Search

Your search keyword '"Lynch, Mj"' showing total 306 results
Start Over Author "Lynch, Mj"
306 results on '"Lynch, Mj"'

1. Linking Physical Activity to Breast Cancer via Sex Hormones, Part 1: The Effect of Physical Activity on Sex Steroid Hormones

Author

Swain, CTV, Drummond, AE, Boing, L, Milne, RL, English, DR, Brown, KA, Van Roekel, EH, Dixon-Suen, Suzanne, Lynch, MJ, Moore, MM, Gaunt, TR, Martin, RM, Lewis, SJ, Lynch, BM, Swain, CTV, Drummond, AE, Boing, L, Milne, RL, English, DR, Brown, KA, Van Roekel, EH, Dixon-Suen, Suzanne, Lynch, MJ, Moore, MM, Gaunt, TR, Martin, RM, Lewis, SJ, and Lynch, BM

Published
2022

3. Low Altitude Solar Magnetic Reconnection, Type III Solar Radio Bursts, and X-ray Emissions

Author

Cairns, IH, Lobzin, VV, Donea, A, Tingay, SJ, McCauley, PI, Oberoi, D, Duffin, RT, Reiner, MJ, Hurley-Walker, N, Kudryavtseva, NA, Melrose, DB, Harding, JC, Bernardi, G, Bowman, JD, Cappallo, RJ, Corey, BE, Deshpande, A, Emrich, D, Goeke, R, Hazelton, BJ, Johnston-Hollitt, M, Kaplan, DL, Kasper, JC, Kratzenberg, E, Lonsdale, CJ, Lynch, MJ, McWhirter, SR, Mitchell, DA, Morales, MF, Morgan, E, Ord, SM, Prabu, T, Roshi, A, Shankar, NU, Srivani, KS, Subrahmanyan, R, Wayth, RB, Waterson, M, Webster, RL, Whitney, AR, Williams, A, Williams, CL, Cairns, IH, Lobzin, VV, Donea, A, Tingay, SJ, McCauley, PI, Oberoi, D, Duffin, RT, Reiner, MJ, Hurley-Walker, N, Kudryavtseva, NA, Melrose, DB, Harding, JC, Bernardi, G, Bowman, JD, Cappallo, RJ, Corey, BE, Deshpande, A, Emrich, D, Goeke, R, Hazelton, BJ, Johnston-Hollitt, M, Kaplan, DL, Kasper, JC, Kratzenberg, E, Lonsdale, CJ, Lynch, MJ, McWhirter, SR, Mitchell, DA, Morales, MF, Morgan, E, Ord, SM, Prabu, T, Roshi, A, Shankar, NU, Srivani, KS, Subrahmanyan, R, Wayth, RB, Waterson, M, Webster, RL, Whitney, AR, Williams, A, and Williams, CL

Abstract

Type III solar radio bursts are the Sun's most intense and frequent nonthermal radio emissions. They involve two critical problems in astrophysics, plasma physics, and space physics: how collective processes produce nonthermal radiation and how magnetic reconnection occurs and changes magnetic energy into kinetic energy. Here magnetic reconnection events are identified definitively in Solar Dynamics Observatory UV-EUV data, with strong upward and downward pairs of jets, current sheets, and cusp-like geometries on top of time-varying magnetic loops, and strong outflows along pairs of open magnetic field lines. Type III bursts imaged by the Murchison Widefield Array and detected by the Learmonth radiospectrograph and STEREO B spacecraft are demonstrated to be in very good temporal and spatial coincidence with specific reconnection events and with bursts of X-rays detected by the RHESSI spacecraft. The reconnection sites are low, near heights of 5-10 Mm. These images and event timings provide the long-desired direct evidence that semi-relativistic electrons energized in magnetic reconnection regions produce type III radio bursts. Not all the observed reconnection events produce X-ray events or coronal or interplanetary type III bursts; thus different special conditions exist for electrons leaving reconnection regions to produce observable radio, EUV, UV, and X-ray bursts.

Published
2018

4. A solar powered handheld plasma source for microbial decontamination applications

Author

Ni, Y, Lynch, MJ, Modic, M, Whalley, RD, and Walsh, JL

Abstract

A fully portable atmospheric pressure air plasma system is reported to be suitable for the microbial decontamination of both surfaces and liquids. The device operates in quiescent air, and includes an integrated battery which is charged from a solar cell and weighs less than 750 g, making it highly amenable for a wide variety of applications beyond the laboratory. Using particle imaging velocimetry to visualise air flows around the device, the geometric configuration of the plasma generating electrodes was enhanced to induce a gas flow on the order of 0.5 m s-1 directed towards a sample placed downstream, thus improving the transport of plasma generated reactive species to the sample. The microbial decontamination efficiency of the system was assessed using potable water samples inoculated with common waterborne organisms Escherichia coli and Pseudomonas fluorescens. The reduction in the number of microorganisms was found to be in the range of 2-8 log and was strongly dependent on the plasma generation conditions.

