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The self designed furnace was used to study the fire performance of two-way concrete slab in a full-scale three-story steel-framed building. This paper introduces the design of the test building and fumace, test plan, measuring contents and method. The test observations, cracking and failure characteristics of the slab were described. The distribution of temperature along the depth of the slab, temperature variation of the steel reinforcement, vertical deflection and horizontal displacement were studied. It is shown that the distribution of temperature along the slab depth is nonlinear, and the temperature gradients are large. The restraint provided by the adjacent structural members has significant effect on the structural fire behavior of the heated two-way concrete slab in a whole structure. Main cracks occur on the top surface of the heated slab, and are located at approximately the 1/4 span near the interior edges of the slab ( the position where the top reinforcing bars are cut off). Because of the structural continuity and interaction between structural members, regular cracks also occur on the top of the adjacent unheated slabs. The largest vertical deflection of the slab occurs at the position a short distance away from the center of the slab to the interior edges due to the redistribution of moment induced by the formation and development of the main cracks. The test results indicate that the two-way concrete slab in a whole structure has good fire performance. [ABSTRACT FROM AUTHOR]

8:2 Chlorinated polyfluoroalkyl ether sulfonate (8:2 Cl-PFESA) is a substitute for perfluorooctane sulfonate and an emerging environmental pollutant, yet its bioaccumulation and health risks are poorly understood. We established a subchronic exposure model in mice (0.04, 0.2, and 1 mg/kg/d) to evaluate its adverse effects. Our findings show extensive distribution of 8:2 Cl-PFESA in various tissues (plasma, liver, kidney, brain, heart, lung, testis, ovary, spleen, thymus, thyroid, uterus, large intestine, small intestine, muscle, and fat), with the highest accumulation in the liver, identified as the primary storage organ. Liver histopathology revealed elevated alanine aminotransferase levels, reduced triglycerides, and ballooning degeneration. Proteomics analysis indicated significant involvement of amino acid metabolism in 8:2 Cl-PFESA-induced hepatotoxicity. Metabolomics analysis further highlighted pronounced alterations in amino acid interconversion. Multi-omics integration revealed disruptions in amino acid metabolism, particularly with alanine, histidine, and tryptophan, identifying key proteins EHHADH, HAL, MAO-A, ALDH3A2, and TDO2 as crucial connectors in these metabolic processes, validated by Western blot experiments. This study provides a comprehensive analysis of 8:2 Cl-PFESA accumulation and distribution in biological systems, demonstrating that hepatotoxicity is primarily mediated through amino acid metabolism disruption, offering insights for pollution mitigation strategies and future toxicological research., Competing Interests: Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper., (Copyright © 2024 Elsevier B.V. All rights reserved.)

Oat protein was purified from oat meal and its effects on swimming performance and related biochemical parameters were investigated. Thirty male Kun-ming mice were divided into the normal control, the oat meal and the oat protein group (n = 10). They were fed with a laboratory food for 30 days, then were subjected to swim to exhaustion. Their swimming endurance and the major metabolic substrates were measured from serum, liver and muscle. The results showed that no significant differences were observed in swimming endurance test between the normal control group and the oat protein group (P > 0.05). Mice in the oat meal group had significantly longer swimming endurance compared to the normal control group (P < 0.05). Furthermore, dietary oat protein increased the levels of liver glycogen, enhanced the activities of lactic dehydrogenase and superoxide dismutase, and decreased the levels of blood urea nitrogen and malondialdehyde in serum. These results suggested that oat protein was effective in improving the physiological condition of the mice.