Search

Your search keyword '"Lyght, Marion"' showing total 2 results
Start Over Author "Lyght, Marion"
2 results on '"Lyght, Marion"'

2. Transforming growth factor beta-1 null mutation in mice causes excessive inflammatory response and early death

Author

Kulkarni, Ashok B., Huh, Chang-Goo, Becker, Dean, Geiser, Andrew, Lyght, Marion, Flanders, Kathleen C., Roberts, Anita B., Sporn, Michael B., Ward, Jerrold M., and Karlsson, Stefan

Subjects
Transforming growth factors -- Physiological aspects, Inflammation -- Mediators, Autoimmunity -- Research, Genetically modified mice -- Research, Science and technology
Abstract

Transgenic mouse lines harboring null mutations in the transforming growth factor-beta-1 (TGF-beta-1) locus were generated to elucidate the physiological role of this isoform of TGF-beta. The homozygous mutants exhibited high intrauterine lethality and the surviving mice had widespread inflammatory reactions in various organs causing death at around three to four weeks. The results indicate that TGF-beta-1 is involved in processes such as inflammation, tissue repair, autoimmune disease and allograftrejection.

Published
1993

Catalog

Books, media, physical & digital resources
See catalog results