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1. WCN23-1027 DISTRIBUTION, PREPAREDNESS AND MANAGEMENT OF UKRAINIAN ADULT REFUGEES ON DIALYSIS— AN INTERNATIONAL SURVEY BY THE RENAL DISASTER RELIEF TASK FORCE OF THE EUROPEAN RENAL ASSOCIATION

Author

Pawlowicz-Szlarska, E., primary, Eckardt, K.U., additional, Gallego, D., additional, Ivanov, D., additional, Luyckx, V., additional, Nistor, I., additional, Noruišiene, E., additional, Sekkarie, M., additional, Sever, M.S., additional, Shroff, R., additional, Škoberne, A., additional, Stuard, S., additional, Tuglular, S., additional, Vanholder, R., additional, and Wiecek, A., additional

Published
2023
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4. POS-968 COVID-19 PANDEMIC IDENTIFIES SIGNIFICANT GLOBAL INEQUITIES IN HEMODIALYSIS CARE IN LOW AND LOWER MIDDLE INCOME COUNTRIES - AN ISN/DOPPS SURVEY

Author

Tannor, E.K., primary, BIEBER, B., additional, Luyckx, V., additional, Shah, D.S., additional, Liew, A., additional, Evans, R., additional, Aylward, R., additional, Guedes, M., additional, Pisoni, R.L., additional, Robinson, B.M., additional, Caskey, F., additional, Jha, V., additional, Pecoits-Filho, R., additional, and Dreyer, G., additional

Published
2022
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5. POS-926 IN-CENTRE HAEMODIALYSIS CENTRES VARIABLY AFFECTED BY THE CORONAVIRUS-2019 PANDEMIC IN DIFFERENT REGIONS OF THE WORLD: THE INTERNATIONAL SOCIETY OF NEPHROLOGY-DIALYSIS OUTCOMES PRACTICE PATTERNS STUDY SURVEY

Author

AYLWARD, R., primary, BIEBER, B., additional, Guedes, M., additional, Pisoni, R., additional, Koranteng Tannor, E., additional, Dreyer, G., additional, Liew, A., additional, Luyckx, V., additional, Singh, D., additional, Phiri, C., additional, Evans, R., additional, Jha, V., additional, Pecoits-Filho, R., additional, Robinson, B., additional, and Caskey, F., additional

Published
2022
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7. Peritoneal Dialysis Use and Practice Patterns: An International Survey Study.

Author

Zhao M.-H., Tesar V., Tungsanga K., Kazancioglu R.T., Yee-Moon Wang A., Yang C.-W., Zemchenkov A., Jager K.J., Caskey F.J., Jindal K.K., Okpechi I.G., Tonelli M., Harris D.C., Johnson D.W., Kerr P.G., Cho Y., Bello A.K., Levin A., Lunney M., Osman M.A., Ye F., Ashuntantang G.E., Bellorin-Font E., Gharbi M.B., Davison S.N., Ghnaimat M., Harden P., Htay H., Jha V., Kalantar-Zadeh K., Klarenbach S., Kovesdy C.P., Luyckx V., Neuen B., O'Donoghue D., Ossareh S., Perl J., Rashid H.U., Rondeau E., See E.J., Saad S., Sola L., Tchokhonelidze I., Zhao M.-H., Tesar V., Tungsanga K., Kazancioglu R.T., Yee-Moon Wang A., Yang C.-W., Zemchenkov A., Jager K.J., Caskey F.J., Jindal K.K., Okpechi I.G., Tonelli M., Harris D.C., Johnson D.W., Kerr P.G., Cho Y., Bello A.K., Levin A., Lunney M., Osman M.A., Ye F., Ashuntantang G.E., Bellorin-Font E., Gharbi M.B., Davison S.N., Ghnaimat M., Harden P., Htay H., Jha V., Kalantar-Zadeh K., Klarenbach S., Kovesdy C.P., Luyckx V., Neuen B., O'Donoghue D., Ossareh S., Perl J., Rashid H.U., Rondeau E., See E.J., Saad S., Sola L., and Tchokhonelidze I.

