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2. Cost-Effectiveness of Lipid-Lowering Treatments in Young Adults

Author

Kohli-Lynch, Ciaran N, Bellows, Brandon K, Zhang, Yiyi, Spring, Bonnie, Kazi, Dhruv S, Pletcher, Mark J, Vittinghoff, Eric, Allen, Norrina B, and Moran, Andrew E

Subjects
Biomedical and Clinical Sciences, Cardiovascular Medicine and Haematology, Comparative Effectiveness Research, Prevention, Cost Effectiveness Research, Patient Safety, Cardiovascular, Heart Disease, Good Health and Well Being, Adolescent, Adult, Aged, Aged, 80 and over, Atherosclerosis, Cardiovascular Diseases, Cholesterol, LDL, Cohort Studies, Cost-Benefit Analysis, Humans, Hydroxymethylglutaryl-CoA Reductase Inhibitors, Life Style, Lipids, Middle Aged, Nutrition Surveys, Probability, Quality-Adjusted Life Years, Risk, Young Adult, cardiovascular disease, cholesterol, cost-effectiveness, statins, young adulthood, Cardiorespiratory Medicine and Haematology, Public Health and Health Services, Cardiovascular System & Hematology, Cardiovascular medicine and haematology
Abstract

BackgroundRaised low-density lipoprotein cholesterol (LDL-C) in young adulthood (aged 18-39 years) is associated with atherosclerotic cardiovascular disease (ASCVD) later in life. Most young adults with elevated LDL-C do not currently receive lipid-lowering treatment.ObjectivesThis study aimed to estimate the prevalence of elevated LDL-C in ASCVD-free U.S. young adults and the cost-effectiveness of lipid-lowering strategies for raised LDL-C in young adulthood compared with standard care.MethodsThe prevalence of raised LDL-C was examined in the U.S. National Health and Nutrition Examination Survey. The CVD Policy Model projected lifetime quality-adjusted life years (QALYs), health care costs, and incremental cost-effectiveness ratios (ICERs) for lipid-lowering strategies. Standard care was statin treatment for adults aged ≥40 years based on LDL-C, ASCVD risk, or diabetes plus young adults with LDL-C ≥190 mg/dL. Lipid lowering incremental to standard care with moderate-intensity statins or intensive lifestyle interventions was simulated starting when young adult LDL-C was either ≥160 mg/dL or ≥130 mg/dL.ResultsApproximately 27% of ASCVD-free young adults have LDL-C of ≥130 mg/dL, and 9% have LDL-C of ≥160 mg/dL. The model projected that young adult lipid lowering with statins or lifestyle interventions would prevent lifetime ASCVD events and increase QALYs compared with standard care. ICERs were US$31,000/QALY for statins in young adult men with LDL-C of ≥130 mg/dL and US$106,000/QALY for statins in young adult women with LDL-C of ≥130 mg/dL. Intensive lifestyle intervention was more costly and less effective than statin therapy.ConclusionsStatin treatment for LDL-C of ≥130 mg/dL is highly cost-effective in young adult men and intermediately cost-effective in young adult women.

Published
2021

5. Beyond ten-year risk : novel approaches to the primary prevention of cardiovascular disease

Author

Kohli-Lynch, Ciaran Navin

Subjects
616.1, HB Economic Theory, RA Public aspects of medicine, RA0421 Public health. Hygiene. Preventive Medicine, RM Therapeutics. Pharmacology
Abstract

