willmann, Jürgen K., additional, Chung, Jaehoon, additional, Ikeno, Fumiaki, additional, Swanson, Julia C., additional, Merk, Denis R., additional, Lyons, Jennifer K., additional, Yerushalmi, David, additional, Teramoto, Tomohiko, additional, Kosuge, Hisanori, additional, Dao, Catherine N., additional, Ray, Pritha, additional, Patel, Manishkumar, additional, Chang, Ya-fang, additional, Mahmoudi, Morteza, additional, Cohen, Jeff Eric, additional, Goldstone, Andrew Brooks, additional, Habte, Frezghi, additional, Bhaumik, Srabani, additional, Yaghoubi, Shahriar, additional, Robbins, Robert C., additional, Dash, Rajesh, additional, Yang, Phillip C., additional, Brinton, Todd J., additional, Yock, Paul G., additional, McConnell, Michael V., additional, and Gambhir, Sanjiv S., additional

Published
2016
Full Text
View/download PDF

9. Multimodality Molecular Imaging of Cardiac Cell Transplantation: Part I. Reporter Gene Design, Characterization, and Optical in Vivo Imaging of Bone Marrow Stromal Cells after Myocardial Infarction

Author

Parashurama, Natesh, primary, Ahn, Byeong-Cheol, additional, Ziv, Keren, additional, Ito, Ken, additional, Paulmurugan, Ramasamy, additional, Willmann, Jürgen K., additional, Chung, Jaehoon, additional, Ikeno, Fumiaki, additional, Swanson, Julia C., additional, Merk, Denis R., additional, Lyons, Jennifer K., additional, Yerushalmi, David, additional, Teramoto, Tomohiko, additional, Kosuge, Hisanori, additional, Dao, Catherine N., additional, Ray, Pritha, additional, Patel, Manishkumar, additional, Chang, Ya-fang, additional, Mahmoudi, Morteza, additional, Cohen, Jeff Eric, additional, Goldstone, Andrew Brooks, additional, Habte, Frezghi, additional, Bhaumik, Srabani, additional, Yaghoubi, Shahriar, additional, Robbins, Robert C., additional, Dash, Rajesh, additional, Yang, Phillip C., additional, Brinton, Todd J., additional, Yock, Paul G., additional, McConnell, Michael V., additional, and Gambhir, Sanjiv S., additional

Published
2016
Full Text
View/download PDF

10. Manganese‐Enhanced Magnetic Resonance Imaging Enables In Vivo Confirmation of Peri‐Infarct Restoration Following Stem Cell Therapy in a Porcine Ischemia–Reperfusion Model

Author

Dash, Rajesh, primary, Kim, Paul J., additional, Matsuura, Yuka, additional, Ikeno, Fumiaki, additional, Metzler, Scott, additional, Huang, Ngan F., additional, Lyons, Jennifer K., additional, Nguyen, Patricia K., additional, Ge, Xiaohu, additional, Wong Po Foo, Cheryl, additional, McConnell, Michael V., additional, Wu, Joseph C., additional, Yeung, Alan C., additional, Harnish, Phillip, additional, and Yang, Phillip C., additional

Published
2015
Full Text
View/download PDF

12. Dual Manganese-Enhanced and Delayed Gadolinium-Enhanced MRI Detects Myocardial Border Zone Injury in a Pig Ischemia-Reperfusion Model

Author

Dash, Rajesh, primary, Chung, Jaehoon, additional, Ikeno, Fumiaki, additional, Hahn-Windgassen, Annett, additional, Matsuura, Yuka, additional, Bennett, Mihoko V., additional, Lyons, Jennifer K., additional, Teramoto, Tomohiko, additional, Robbins, Robert C., additional, McConnell, Michael V., additional, Yeung, Alan C., additional, Brinton, Todd J., additional, Harnish, Phillip P., additional, and Yang, Phillip C., additional

Published
2011
Full Text
View/download PDF

13. Preclinical Derivation and Imaging of Autologously Transplanted Canine Induced Pluripotent Stem Cells

Author

Lee, Andrew S., primary, Xu, Dan, additional, Plews, Jordan R., additional, Nguyen, Patricia K., additional, Nag, Divya, additional, Lyons, Jennifer K., additional, Han, Leng, additional, Hu, Shijun, additional, Lan, Feng, additional, Liu, Junwei, additional, Huang, Mei, additional, Narsinh, Kazim H., additional, Long, Charles T., additional, de Almeida, Patricia E., additional, Levi, Benjamin, additional, Kooreman, Nigel, additional, Bangs, Charles, additional, Pacharinsak, Cholawat, additional, Ikeno, Fumiaki, additional, Yeung, Alan C., additional, Gambhir, Sanjiv S., additional, Robbins, Robert C., additional, Longaker, Michael T., additional, and Wu, Joseph C., additional

Published
2011
Full Text
View/download PDF

16. Corrigendum to ‘‘The conversion in application of percutaneous coronary intervention following the introduction of drug eluting stents” [International Journal of Cardiology 113/2 (2006) 279–280]

Author

Ikeno, Fumiaki, primary, Shabari, Farshad Raissi, additional, Sadoughi, Ali, additional, Lyons, Jennifer K., additional, Pourdehmobed, Kourosh, additional, Hashemi, Vahideh, additional, Emami, Sacha, additional, Kaneda, Hideaki, additional, Yeung, Alan C., additional, and Rezaee, Mehrdad, additional

Published
2007
Full Text
View/download PDF

17. Arteriotomy closure device application following percutaneous coronary intervention may prevent bleeding complications in patients with acute myocardial infarction

