125 results on '"Lyne, Paul D."'
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2. Supplementary Figures from Pharmacological Inhibition of PARP6 Triggers Multipolar Spindle Formation and Elicits Therapeutic Effects in Breast Cancer
3. Supplementary table from Pharmacological Inhibition of PARP6 Triggers Multipolar Spindle Formation and Elicits Therapeutic Effects in Breast Cancer
4. Supplemental Materials from Pharmacological Inhibition of PARP6 Triggers Multipolar Spindle Formation and Elicits Therapeutic Effects in Breast Cancer
5. AZD1208, a potent and selective pan-Pim kinase inhibitor, demonstrates efficacy in preclinical models of acute myeloid leukemia
6. Discovery of (2R)-N-[3-[2-[(3-Methoxy-1-methyl-pyrazol-4-yl)amino]pyrimidin-4-yl]-1H-indol-7-yl]-2-(4-methylpiperazin-1-yl)propenamide (AZD4205) as a Potent and Selective Janus Kinase 1 Inhibitor
7. Insights into chorismate mutase catalysis from a combined QM/MM simulation of the enzyme reaction
8. Discovery of 2,6-disubstituted pyrazine derivatives as inhibitors of CK2 and PIM kinases
9. Molecular orbital analysis of the intermediates and products generated by the photooxidation of iron pentacarbonyl
10. Pharmacological Inhibition of PARP6 Triggers Multipolar Spindle Formation and Elicits Therapeutic Effects in Breast Cancer
11. Structure-based virtual screening: an overview
12. Modulating the strength of hydrogen bond acceptors to achieve low Caco2 efflux for oral bioavailability of PARP inhibitors blocking centrosome clustering
13. BRD4 amplification facilitates an oncogenic gene expression program in high-grade serous ovarian cancer and confers sensitivity to BET inhibitors
14. Adventures in Scaffold Morphing: Discovery of Fused Ring Heterocyclic Checkpoint Kinase 1 (CHK1) Inhibitors
15. Discovery of AZ0108, an orally bioavailable phthalazinone PARP inhibitor that blocks centrosome clustering
16. Abstract 5095: Development of a pharmacodynamic biomarker assay for AZD4785, an antisense oligonucleotide targeting KRAS
17. Targeting KRAS-dependent tumors with AZD4785, a high-affinity therapeutic antisense oligonucleotide inhibitor of KRAS
18. Adventures in Scaffold Morphing: Discovery of Fused Ring Heterocyclic Checkpoint Kinase 1 (CHK1) Inhibitors
19. Potent and Selective CK2 Kinase Inhibitors with Effects on Wnt Pathway Signaling in Vivo
20. Adventures in Scaffold Morphing: Discovery of Fused Ring Heterocyclic Checkpoint Kinase 1 (CHK1) Inhibitors.
21. Discovery of novel benzylidene-1,3-thiazolidine-2,4-diones as potent and selective inhibitors of the PIM-1, PIM-2, and PIM-3 protein kinases
22. Ab initio QM/MM study of the citrate synthase mechanism. A low-barrier hydrogen bond is not involved
23. Determination of the pKa of the 2'-hydroxyl group of a phosphorylated ribose: Implications for the mechanism of hammerhead ribozyme catalysis
24. Identification of amidoheteroaryls as potent inhibitors of mutant (V600E) B-Raf kinase with in vivo activity
25. Combined quantum and molecular mechanical study of DNA cross-linking by nitrous acid
26. Structure and Property Based Design of Pyrazolo[1,5-a]pyrimidine Inhibitors of CK2 Kinase with Activity in Vivo
27. Abstract 2353: Novel inhibitors of PIM-1, PIM-2, and PIM-3 protein kinases: medicinal chemistry leading to AZD1208.
28. Pyridyl and thiazolyl bisamide CSF-1R inhibitors for the treatment of cancer
29. Discovery of Disubstituted Imidazo[4,5-b]pyridines and Purines as Potent TrkA Inhibitors
30. Abstract 3770: PK/PD/Efficacy characterization of AZ285, a selective CK2 kinase inhibitor
31. Abstract 3907: Discovery and characterization of AZ285 as a potent and selective inhibitor of CK2 kinase
32. Potent and Selective Inhibitors of CK2 Kinase Identified through Structure-Guided Hybridization
33. ChemInform Abstract: Alignment of 3D-Structures by the Method of 2D-Projections.
34. Identification of 4-Aminopyrazolylpyrimidines as Potent Inhibitors of Trk Kinases
35. On Evaluating Molecular-Docking Methods for Pose Prediction and Enrichment Factors. [J. Chem. Inf. Model. 46, 401−415 (2006)] by
36. Accurate Prediction of the Relative Potencies of Members of a Series of Kinase Inhibitors Using Molecular Docking and MM-GBSA Scoring
37. On Evaluating Molecular-Docking Methods for Pose Prediction and Enrichment Factors
38. Lead Hopping Using SVM and 3D Pharmacophore Fingerprints.
39. Identification of Compounds with Nanomolar Binding Affinity for Checkpoint Kinase-1 Using Knowledge-Based Virtual Screening
40. Partial Molecular Alignment via Local Structure Analysis
41. Molecular structure and gas-phase reactivity of zileuton and its N-dehydroxylated metabolite: two-layered ONIOM calculations
42. Determination of the pKa of the 2‘-Hydroxyl Group of a Phosphorylated Ribose: Implications for the Mechanism of Hammerhead Ribozyme Catalysis
43. Modelling the catalytic reaction in human aldose reductase
44. A hybrid QM-MM potential employing Hartree-Fock or density functional methods in the quantum region
45. Alignment of 3D-Structures by the Method of 2D-Projections
46. A Hybrid QM−MM Potential Employing Hartree−Fock or Density Functional Methods in the Quantum Region
47. Self-Organizing Molecular Field Analysis: A Tool for Structure−Activity Studies
48. Molecular structure, gas-phase acidity and basicity of N-hydroxyurea
49. A partial model of the erythropoietin receptor complex
50. Combined Quantum and Molecular Mechanical Study of DNA Crosslinking by Nitrous Acid
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