In cost-effectiveness analysis, outcomes are typically averaged across large groups to represent a patient population. Implementation and reimbursement decisions based on such analyses often ignore considerable heterogeneity in cost-effectiveness between patients. While good practice guidance for economic evaluations suggest including subgroup analysis, in practice this is frequently overlooked or underutilised. This thesis shows that failing to adequately represent heterogeneity in decision-making leads to an inefficient distribution of healthcare resources. This theory is applied in a study of cholesterol-reducing medication for the primary prevention of cardiovascular disease (CVD). Despite improvements in recent years, CVD remains a significant cause of mortality, morbidity, and health inequality around the world. Rates of the disease have begun to plateau in recent years and novel approaches to its prevention are required. Cholesterol reduction for the primary prevention of cardiovascular disease is a clinical area where better reflection of heterogeneity in cost-effectiveness could significantly improve current practice. Statins are a widely prescribed cholesterol-reducing medication which have recently come off patent. This has led them to become cheaper and cost-effective in a large proportion of CVD-free populations in high-income countries. PCSK9 inhibitors are a more expensive and more effective cholesterol-reducing medication. For both treatments, decision-makers must establish which groups they will prioritise for treatment. Through epidemiologic and health economic analysis, this thesis aims to establish optimal approaches for prioritising patients for cholesterol-reducing therapy. Preventive statin therapy is typically targeted at individuals estimated to have a high ten-year risk of developing CVD. However, individuals with the same ten-year risk may experience different outcomes from preventive treatment. The epidemiologic bases for three alternative approaches to the CVD prevention are discussed. These are: (i) continued use of ten-year risk scoring, (ii) novel decision mechanisms which incorporate ten-year risk, and (iii) direct use of decision-analytic models in clinical practice to guide treatment decisions. Several treatment policies may be characterised by one of the aforementioned approaches to prevention. These include: lowering the risk threshold for treatment initiation, improving the discrimination of risk scores with novel biomarker testing, age-stratified risk thresholds, absolute risk reduction-guided therapy, and outcome maximisation with decision-analytic models. Decision-analytic modelling was employed to assess the long-term effectiveness and cost-effectiveness of these policies. Additional analysis showed how decision-makers can signal demand for PCSK9 inhibitors and achieve welfare gains by reflecting heterogeneity in their decision-making. This thesis demonstrates the importance of reflecting heterogeneity in cost-effectiveness. It shows that standard care regarding the primary prevention of CVD often ignores heterogeneity, leading to suboptimal decision-making. This holds true for long-established, inexpensive treatments like statin therapy and novel, expensive treatments like PCSK9 inhibitors.

Published
2019
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8. Effect of Simulation-based Training on Surgical Proficiency and Patient Outcomes: A Randomised Controlled Clinical and Educational Trial

Author

Baig, Umair, Aya, Haleema, Husnain Iqbal, Mohammed, Kum, Francesca, Bultitude, Matthew, Glass, Jonathan, Khan, Azhar, Makanjuola, Jonathan, McCabe, John E., Samsuddin, Azi, McIlhenny, Craig, Brewin, James, Kulkarni, Shashank, Khwaja, Sikandar, Islam, Waliul, Marsh, Howard, Bhat, Taher, Thomas, Benjamin, Cutress, Mark, Housami, Fadi, Nedas, Timothy, Bates, Timothy, Mukherjee, Rono, Graham, Stuart, Bordenave, Matthieu, Coker, Charles, Ahmed, Shwan, Symes, Andrew, Calvert, Robert, Lynch, Ciaran, Long, Ronan, Patterson, Jacob M., Rukin, Nicholas J., Khan, Shahid A., Dasgupta, Ranan, Brown, Stephen, Grey, Ben, Mahmalji, Waseem, Lam, Wayne, Scheitlin, Walter, Saelzler, Norbert, Fiedler, Marcel, Ishikawa, Shuhei, Sasaki, Yoshihiro, Sazawa, Ataru, Shinno, Yuichiro, Mochizuki, Tango, Peter Jessen, Jan, Steiner, Roland, Wendt-Nordahl, Gunnar, Atassi, Nabil, Kohns, Heiko, Cox, Ashley, Rendon, Ricardo, Lawen, Joseph, Bailly, Greg, Marsh, Trevor, Aydın, Abdullatif, Ahmed, Kamran, Abe, Takashige, Raison, Nicholas, Van Hemelrijck, Mieke, Garmo, Hans, Ahmed, Hashim U., Mukhtar, Furhan, Al-Jabir, Ahmed, Brunckhorst, Oliver, Shinohara, Nobuo, Zhu, Wei, Zeng, Guohua, Sfakianos, John P., Gupta, Mantu, Tewari, Ashutosh, Gözen, Ali Serdar, Rassweiler, Jens, Skolarikos, Andreas, Kunit, Thomas, Knoll, Thomas, Moltzahn, Felix, Thalmann, George N., Lantz Powers, Andrea G., Chew, Ben H., Sarica, Kemal, Shamim Khan, Muhammad, and Dasgupta, Prokar