Abstract

Rationale & Objective: Approximately 11% of people with kidney failure worldwide are treated with peritoneal dialysis (PD). This study examined PD use and practice patterns across the globe. Study Design: A cross-sectional survey. Setting & Participants: Stakeholders including clinicians, policy makers, and patient representatives in 182 countries convened by the International Society of Nephrology between July and September 2018. Outcome(s): PD use, availability, accessibility, affordability, delivery, and reporting of quality outcome measures. Analytical Approach: Descriptive statistics. Result(s): Responses were received from 88% (n = 160) of countries and there were 313 participants (257 nephrologists [82%], 22 non-nephrologist physicians [7%], 6 other health professionals [2%], 17 administrators/policy makers/civil servants [5%], and 11 others [4%]). 85% (n = 156) of countries responded to questions about PD. Median PD use was 38.1 per million population. PD was not available in 30 of the 156 (19%) countries responding to PD-related questions, particularly in countries in Africa (20/41) and low-income countries (15/22). In 69% of countries, PD was the initial dialysis modality for <=10% of patients with newly diagnosed kidney failure. Patients receiving PD were expected to pay 1% to 25% of treatment costs, and higher (>75%) copayments (out-of-pocket expenses incurred by patients) were more common in South Asia and low-income countries. Average exchange volumes were adequate (defined as 3-4 exchanges per day or the equivalent for automated PD) in 72% of countries. PD quality outcome monitoring and reporting were variable. Most countries did not measure patient-reported PD outcomes. Limitation(s): Low responses from policy makers; limited ability to provide more in-depth explanations underpinning outcomes from each country due to lack of granular data; lack of objective data. Conclusion(s): Large inter- and intraregional disparities exist in PD availability, acce

Published
2021

8. Current status of health systems financing and oversight for end-stage kidney disease care: A cross-sectional global survey.

Author

Yeung E., Bello A.K., Levin A., Lunney M., Osman M.A., Ye F., Ashuntantang G., Bellorin-Font E., Benghanem Gharbi M., Davison S., Ghnaimat M., Harden P., Jha V., Kalantar-Zadeh K., Kerr P., Klarenbach S., Kovesdy C., Luyckx V., Neuen B., O'Donoghue D., Ossareh S., Perl J., Ur Rashid H., Rondeau E., See E., Saad S., Sola L., Tchokhonelidze I., Tesar V., Tungsanga K., Turan Kazancioglu R., Wang A.Y.-M., Wiebe N., Yang C.-W., Zemchenkov A., Zhao M., Jager K.J., Caskey F., Perkovic V., Jindal K., Okpechi I.G., Tonelli M., Feehally J., Harris D.C.H., Johnson D., Yeung E., Bello A.K., Levin A., Lunney M., Osman M.A., Ye F., Ashuntantang G., Bellorin-Font E., Benghanem Gharbi M., Davison S., Ghnaimat M., Harden P., Jha V., Kalantar-Zadeh K., Kerr P., Klarenbach S., Kovesdy C., Luyckx V., Neuen B., O'Donoghue D., Ossareh S., Perl J., Ur Rashid H., Rondeau E., See E., Saad S., Sola L., Tchokhonelidze I., Tesar V., Tungsanga K., Turan Kazancioglu R., Wang A.Y.-M., Wiebe N., Yang C.-W., Zemchenkov A., Zhao M., Jager K.J., Caskey F., Perkovic V., Jindal K., Okpechi I.G., Tonelli M., Feehally J., Harris D.C.H., and Johnson D.

