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Cnidii Fructus, derived from the dried ripe fruit of Cnidium monnieri (L.) Cuss, has the effect of warming kidneys and invigorating Yang. This study established the spectrum–effect relationships between ultra‐high‐performance liquid chromatography (UHPLC) fingerprints and the antitumor activities of Cnidii Fructus on human hepatocellular carcinoma (HepG2) cells. In UHPLC fingerprints, 19 common peaks were obtained, and 17 batches of herbs had similarity >0.948. In Cell Counting Kit‐8 (CCK‐8) test, 17 batches of Cnidii Fructus extract significantly inhibited the proliferation of HepG2 cells to different degrees, showing different half‐maximal inhibitory concentration (IC50) values. Furthermore, gray correlation analysis, Pearson's analysis, and orthogonal partial least squares discriminant analysis were performed to screen out eight components. The analysis of mass spectrum data and a comparison with standards revealed that the eight components were methoxsalen, isopimpinellin, osthenol, imperatorin, osthole, ricinoleic acid, linoleic acid, and oleic acid. The verification experiments by testing single compounds indicated that these eight compounds were the major anti‐hepatoma compounds in Cnidii Fructus. This work provides a model combining UHPLC fingerprints and antitumor activities to study the spectrum–effect relationships of Cnidii Fructus, which can be used to determine the principal components responsible for the bioactivity. [ABSTRACT FROM AUTHOR]

Physochlainae Radix (PR) is an essential herbal medicine that has been generally applied for treating cough and asthma. In this study, a comprehensive strategy for quality evaluation of PR from different origins was established by integrating qualitative identification, quantitative analysis, and chemometric methods. A total of 58 chemical components were identified by ultra‐high‐performance liquid chromatography coupled with quadrupole time‐of‐flight tandem mass spectrometry (UHPLC‐Q‐TOF‐MS/MS), and a sensitive and rapid UHPLC‐QqQ‐MS/MS method was established for the simultaneous determination of 12 compounds. In addition, multivariate statistical analysis was applied for discriminant analysis to compare the differences among 30 batches of PR samples. The results showed that the 30 batches of PR collected from four provinces could be clustered into three categories, in which scoparone, protocatechuic acid, tropic acid, and scopolin were important components to distinguish the primary and non‐primary producing areas, as well as superior and inferior products of PR. Chemometric results were consistent and validated each other, and systematically explained the intrinsic quality characteristics of PR. This study first demonstrated that LC‐MS combined with multivariate statistical analysis, provided a comprehensive and effective means for quality evaluation of PR. [ABSTRACT FROM AUTHOR]

The tensile and impact properties of X70 pipeline steels exposed to wet H 2 S environments were investigated by corrosion and mechanical testing. The results suggest that the Charpy absorbed energy, tensile strength and reduction in area of X70 steel decreased after H 2 S corrosion. When hydrogen was released, Charpy absorbed energy and reduction in area exhibited a certain recovery. Fractography of the tensile and impact specimens exhibited mixed ductile–brittle rupture after corrosion and hydrogen release. Fractured areas with brittle features diminished after hydrogen release. Hydrogen was closely associated with mechanical property degradation and fracture features. [ABSTRACT FROM AUTHOR]

The effect of H 2 /CO 2 partial pressure ratio on the tensile properties of X80 pipeline steel in the absence and presence of water were investigated by slow strain rate test (SSRT) and scanning electron microscope (SEM) measurements in this paper. The results show that the tensile strength and elongation to failure of X80 pipeline steel in H 2 /CO 2 atmosphere were deteriorated significantly. The relative tensile strength and plasticity loss of X80 pipeline steel increased with increasing H 2 /CO 2 partial pressure ratio in the absence of water. The increasing volume fraction of hydrogen gas is the key influencing factor in this condition. For the H 2 /CO 2 environments in the presence of water, the relative tensile property loss decreased first and then increased with H 2 /CO 2 partial pressure ratio. The probable reason is that the corrosion process changed gradually from CO 2 -dominant to H 2 -dominant. Water played a significant role in the tensile property damage of X80 pipeline steel in the H 2 /CO 2 environments. [ABSTRACT FROM AUTHOR]

Abstract: Effect of H2S partial pressure on the tensile properties of A350LF2 steel with and without pre-immersion was investigated by slow strain rate testing and electrochemical impedance spectroscopy. The results show that relative tensile strength and plasticity loss increased with increasing in the absence and presence of pre-immersion. Greater tensile property damage occurred in steel without pre-immersion compared to that with pre-immersion. The relative plasticity loss increment of steel without pre-immersion was larger than that with pre-immersion as was increased from 0.1MPa to 1.6MPa. Fractography exhibited flat brittle fracture on the samples without pre-immersion and mixed ductile-brittle fracture on the pre-immersed samples. Furthermore, the embrittled regions on the fracture surface of pre-immersed specimens increased with . In addition, no cracks existed in the steel after pre-immersion. The cracks on the fracture surface of steel could be attributed to the combination of tensile stress and high hydrogen concentration induced by the hydrogen diffusion and accumulation during the tensile test. [Copyright &y& Elsevier]

Highlights: [•] Tensile and impact behavior of the steel had different change law with H2S pressure. [•] Charpy absorbed energy exhibited no obvious change with increasing H2S pressure. [•] Fractography showed mixed ductile–brittle rupture for the corroded mechanical samples. [•] Hydrogen has a profound effect on the tensile and impact behavior of steel. [•] A probable mechanism is proposed to interpret the tensile and impact results. [Copyright &y& Elsevier]