Published
2022
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13. Comparative Cost-Effectiveness of Conservative or Intensive Blood Pressure Treatment Guidelines in Adults Aged 35–74 Years

Author

Moise, Nathalie, Huang, Chen, Rodgers, Anthony, Kohli-Lynch, Ciaran N, Tzong, Keane Y, Coxson, Pamela G, Bibbins-Domingo, Kirsten, Goldman, Lee, and Moran, Andrew E

Subjects
Biomedical and Clinical Sciences, Cardiovascular Medicine and Haematology, Clinical Sciences, Health Services, Hypertension, Patient Safety, Clinical Research, Heart Disease, Cardiovascular, Comparative Effectiveness Research, Prevention, Cost Effectiveness Research, Evaluation of treatments and therapeutic interventions, 6.1 Pharmaceuticals, Good Health and Well Being, Adult, Age Factors, Aged, Antihypertensive Agents, Blood Pressure Determination, Cardiovascular Diseases, Conservative Treatment, Cost-Benefit Analysis, Dose-Response Relationship, Drug, Drug Administration Schedule, Female, Health Care Costs, Health Policy, Humans, Male, Markov Chains, Middle Aged, Policy Making, Practice Guidelines as Topic, Quality-Adjusted Life Years, Risk Assessment, United States, cardiovascular diseases, cost-benefit analysis, hypertension, guideline, policy, Cardiorespiratory Medicine and Haematology, Public Health and Health Services, Cardiovascular System & Hematology, Cardiovascular medicine and haematology, Clinical sciences
Abstract

The population health effect and cost-effectiveness of implementing intensive blood pressure goals in high-cardiovascular disease (CVD) risk adults have not been described. Using the CVD Policy Model, CVD events, treatment costs, quality-adjusted life years, and drug and monitoring costs were simulated over 2016 to 2026 for hypertensive patients aged 35 to 74 years. We projected the effectiveness and costs of hypertension treatment according to the 2003 Joint National Committee (JNC)-7 or 2014 JNC8 guidelines, and then for adults aged ≥50 years, we assessed the cost-effectiveness of adding an intensive goal of systolic blood pressure

Published
2016

18. Erratum to “Effect of Simulation-based Training on Surgical Proficiency and Patient Outcomes: A Randomised Controlled Clinical and Educational Trial” [Eur Urol 2022;81:385–393]

Author

Aydın, Abdullatif, primary, Ahmed, Kamran, additional, Abe, Takashige, additional, Raison, Nicholas, additional, Van Hemelrijck, Mieke, additional, Garmo, Hans, additional, Ahmed, Hashim U., additional, Mukhtar, Furhan, additional, Al-Jabir, Ahmed, additional, Brunckhorst, Oliver, additional, Shinohara, Nobuo, additional, Zhu, Wei, additional, Zeng, Guohua, additional, Sfakianos, John P., additional, Gupta, Mantu, additional, Tewari, Ashutosh, additional, Serdar Gözen, Ali, additional, Rassweiler, Jens, additional, Skolarikos, Andreas, additional, Kunit, Thomas, additional, Knoll, Thomas, additional, Moltzahn, Felix, additional, Thalmann, George N., additional, Lantz Powers, Andrea G., additional, Chew, Ben H., additional, Sarica, Kemal, additional, Shamim Khan, Muhammad, additional, Dasgupta, Prokar, additional, Baig, Umair, additional, Aya, Haleema, additional, Husnain Iqbal, Mohammed, additional, Kum, Francesca, additional, Bultitude, Matthew, additional, Glass, Jonathan, additional, Khan, Azhar, additional, Makanjuola, Jonathan, additional, McCabe, John E., additional, Samsuddin, Azi, additional, McIlhenny, Craig, additional, Brewin, James, additional, Kulkarni, Shashank, additional, Khwaja, Sikandar, additional, Islam, Waliul, additional, Marsh, Howard, additional, Bhat, Taher, additional, Thomas, Benjamin, additional, Cutress, Mark, additional, Housami, Fadi, additional, Nedas, Timothy, additional, Bates, Timothy, additional, Mukherjee, Rono, additional, Graham, Stuart, additional, Bordenave, Matthieu, additional, Coker, Charles, additional, Ahmed, Shwan, additional, Symes, Andrew, additional, Calvert, Robert, additional, Lynch, Ciaran, additional, Long, Ronan, additional, Patterson, Jacob M., additional, Rukin, Nicholas J., additional, Khan, Shahid A., additional, Dasgupta, Ranan, additional, Brown, Stephen, additional, Grey, Ben, additional, Mahmalji, Waseem, additional, Lam, Wayne, additional, Scheitlin, Walter, additional, Saelzler, Norbert, additional, Fiedler, Marcel, additional, Ishikawa, Shuhei, additional, Sasaki, Yoshihiro, additional, Sazawa, Ataru, additional, Shinno, Yuichiro, additional, Mochizuki, Tango, additional, Peter Jessen, Jan, additional, Steiner, Roland, additional, Wendt-Nordahl, Gunnar, additional, Atassi, Nabil, additional, Kohns, Heiko, additional, Cox, Ashley, additional, Rendon, Ricardo, additional, Lawen, Joseph, additional, Bailly, Greg, additional, and Marsh, Trevor, additional