Published
2016

5. Serious Asthma Events with Fluticasone plus Salmeterol versus Fluticasone Alone

Author

Stempel, Da, Raphiou, Ih, Kral, Km, Yeakey, Am, Emmett, Ah, Prazma, Cm, Buaron, Ks, Pascoe, Sj, Austri, Investigators, Altieri, Hh, Antuni, Jd, Bergna, Ma, Cuadrado, Ja, De Gennaro MS, Fazio Lizandrelo CL, Gattolin, G, Gosn, Am, Larrateguy, Ld, Marcipar, Am, Maspero, Jf, Medina, Iv, Perez Chada RD, Silva, D, Victorio, Cf, Bardin, Pg, Carroll, Pa, Clements, Bs, Dore, Nd, Robinson, Pd, Fitzgerald, Da, Robinson, Pj, Russo, Ma, Sajkov, D, Thomas, Ps, Upham, Jw, Forstner, B, Kaik, G, Koeberl, Gh, Studnicka, M, Wallner, G, Balthazar, Y, Bauler, A, Dupont, Lj, Martinot, Jb, Ninane, V, Peché, R, Pilette, C, Dimitrova, R, Dimova, D, Kissyova Ibrishimova, G, Loboshka Becheva, M, Machkovska, M, Madjarov, S, Mandazhieva Pepelanova, M, Naidenova, I, Noleva, K, Takovska, N, Terziev, C, Aggarwal, Nk, Chapman, Kr, Csanadi, Ma, Dhillon, R, Henein, S, Kelly, Aj, Lam, As, Liem, Jj, Lougheed, Md, Lowe, Dw, Rizvi, Q, van den Berg, L, Zidel, B, Barros Monge MJ, Calvo Gil MA, Castillo Hofer CR, Diaz Amor PV, Lezana Soya, V, Quilodran Silva CN, Bolivar Grimaldos, F, Solarte-Rodriguez, I, Butkovic-Tomljanovic, R, Hegedus-Jungvirth, M, Ivkovic-Jurekovic, I, Simunov-Karuza, G, Buresova, M, Bursova, J, Fratrik, J, Guttlerova, E, Hartman, P, Jirmanova, I, Kalina, P, Kolman, P, Kucera, M, Povysilova, L, Pravda, P, Svabkova, A, Zakova, L, Backer, V, Maltbaek, N, Johnsen, Cr, Aries, Sp, Babyesiza, A, Barth, D, Benedix, A, Berg, P, Bergtholdt, B, Bettig, U, Bindig, Hw, Botzen, U, Brehler, R, Breyer, Go, Bruckhaus-Walter, M, Dapper, T, Eckhard, Jg, Engelhard, R, Feldmeyer, F, Fissan, H, Franz, Kh, Frick, Bs, Funck, J, Gessner, Cm, Ginko, T, Grigat, Ce, Grimm-Sachs, V, Groth, G, Hampf, J, Hanf, G, Havasi-Jost, G, Heinz, Gu, Helm, K, Hoeltz, S, Hofmann, S, Jander, R, Jandl, M, Jasch-Hoppe, B, Jung, T, Junggeburth, Jj, Kardos, P, Knueppel, W, Koch, T, Kolorz, C, Korduan, M, Korth-Wiemann, B, Krezdorn, Hg, Kroker, A, Kruell, M, Kuehne, P, Lenk, U, Liefring, E, Merke, J, Micke, L, Mitlehner, W, Mueller, H, Naudts, If, Neumann, G, Oldenburg, W, Overlack, A, Panzer, F, Reinholz, N, Remppis, R, Riegel, P, Rueckert, P, Schaetzl, Rj, Schauer, U, Hamelmann, E, Schenkenberger, I, Schlegel, V, Scholz, G, Schroers, M, Schwittay, A, Sebert, M, Tyler, K, Soemantri, Pa, Stock, P, Stuchlik, G, Unland, M, von Mallinckrodt, C, Wachter, J, Weber, U, Weberling, F, Wehgartner-Winkler, S, Weimer, J, Wiemer, S, Winkelmann, Ej, Zeisler, Kh, Ziegner, A, Zimny, Hh, Andrasofszky, Z, Bartha, A, Farkas, M, Gömöri, K, Kis, S, Major, K, Mészáros, I, Mezei, M, Rakvacs, M, Szalai, Z, Szántó, J, Szentesi, M, Szolnoki, E, Valyon, E, Zibotics, H, Anwar, J, Arimah, C, Djajalaksana, S, Rai, Ib, Setijadi, Ar, Setyanto, Db, Susanti, F, Syafiuddin, T, Syamsi, Ln, Wijanarko, P, Yunus, F, Bonavia, M, Braga, M, Chetta, Aa, Cerveri, I, Luisetti, M, Crimi, N, Cutrera, R, De Rosa, M, Esposito, S, Foresi, A, Gammeri, E, Iemoli, E, Legnani, Dl, Michetti, G, Pastorello, Ea, Pesci, A, Pistolesi, M, Riva, E, Romano, A, Scichilone, N, Terracciano, L, Tripodi, S, Choi, I, Kim, C, Kim, Js, Kim, Wj, Koh, Yy, Kwon, Ss, Lee, Sh, Lee, S, Lee, Sk, Park, Cs, Cirule, I, Eglite, R, Petrova, I, Poga, M, Smiltena, I, Chomiciene, A, Davoliene, I, Griskeviciene, V, Naudziunas, A, Naudziunas, S, Rudzeviciene, O, Sitkauskiene, B, Urbonas, G, Vaicius, D, Valavicius, A, Valiulis, A, Vebriene, J, bin Abdul Aziz FA, Daud, M, Ismail, Ai, Tengku Saifudin TI, Md Kassim RM, Mohd Fadzli FB, Wan Mohamad WH, Aguilar Dominguez PE, Aguilar-Orozco, Ra, Garza-Salinas, S, Ramirez-Diaz, Sp, Sánchez Llamas, F, Soto-Ramos, M, Velarde-Mora, Hj, Aguirre Sosa, I, Cisneros, Am, Estrella Viladegut RA, Matsuno Fuchigami, A, Adiaz-Baui, Tt, Bernan, Ap, Onia, Af, Sandagon, Mj, S-Naval, S, Yu, Cy, Bartuzi, Z, Bielous-Wilk, A, Błażowski, Ł, Bożek, A, Brzostek, J, Chorostowska-Wynimko, J, Ciekalska, K, Ziora, D, Cieslicki, J, Emeryk, A, Folcik, K, Gałuszka-Bilińska, A, Gawlik, R, Giejlo, M, Harat, R, Hofman, T, Jahnz-Różyk, K, Jedrzejczak, M, Kachel, T, Kamiński, D, Kelm Warchol, A, Konieczny, Z, Kwasniewski, A, Leszczyński, W, Mincewicz, G, Niezgoda, K, Olszewska-Ziąber, A, Onasz-Manitius, M, Pawlukiewicz, M, Piotrowicz, P, Piotrowski, W, Pisarczyk-Bogacka, E, Piskorz, P, Prokop-Staszecka, A, Roslan, A, Słomka, A, Smalera, E, Stelmach, I, Swierczynska-Krepa, M, Szmidt, M, Tarnowska-Matusiak, M, Tłuczykont, B, Tyminska, K, Waszkuc-Golonko, J, Wojciechowska, I, Alexandrescu, Ds, Neamtu, Ml, Todea, D, Alekseeva, E, Aleksandrova, E, Asherova, I, Barbarash, Ol, Bugrova, O, Bukreeva, Eb, Chermenskiy, A, Chizhova, O, Demko, I, Evdokimova, A, Giorgadze, Ml, Grigoryev, S, Irkhina, I, Khurkhurova, Nv, Kondyurina, Eg, Kostin, Vi, Kudelya, L, Laleko, Sl, Lenskaya, L, Levashov, S, Logvinenko, N, Martynov, A, Mizernitski, Y, Nemtsov, B, Novozhenov, Vg, Pavlishchuk, S, Popova, Vv, Reshetko, Ov, Sherenkov, A, Shirinsky, Vs, Shpagina, L, Soloviev, Ki, Tkachev, A, Trofimov, Vi, Vertkin, Al, Vorobeva, E, Idrisova, E, Yakushin, S, Zadionchenko, V, Zhiglinskaya, O, Zykov, K, Dopudja Pantic, V, Nadaskic, R, Nestorovic, B, Skodric Trifunovic, V, Stojanovic, A, Vukcevic, M, Vujic, T, Mitic Milikic, M, Banovcin, P, Horvathova, H, Karako, P Sr, Plutinsky, J, Pribulova, E, Szarazova, M, Zlatos, A, Adams, L, Badat, A, Bassa, A, Breedt, J, Bruning, A, Ellis, Gc, Emanuel, S, Fouche, Lf, Fulat, Ma, Gani, M, Ismail, Ms, Jurgens, Jc, Nell, H, Nieuwoudt, G, Noor, F, Bolliger, Ct, Puterman, As, Siddique, N, Trokis, Js, Vahed, Ya, Van Der Berg BJ, Van der Linden, M, Van Zyl, L, Visser, Ss, Antépara Ercoreca, I, Arnedillo Muñoz, A, Barbe Illa, F, Barreiro López, B, Blanco Aparicio, M, Boada Valmaseda, A, Bosque García, M, Bustamante Ruiz, A, Carretero Anibarro, P, Del Campo Matias, F, Echave-Sustaet, Jm, Espinosa de los Monteros Garde MJ, Garcia Hernandez GM, López Viña, A, Lores Obradors, L, Luengo Planas MT, Monsó Molas, E, Navarro Dourdil, A, Nieto García AJ, Perpina Tordera, M, Picado Valles, C, Rodriguez Alvarez Mdel, M, Saura Vinuesa, A, Serra Batlles, J, Soler Sempere MJ, Toran Montserrat, P, Valdés Cuadrado LG, Villasante Fernandez-Montes, C, Cheng, Sl, Chern, Jh, Chiu, Mh, Chung, Cl, Lai, Rs, Lin, Ck, Liu, Yc, Wang, Cc, Wei, Yf, Amer, L, Berenfus, Vi, Besh, L, Duka, Kd, Fushtey, Im, Garmash, N, Dudnyk, O, Godlevska, O, Vlasenko, Ma, Hospodarskyy, I, Iashyna, L, Kaladze, M, Khvelos, Si, Kostromina, Vp, Krakhmalova, O, Kryuchko, T, Kulynych, Ov, Krasko, Mp, Levchenko, O, Litvinova, T, Panina, Ss, Pasiyeshvili, Lm, Prystupa, Ln, Romaniuk, Li, Sirenko, I, Synenko, Vi, Vynnychenko, Lb, Yatsyshyn, Ri, Zaitsev, I, Zhebel, V, Zubarenko, O, Arthur, Cp, Brown, V, Burhan, H, Chaudhuri, R, Collier, D, Barnes, Nc, Davies, Ej, Ellery, A, Kwok, S, Lenney, W, Nordstrom, M, Pandya, Hc, Parker, Iw, Rajakulasingam, K, Seddon, P, Sharma, R, Thomas, Ec, Wakeling, Ja, Abalos-Galito, M, Abboy, C, Abreu, E, Ackerman, If, Acosta, Ia, Adaoag, Aa, Ahmed, M, Ali, Mi, Allen, Dr, Allen GG Jr, Diogo, Jj, Allison, Dc, Alwine, Lk, Apaliski, Sj, Arastu, Rs, Arora, Cm, Auerbach, D, Azzam, Sj, Badar FL 3rd, Baker, Jw, Barasch, Jp, Barber, Ma, Bardinas-Rodriguez, R, Barreiro, Tj, Baumbach, Rr, Baur, Ce, Baxter, Bs, Beach, Jl, Beasley, Rl, Beavins, Je, Beliveau, Wj, Benbow, Mj, Bennett, Nl, Bennett, Rl, Bernal, H, Bernstein, Di, Blaiss, Ms, Blumenthal, Kw, Boas, Sr, Borders, Jl, Boscia, Ja, Boulware, Wn, Bowling, Bt, Brabec, Ba, Bramlet, Dg, Figueroa, Dp, Brautigam, Df, Brownell, Jm, Bruce, Tr, Call, Rs, Campbell, Ca, Canaan, Ya, Cannon, Df, Carpio, Jm, Cathcart, Ws, Cevallos, Jp, Chauhan, Av, Chuang, Rb, Chevalier, D, Christensen, J, Christensen, Ta, Christina, Mo, Chrzanowski, Rr, Civitarese, Fa, Clark, Jp, Clifford, Dp, Lapidus, Rj, Coggi, Ja, Lenz, Jj, Cohen, Kr, Collins, Bg, Collins, H, Comellas, A, Condit, J, Cordasco EM Jr, Corder, Cn, Covar, Ra, Coverston, Kd, Croce, Sa, Cruz, H, Curtis, Ct, Daftary, Pk, Dalan, D, Dalawari, Sp, Daly, Wc, Davis, Kc, Dawes, Kw, Decotiis, Ba, Deluca, Rf, Desantis, Dm, De Valle OL, Diaz, Jl, Diaz, Jd, Dice, Jp, Elizalde, A, Hosler, Mr, Dixon, C, Dobkin, La, Dobrusin, Rs, Dransfield, Mt, Ebbeling, Wl, Edwards, Jd, Elacion, Jm, Elkayam, D, Ellison, Wt, Elsen, Jr, Engel, Lr, Ensz, Dj, Ericksen, Cl, Ervin, Je, Fang, C, Abrahamian, F, Farrah, Vb, Field, Jd, Fishman, Hj, Florea, R, Nayyar, S, Focil, A, Focauld, F, Franco MA Jr, Frandsen, Br, Ganti, K, Garcia, Fl, Lee, Wm, Garscadden, Ag, Gatti, Ea, Gellady, Am, George, Ar, Gibbon, Gw, Gleason, Gp, Goldberg, P, Goldstein, Mf, Gonzalez, Ge, Gower, Rg, Grande, Ja, Gregory, D, Grubb, Sd, Guthrie, Rp, Haas, Ta, Haft, Ks, Hajal, R, Hammond, Gd, Hansel, Nn, Hansen, Vr, Harris, Af, Hartman, An, Harvey, Rr, Hazan-Steinberg, S, Headley, Dm, Heigerick, Gc, Heller, Bn, Hendrix, El, Herrod, Jn, Hewitt, Mj, Hines, Rl, Hirdt, Ap, Hirschfield, Ja, Hoffman, Ks, Hogan, Ad, Howland, Wc, Hsu, Cc, Hsu, Fj, Hubbard, Wm, Hudson, Jd, Huffman, C, Hussain, M, Ioachimescu, Oc, Ismail, Ym, Jaffrani, Na, Jiang, N, Jones, Sw, Jordan, Rs, Joshi, Ke, Kaashmiri, Mw, Kalafer, M, Kamdar, Ba, Kanuga, Jg, Kao, Nl, Karetzky, M, Katsetos, Jc, Kay, Js, Kimmel, Ma, Kimura, Sh, Kingsley, Jk, Mahmood, Sm, Subich, Dc, Kirstein, Jl, Kleerup, Ec, Klein, Rm, Koh, Dw, Kohli, N, Koura, Fa, Kovacs, Sp, Kratzer, J, Kreit, Ci, Kreutter, Fm, Kubicki, Tm, Labuda, Jm, Latorre, Aj, Lara, Mm, Lechin, Ae, Lee, Jj, Lee, Md, Lentnek, Al, Lesh, Kw, Levins, Pf, Anspach, Rb, Levinsky, Dm, Lillestol, Mj, Lim, H, Livezey, Md, Lloyd-Turney, Cw, Lockey, Rf, Long, Ra, Lynch, Mj, Macgillivray, Bk, Mahadevan, Kp, Makam, Sk, Maloney, Mj, Mapel, D, Margolis, Bd, Margulies, J, Martin, Ef, Martin, Ee, Mascolo, M, Mataria, H, Sunbuli, M, Mathur, Rn, Mattar, Pn, Maynard, Km, Maynard, N, Mccormick, B, Mcelya, M, Mcevoy, Ce, Mckenzie, Wc, Medwedeff, Le, Mehta, Kd, Melamed, Ir, Meli, Jv, Merrick, Bh, Meyers, Pj, Miller, Bt, Minton, Sm, Miranda, Fg, Mohar, De, Montenegro, Ch, Morris, Fa, Morrison, Bs, Moss, Mh, Munoz, F, Naini, Gr, Nakamura, Ct, Naseeruddin, S, Nassim, C, Navazo, Lj, Nissim, Je, Norman, D, Oberoi, Ms, O'Connor, Tm, Offenberger, J, Orr, Rr, Osea, Ea, Paine, Wj, Rasmussen, Nl, Palatnik, M, Pangtay, D, Panuto, Ja, Patel, M, Perera, Ms, Perez, A, Peters PH Jr, Pimentel SM Jr, Pluto, Tm, Pollock, Mt, Posner, Ls, Pritchard, Jc, Pudi, Kk, Puig, Cm, Qaqundah, Py, Radbill, Mk, Rahman, St, Raikhel, M, Raissy, Hh, Ramstad, Ds, Ranasinghe, Es, Rangel, Os, Rapo, Se, Raschal, Sp, Reddy, Dg, Rehman, Sm, Reyes, Sr, Rhodes, Rb, Riffer, E, Rihal, Ps, Riley ED 4th, Rodriguez, Dh, Rogers, Cm, Rohlf, Jl, Romeu, H, Roney, Cw, Ronsick, So, Rosen, Jb, Rowe, Ms, Ruoff, Ge, Ryan, Eh, Saff, Rh, Saini, N, Anand, S, Balakrishnan, K, Samuels, Bs, Samuelson, Rj, Saniuk, Rj, Sargeant, Wo, Saunders, Mk, Saway, W, Scarupa, Md, White, Mv, Schear, Mj, Schwarz, Cm, Scott, Rb, Segall, N, Seibert, Af, Seidmeyer, V, Seidner, Mr, Seifer, Fd, Serje, J, Shah, Ms, Shah, Sb, Shapero, Pa, Shearer, Sd, Sheikh, Sq, Shepherd, Ts, Sher, Er, Sher, Ld, Short, Bh, Silas, Pe, Alvey, Jc, Silverfield, Jc, Simon, Sj, Sitar, S, Skoner, Dp, Smallow, Sa, Smart, Ba, Smith, Ca, Smith, Ke, Smith, Sk, Snyders, Gc, Soong, W, Soufer, J, Spangenthal, S, Stahlman, Je, Steele, Lg, Stegemoller, Rk, Stocks, J, Storms, Ww, Suen, J, Surowitz, Rz, Swauger, Jr, Taber, La, Tan, Ae, Pratt, Se, Tanus, T, Tarpay, Mm, Tarshis, Ga, Tenney, Jw, Tilghman, Kg, Trevino, Me, Troyan, Be, Twiddy, Sk, Updegrove, Jd, Urval, Kr, Uusinarkaus, Kt, Vaela, R, Van Cleeff, M, Varano, S, Vo, Qd, Wainz, Rj, Wald, Ja, Wall, Sj, Wasserman, Rl, Weinstein, Dl, Welker, Ja, Wellmon, B 2nd, Wells, T, Wenocur, Hs, Williams, Dl, Williams, Sl, Win, Ph, Wingo, Td, Wisman PP Jr, Wyszomierski, Da, Yamada, Hm, Yarows, S, Yunger TM Jr, Ziering, Rw., the AUSTRI Investigators, Stempel, D., Raphiou, I., Kral, K., Yeakey, A., Emmett, A., Prazma, C., Buaron, K., and Pascoe, S. Scichilone N tra i collaboratori

