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12 results on '"Lyng, F.M."'

2. Comparability of Raman Spectroscopic Configurations: A Large Scale Cross-Laboratory Study

Author

Guo, S. Beleites, C. Neugebauer, U. Abalde-Cela, S. Afseth, N.K. Alsamad, F. Anand, S. Araujo-Andrade, C. Aškrabić, S. Avci, E. Baia, M. Baranska, M. Baria, E. Batista De Carvalho, L.A.E. De Bettignies, P. Bonifacio, A. Bonnier, F. Brauchle, E.M. Byrne, H.J. Chourpa, I. Cicchi, R. Cuisinier, F. Culha, M. Dahms, M. David, C. Duponchel, L. Duraipandian, S. El-Mashtoly, S.F. Ellis, D.I. Eppe, G. Falgayrac, G. Gamulin, O. Gardner, B. Gardner, P. Gerwert, K. Giamarellos-Bourboulis, E.J. Gizurarson, S. Gnyba, M. Goodacre, R. Grysan, P. Guntinas-Lichius, O. Helgadottir, H. Grošev, V.M. Kendall, C. Kiselev, R. Kölbach, M. Krafft, C. Krishnamoorthy, S. Kubryck, P. Lendl, B. Loza-Alvarez, P. Lyng, F.M. Machill, S. Malherbe, C. Marro, M. Marques, M.P.M. Matuszyk, E. Morasso, C.F. Moreau, M. Muhamadali, H. Mussi, V. Notingher, I. Pacia, M.Z. Pavone, F.S. Penel, G. Petersen, D. Piot, O. Rau, J.V. Richter, M. Rybarczyk, M.K. Salehi, H. Schenke-Layland, K. Schlücker, S. Schosserer, M. Schütze, K. Sergo, V. Sinjab, F. Smulko, J. Sockalingum, G.D. Stiebing, C. Stone, N. Untereiner, V. Vanna, R. Wieland, K. Popp, J. Bocklitz, T.

Abstract

The variable configuration of Raman spectroscopic platforms is one of the major obstacles in establishing Raman spectroscopy as a valuable physicochemical method within real-world scenarios such as clinical diagnostics. For such real world applications like diagnostic classification, the models should ideally be usable to predict data from different setups. Whether it is done by training a rugged model with data from many setups or by a primary-replica strategy where models are developed on a 'primary' setup and the test data are generated on 'replicate' setups, this is only possible if the Raman spectra from different setups are consistent, reproducible, and comparable. However, Raman spectra can be highly sensitive to the measurement conditions, and they change from setup to setup even if the same samples are measured. Although increasingly recognized as an issue, the dependence of the Raman spectra on the instrumental configuration is far from being fully understood and great effort is needed to address the resulting spectral variations and to correct for them. To make the severity of the situation clear, we present a round robin experiment investigating the comparability of 35 Raman spectroscopic devices with different configurations in 15 institutes within seven European countries from the COST (European Cooperation in Science and Technology) action Raman4clinics. The experiment was developed in a fashion that allows various instrumental configurations ranging from highly confocal setups to fibre-optic based systems with different excitation wavelengths. We illustrate the spectral variations caused by the instrumental configurations from the perspectives of peak shifts, intensity variations, peak widths, and noise levels. We conclude this contribution with recommendations that may help to improve the inter-laboratory studies. © 2020 American Chemical Society.

Published
2020

6. Discrimination of breast cancer from benign tumours using Raman spectroscopy

Author

Lyng F.M., Traynor D., Nguyen T.N.Q., Meade A.D., Rakib F., Al-Saady R., Goormaghtigh E., Al-Saad K., and Ali M.H.

Subjects
breast cancer, Raman spectroscopy, skin and connective tissue diseases
Abstract

Breast cancer is the most common cancer among women worldwide, with an estimated 1.7 million cases and 522,000 deaths in 2012. Breast cancer is diagnosed by histopathological examination of breast biopsy material but this is subjective and relies on morphological changes in the tissue. Raman spectroscopy uses incident radiation to induce vibrations in the molecules of a sample and the scattered radiation can be used to characterise the sample. This technique is rapid and non-destructive and is sensitive to subtle biochemical changes occurring at the molecular level. This allows spectral variations corresponding to disease onset to be detected. The aim of this work was to use Raman spectroscopy to discriminate between benign lesions (fibrocystic, fibroadenoma, intraductal papilloma) and cancer (invasive ductal carcinoma and lobular carcinoma) using formalin fixed paraffin preserved (FFPP) tissue. Haematoxylin and Eosin stained sections from the patient biopsies were marked by a pathologist. Raman maps were recorded from parallel unstained tissue sections. Immunohistochemical staining for estrogen receptor (ER) and human epidermal growth factor receptor 2 (HER2/neu) was performed on a further set of parallel sections. Both benign and cancer cases were positive for ER while only the cancer cases were positive for HER2. Significant spectral differences were observed between the benign and cancer cases and the benign cases could be differentiated from the cancer cases with good sensitivity and specificity. This study has shown the potential of Raman spectroscopy as an aid to histopathological diagnosis of breast cancer, in particular in the discrimination between benign and malignant tumours. Scopus

Published
2019

7. Temperature-induced nucleation of poly(p-phenylenevinylene-co-2,5-dioctyloxy-m-phenylene vinylene) crystallization by HiPco single-walled carbon nanotubes

Author

Keogh, S.M., Farrell, G.F., Hedderman, T.G., Chambers, G., Ruther, M.G., Byrne, H.J., Lyng, F.M., and Gregan, E.