Published
2022
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19. A Middleware Architecture Supporting Native Mobile Agents for Wireless Sensor Networks

Author

Lynch, Ciarán, Pesch, Dirk, Akan, Ozgur, Series editor, Bellavista, Paolo, Series editor, Cao, Jiannong, Series editor, Dressler, Falko, Series editor, Ferrari, Domenico, Series editor, Gerla, Mario, Series editor, Kobayashi, Hisashi, Series editor, Palazzo, Sergio, Series editor, Sahni, Sartaj, Series editor, Shen, Xuemin (Sherman), Series editor, Stan, Mircea, Series editor, Xiaohua, Jia, Series editor, Zomaya, Albert, Series editor, Coulson, Geoffrey, Series editor, Hesselman, Cristian, editor, and Giannelli, Carlo, editor

Published
2009
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20. Long-term weight loss trajectories following participation in a randomised controlled trial of a weight management programme for men delivered through professional football clubs: a longitudinal cohort study and economic evaluation

Author

Gray, Cindy M., Wyke, Sally, Zhang, Ruiqi, Anderson, Annie S., Barry, Sarah, Boyer, Nicki, Brennan, Graham, Briggs, Andrew, Bunn, Christopher, Donnachie, Craig, Grieve, Eleanor, Kohli-Lynch, Ciaran, Lloyd, Suzanne M., McConnachie, Alex, McCowan, Colin, MacLean, Alice, Mutrie, Nanette, and Hunt, Kate

Published
2018
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21. Cost-Effectiveness of Masked Hypertension Screening and Treatment in US Adults With Suspected Masked Hypertension: A Simulation Study

Author

Green, Matthew B, primary, Shimbo, Daichi, additional, Schwartz, Joseph E, additional, Bress, Adam P, additional, King, Jordan B, additional, Muntner, Paul, additional, Sheppard, James P, additional, McManus, Richard J, additional, Kohli-Lynch, Ciaran N, additional, Zhang, Yiyi, additional, Shea, Steven, additional, Moran, Andrew E, additional, and Bellows, Brandon K, additional

Published
2022
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25. Effect of Simulation-based Training on Surgical Proficiency and Patient Outcomes: A Randomised Controlled Clinical and Educational Trial