Abstract

The Global Kidney Health Atlas (GKHA) is a multinational, cross-sectional survey designed to assess the current capacity for kidney care across all world regions. The 2017 GKHA involved 125 countries and identified significant gaps in oversight, funding and infrastructure to support care for patients with kidney disease, especially in lower-middle-income countries. Here, we report results from the survey for the second iteration of the GKHA conducted in 2018, which included specific questions about health financing and oversight of end-stage kidney disease (ESKD) care worldwide. A cross-sectional global survey. Key stakeholders from 182 countries were invited to participate. Of those, stakeholders from 160 countries participated and were included. Primary outcomes included cost of kidney replacement therapy (KRT), funding for dialysis and transplantation, funding for conservative kidney management, extent of universal health coverage, out-of-pocket costs for KRT, within-country variability in ESKD care delivery and oversight systems for ESKD care. Outcomes were determined from a combination of desk research and input from key stakeholders in participating countries. 160 countries (covering 98% of the world's population) responded to the survey. Economic factors were identified as the top barrier to optimal ESKD care in 99 countries (64%). Full public funding for KRT was more common than for conservative kidney management (43% vs 28%). Among countries that provided at least some public coverage for KRT, 75% covered all citizens. Within-country variation in ESKD care delivery was reported in 40% of countries. Oversight of ESKD care was present in all high-income countries but was absent in 13% of low-income, 3% of lower-middle-income, and 10% of upper-middle-income countries. Significant gaps and variability exist in the public funding and oversight of ESKD care in many countries, particularly for those in low-income and lower-middle-income countries.Copyright © Autho

Published
2021

9. Availability, coverage, and scope of health information systems for kidney care across world countries and regions.

Author

Kazancioglu R.T., Rashid H.U., Rondeau E., Syed S., Sola L., Tchokhonelidze I., Tesar V., Tungsanga K., Wang A.Y.-M., Johnson D.W., Harris D.C., Feehally J., Tonelli M., Okpechi I.G., Jindal K.K., Perkovic V., Caskey F., Jager K.J., Zhao M.-H., Zemchenkov A., Yang C.-W., See E.J., Bello A.K., Levin A., Lunney M., Osman M.A., Ye F., Ashuntantang G.E., Bellorin-Font E., Benghanem Gharbi M., Davison S., Ghnaimat M., Harden P., Htay H., Jha V., Kalantar-Zadeh K., Kerr P.G., Klarenbach S., Kovesdy C.P., Luyckx V., Neuen B., O'Donoghue D., Ossareh S., Perl J., Kazancioglu R.T., Rashid H.U., Rondeau E., Syed S., Sola L., Tchokhonelidze I., Tesar V., Tungsanga K., Wang A.Y.-M., Johnson D.W., Harris D.C., Feehally J., Tonelli M., Okpechi I.G., Jindal K.K., Perkovic V., Caskey F., Jager K.J., Zhao M.-H., Zemchenkov A., Yang C.-W., See E.J., Bello A.K., Levin A., Lunney M., Osman M.A., Ye F., Ashuntantang G.E., Bellorin-Font E., Benghanem Gharbi M., Davison S., Ghnaimat M., Harden P., Htay H., Jha V., Kalantar-Zadeh K., Kerr P.G., Klarenbach S., Kovesdy C.P., Luyckx V., Neuen B., O'Donoghue D., Ossareh S., and Perl J.

Abstract

BACKGROUND: Health information systems (HIS) are fundamental tools for the surveillance of health services, estimation of disease burden and prioritization of health resources. Several gaps in the availability of HIS for kidney disease were highlighted by the first iteration of the Global Kidney Health Atlas. METHOD(S): As part of its second iteration, the International Society of Nephrology conducted a cross-sectional global survey between July and October 2018 to explore the coverage and scope of HIS for kidney disease, with a focus on kidney replacement therapy (KRT). RESULT(S): Out of a total of 182 invited countries, 154 countries responded to questions on HIS (85% response rate). KRT registries were available in almost all high-income countries, but few low-income countries, while registries for non-dialysis chronic kidney disease (CKD) or acute kidney injury (AKI) were rare. Registries in high-income countries tended to be national, in contrast to registries in low-income countries, which often operated at local or regional levels. Although cause of end-stage kidney disease, modality of KRT and source of kidney transplant donors were frequently reported, few countries collected data on patient-reported outcome measures and only half of low-income countries recorded process-based measures. Almost no countries had programs to detect AKI and practices to identify CKD-targeted individuals with diabetes, hypertension and cardiovascular disease, rather than members of high-risk ethnic groups. CONCLUSION(S): These findings confirm significant heterogeneity in the global availability of HIS for kidney disease and highlight important gaps in their coverage and scope, especially in low-income countries and across the domains of AKI, non-dialysis CKD, patient-reported outcomes, process-based measures and quality indicators for KRT service delivery.Copyright © The Author(s) 2020. Published by Oxford University Press on behalf of ERA-EDTA. All rights reserved.