Subjects
Male, asthma, serious events, fluticasone, salmeterol, AUSTRI, Exacerbation, Intention to Treat Analysi, INHALED CORTICOSTEROIDS, Severity of Illness Index, law.invention, 0302 clinical medicine, Randomized controlled trial, law, immune system diseases, Ús terapèutic, Broncodilatadors, 030212 general & internal medicine, Child, Fluticasone, RISK, ACTING BETA-AGONISTS, EXACERBATIONS, METAANALYSIS, MORTALITY, SAFETY, DEATH, FDA, Medicine (all), Hazard ratio, General Medicine, Bronchodilator agents, Middle Aged, Fluticasone-Salmeterol Drug Combination, Bronchodilator Agents, Intention to Treat Analysis, Anesthesia, Female, Salmeterol, medicine.drug, Human, Adult, medicine.medical_specialty, Adolescent, Settore MED/10 - Malattie Dell'Apparato Respiratorio, Fluticasone propionate, 03 medical and health sciences, Double-Blind Method, Internal medicine, Administration, Inhalation, medicine, Humans, Asma, Bronchodilator Agent, Asthma, Aged, Proportional Hazards Models, business.industry, Therapeutic use, medicine.disease, respiratory tract diseases, 030228 respiratory system, Fluticasone Propionate, Salmeterol Xinafoate Drug Combination, Proportional Hazards Model, business
Abstract

BACKGROUND The safe and appropriate use of long-acting beta-agonists (LABAs) for the treatment of asthma has been widely debated. In two large clinical trials, investigators found a potential risk of serious asthma-related events associated with LABAs. This study was designed to evaluate the risk of administering the LABA salmeterol in combination with an inhaled glucocorticoid, fluticasone propionate. METHODS In this multicenter, randomized, double-blind trial, adolescent and adult patients (age, ≥12 years) with persistent asthma were assigned to receive either fluticasone with salmeterol or fluticasone alone for 26 weeks. All the patients had a history of a severe asthma exacerbation in the year before randomization but not during the previous month. Patients were excluded from the trial if they had a history of lifethreatening or unstable asthma. The primary safety end point was the first serious asthma-related event (death, endotracheal intubation, or hospitalization). Noninferiority of fluticasone–salmeterol to fluticasone alone was defined as an upper boundary of the 95% confidence interval for the risk of the primary safety end point of less than 2.0. The efficacy end point was the first severe asthma exacerbation. RESULTS Of 11,679 patients who were enrolled, 67 had 74 serious asthma-related events, with 36 events in 34 patients in the fluticasone–salmeterol group and 38 events in 33 patients in the fluticasone-only group. The hazard ratio for a serious asthmarelated event in the fluticasone–salmeterol group was 1.03 (95% confidence interval [CI], 0.64 to 1.66), and noninferiority was achieved (P = 0.003). There were no asthma-related deaths; 2 patients in the fluticasone-only group underwent asthmarelated intubation. The risk of a severe asthma exacerbation was 21% lower in the fluticasone–salmeterol group than in the fluticasone-only group (hazard ratio, 0.79; 95% CI, 0.70 to 0.89), with at least one severe asthma exacerbation occurring in 480 of 5834 patients (8%) in the fluticasone–salmeterol group, as compared with 597 of 5845 patients (10%) in the fluticasone-only group (P

Published
2016

6. Antarctic ice sheet mass loss estimates using Modified Antarctic Mapping Mission surface flow observations

Author

Ren, D, Leslie, LM, and Lynch, MJ

Abstract

The long residence time of ice and the relatively gentle slopes of the Antarctica Ice Sheet make basal sliding a unique positive feedback mechanism in enhancing ice discharge along preferred routes. The highly organized ice stream channels extending to the interior from the lower reach of the outlets are a manifestation of the role of basal granular material in enhancing the ice flow. In this study, constraining the model-simulated year 2000 ice flow fields with surface velocities obtained from InSAR measurements permits retrieval of the basal sliding parameters. Forward integrations of the ice model driven by atmospheric and oceanic parameters from coupled general circulation models under different emission scenarios provide a range of estimates of total ice mass loss during the 21st century. The total mass loss rate has a small intermodel and interscenario spread, rising from approximately -160 km3/yr at present to approximately -220 km3/yr by 2100. The accelerated mass loss rate of the Antarctica Ice Sheet in a warming climate is due primarily to a dynamic response in the form of an increase in ice flow speed. Ice shelves contribute to this feedback through a reduced buttressing effect due to more frequent systematic, tabular calving events. For example, by 2100 the Ross Ice Shelf is projected to shed ~40 km3 during each systematic tabular calving. After the frontal section's attrition, the remaining shelf will rebound. Consequently, the submerged cross-sectional area will reduce, as will the buttressing stress. Longitudinal differential warming of ocean temperature contributes to tabular calving. Because of the prevalence of fringe ice shelves, oceanic effects likely will play a very important role in the future mass balance of the Antarctica Ice Sheet, under a possible future warming climate. © 2013. American Geophysical Union. All Rights Reserved.

Published
2013

7. THE SPECTRAL VARIABILITY OF THE GHZ-PEAKED SPECTRUM RADIO SOURCE PKS 1718-649 AND A COMPARISON OF ABSORPTION MODELS

Author

Tingay, SJ, Macquart, J-P, Collier, JD, Rees, G, Callingham, JR, Stevens, J, Carretti, E, Wayth, RB, Wong, GF, Trott, CM, McKinley, B, Bernardi, G, Bowman, JD, Briggs, F, Cappallo, RJ, Corey, BE, Deshpande, AA, Emrich, D, Gaensler, BM, Goeke, R, Greenhill, LJ, Hazelton, BJ, Johnston-Hollitt, M, Kaplan, DL, Kasper, JC, Kratzenberg, E, Lonsdale, CJ, Lynch, MJ, McWhirter, SR, Mitchell, DA, Morales, MF, Morgan, E, Oberoi, D, Ord, SM, Prabu, T, Rogers, AEE, Roshi, A, Shankar, NU, Srivani, KS, Subrahmanyan, R, Waterson, M, Webster, RL, Whitney, AR, Williams, A, Williams, CL, Tingay, SJ, Macquart, J-P, Collier, JD, Rees, G, Callingham, JR, Stevens, J, Carretti, E, Wayth, RB, Wong, GF, Trott, CM, McKinley, B, Bernardi, G, Bowman, JD, Briggs, F, Cappallo, RJ, Corey, BE, Deshpande, AA, Emrich, D, Gaensler, BM, Goeke, R, Greenhill, LJ, Hazelton, BJ, Johnston-Hollitt, M, Kaplan, DL, Kasper, JC, Kratzenberg, E, Lonsdale, CJ, Lynch, MJ, McWhirter, SR, Mitchell, DA, Morales, MF, Morgan, E, Oberoi, D, Ord, SM, Prabu, T, Rogers, AEE, Roshi, A, Shankar, NU, Srivani, KS, Subrahmanyan, R, Waterson, M, Webster, RL, Whitney, AR, Williams, A, and Williams, CL

Abstract

Using the new wideband capabilities of the Australia Telescope Compact Array (ATCA), we obtain spectra for PKS 1718-649, a well-known gigahertz-peaked spectrum radio source. The observations, between approximately 1 and 10 GHz over three epochs spanning approximately 21 months, reveal variability both above the spectral peak at ~3 GHz and below the peak. The combination of the low and high frequency variability cannot be easily explained using a single absorption mechanism, such as free-free absorption or synchrotron self-absorption. We find that the PKS 1718-649 spectrum and its variability are best explained by variations in the free-free optical depth on our line-of-sight to the radio source at low frequencies (below the spectral peak) and the adiabatic expansion of the radio source itself at high frequencies (above the spectral peak). The optical depth variations are found to be plausible when X-ray continuum absorption variability seen in samples of Active Galactic Nuclei is considered. We find that the cause of the peaked spectrum in PKS 1718-649 is most likely due to free-free absorption. In agreement with previous studies, we find that the spectrum at each epoch of observation is best fit by a free-free absorption model characterised by a power-law distribution of free-free absorbing clouds. This agreement is extended to frequencies below the 1 GHz lower limit of the ATCA by considering new observations with Parkes at 725 MHz and 199 MHz observations with the newly operational Murchison Widefield Array. These lower frequency observations argue against families of absorption models (both free-free and synchrotron self-absorption) that are based on simple homogenous structures.