Author

Aydın, Abdullatif, primary, Ahmed, Kamran, additional, Abe, Takashige, additional, Raison, Nicholas, additional, Van Hemelrijck, Mieke, additional, Garmo, Hans, additional, Ahmed, Hashim U., additional, Mukhtar, Furhan, additional, Al-Jabir, Ahmed, additional, Brunckhorst, Oliver, additional, Shinohara, Nobuo, additional, Zhu, Wei, additional, Zeng, Guohua, additional, Sfakianos, John P., additional, Gupta, Mantu, additional, Tewari, Ashutosh, additional, Gözen, Ali Serdar, additional, Rassweiler, Jens, additional, Skolarikos, Andreas, additional, Kunit, Thomas, additional, Knoll, Thomas, additional, Moltzahn, Felix, additional, Thalmann, George N., additional, Lantz Powers, Andrea G., additional, Chew, Ben H., additional, Sarica, Kemal, additional, Shamim Khan, Muhammad, additional, Dasgupta, Prokar, additional, Baig, Umair, additional, Aya, Haleema, additional, Husnain Iqbal, Mohammed, additional, Kum, Francesca, additional, Bultitude, Matthew, additional, Glass, Jonathan, additional, Khan, Azhar, additional, Makanjuola, Jonathan, additional, McCabe, John E., additional, Samsuddin, Azi, additional, McIlhenny, Craig, additional, Brewin, James, additional, Kulkarni, Shashank, additional, Khwaja, Sikandar, additional, Islam, Waliul, additional, Marsh, Howard, additional, Bhat, Taher, additional, Thomas, Benjamin, additional, Cutress, Mark, additional, Housami, Fadi, additional, Nedas, Timothy, additional, Bates, Timothy, additional, Mukherjee, Rono, additional, Graham, Stuart, additional, Bordenave, Matthieu, additional, Coker, Charles, additional, Ahmed, Shwan, additional, Symes, Andrew, additional, Calvert, Robert, additional, Lynch, Ciaran, additional, Long, Ronan, additional, Patterson, Jacob M., additional, Rukin, Nicholas J., additional, Khan, Shahid A., additional, Dasgupta, Ranan, additional, Brown, Stephen, additional, Grey, Ben, additional, Mahmalji, Waseem, additional, Lam, Wayne, additional, Scheitlin, Walter, additional, Saelzler, Norbert, additional, Fiedler, Marcel, additional, Ishikawa, Shuhei, additional, Sasaki, Yoshihiro, additional, Sazawa, Ataru, additional, Shinno, Yuichiro, additional, Mochizuki, Tango, additional, Peter Jessen, Jan, additional, Steiner, Roland, additional, Wendt-Nordahl, Gunnar, additional, Atassi, Nabil, additional, Kohns, Heiko, additional, Cox, Ashley, additional, Rendon, Ricardo, additional, Lawen, Joseph, additional, Bailly, Greg, additional, and Marsh, Trevor, additional

Published
2022
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26. Costs of seasonal influenza vaccination in South Africa

Author

Fraser, Heather, primary, Tombe‐Mdewa, Winfrida, additional, Kohli‐Lynch, Ciaran, additional, Hofman, Karen, additional, Tempia, Stefano, additional, McMorrow, Meredith, additional, Lambach, Philipp, additional, Ramkrishna, Wayne, additional, Cohen, Cheryl, additional, Hutubessy, Raymond, additional, and Edoka, Ijeoma, additional

Published
2022
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33. Contributors

Author

Abraham, Suzanne, primary, Aitken, Stuart, additional, Barlow-Stewart, Kristine, additional, Bennett, David, additional, Brass, Laura, additional, Braun, Lesley, additional, Brophy, Elizabeth, additional, Chenoweth, Ian, additional, Chin, Warren N, additional, Conomos, Jacqui, additional, Colquhoun, David, additional, Cracknell, Grant, additional, Eden, John, additional, Evans, Susan, additional, Fardy, H John, additional, Frydenberg, Mark, additional, Gates, Peter, additional, Gold, Michelle, additional, Goldberg, Ivan, additional, Hardy, Mark, additional, Hegarty, Kelsey, additional, Howard, Anne, additional, Hunter, Jennifer, additional, Jayasinghe, Rohan, additional, Joske, David, additional, Kang, Melissa, additional, Kong, Kelvin, additional, Lack, Leon, additional, Leggat, Peter A, additional, Lowy, Michael, additional, Lynch, Ciaran, additional, MacKay, Stuart, additional, Masters, Scott, additional, Melrose, Katy, additional, Newton, Robert, additional, Nguyen, Tuan, additional, Orchard, John, additional, Price, Dzung, additional, Reynolds, Graham J, additional, Robertson, Kathryn, additional, Rubin, George, additional, Sali, Avni, additional, Sambrook, Philip, additional, Sheehan, Penelope, additional, Siddall, Philip, additional, Stricker, Phillip D, additional, Talbot, Michael, additional, Thanigasalam, Ruban, additional, Thompson, Julie, additional, Tomas, Lily, additional, Vitetta, Luis, additional, Walters, John, additional, Wijesinha, Sanjiva, additional, Woodward, Michael, additional, Wright, Helen, additional, Zeldovich, Alina, additional, Zorbas, Helen, additional, Omar, Eshaifol Azam, additional, Bridgman, Karen E, additional, Huang, Tom Hsun-Wei, additional, Liew, Yuk Lan, additional, Li, George Q, additional, Nammi, Srinivas, additional, Narayan, Indu, additional, and Li, Lily Yingmin, additional