Published
2021

10. Current status of health systems financing and oversight for end-stage kidney disease care: a cross-sectional global survey

Author

Yeung, E, Bello, AK, Levin, A, Lunney, M, Osman, MA, Ye, F, Ashuntantang, G, Bellorin-Font, E, Benghanem Gharbi, M, Davison, S, Ghnaimat, M, Harden, P, Jha, V, Kalantar-Zadeh, K, Kerr, P, Klarenbach, S, Kovesdy, C, Luyckx, V, Neuen, B, O'Donoghue, D, Ossareh, S, Perl, J, Ur Rashid, H, Rondeau, E, See, E, Saad, S, Sola, L, Tchokhonelidze, I, Tesar, V, Tungsanga, K, Turan Kazancioglu, R, Wang, AY-M, Wiebe, N, Yang, C-W, Zemchenkov, A, Zhao, M, Jager, KJ, Caskey, F, Perkovic, V, Jindal, K, Okpechi, IG, Tonelli, M, Feehally, J, Harris, DCH, Johnson, D, Yeung, E, Bello, AK, Levin, A, Lunney, M, Osman, MA, Ye, F, Ashuntantang, G, Bellorin-Font, E, Benghanem Gharbi, M, Davison, S, Ghnaimat, M, Harden, P, Jha, V, Kalantar-Zadeh, K, Kerr, P, Klarenbach, S, Kovesdy, C, Luyckx, V, Neuen, B, O'Donoghue, D, Ossareh, S, Perl, J, Ur Rashid, H, Rondeau, E, See, E, Saad, S, Sola, L, Tchokhonelidze, I, Tesar, V, Tungsanga, K, Turan Kazancioglu, R, Wang, AY-M, Wiebe, N, Yang, C-W, Zemchenkov, A, Zhao, M, Jager, KJ, Caskey, F, Perkovic, V, Jindal, K, Okpechi, IG, Tonelli, M, Feehally, J, Harris, DCH, and Johnson, D

Abstract

OBJECTIVES: The Global Kidney Health Atlas (GKHA) is a multinational, cross-sectional survey designed to assess the current capacity for kidney care across all world regions. The 2017 GKHA involved 125 countries and identified significant gaps in oversight, funding and infrastructure to support care for patients with kidney disease, especially in lower-middle-income countries. Here, we report results from the survey for the second iteration of the GKHA conducted in 2018, which included specific questions about health financing and oversight of end-stage kidney disease (ESKD) care worldwide. SETTING: A cross-sectional global survey. PARTICIPANTS: Key stakeholders from 182 countries were invited to participate. Of those, stakeholders from 160 countries participated and were included. PRIMARY OUTCOMES: Primary outcomes included cost of kidney replacement therapy (KRT), funding for dialysis and transplantation, funding for conservative kidney management, extent of universal health coverage, out-of-pocket costs for KRT, within-country variability in ESKD care delivery and oversight systems for ESKD care. Outcomes were determined from a combination of desk research and input from key stakeholders in participating countries. RESULTS: 160 countries (covering 98% of the world's population) responded to the survey. Economic factors were identified as the top barrier to optimal ESKD care in 99 countries (64%). Full public funding for KRT was more common than for conservative kidney management (43% vs 28%). Among countries that provided at least some public coverage for KRT, 75% covered all citizens. Within-country variation in ESKD care delivery was reported in 40% of countries. Oversight of ESKD care was present in all high-income countries but was absent in 13% of low-income, 3% of lower-middle-income, and 10% of upper-middle-income countries. CONCLUSION: Significant gaps and variability exist in the public funding and oversight of ESKD care in many countries, particularly f