Published
2015

8. Ionospheric Modelling using GPS to Calibrate the MWA. I: Comparison of First Order Ionospheric Effects between GPS Models and MWA Observations

Author

Arora, BS, Morgan, J, Ord, SM, Tingay, SJ, Hurley-Walker, N, Bell, M, Bernardi, G, Bhat, NDR, Briggs, F, Callingham, JR, Deshpande, AA, Dwarakanath, KS, Ewall-Wice, A, Feng, L, For, B-Q, Hancock, P, Hazelton, BJ, Hindson, L, Jacobs, D, Johnston-Hollitt, M, Kapinska, AD, Kudryavtseva, N, Lenc, E, McKinley, B, Mitchell, D, Oberoi, D, Offringa, AR, Pindor, B, Procopio, P, Riding, J, Staveley-Smith, L, Wayth, RB, Wu, C, Zheng, Q, Bowman, JD, Cappallo, RJ, Corey, BE, Emrich, D, Goeke, R, Greenhill, LJ, Kaplan, DL, Kasper, JC, Kratzenberg, E, Lonsdale, CJ, Lynch, MJ, McWhirter, SR, Morales, MF, Morgan, E, Prabu, T, Rogers, AEE, Roshi, A, Shankar, NU, Srivani, KS, Subrahmanyan, R, Waterson, M, Webster, RL, Whitney, AR, Williams, A, Williams, CL, Arora, BS, Morgan, J, Ord, SM, Tingay, SJ, Hurley-Walker, N, Bell, M, Bernardi, G, Bhat, NDR, Briggs, F, Callingham, JR, Deshpande, AA, Dwarakanath, KS, Ewall-Wice, A, Feng, L, For, B-Q, Hancock, P, Hazelton, BJ, Hindson, L, Jacobs, D, Johnston-Hollitt, M, Kapinska, AD, Kudryavtseva, N, Lenc, E, McKinley, B, Mitchell, D, Oberoi, D, Offringa, AR, Pindor, B, Procopio, P, Riding, J, Staveley-Smith, L, Wayth, RB, Wu, C, Zheng, Q, Bowman, JD, Cappallo, RJ, Corey, BE, Emrich, D, Goeke, R, Greenhill, LJ, Kaplan, DL, Kasper, JC, Kratzenberg, E, Lonsdale, CJ, Lynch, MJ, McWhirter, SR, Morales, MF, Morgan, E, Prabu, T, Rogers, AEE, Roshi, A, Shankar, NU, Srivani, KS, Subrahmanyan, R, Waterson, M, Webster, RL, Whitney, AR, Williams, A, and Williams, CL

Abstract

We compare first-order (refractive) ionospheric effects seen by the MWA with the ionosphere as inferred from GPS data. The first-order ionosphere manifests itself as a bulk position shift of the observed sources across an MWA field of view. These effects can be computed from global ionosphere maps provided by GPS analysis centres, namely the CODE. However, for precision radio astronomy applications, data from local GPS networks needs to be incorporated into ionospheric modelling. For GPS observations, the ionospheric parameters are biased by GPS receiver instrument delays, among other effects, also known as receiver DCBs. The receiver DCBs need to be estimated for any non-CODE GPS station used for ionosphere modelling. In this work, single GPS station-based ionospheric modelling is performed at a time resolution of 10 min. Also the receiver DCBs are estimated for selected Geoscience Australia GPS receivers, located at Murchison Radio Observatory, Yarragadee, Mount Magnet and Wiluna. The ionospheric gradients estimated from GPS are compared with that inferred from MWA. The ionospheric gradients at all the GPS stations show a correlation with the gradients observed with the MWA. The ionosphere estimates obtained using GPS measurements show promise in terms of providing calibration information for the MWA.

Published
2015

9. FOREGROUNDS IN WIDE-FIELD REDSHIFTED 21 cm POWER SPECTRA

Author

Thyagarajan, N, Jacobs, DC, Bowman, JD, Barry, N, Beardsley, AP, Bernardi, G, Briggs, F, Cappallo, RJ, Carroll, P, Corey, BE, de Oliveira-Costa, A, Dillon, JS, Emrich, D, Ewall-Wice, A, Feng, L, Goeke, R, Greenhill, LJ, Hazelton, BJ, Hewitt, JN, Hurley-Walker, N, Johnston-Hollitt, M, Kaplan, DL, Kasper, JC, Kim, H-S, Kittiwisit, P, Kratzenberg, E, Lenc, E, Line, J, Loeb, A, Lonsdale, CJ, Lynch, MJ, McKinley, B, McWhirter, SR, Mitchell, DA, Morales, MF, Morgan, E, Neben, AR, Oberoi, D, Offringa, AR, Ord, SM, Paul, S, Pindor, B, Pober, JC, Prabu, T, Procopio, P, Riding, J, Rogers, AEE, Roshi, A, Shankar, NU, Sethi, SK, Srivani, KS, Subrahmanyan, R, Sullivan, IS, Tegmark, M, Tingay, SJ, Trott, CM, Waterson, M, Wayth, RB, Webster, RL, Whitney, AR, Williams, A, Williams, CL, Wu, C, Wyithe, JSB, Thyagarajan, N, Jacobs, DC, Bowman, JD, Barry, N, Beardsley, AP, Bernardi, G, Briggs, F, Cappallo, RJ, Carroll, P, Corey, BE, de Oliveira-Costa, A, Dillon, JS, Emrich, D, Ewall-Wice, A, Feng, L, Goeke, R, Greenhill, LJ, Hazelton, BJ, Hewitt, JN, Hurley-Walker, N, Johnston-Hollitt, M, Kaplan, DL, Kasper, JC, Kim, H-S, Kittiwisit, P, Kratzenberg, E, Lenc, E, Line, J, Loeb, A, Lonsdale, CJ, Lynch, MJ, McKinley, B, McWhirter, SR, Mitchell, DA, Morales, MF, Morgan, E, Neben, AR, Oberoi, D, Offringa, AR, Ord, SM, Paul, S, Pindor, B, Pober, JC, Prabu, T, Procopio, P, Riding, J, Rogers, AEE, Roshi, A, Shankar, NU, Sethi, SK, Srivani, KS, Subrahmanyan, R, Sullivan, IS, Tegmark, M, Tingay, SJ, Trott, CM, Waterson, M, Wayth, RB, Webster, RL, Whitney, AR, Williams, A, Williams, CL, Wu, C, and Wyithe, JSB

Abstract

Detection of 21~cm emission of HI from the epoch of reionization, at redshifts z>6, is limited primarily by foreground emission. We investigate the signatures of wide-field measurements and an all-sky foreground model using the delay spectrum technique that maps the measurements to foreground object locations through signal delays between antenna pairs. We demonstrate interferometric measurements are inherently sensitive to all scales, including the largest angular scales, owing to the nature of wide-field measurements. These wide-field effects are generic to all observations but antenna shapes impact their amplitudes substantially. A dish-shaped antenna yields the most desirable features from a foreground contamination viewpoint, relative to a dipole or a phased array. Comparing data from recent Murchison Widefield Array observations, we demonstrate that the foreground signatures that have the largest impact on the HI signal arise from power received far away from the primary field of view. We identify diffuse emission near the horizon as a significant contributing factor, even on wide antenna spacings that usually represent structures on small scales. For signals entering through the primary field of view, compact emission dominates the foreground contamination. These two mechanisms imprint a characteristic "pitchfork" signature on the "foreground wedge" in Fourier delay space. Based on these results, we propose that selective down-weighting of data based on antenna spacing and time can mitigate foreground contamination substantially by a factor ~100 with negligible loss of sensitivity.

Published
2015

10. Limits on low-frequency radio emission from southern exoplanets with the Murchison Widefield Array

Author

Murphy, T, Bell, ME, Kaplan, DL, Gaensler, BM, Offringa, AR, Lenc, E, Hurley-Walker, N, Bernardi, G, Bowman, JD, Briggs, F, Cappallo, RJ, Corey, BE, Deshpande, AA, Emrich, D, Goeke, R, Greenhill, LJ, Hazelton, BJ, Hewitt, JN, Johnston-Hollitt, M, Kasper, JC, Kratzenberg, E, Lonsdale, CJ, Lynch, MJ, McWhirter, SR, Mitchell, DA, Morales, MF, Morgan, E, Oberoi, D, Ord, SM, Prabu, T, Rogers, AEE, Roshi, DA, Shankar, NU, Srivani, KS, Subrahmanyan, R, Tingay, SJ, Waterson, M, Wayth, RB, Webster, RL, Whitney, AR, Williams, A, Williams, CL, Murphy, T, Bell, ME, Kaplan, DL, Gaensler, BM, Offringa, AR, Lenc, E, Hurley-Walker, N, Bernardi, G, Bowman, JD, Briggs, F, Cappallo, RJ, Corey, BE, Deshpande, AA, Emrich, D, Goeke, R, Greenhill, LJ, Hazelton, BJ, Hewitt, JN, Johnston-Hollitt, M, Kasper, JC, Kratzenberg, E, Lonsdale, CJ, Lynch, MJ, McWhirter, SR, Mitchell, DA, Morales, MF, Morgan, E, Oberoi, D, Ord, SM, Prabu, T, Rogers, AEE, Roshi, DA, Shankar, NU, Srivani, KS, Subrahmanyan, R, Tingay, SJ, Waterson, M, Wayth, RB, Webster, RL, Whitney, AR, Williams, A, and Williams, CL

Abstract

We present the results of a survey for low frequency radio emission from 17 known exoplanetary systems with the Murchison Widefield Array. This sample includes 13 systems that have not previously been targeted with radio observations. We detected no radio emission at 154 MHz, and put 3 sigma upper limits in the range 15.2-112.5 mJy on this emission. We also searched for circularly polarised emission and made no detections, obtaining 3 sigma upper limits in the range 3.4-49.9 mJy. These are comparable with the best low frequency radio limits in the existing literature and translate to luminosity limits of between 1.2 x 10^14 W and 1.4 x 10^17 W if the emission is assumed to be 100% circularly polarised. These are the first results from a larger program to systematically search for exoplanetary emission with the MWA.