Published
2011
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36. Erratum to “Effect of Simulation-based Training on Surgical Proficiency and Patient Outcomes: A Randomised Controlled Clinical and Educational Trial” [Eur Urol 2022;81:385–393]

Author

Baig, Umair, Aya, Haleema, Husnain Iqbal, Mohammed, Kum, Francesca, Bultitude, Matthew, Glass, Jonathan, Khan, Azhar, Makanjuola, Jonathan, McCabe, John E., Samsuddin, Azi, McIlhenny, Craig, Brewin, James, Kulkarni, Shashank, Khwaja, Sikandar, Islam, Waliul, Marsh, Howard, Bhat, Taher, Thomas, Benjamin, Cutress, Mark, Housami, Fadi, Nedas, Timothy, Bates, Timothy, Mukherjee, Rono, Graham, Stuart, Bordenave, Matthieu, Coker, Charles, Ahmed, Shwan, Symes, Andrew, Calvert, Robert, Lynch, Ciaran, Long, Ronan, Patterson, Jacob M., Rukin, Nicholas J., Khan, Shahid A., Dasgupta, Ranan, Brown, Stephen, Grey, Ben, Mahmalji, Waseem, Lam, Wayne, Scheitlin, Walter, Saelzler, Norbert, Fiedler, Marcel, Ishikawa, Shuhei, Sasaki, Yoshihiro, Sazawa, Ataru, Shinno, Yuichiro, Mochizuki, Tango, Peter Jessen, Jan, Steiner, Roland, Wendt-Nordahl, Gunnar, Atassi, Nabil, Kohns, Heiko, Cox, Ashley, Rendon, Ricardo, Lawen, Joseph, Bailly, Greg, Marsh, Trevor, Aydın, Abdullatif, Ahmed, Kamran, Abe, Takashige, Raison, Nicholas, Van Hemelrijck, Mieke, Garmo, Hans, Ahmed, Hashim U., Mukhtar, Furhan, Al-Jabir, Ahmed, Brunckhorst, Oliver, Shinohara, Nobuo, Zhu, Wei, Zeng, Guohua, Sfakianos, John P., Gupta, Mantu, Tewari, Ashutosh, Serdar Gözen, Ali, Rassweiler, Jens, Skolarikos, Andreas, Kunit, Thomas, Knoll, Thomas, Moltzahn, Felix, Thalmann, George N., Lantz Powers, Andrea G., Chew, Ben H., Sarica, Kemal, Shamim Khan, Muhammad, and Dasgupta, Prokar

Published
2022
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40. Anthelmintic-resistant nematodes in Irish commercial sheep flocks- the state of play

Author

Good Barbara, Hanrahan James Patrick, de Waal Daniel Theodorus, Patten Thomas, Kinsella Andrew, and Lynch Ciaran Oliver

Subjects
Anthelmintic resistance, Nematodes, Sheep Ireland, Benzimidazole, Levamizole, Ivermectin, MALDT, FECRT, Veterinary medicine, SF600-1100
Abstract

Abstract Anthelmintic resistance has been reported in most sheep producing countries. Prior to the mid 1990s, reports of anthelmintic resistance in Ireland were sparse and focused on benzimidazole, one of the three classes of anthelmintic available during this period. This evidence for efficacy issues on Irish farms combined with awareness that anthelmintic resistance was increasingly being reported in other countries prompted the need for more comprehensive investigations on Irish farms. Faecal egg count reduction and micro-agar larval development tests were employed to investigate resistance to benzimidazole, levamisole and macrocyclic lactone. There is compelling evidence for resistance to both benzimidazole (>88% of flocks) and levamisole (>39% of flocks). Resistance of nematode populations to macrocyclic lactone was suspected on a small number of farms (11%) but needs to be confirmed. The recent introduction of two new classes of anthelmintics, after over a 25 year interval, together with the evidence that anthelmintic resistance is reported within a relatively short time following the introduction of a new anthelmintic compound means that the challenge to the industry is immediate. Actions are urgently required to manage anthelmintic resistance so as to prolong the lifespan of anthelmintics.

