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18 results on '"Lv, Hailin"'

4. Effect of ubiquinol on cardiorespiratory fitness during high-altitude acclimatization and de-acclimatization in healthy adults: the Shigatse CARdiorespiratory fitness study design

Author

Yang, Jie, primary, Ye, Xiaowei, additional, Liu, Zhen, additional, Sun, Mengjia, additional, Yu, Shiyong, additional, Lv, Hailin, additional, Wu, Boji, additional, Zhang, Chen, additional, Gu, Wenzhu, additional, He, Jingyu, additional, Wang, Xuhong, additional, and Huang, Lan, additional

Published
2023
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9. Single‐cell RNA sequencing reveals a mechanism underlying the susceptibility of the left atrial appendage to intracardiac thrombogenesis during atrial fibrillation.

Author

Yang, Jie, Tan, Hu, Sun, Mengjia, Chen, Renzheng, Jian, Zhao, Song, Yuanbin, Zhang, Jihang, Bian, Shizhu, Zhang, Bo, Zhang, Yi, Gao, Xubin, Chen, Zhen, Wu, Boji, Ye, Xiaowei, Lv, Hailin, Liu, Zhen, and Huang, Lan

Subjects
ATRIAL fibrillation, LEFT heart atrium, RNA sequencing, ENDOTHELIAL cells, SHEARING force, GLUTATHIONE transferase
Abstract

Background: Atrial fibrillation (AF) is associated with an increased risk of thrombosis of the left atrial appendage (LAA). However, the molecular mechanisms underlying this site‐specificity remain poorly understood. Here, we present a comparative single‐cell transcriptional profile of paired atrial appendages from patients with AF and illustrate the chamber‐specific properties of the main cell types. Methods: Single‐cell RNA sequencing analysis of matched atrial appendage samples from three patients with persistent AF was evaluated by 10× genomics. The AF mice model was created using Tbx5 knockout mice. Validation experiments were performed by glutathione S‐transferase pull‐down assays, coimmunoprecipitation (Co‐IP), cleavage assays and shear stress experiments in vitro. Results: In LAA, phenotype switching from endothelial cells to fibroblasts and inflammation associated with proinflammatory macrophage infiltration were observed. Importantly, the coagulation cascade is highly enriched in LAA endocardial endothelial cells (EECs), accompanying the up‐regulation of a disintegrin and metalloproteinase with thrombospondin motifs 1 (ADAMTS1) and the down‐regulation of the tissue factor pathway inhibitor (TFPI) and TFPI2. Similar alterations were verified in an AF mouse model (Tbx5+/−) and EECs treated with simulated AF shear stress in vitro. Furthermore, we revealed that the cleavage of both TFPI and TFPI2 based on their interaction with ADAMTS1 would lead to loss of anticoagulant activities of EECs. Conclusions: This study highlights the decrease in the anticoagulant status of EECs in LAA as a potential mechanism underlying the propensity for thrombosis, which may aid the development of anticoagulation therapeutic approaches targeting functionally distinct cell subsets or molecules during AF. [ABSTRACT FROM AUTHOR]

Published
2023
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10. Prognostic significance of day‐by‐day in‐hospital blood pressure variability in COVID‐19 patients with hypertension

Author

He, Chunyan, primary, Liu, Chuan, additional, Yang, Jie, additional, Tan, Hu, additional, Ding, Xiaohan, additional, Gao, Xubin, additional, Yang, Yuanqi, additional, Shen, Yang, additional, Xiang, Hedong, additional, Ke, Jingbin, additional, Yuan, Fangzhengyuan, additional, Chen, Renzheng, additional, Cheng, Ran, additional, Lv, Hailin, additional, Li, Ping, additional, Zhang, Limin, additional, and Huang, Lan, additional

Published
2022
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11. Blood Pressure Load: An Effective Indicator of Systemic Circulation Status in Individuals With Acute Altitude Sickness

Author

Chen, Renzheng, primary, Ye, Xiaowei, additional, Sun, Mengjia, additional, Yang, Jie, additional, Zhang, Jihang, additional, Gao, Xubin, additional, Liu, Chuan, additional, Ke, Jingbin, additional, He, Chunyan, additional, Yuan, Fangzhengyuan, additional, Lv, Hailin, additional, Yang, Yuanqi, additional, Cheng, Ran, additional, Tan, Hu, additional, and Huang, Lan, additional

Published
2022
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12. Sex-Dependent Association Between Early Morning Ambulatory Blood Pressure Variations and Acute Mountain Sickness

Author

Chen, Renzheng, primary, Yang, Jie, additional, Liu, Chuan, additional, Sun, Mengjia, additional, Ke, Jingbin, additional, Yang, Yuanqi, additional, Shen, Yang, additional, Yuan, Fangzhengyuan, additional, He, Chunyan, additional, Cheng, Ran, additional, Lv, Hailin, additional, Tan, Hu, additional, Gao, Xubin, additional, Zhang, Jihang, additional, and Huang, Lan, additional

Published
2021
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13. Blood pressure and left ventricular function changes in different ambulatory blood pressure patterns at high altitude

Author

Chen, Renzheng, primary, Yang, Jie, additional, Liu, Chuan, additional, Ke, Jingbin, additional, Gao, Xubin, additional, Yang, Yuanqi, additional, Shen, Yang, additional, Yuan, Fangzhengyuan, additional, He, Chunyan, additional, Cheng, Ran, additional, Lv, Hailin, additional, Zhang, Chen, additional, Gu, Wenzhu, additional, Tan, Hu, additional, Zhang, Jihang, additional, and Huang, Lan, additional

Published
2021
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14. Influence of blood pressure control and application of renin‐angiotensin‐aldosterone system inhibitors on the outcomes in COVID‐19 patients with hypertension

Author

Chen, Renzheng, primary, Yang, Jie, additional, Gao, Xubin, additional, Ding, Xiaohan, additional, Yang, Yuanqi, additional, Shen, Yang, additional, He, Chunyan, additional, Xiang, Hedong, additional, Ke, Jingbin, additional, Yuan, Fangzhengyuan, additional, Cheng, Ran, additional, Lv, Hailin, additional, Li, Ping, additional, Zhang, Limin, additional, Liu, Chuan, additional, Tan, Hu, additional, and Huang, Lan, additional

Published
2020
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