Published
2015

11. Power spectrum analysis of ionospheric fluctuations with the Murchison Widefield Array

Author

Loi, ST, Trott, CM, Murphy, T, Cairns, IH, Bell, M, Hurley-Walker, N, Morgan, J, Lenc, E, Offringa, AR, Feng, L, Hancock, PJ, Kaplan, DL, Kudryavtseva, N, Bernardi, G, Bowman, JD, Briggs, F, Cappallo, RJ, Corey, BE, Deshpande, AA, Emrich, D, Gaensler, BM, Goeke, R, Greenhill, LJ, Hazelton, BJ, Johnston-Hollitt, M, Kasper, JC, Kratzenberg, E, Lonsdale, CJ, Lynch, MJ, McWhirter, SR, Mitchell, DA, Morales, MF, Morgan, E, Oberoi, D, Ord, SM, Prabu, T, Rogers, AEE, Roshi, A, Shankar, NU, Srivani, KS, Subrahmanyan, R, Tingay, SJ, Waterson, M, Wayth, RB, Webster, RL, Whitney, AR, Williams, A, Williams, CL, Loi, ST, Trott, CM, Murphy, T, Cairns, IH, Bell, M, Hurley-Walker, N, Morgan, J, Lenc, E, Offringa, AR, Feng, L, Hancock, PJ, Kaplan, DL, Kudryavtseva, N, Bernardi, G, Bowman, JD, Briggs, F, Cappallo, RJ, Corey, BE, Deshpande, AA, Emrich, D, Gaensler, BM, Goeke, R, Greenhill, LJ, Hazelton, BJ, Johnston-Hollitt, M, Kasper, JC, Kratzenberg, E, Lonsdale, CJ, Lynch, MJ, McWhirter, SR, Mitchell, DA, Morales, MF, Morgan, E, Oberoi, D, Ord, SM, Prabu, T, Rogers, AEE, Roshi, A, Shankar, NU, Srivani, KS, Subrahmanyan, R, Tingay, SJ, Waterson, M, Wayth, RB, Webster, RL, Whitney, AR, Williams, A, and Williams, CL

Abstract

Low‐frequency, wide field‐of‐view (FOV) radio telescopes such as the Murchison Widefield Array (MWA) enable the ionosphere to be sampled at high spatial completeness. We present the results of the first power spectrum analysis of ionospheric fluctuations in MWA data, where we examined the position offsets of radio sources appearing in two data sets. The refractive shifts in the positions of celestial sources are proportional to spatial gradients in the electron column density transverse to the line of sight. These can be used to probe plasma structures and waves in the ionosphere. The regional (10–100 km) scales probed by the MWA, determined by the size of its FOV and the spatial density of radio sources (typically thousands in a single FOV), complement the global (100–1000 km) scales of GPS studies and local (0.01–1 km) scales of radar scattering measurements. Our data exhibit a range of complex structures and waves. Some fluctuations have the characteristics of traveling ionospheric disturbances, while others take the form of narrow, slowly drifting bands aligned along the Earth's magnetic field.

Published
2015

12. Quantifying ionospheric effects on time-domain astrophysics with the Murchison Widefield Array

Author

Loi, ST, Murphy, T, Bell, ME, Kaplan, DL, Lenc, E, Offringa, AR, Hurley-Walker, N, Bernardi, G, Bowman, JD, Briggs, F, Cappallo, RJ, Corey, BE, Deshpande, AA, Emrich, D, Gaensler, BM, Goeke, R, Greenhill, LJ, Hazelton, BJ, Johnston-Hollitt, M, Kasper, JC, Kratzenberg, E, Lonsdale, CJ, Lynch, MJ, McWhirter, SR, Mitchell, DA, Morales, MF, Morgan, E, Oberoi, D, Ord, SM, Prabu, T, Rogers, AEE, Roshi, A, Shankar, NU, Srivani, KS, Subrahmanyan, R, Tingay, SJ, Waterson, M, Wayth, RB, Webster, RL, Whitney, AR, Williams, A, Williams, CL, Loi, ST, Murphy, T, Bell, ME, Kaplan, DL, Lenc, E, Offringa, AR, Hurley-Walker, N, Bernardi, G, Bowman, JD, Briggs, F, Cappallo, RJ, Corey, BE, Deshpande, AA, Emrich, D, Gaensler, BM, Goeke, R, Greenhill, LJ, Hazelton, BJ, Johnston-Hollitt, M, Kasper, JC, Kratzenberg, E, Lonsdale, CJ, Lynch, MJ, McWhirter, SR, Mitchell, DA, Morales, MF, Morgan, E, Oberoi, D, Ord, SM, Prabu, T, Rogers, AEE, Roshi, A, Shankar, NU, Srivani, KS, Subrahmanyan, R, Tingay, SJ, Waterson, M, Wayth, RB, Webster, RL, Whitney, AR, Williams, A, and Williams, CL

Published
2015

13. A digital-receiver for the Murchison Widefield Array

Author

Prabu, T, Srivani, KS, Roshi, DA, Kamini, PA, Madhavi, S, Emrich, D, Crosse, B, Williams, AJ, Waterson, M, Deshpande, AA, Shankar, NU, Subrahmanyan, R, Briggs, FH, Goeke, RF, Tingay, SJ, Johnston-Hollitt, M, Gopalakrishna, MR, Morgan, EH, Pathikulangara, J, Bunton, JD, Hampson, G, Williams, C, Ord, SM, Wayth, RB, Kumar, D, Morales, MF, deSouza, L, Kratzenberg, E, Pallot, D, McWhirter, R, Hazelton, BJ, Arcus, W, Barnes, DG, Bernardi, G, Booler, T, Bowman, JD, Cappallo, RJ, Corey, BE, Greenhill, LJ, Herne, D, Hewitt, JN, Kaplan, DL, Kasper, JC, Kincaid, BB, Koenig, R, Lonsdale, CJ, Lynch, MJ, Mitchell, DA, Oberoi, D, Remillard, RA, Rogers, AE, Salah, JE, Sault, RJ, Stevens, JB, Tremblay, S, Webster, RL, Whitney, AR, Wyithe, SB, Prabu, T, Srivani, KS, Roshi, DA, Kamini, PA, Madhavi, S, Emrich, D, Crosse, B, Williams, AJ, Waterson, M, Deshpande, AA, Shankar, NU, Subrahmanyan, R, Briggs, FH, Goeke, RF, Tingay, SJ, Johnston-Hollitt, M, Gopalakrishna, MR, Morgan, EH, Pathikulangara, J, Bunton, JD, Hampson, G, Williams, C, Ord, SM, Wayth, RB, Kumar, D, Morales, MF, deSouza, L, Kratzenberg, E, Pallot, D, McWhirter, R, Hazelton, BJ, Arcus, W, Barnes, DG, Bernardi, G, Booler, T, Bowman, JD, Cappallo, RJ, Corey, BE, Greenhill, LJ, Herne, D, Hewitt, JN, Kaplan, DL, Kasper, JC, Kincaid, BB, Koenig, R, Lonsdale, CJ, Lynch, MJ, Mitchell, DA, Oberoi, D, Remillard, RA, Rogers, AE, Salah, JE, Sault, RJ, Stevens, JB, Tremblay, S, Webster, RL, Whitney, AR, and Wyithe, SB

Published
2015

14. The Murchison Widefield Array Correlator

Author

Ord, SM, Crosse, B, Emrich, D, Pallot, D, Wayth, RB, Clark, MA, Tremblay, SE, Arcus, W, Barnes, D, Bell, M, Bernardi, G, Bhat, NDR, Bowman, JD, Briggs, F, Bunton, JD, Cappallo, RJ, Corey, BE, Deshpande, AA, deSouza, L, Ewell-Wice, A, Feng, L, Goeke, R, Greenhill, LJ, Hazelton, BJ, Herne, D, Hewitt, JN, Hindson, L, Hurley-Walker, N, Jacobs, D, Johnston-Hollitt, M, Kaplan, DL, Kasper, JC, Kincaid, BB, Koenig, R, Kratzenberg, E, Kudryavtseva, N, Lenc, E, Lonsdale, CJ, Lynch, MJ, McKinley, B, McWhirter, SR, Mitchell, DA, Morales, MF, Morgan, E, Oberoi, D, Offringa, A, Pathikulangara, J, Pindor, B, Prabu, T, Procopio, P, Remillard, RA, Riding, J, Rogers, AEE, Roshi, A, Salah, JE, Sault, RJ, Shankar, NU, Srivani, KS, Stevens, J, Subrahmanyan, R, Tingay, SJ, Waterson, M, Webster, RL, Whitney, AR, Williams, A, Williams, CL, Wyithe, JSB, Ord, SM, Crosse, B, Emrich, D, Pallot, D, Wayth, RB, Clark, MA, Tremblay, SE, Arcus, W, Barnes, D, Bell, M, Bernardi, G, Bhat, NDR, Bowman, JD, Briggs, F, Bunton, JD, Cappallo, RJ, Corey, BE, Deshpande, AA, deSouza, L, Ewell-Wice, A, Feng, L, Goeke, R, Greenhill, LJ, Hazelton, BJ, Herne, D, Hewitt, JN, Hindson, L, Hurley-Walker, N, Jacobs, D, Johnston-Hollitt, M, Kaplan, DL, Kasper, JC, Kincaid, BB, Koenig, R, Kratzenberg, E, Kudryavtseva, N, Lenc, E, Lonsdale, CJ, Lynch, MJ, McKinley, B, McWhirter, SR, Mitchell, DA, Morales, MF, Morgan, E, Oberoi, D, Offringa, A, Pathikulangara, J, Pindor, B, Prabu, T, Procopio, P, Remillard, RA, Riding, J, Rogers, AEE, Roshi, A, Salah, JE, Sault, RJ, Shankar, NU, Srivani, KS, Stevens, J, Subrahmanyan, R, Tingay, SJ, Waterson, M, Webster, RL, Whitney, AR, Williams, A, Williams, CL, and Wyithe, JSB

Abstract

The Murchison Widefield Array is a Square Kilometre Array Precursor. The telescope is located at the Murchison Radio–astronomy Observatory in Western Australia. The MWA consists of 4 096 dipoles arranged into 128 dual polarisation aperture arrays forming a connected element interferometer that cross-correlates signals from all 256 inputs. A hybrid approach to the correlation task is employed, with some processing stages being performed by bespoke hardware, based on Field Programmable Gate Arrays, and others by Graphics Processing Units housed in general purpose rack mounted servers. The correlation capability required is approximately 8 tera floating point operations per second. The MWA has commenced operations and the correlator is generating 8.3 TB day−1 of correlation products, that are subsequently transferred 700 km from the MRO to Perth (WA) in real-time for storage and offline processing. In this paper, we outline the correlator design, signal path, and processing elements and present the data format for the internal and external interfaces.