Published
2012
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41. Additional file 2: of Long-term weight loss trajectories following participation in a randomised controlled trial of a weight management programme for men delivered through professional football clubs: a longitudinal cohort study and economic evaluation

Author

Gray, Cindy, Wyke, Sally, Ruiqi Zhang, Anderson, Annie, Barry, Sarah, Boyer, Nicki, Brennan, Graham, Briggs, Andrew, Bunn, Christopher, Donnachie, Craig, Grieve, Eleanor, Kohli-Lynch, Ciaran, Lloyd, Suzanne, McConnachie, Alex, McCowan, Colin, MacLean, Alice, Mutrie, Nanette, and Hunt, Kate

Abstract

Additional follow up study results tables (baseline characteristics, clinical and psychological outcomes, and lifetime economic evaluation). (DOCX 103 kb)

Published
2018
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42. Additional file 1: of Long-term weight loss trajectories following participation in a randomised controlled trial of a weight management programme for men delivered through professional football clubs: a longitudinal cohort study and economic evaluation

Author

Gray, Cindy, Wyke, Sally, Ruiqi Zhang, Anderson, Annie, Barry, Sarah, Boyer, Nicki, Brennan, Graham, Briggs, Andrew, Bunn, Christopher, Donnachie, Craig, Grieve, Eleanor, Kohli-Lynch, Ciaran, Lloyd, Suzanne, McConnachie, Alex, McCowan, Colin, MacLean, Alice, Mutrie, Nanette, and Hunt, Kate

Abstract

Economic evaluation supplementary tables. (DOCX 57 kb)

Published
2018
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43. Cost-effectiveness of Low-density Lipoprotein Cholesterol Level–Guided Statin Treatment in Patients With Borderline Cardiovascular Risk

Author

Kohli-Lynch, Ciaran N., primary, Bellows, Brandon K., additional, Thanassoulis, George, additional, Zhang, Yiyi, additional, Pletcher, Mark J., additional, Vittinghoff, Eric, additional, Pencina, Michael J., additional, Kazi, Dhruv, additional, Sniderman, Allan D., additional, and Moran, Andrew E., additional

Published
2019
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44. DT-02-06: A NOVEL SMALL MOLECULE INHIBITOR OF THE DISCOIDIN DOMAIN RECEPTORS (DDR) REDUCES TAU AND AMYLOID-β AND IMPROVES COGNITION IN MODELS OF ALZHEIMER'S DISEASE

Author

Fowler, Alan J., primary, Hebron, Michaeline, additional, Shi, Wangke, additional, Missner, Alexander A., additional, Hassan, Diandra, additional, Lynch, Ciaran, additional, Kavulu, Balaraman, additional, Liu, Xiaoguang, additional, Wolf, Christian, additional, and E-H Moussa, Charbel, additional

Published
2019
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45. Between a Rock and an Airspace

Author

Frost, Freddy, primary, Griffiths, Paul, additional, Brockelsby, Chris, additional, Lynch, Ciaran, additional, Walshaw, Martin J., additional, and Nazareth, Dilip, additional

Published
2018
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46. Long-term weight loss following a randomised controlled trial of a weight management programme for men delivered through professional football clubs: the Football Fans in Training follow-up study

Author

Gray, Cindy M, primary, Wyke, Sally, additional, Zhang, Rachel, additional, Anderson, Annie S, additional, Barry, Sarah, additional, Brennan, Graham, additional, Briggs, Andrew, additional, Boyer, Nicki, additional, Bunn, Christopher, additional, Donnachie, Craig, additional, Grieve, Eleanor, additional, Kohli-Lynch, Ciaran, additional, Lloyd, Suzanne, additional, McConnachie, Alex, additional, McCowan, Colin, additional, McLean, Alice, additional, Mutrie, Nanette, additional, and Hunt, Kate, additional

Published
2018
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