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The ability of neural networks (NNs) to learn and remember multiple tasks sequentially is facing tough challenges in achieving general artificial intelligence due to their catastrophic forgetting (CF) issues. Fortunately, the latest OWM Orthogonal Weights Modification) and other several continual learning (CL) methods suggest some promising ways to overcome the CF issue. However, none of existing CL methods explores the following three crucial questions for effectively overcoming the CF issue: that is, what knowledge does it contribute to the effective weights modification of the NN during its sequential tasks learning? When the data distribution of a new learning task changes corresponding to the previous learned tasks, should a uniform/specific weight modification strategy be adopted or not? what is the upper bound of the learningable tasks sequentially for a given CL method? ect. To achieve this, in this paper, we first reveals the fact that of the weight gradient of a new learning task is determined by both the input space of the new task and the weight space of the previous learned tasks sequentially. On this observation and the recursive least square optimal method, we propose a new efficient and effective continual learning method EOWM via enhanced OWM. And we have theoretically and definitively given the upper bound of the learningable tasks sequentially of our EOWM. Extensive experiments conducted on the benchmarks demonstrate that our EOWM is effectiveness and outperform all of the state-of-the-art CL baselines.

Today, we are all threatened by an unprecedented pandemic: COVID-19. How different is it from other coronaviruses? Will it be attenuated or become more virulent? Which animals may be its original host? In this study, we collected and analyzed nearly thirty thousand publicly available complete genome sequences for COVID-19 virus from 79 different countries, the previously known flu-causing coronaviruses (HCov-229E, HCov-OC43, HCov-NL63 and HCov-HKU1) and the lethal, pathogenic viruses, SARS, MERS, Victoria, Lassa, Yamagata, Ebola, and Dengue. We found strong similarities between the current circulating COVID-19 and SARS and MERS, as well as COVID-19 in rhinolophines and pangolins. On the contrary, COVID-19 shares little similarity with the flu-causing coronaviruses and the other known viruses. Strikingly, we observed that the divergence of COVID-19 strains isolated from human hosts has steadily increased from December 2019 to May 2020, suggesting COVID-19 is actively evolving in human hosts. In this paper, we first propose a novel MLCS algorithm NP-MLCS1 for the big sequence analysis, which can calculate the common model for COVID-19 complete genome sequences to provide important information for vaccine and antibody development. Geographic and time-course analysis of the evolution trees of the human COVID-19 reveals possible evolutional paths among strains from 79 countries. This finding has important implications to the management of COVID-19 and the development of vaccines and medications.