Published
2015

15. An analysis of the halo and relic radio emission from Abell 3376 from Murchison Widefield Array observations

Author

George, LT, Dwarakanath, KS, Johnston-Hollitt, M, Hurley-Walker, N, Hindson, L, Kapinska, AD, Tingay, SJ, Bell, M, Callingham, JR, For, B-Q, Hancock, PJ, Lenc, E, McKinley, B, Morgan, J, Offringa, A, Procopio, P, Staveley-Smith, L, Wayth, RB, Wu, C, Zheng, Q, Bernardi, G, Bowman, JD, Briggs, F, Cappallo, RJ, Corey, BE, Deshpande, AA, Emrich, D, Goeke, R, Greenhill, LJ, Hazelton, BJ, Kaplan, DL, Kasper, JC, Kratzenberg, E, Lonsdale, CJ, Lynch, MJ, McWhirter, SR, Mitchell, DA, Morales, MF, Morgan, E, Oberoi, D, Ord, SM, Prabu, T, Rogers, AEE, Roshi, A, Shankar, NU, Srivani, KS, Subrahmanyan, R, Waterson, M, Webster, RL, Whitney, AR, Williams, A, Williams, CL, George, LT, Dwarakanath, KS, Johnston-Hollitt, M, Hurley-Walker, N, Hindson, L, Kapinska, AD, Tingay, SJ, Bell, M, Callingham, JR, For, B-Q, Hancock, PJ, Lenc, E, McKinley, B, Morgan, J, Offringa, A, Procopio, P, Staveley-Smith, L, Wayth, RB, Wu, C, Zheng, Q, Bernardi, G, Bowman, JD, Briggs, F, Cappallo, RJ, Corey, BE, Deshpande, AA, Emrich, D, Goeke, R, Greenhill, LJ, Hazelton, BJ, Kaplan, DL, Kasper, JC, Kratzenberg, E, Lonsdale, CJ, Lynch, MJ, McWhirter, SR, Mitchell, DA, Morales, MF, Morgan, E, Oberoi, D, Ord, SM, Prabu, T, Rogers, AEE, Roshi, A, Shankar, NU, Srivani, KS, Subrahmanyan, R, Waterson, M, Webster, RL, Whitney, AR, Williams, A, and Williams, CL

Abstract

We have carried out multiwavelength observations of the near-by ($z=0.046$) rich, merging galaxy cluster Abell 3376 with the Murchison Widefield Array (MWA). As a part of the GaLactic and Extragalactic All-sky MWA survey (GLEAM), this cluster was observed at 88, 118, 154, 188 and 215 MHz. The known radio relics, towards the eastern and western peripheries of the cluster, were detected at all the frequencies. The relics, with a linear extent of $\sim$ 1 Mpc each, are separated by $\sim$ 2 Mpc. Combining the current observations with those in the literature, we have obtained the spectra of these relics over the frequency range 80 -- 1400 MHz. The spectra follow power laws, with $\alpha$ = $-1.17\pm0.06$ and $-1.37\pm0.08$ for the west and east relics, respectively ($S \propto \nu^{\alpha}$). Assuming the break frequency to be near the lower end of the spectrum we estimate the age of the relics to be $\sim$ 0.4 Gyr. No diffuse radio emission from the central regions of the cluster (halo) was detected. The upper limit on the radio power of any possible halo that might be present in the cluster is a factor of 35 lower than that expected from the radio power and X-ray luminosity correlation for cluster halos. From this we conclude that the cluster halo is very extended ($>$ 500 kpc) and/or most of the radio emission from the halo has decayed. The current limit on the halo radio power is a factor of ten lower than the existing upper limits with possible implications for models of halo formation.

Published
2015

16. The First Murchison Widefield Array low-frequency radio observations of cluster scale non-thermal emission: the case of Abell 3667

Author

Hindson, L, Johnston-Hollitt, M, Hurley-Walker, N, Buckley, K, Morgan, J, Carretti, E, Dwarakanath, KS, Bell, M, Bernardi, G, Bhat, NDR, Bowman, JD, Briggs, F, Cappallo, RJ, Corey, BE, Deshpande, AA, Emrich, D, Ewall-Wice, A, Feng, L, Gaensler, BM, Goeke, R, Greenhill, LJ, Hazelton, BJ, Jacobs, D, Kaplan, DL, Kasper, JC, Kratzenberg, E, Kudryavtseva, N, Lenc, E, Lonsdale, CJ, Lynch, MJ, McWhirter, SR, McKinley, B, Mitchell, DA, Morales, MF, Morgan, E, Oberoi, D, Ord, SM, Pindor, B, Prabu, T, Procopio, P, Offringa, AR, Riding, J, Rogers, AEE, Roshi, A, Shankar, NU, Srivani, KS, Subrahmanyan, R, Tingay, SJ, Waterson, M, Wayth, RB, Webster, RL, Whitney, AR, Williams, A, Williams, CL, Hindson, L, Johnston-Hollitt, M, Hurley-Walker, N, Buckley, K, Morgan, J, Carretti, E, Dwarakanath, KS, Bell, M, Bernardi, G, Bhat, NDR, Bowman, JD, Briggs, F, Cappallo, RJ, Corey, BE, Deshpande, AA, Emrich, D, Ewall-Wice, A, Feng, L, Gaensler, BM, Goeke, R, Greenhill, LJ, Hazelton, BJ, Jacobs, D, Kaplan, DL, Kasper, JC, Kratzenberg, E, Kudryavtseva, N, Lenc, E, Lonsdale, CJ, Lynch, MJ, McWhirter, SR, McKinley, B, Mitchell, DA, Morales, MF, Morgan, E, Oberoi, D, Ord, SM, Pindor, B, Prabu, T, Procopio, P, Offringa, AR, Riding, J, Rogers, AEE, Roshi, A, Shankar, NU, Srivani, KS, Subrahmanyan, R, Tingay, SJ, Waterson, M, Wayth, RB, Webster, RL, Whitney, AR, Williams, A, and Williams, CL

Abstract

We present the first Murchison Widefield Array observations of the well-known cluster of galaxies Abell 3667 (A3667) between 105 and 241 MHz. A3667 is one of the best known examples of a galaxy cluster hosting a double radio relic and has been reported to contain a faint radio halo and bridge. The origins of radio halos, relics and bridges is still unclear, however galaxy cluster mergers seems to be an important factor. We clearly detect the North-West (NW) and South-East (SE) radio relics in A3667 and find an integrated flux density at 149 MHz of 28.1 +/- 1.7 and 2.4 +/- 0.1 Jy, respectively, with an average spectral index, between 120 and 1400 MHz, of -0.9 +/- 0.1 for both relics. We find evidence of a spatial variation in the spectral index across the NW relic steepening towards the centre of the cluster, which indicates an ageing electron population. These properties are consistent with higher frequency observations. We detect emission that could be associated with a radio halo and bridge. How- ever, due to the presence of poorly sampled large-scale Galactic emission and blended point sources we are unable to verify the exact nature of these features.

Published
2014

17. STUDY OF REDSHIFTED H I FROM THE EPOCH OF REIONIZATION WITH DRIFT SCAN

Author

Paul, S, Sethi, SK, Subrahmanyan, R, Shankar, NU, Dwarakanath, KS, Deshpande, AA, Bernardi, G, Bowman, JD, Briggs, F, Cappallo, RJ, Corey, BE, Emrich, D, Gaensler, BM, Goeke, RF, Greenhill, LJ, Hazelton, BJ, Hewitt, JN, Johnston-Hollitt, M, Kaplan, DL, Kasper, JC, Kratzenberg, E, Lonsdale, CJ, Lynch, MJ, McWhirter, SR, Mitchell, DA, Morales, MF, Morgan, EH, Oberoi, D, Ord, SM, Prabu, T, Rogers, AEE, Roshi, AA, Srivani, KS, Tingay, SJ, Wayth, RB, Waterson, M, Webster, RL, Whitney, AR, Williams, AJ, Williams, CL, Paul, S, Sethi, SK, Subrahmanyan, R, Shankar, NU, Dwarakanath, KS, Deshpande, AA, Bernardi, G, Bowman, JD, Briggs, F, Cappallo, RJ, Corey, BE, Emrich, D, Gaensler, BM, Goeke, RF, Greenhill, LJ, Hazelton, BJ, Hewitt, JN, Johnston-Hollitt, M, Kaplan, DL, Kasper, JC, Kratzenberg, E, Lonsdale, CJ, Lynch, MJ, McWhirter, SR, Mitchell, DA, Morales, MF, Morgan, EH, Oberoi, D, Ord, SM, Prabu, T, Rogers, AEE, Roshi, AA, Srivani, KS, Tingay, SJ, Wayth, RB, Waterson, M, Webster, RL, Whitney, AR, Williams, AJ, and Williams, CL

Abstract

The detection of the Epoch of Reionization (EoR) in the redshifted 21-cm line is a challenging task. Here we formulate the detection of the EoR signal using the drift scan strategy. This method potentially has better instrumental stability as compared to the case where a single patch of sky is tracked. We demonstrate that the correlation time between measured visibilities could extend up to 1-2 hr for an interferometer array such as the Murchison Widefield Array (MWA), which has a wide primary beam. We estimate the EoR power based on cross-correlation of visibilities across time and show that the drift scan strategy is capable of the detection of the EoR signal with comparable/better signal-to-noise as compared to the tracking case. We also estimate the visibility correlation for a set of bright point sources and argue that the statistical inhomogeneity of bright point sources might allow their separation from the EoR signal.