Author

Ikeno, Fumiaki, primary, Ali Sadoughi, M., additional, Lyons, Jennifer K., additional, Raissi Shabari, Farshad, additional, Pourdehmobed, Kourosh, additional, Hashemi, Vahideh, additional, Emami, Sacha, additional, Kaneda, Hideaki, additional, Yeung, Alan C., additional, and Rezaee, Mehrdad, additional

Published
2007
Full Text
View/download PDF

20. Percutaneous endocardial versus selective coronary venous cellular delivery: Comparisons of transplant efficiency, distribution, and efficacy in reducing infarct size and improving myocardial function

Author

Price, Erik T., primary, Ikeno, Fumiaki, additional, Fenn, Ralph C., additional, Chu, Pauline, additional, Lyons, Jennifer K., additional, Fitzgerald, Peter J., additional, Yeung, Alan C., additional, Yock, Paul G., additional, and Rezaee, Mehrdad, additional

Published
2003
Full Text
View/download PDF

21. Differences in Vascular Response between Balloon Overstretch and Stent Overexpansion in Nonatherosclerotic Porcine Coronary Arteries.

Author

Mitsutake Y, Reifart J, Pyun WB, Lyons JK, Deuse T, Schrepfer S, and Ikeno F

Subjects
Animals, Coronary Angiography, Coronary Restenosis diagnostic imaging, Coronary Restenosis pathology, Coronary Vessels diagnostic imaging, Disease Models, Animal, Female, Sus scrofa, Time Factors, Tomography, Optical Coherence, Ultrasonography, Interventional, Angioplasty, Balloon, Coronary adverse effects, Angioplasty, Balloon, Coronary instrumentation, Coronary Restenosis etiology, Coronary Vessels pathology, Neointima, Plaque, Atherosclerotic, Stents
Abstract

Which preclinical models are best suited for restenosis research remains uncertain. Here we compared the restenotic responses after balloon or stent overstretch injury in a porcine coronary artery. A total of 30 coronary lesions in 5 pigs were treated by balloon overdilatation or oversized stent implantation at various balloon-to-artery (B:A) ratios. Four weeks later, the lesions were examined in vivo by using coronary angiography, intravascular ultrasound, and optical coherence tomography (OCT). At follow-up, the lumen area stenosis and plaque burden at the minimal lumen area site were greater in stented sites than in balloon injury site (lumen area stenosis, 21.7 ± 8.9% compared with 32.8 ± 12.1%; plaque burden, 30.1% ± 10.1% compared with 44.7% ± 10.1%, respectively). The remodeling index was significantly smaller for the balloon-injury group than the stent group (0.86 ± 0.11 compared with 1.00 ±0.04). Only the stent group that was dilated at a high B:A ratio resulted in increased plaque burden. In the balloon-injury sites, high B:A ratios were significantly associated with greater negative remodeling. Tissue morphology assessment by OCT revealed that the predominant pattern in balloon injury sites was homogeneous, whereas that in stented sites was a layered to heterogeneous pattern. Neointimal proliferation was significantly greater after oversized stenting than after balloon overstretch injury. Together these findings suggest that stent overexpansion of porcine coronary arteries might be appropriate for researching restenosis than is the balloon overstretch injury model.

Published
2017

22. The porcine restenosis model using thermal balloon injury: comparison with the model by coronary stenting.

Author

Suzuki Y, Lyons JK, Yeung AC, and Ikeno F

Subjects
Animals, Coronary Angiography, Coronary Vessels diagnostic imaging, Disease Models, Animal, Reproducibility of Results, Swine, Ultrasonography, Interventional, Angioplasty, Balloon, Coronary adverse effects, Coronary Restenosis etiology, Stents adverse effects
Abstract

Background: Percutaneous coronary intervention (PCI) continues to revolutionize the treatment of coronary atherosclerosis and technologic advances require a preclinical coronary stenosis model. The purpose of this study was to systematically evaluate a porcine restenosis model of thermal balloon injury compared to stent overstretching., Methods: To evaluate this injury model, 22 swine were utilized. For the induction of coronary stenoses, the thermal balloon-to-artery ratio was equal to the range of 1.2-1.3 and was placed at a desired location in the coronary arteries, inflated with 2 atm, and heated to 80 degrees C for 80 seconds. Quantitative coronary angiography was analyzed at baseline, immediately postprocedure, and 4 weeks at harvest. Quantitative coronary ultrasound analysis and histopathologic evaluation were also performed at 4 weeks postprocedure., Results: A total of 54 coronary arteries (thermal balloon injury [Thermo]; n = 43, coronary stenting [Stent]; n = 11) from a total of 18 animals were analyzed for this study. At 4 weeks postprocedure, significantly greater coronary stenoses were observed in the Thermo Group versus the Stent Group (minimum lumen diameter: 1.00 % 0.63 mm vs. 1.58 % 0.44 mm; p = 0.009, % diameter stenosis [DS]: 66.2 +/- 21.6% vs. 48.1 +/- 11.4%; p = 0.02). There were significant linear correlations between the balloon-to-artery ratio, post %DS and %DS at 4 weeks (balloon-to-artery ratio; r = 0.538; p = 0.0012, post %DS; r = -0.744; p < 0.0001, respectively)., Conclusion: This methodology may provide reproducible and consistent coronary stenoses. This model can be useful fnot only for the evaluation of medical devices, but also for technical training in PCI and development of coronary imaging technologies.

Published
2008

Catalog

Books, media, physical & digital resources
See catalog results