Subjects
Crystallization -- Research, Carbon -- Thermal properties, Nanotubes -- Research, Chemicals, plastics and rubber industries
Abstract

Hybrid systems of the conjugated organic polymer poly(p-phenylene vinylene-co-2,5-dioctyloxy-m-phenylene vinylene) (PmPV) and HiPco single-walled carbon nanotubes are explored using spectroscopic and thermal techniques to determine specific interactions. The results revealed that the optimum polymer-tube interaction does not occur at ambient temperature.

Published
2005

8. The Science Case for 4GLS

Author

Allan, R.J., Allen, M.P., Alexandrov, A.S., Ashfold, M.N.R., Atkinson, R., Avaldi, L., Bain, C.D., Bancroft, J., Barrett, S.D., Barron, L.D., Bayliss, S., Becker, U., Benning, L.G., Berrah, N., Binns, C., Bisby, R.H., Bizau, J.M., Blake, R.J., Bowler, M.A., Bowyer, J., Brettle, J., Briggs, D., Brown, L.M., Brown, W.A., Burke, P.G., Cacho, C., Carter, R., Catlow, R., Cernik, R.J., Chesters, M., Clark, S.A., Clarke, D.T., Clarke, J.A., Codling, K., Cogdell, R., Connaughton, D., Connerade, J.P., Costello, J.T., Crapper, M.D., Creaser, C., Currell, F.J., Davies, P.B., de Jong, M., Dessent, C., Dhanak, V.R., Dobson, D.M., Dobson, P.J., Doig, A.J., Donovan, R.J., Dumas, P., Dunn, K., Dutuit, O., Dyke, J.M., Eastham, D.A., Egdell, R.G., Eland, J.H.D., Emerson, D.R., Eriksson, M., Erman, P., Evans, A., Evans, H., Evans, S., Field, T., Fielding, H., Fisher, A., Flavell, W.R., Ford, R., Frasinski, L.J., Freeman, N., Galayda, J.N., Gardner, P., Garside, J., Gay, N.J., Gejo, T., George, M., Gray, M.D., Greenshaw, T.J., Greig, D., Halsall, M.P., Hamilton, B., Harrison, N.M., Hasnain, S.S., Hatherly, P.A., Heathcote, P., Helliwell, J.R., Henderson, C.M.B, Hepburn, J., Hill, J., Hirst, G., Hirst, J.D., Holland, D.M.P., Horn, A.B., Horton, P., Hunt, M.R.C., Hutchinson, H., Inglesfield, J.E., Ivanov, V.K., Johnson, C.A.F., Johnson, L.N., Jones, D., Jones, F.H., Jones, G.R., Jones, L., Kadodwala, M., Karlsson, L., Kennedy, E.T., King, G.C., King, M.R.F., Kirkman, I.W., Kleese, K., Knight, P.L., Kylstra, N., Larkins, F.P., Latimer, C., Lawley, K.P., Leggett, G.J., Lewis, R.A., Lindsey, K., Lu, J.R., Lyng, F.M., Macdonald, M.A., Malins, A., Marangos, J.P., Margaritondo, G., Marsi, M., Marston, G., Martin, S.R., Martin-Fernandez, M.L., Mason, N.J., Matthew, J.A.D., McCoustra, M.R.S., McGilp, J., McGovern, I.T., McGrath, R., Meldrum, R.A., Meyer, M., Millar, T.J., Mitchell, D., Møller, S.P., Molster, F.J., Moriarty, P., Morin, P., Munro, I.H., Murdin, B.N., Nahon, L., Newell, W.R., Noble, C.J., Nordgren, E.J., Norman, P.R., O'Brien, P., O'Neill, P., O'Shea, P., Owen, H., Pain, R., Papiz, M., Parker, A., Parker, J., Parr, A., Pattrick, R., Pemble, M.E., Picardo, M., Pidgeon, C.R., Pinheiro, T.J.T., Poliakoff, E.D., Poole, M.W., Potts, A., Potvliege, R., Powis, I., Price, S.D., Quinn, F.M., Radford, S., Rachlew-Källne, E., Raval, R., Read, F.H., Reddish, T.J., Ridley, P.A., Roberts, G., Russell, A.E., Ryan, A.J., Sapelkin, A., Sato, S., Schneider, A., Seddon, E.A., Shaw, E.A., Shen, T., Sherwood, P., Šiller, L., Smith, A.D., Smith, D.A., Smith, I., Smith, S.L., Snowdon, K., Softley, T.P., Sokell, E., Southworth, S.H., Srivistava, G.P., Stankiewicz, M., Sule-Suso, J., Sutherland, J.C., Surman, M., Svensson, S., Taylor, A.O., Temmerman, W.M., Thomas, A., Tiddy, G.J., Tobin, M., Towns-Andrews, Elizabeth, Towrie, M., Truscott, G., Tuckett, R.P., Turner, Tracy, Twigg, M.V., Vagdama, P., van der Hart, H.W., Volk, M., Vrakkring, M.J.J., Walker, I.C., Wander, A., Wasserman, S.P., Watanabe, M., Weightman, P., Welton, T., West, J.B., Wharton, C.W., Whitehead, J.C., Williams, G.P., Winick, H., Withnall, R., Woodruff, D.P., and Zayats, A.

Subjects
Q1
Published
2001

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