Published
2014

18. Observing the Sun with the Murchison Widefield Array

Author

Oberoi, D, Sharma, R, Bhatnagar, S, Lonsdale, CJ, Matthews, LD, Cairns, IH, Tingay, SJ, Benkevitch, L, Donea, A, White, SM, Bernardi, G, Bowman, JD, Briggs, F, Cappallo, RJ, Corey, BE, Deshpande, A, Emrich, D, Gaensler, BM, Goeke, R, Greenhill, LJ, Hazelton, BJ, Johnston-Hollitt, M, Kaplan, DL, Kasper, JC, Kratzenberg, E, Lynch, MJ, McWhirter, SR, Mitchell, DA, Morales, MF, Morgan, E, Offringa, AR, Ord, SM, Prabu, T, Rogers, AEE, Roshi, A, Salah, JE, Shankar, NU, Srivani, KS, Subrahmanyan, R, Waterson, M, Wayth, RB, Webster, RL, Whitney, AR, William, A, Williams, CL, Oberoi, D, Sharma, R, Bhatnagar, S, Lonsdale, CJ, Matthews, LD, Cairns, IH, Tingay, SJ, Benkevitch, L, Donea, A, White, SM, Bernardi, G, Bowman, JD, Briggs, F, Cappallo, RJ, Corey, BE, Deshpande, A, Emrich, D, Gaensler, BM, Goeke, R, Greenhill, LJ, Hazelton, BJ, Johnston-Hollitt, M, Kaplan, DL, Kasper, JC, Kratzenberg, E, Lynch, MJ, McWhirter, SR, Mitchell, DA, Morales, MF, Morgan, E, Offringa, AR, Ord, SM, Prabu, T, Rogers, AEE, Roshi, A, Salah, JE, Shankar, NU, Srivani, KS, Subrahmanyan, R, Waterson, M, Wayth, RB, Webster, RL, Whitney, AR, William, A, and Williams, CL

Published
2014

19. THE LOW-FREQUENCY CHARACTERISTICS OF PSR J0437-4715 OBSERVED WITH THE MURCHISON WIDE-FIELD ARRAY

Author

Bhat, NDR, Ord, SM, Tremblay, SE, Tingay, SJ, Deshpande, AA, van Straten, W, Oronsaye, S, Bernardi, G, Bowman, JD, Briggs, F, Cappallo, RJ, Corey, BE, Emrich, D, Goeke, R, Greenhill, LJ, Hazelton, BJ, Hewitt, JN, Johnston-Hollitt, M, Kaplan, DL, Kasper, JC, Kratzenberg, E, Lonsdale, CJ, Lynch, MJ, McWhirter, SR, Mitchell, DA, Morales, MF, Morgan, E, Oberoi, D, Prabu, T, Rogers, AEE, Roshi, DA, Shankar, NU, Srivani, KS, Subrahmanyan, R, Waterson, M, Wayth, RB, Webster, RL, Whitney, AR, Williams, A, Williams, CL, Bhat, NDR, Ord, SM, Tremblay, SE, Tingay, SJ, Deshpande, AA, van Straten, W, Oronsaye, S, Bernardi, G, Bowman, JD, Briggs, F, Cappallo, RJ, Corey, BE, Emrich, D, Goeke, R, Greenhill, LJ, Hazelton, BJ, Hewitt, JN, Johnston-Hollitt, M, Kaplan, DL, Kasper, JC, Kratzenberg, E, Lonsdale, CJ, Lynch, MJ, McWhirter, SR, Mitchell, DA, Morales, MF, Morgan, E, Oberoi, D, Prabu, T, Rogers, AEE, Roshi, DA, Shankar, NU, Srivani, KS, Subrahmanyan, R, Waterson, M, Wayth, RB, Webster, RL, Whitney, AR, Williams, A, and Williams, CL

Published
2014

20. Trends in storm-triggered landslides over Southern California

Author

Ren, D, Leslie, LM, Lynch, MJ, Ren, D, Leslie, LM, and Lynch, MJ

Abstract

Changes in storm-triggered landslide activity for Southern California in a future warming climate are estimated using an advanced, fully three-dimensional, process-based landslide model, the Scalable and Extensible GeofluidModeling Systemfor landslides (SEGMENT-Landslide). SEGMENT-Landslide is driven by extreme rainfall projections from the Geophysical Fluid Dynamics Laboratory High Resolution Atmospheric Model (GFDL-HIRAM). Landslide changes are derived from GFDL-HIRAM forcing for two periods: 1) the twentieth century (CNTRL) and 2) the twenty-first century under themoderate Intergovernmental Panel onClimate Change Special Report on Emissions Scenarios A1B enhanced greenhouse gas emissions scenario (EGHG). Here, differences are calculated in landslide frequency and magnitude between the CNTRL and EGHG projections; kernel density estimation (KDE) is used to determine differences in projected landslide locations. This study also reveals that extreme precipitation events in Southern California are strongly correlated with several climate drivers and that GFDL-HIRAM simulates well the southern (relative to Aleutian synoptic systems) storm tracks in El Ni~no years and the rare (~27-yr recurrence period) hurricane-landfalling events. GFDLHIRAM therefore can provide satisfactory projections of the geographical distribution, seasonal cycle, and interannual variability of future extreme precipitation events (>50mm) that have possible landslide consequences for Southern California. Although relatively infrequent, extreme precipitation events contribute most of the annual total precipitation in Southern California. Two findings of this study have major implications for Southern California. First is a possible increase in landslide frequency and areal distribution during the twentyfirst century. Second, the KDE reveals three clusters in both the CNTRL and EGHG model mean scarp positions, with a future eastward (inland) shift of ~0.5° and a northward shift of ~1°. These finding

Published
2014

21. Verification of model simulated mass balance, flow fields and tabular calving events of the Antarctic ice sheet against remotely sensed observations

Author

Ren, D, Leslie, LM, Lynch, MJ, Ren, D, Leslie, LM, and Lynch, MJ

Abstract

The Antarctic ice sheet (AIS) has the greatest potential for global sea level rise. This study simulates AIS ice creeping, sliding, tabular calving, and estimates the total mass balances, using a recently developed, advanced ice dynamics model, known as SEGMENT-Ice. SEGMENT-Ice is written in a spherical Earth coordinate system. Because the AIS contains the South Pole, a projection transfer is performed to displace the pole outside of the simulation domain. The AIS also has complex ice-water-granular material-bedrock configurations, requiring sophisticated lateral and basal boundary conditions. Because of the prevalence of ice shelves, a 'girder yield' type calving scheme is activated. The simulations of present surface ice flow velocities compare favorably with InSAR measurements, for various ice-water-bedrock configurations. The estimated ice mass loss rate during 2003-2009 agrees with GRACE measurements and provides more spatial details not represented by the latter. The model estimated calving frequencies of the peripheral ice shelves from 1996 (roughly when the 5-km digital elevation and thickness data for the shelves were collected) to 2009 compare well with archived scatterometer images. SEGMENT-Ice's unique, non-local systematic calving scheme is found to be relevant for tabular calving. However, the exact timing of calving and of iceberg sizes cannot be simulated accurately at present. A projection of the future mass change of the AIS is made, with SEGMENT-Ice forced by atmospheric conditions from three different coupled general circulation models. The entire AIS is estimated to be losing mass steadily at a rate of ~120 km3/a at present and this rate possibly may double by year 2100. © 2012 The Author(s).

Published
2013

22. Immobilisation of pinniped species

Author

Lynch Mj, Tahmindjis Ma, and Gardner H

Subjects
Male, Restraint, Physical, Xylazine, Analgesics, Tiletamine, General Veterinary, Seals, Earless, Yohimbine, General Medicine, Biology, Zolazepam, Drug Combinations, Immobilization, Species Specificity, Evolutionary biology, Animals, Female, Ketamine, Adrenergic alpha-Agonists, Adrenergic alpha-Antagonists, Anesthetics, Monitoring, Physiologic
Published
1999

24. The Wardill test: does it predict future voiding flow?

Author

Stewart Pa and Lynch Mj

Subjects
Male, Prostatectomy, medicine.medical_specialty, Surgical approach, business.industry, Urology, medicine.medical_treatment, Urinary Bladder, Prostatic Neoplasms, Urination, Predictive value, Transurethral prostatectomy, Flow (mathematics), Predictive Value of Tests, Pressure, Medicine, Humans, Prospective Studies, business, Prospective cohort study, Aged
Abstract

A prospective study was undertaken to assess the predictive value of measuring the peak flow rate at completion of a transurethral prostatectomy with suprapubic pressure (the Wardill test). Twenty-six patients had their expressed flow rate measured on applying a standardised suprapubic pressure and compared to their peak flow rate measured at least 6 weeks postoperatively. No significant correlation was found to exist between the two variables.

Published
1992

30. Long term outcome after surgery for extrahepatic portal vein thrombosis.

Author

Losty PD, Lynch MJ, Guiney EJ, Losty, P D, Lynch, M J, and Guiney, E J

Abstract

The long term outcome of 21 children with extrahepatic portal hypertension secondary to portal vein thrombosis managed by surgical intervention was evaluated. Portosystemic shunts, used primarily in nine patients (eight central splenorenal, one mesocaval) after conservative treatment had failed, had no associated mortality and a 56% patency rate. Five of these shunted patients had no further bleeding episodes and did not show encephalopathic impairment. Direct attack procedures-portoazygos operation (four patients) was associated with significant complications, including one fatality. Other direct approaches-oesophageal transection and variceal plication (five patients) had variable outcome. Splenectomy alone (three patients) ameliorated hypersplenism; however, further surgery for recurrent haemorrhage (two patients) was necessary. Endoscopic sclerotherapy controlled recurrent variceal bleeding (three patients) when it became available to the unit. Conservative treatment practised in five children had little success: two patients survived, two died from further haemorrhage, and one was lost to follow up. These results suggest that in centres without endoscopic expertise, and for patients who are sclerotherapy 'failures', surgery can be performed safely and achieve reasonable long term success rates in childhood extrahepatic portal hypertension. [ABSTRACT FROM AUTHOR]

Published
1994
Full Text
View/download PDF

31. Updating Tuberculosis Control in Occupational Medicine

Author

Lynch Mj and DeMeo An

Subjects
medicine.medical_specialty, business.industry, Occupational Health Services, Public Health, Environmental and Occupational Health, Alternative medicine, Mass Chest X-Ray, United States, Occupational medicine, National Institutes of Health (U.S.), Family medicine, Isoniazid, medicine, Physical therapy, Tuberculosis control, business, Tuberculosis, Pulmonary
Published
1968
Full Text
View/download PDF

32. Toxic shock syndrome without rash in a 14-year-old girl

Author

Englund K, Lynch Mj, and Baptist Ec

Subjects
medicine.medical_specialty, Adolescent, Urticaria, business.industry, media_common.quotation_subject, Toxic shock syndrome, General Medicine, Staphylococcal Infections, medicine.disease, Rash, Dermatology, Shock, Septic, medicine, Humans, Female, Girl, medicine.symptom, business, media_common
Published
1981

33. Detection of crab giant pulses using the Mileura widefield array low frequency demonstrator field prototype system

Author

Bhat, NDR, Kocz, J, Lonsdale, CJ, Lynch, MJ, Stansby, B, Stevens, JB, Torr, G, Webster, RL, Wythe, JSB, Wayth, RB, Knight, HS, Bowman, JD, Oberoi, D, Barnes, DG, Briggs, FH, Cappallo, RJ, Herne, D, Bhat, NDR, Kocz, J, Lonsdale, CJ, Lynch, MJ, Stansby, B, Stevens, JB, Torr, G, Webster, RL, Wythe, JSB, Wayth, RB, Knight, HS, Bowman, JD, Oberoi, D, Barnes, DG, Briggs, FH, Cappallo, RJ, and Herne, D

Abstract

We report on the detection of giant pulses from the Crab Nebula pulsar at a frequency of 200 MHz using the field deployment system designed for the MileuraWidefield Array’s Low Frequency Demonstrator (MWA-LFD). Our observations are among the first high-quality detections at such low frequencies. The measured pulse shapes are deconvolved for interstellar pulse broadening, yielding a pulse-broadening time of 670 100 s, and the implied strength of scattering (scattering measure) is the lowest that is estimated toward the Crab Nebula from observations made so far. The sensitivity of the system is largely dictated by the sky background, and our simple equipment is capable of detecting pulses that are brighter than 9 kJy in amplitude. The brightest giant pulse detected in our data has a peak amplitude of 50 kJy, and the implied brightness temperature is 1031.6 K.We discuss the giant pulse detection prospects with the fullMWA-LFD system.With a sensitivity over 2 orders of magnitude larger than the prototype equipment, the full system will be capable of detecting such bright giant pulses out to a wide range of Galactic distances; from15 to30 kpc depending on the frequency. TheMWA-LFD will thus be a highly promising instrument for the studies of giant pulses and other fast radio transients at low frequencies.

34. Field deployment of prototype antenna tiles for the Mileura widefield array low frequency demonstrator

Author

Bowman, JD, Herne, D, Hewitt, JN, Johnston, C, Kasper, JC, Kocz, J, Kratzenberg, E, Lonsdale, CJ, Morales, MF, Oberoi, D, Salah, JE, Barnes, DG, Stansby, B, Stevens, JB, Torr, G, Wayth, RB, Webster, RL, Wyithe, JSB, Briggs, FH, Corey, BE, Lynch, MJ, Bhat, NDR, Cappallo, RJ, Doeleman, SS, Fanous, BJ, Bowman, JD, Herne, D, Hewitt, JN, Johnston, C, Kasper, JC, Kocz, J, Kratzenberg, E, Lonsdale, CJ, Morales, MF, Oberoi, D, Salah, JE, Barnes, DG, Stansby, B, Stevens, JB, Torr, G, Wayth, RB, Webster, RL, Wyithe, JSB, Briggs, FH, Corey, BE, Lynch, MJ, Bhat, NDR, Cappallo, RJ, Doeleman, SS, and Fanous, BJ

Abstract

Experiments were performed with prototype antenna tiles for the Mileura Widefield Array Low Frequency Demonstrator (MWA LFD) to better understand the wide-field, wide-band properties of their design and to characterize the radio-frequency interference (RFI) between 80 and 300 MHz at the site in Western Australia. Observations acquired during the 6 month deployment confirmed the predicted sensitivity of the antennas, sky-noise-dominated system temperatures, and phase-coherent interferometric measurements. The radio spectrum is remarkably free of strong terrestrial signals, with the exception of two narrow frequency bands allocated to satellite downlinks, and rare bursts due to ground-based transmissions being scattered from aircraft and meteor trails. Results indicate the potential of the MWA LFD to make significant achievements in its three key science objectives: epoch of reionization science, heliospheric science, and radio transient detection.

48. Regulation by estrogen through the 5'-flanking region of the transforming growth factor alpha gene

Author

Audrey Cristiano, Michael G. Brattain, David S. Salomon, Nicholas Kenney, Fortunato Ciardiello, Nicola Normanno, Mark Lynch, Toshiaki Saeki, N. Kim, Saeki, T, Cristiano, A, Lynch, Mj, Brattain, M, Kim, N, Normanno, N, Kenney, N, Ciardiello, Fortunato, and Salomon, Ds

Subjects
Molecular Sequence Data, 5' flanking region, Radioimmunoassay, Breast Neoplasms, Biology, Transfection, Chloramphenicol acetyltransferase, Endocrinology, Gene expression, Tumor Cells, Cultured, Animals, Humans, Luciferases, Molecular Biology, Cells, Cultured, Progesterone, Base Sequence, Dose-Response Relationship, Drug, Estrogens, DNA, Neoplasm, General Medicine, Transforming Growth Factor alpha, Molecular biology, Gene Expression Regulation, Neoplastic, Cell culture, Regulatory sequence, Cancer cell, Cats, Female, Plasmids, Transforming growth factor
Abstract

Expression of transforming growth factor alpha (TGF alpha) mRNA and protein can be stimulated by estrogens such as 17 beta-estradiol (E2) in estrogen-responsive rodent and human breast cancer cells. To ascertain if E2 can directly regulate TGF alpha expression through the 5'-flanking region of the human TGF alpha gene, E2-responsive MCF-7 or ZR-75-1 human breast cancer cells or E2-nonresponsive MDA-MB-231 breast cancer cells were transiently transfected with a plasmid containing an 1140-base pair (bp) Sac-I fragment of the TGF alpha 5'-flanking region ligated to the chloramphenicol acetyltransferase (CAT) gene. Cells that were transfected and subsequently treated with physiological concentrations of E2 (10(-11)-10(-8) M) for 24 h exhibited a 2- to 10-fold increase in CAT activity. The E2 stimulation of CAT activity was dose-dependent with an increase first found at 10(-10) M E2. The increase in CAT activity could be detected within 24-36 h after the addition of E2. There was no significant change in CAT activity in transiently transfected MDA-MB-231 cells as mediated through the TGF alpha 5'-flanking region after E2 treatment. MCF-7 cells were also transiently transfected with different fragments of the TGF alpha 5'-flanking region ligated to the luciferase gene. In the absence of E2 treatment, no detectable luciferase activity was found.(ABSTRACT TRUNCATED AT 250 WORDS)

Published
1991

49. Severe Outcomes in Suspected Pediatric Delta-8-THC Exposures.

Author

Ostrowski SJ, Scanlon MP, Barton DJ, Lynch MJ, and Trautman WJ

Abstract

Competing Interests: Declarations. Trial Registration: Not applicable. Conflicts of Interest: SO reports grant support from ACMT’s MTF and ACMT’s ANTIDOTE Institute program. MS, DB, ML, WT declare they have no conflict of interest.

Published
2025
Full Text
View/download PDF

50. MCP5, a methyl-accepting chemotaxis protein regulated by both the Hk1-Rrp1 and Rrp2-RpoN-RpoS pathways, is required for the immune evasion of Borrelia burgdorferi.

Author

Raghunandanan S, Zhang K, Zhang Y, Priya R, Sze CW, Lou Y, Lynch MJ, Crane BR, Kaplan MH, Li C, and Yang XF

Subjects
Animals, Mice, Chemotaxis, Mice, SCID, Gene Expression Regulation, Bacterial, Borrelia burgdorferi immunology, Lyme Disease immunology, Lyme Disease microbiology, Immune Evasion, Bacterial Proteins metabolism, Bacterial Proteins genetics, Bacterial Proteins immunology, Mice, Inbred C3H
Abstract

Borrelia (or Borreliella) burgdorferi, the causative agent of Lyme disease, is a motile and invasive zoonotic pathogen adept at navigating between its arthropod vector and mammalian host. While motility and chemotaxis are well known to be essential for its enzootic cycle, the role of each methyl-accepting chemotaxis proteins (MCPs) in the infectious cycle of B. burgdorferi remains unclear. In this study, we show that mcp5, a gene encoding one of the most abundant MCPs in B. burgdorferi, is differentially expressed in response to environmental signals and at distinct stages of the pathogen's enzootic cycle. Notably, mcp5 expression is regulated by the Hk1-Rrp1 and Rrp2-RpoN-RpoS pathways, two key regulatory pathways that are critical for the spirochete's colonization of the tick vector and mammalian host, respectively. Infection experiments with an mcp5 mutant revealed that spirochetes lacking MCP5 were unable to establish infections in either C3H/HeN mice or Severe Combined Immunodeficiency (SCID) mice, which are deficient in adaptive immunity, underscoring MCP5's critical role in mammalian infection. However, the mcp5 mutant was able to establish infection and disseminate in NOD SCID Gamma (NSG) mice, which are deficient in both adaptive and most innate immune responses, suggesting that MCP5 plays an important role in evading host innate immunity. Moreover, NK cell depletion in C3H and SCID mice restored the infectivity of the mcp5 mutant, further highlighting MCP5's role in evading NK cell-associated immunity. Co-culture assays with NK cells and macrophages revealed that the mcp5 mutant enhanced interferon-gamma production by NK cells. In the tick vector, the mcp5 mutants survived feeding but failed to transmit to mice. These findings reveal that MCP5, regulated by both the Rrp1 and Rrp2 pathways, is critical for establishing infection in mammalian hosts by evading NK cell-mediated host innate immunity and is important for the transmission of spirochetes from ticks to mammalian hosts. This work provides a foundation for further elucidation of chemotactic signals sensed by MCP5 that facilitate B. burgdorferi in evading host defenses., Competing Interests: The authors have declared that no competing interests exist., (Copyright: © 2024 Raghunandanan et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.)

Published
2024
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results