Published
2021

14. Developmental Programming of Blood Pressure and Renal Function

Author

Yu, Alan SL, Chertow, Glen M, Luyckx, Valerie; https://orcid.org/0000-0001-7066-8135, Marsden, Philip, Skorecki, Karl, Taal, Maarten, Yu, A S ( Alan SL ), Chertow, G M ( Glen M ), Luyckx, V ( Valerie ), Marsden, P ( Philip ), Skorecki, K ( Karl ), Taal, M ( Maarten ), Moritz, Karen, Bertram, John, Yu, Alan SL, Chertow, Glen M, Luyckx, Valerie; https://orcid.org/0000-0001-7066-8135, Marsden, Philip, Skorecki, Karl, Taal, Maarten, Yu, A S ( Alan SL ), Chertow, G M ( Glen M ), Luyckx, V ( Valerie ), Marsden, P ( Philip ), Skorecki, K ( Karl ), Taal, M ( Maarten ), Moritz, Karen, and Bertram, John

Published
2020

15. Global Challenges and Initiatives in Kidney Health

Author

Yu, Alan SL, Chertow, Glen M, Luyckx, Valerie; https://orcid.org/0000-0001-7066-8135, Marsden, Philipp, Skorecki, Karl, Taal, Maarten, Yu, A S ( Alan SL ), Chertow, G M ( Glen M ), Luyckx, V ( Valerie ), Marsden, P ( Philipp ), Skorecki, K ( Karl ), Taal, M ( Maarten ), Bikbov, Boris, Bello, Aminu, Yu, Alan SL, Chertow, Glen M, Luyckx, Valerie; https://orcid.org/0000-0001-7066-8135, Marsden, Philipp, Skorecki, Karl, Taal, Maarten, Yu, A S ( Alan SL ), Chertow, G M ( Glen M ), Luyckx, V ( Valerie ), Marsden, P ( Philipp ), Skorecki, K ( Karl ), Taal, M ( Maarten ), Bikbov, Boris, and Bello, Aminu

Published
2020

20. The Impact of Kidney Development on the Life Course: A Consensus Document for Action The Low Birth Weight and Nephron Number Working Group

Author

Brenner, BM, Charlton, J, Luyckx, V, Manfellotto, D, Perico, N, Remuzzi, G, Somaschini, M, Valensise, H, Adu, D, Allegaert, Karel, Benedetto, C, Cetin, I, Chevalier, R, Cortinovis, M, D'Anna, R, Duvekot, J.J., Escribano, J, Fanos, V, Ferrazzi, E, Frusca, T, Glassock, RJ, Gyselaers, W, Mecacci, F, Montini, G, Osmond, C, Ramenghi, L, Romagnani, P, Santoro, A, Simeoni, U, Steegers, Eric, Vikse, BE, Pediatric Surgery, and Obstetrics & Gynecology

Published
2017

21. The Impact of Kidney Development on the Life Course: A Consensus Document for Action

Author

Brenner, B.M. (Barry M.), Charlton, J. (Jennifer), Luyckx, V. (Valerie), Manfellotto, D. (Dario), Perico, N. (Norberto), Remuzzi, G. (Giuseppe), Somaschini, M. (Marco), Valensise, H. (Herbert), Adu, D. (Dwomoa), Allegaert, K.M. (Karel), Benedetto, C. (Chiara), Cetin, I. (Irene), Chevalier, R. (Robert), Cortinovis, M. (Monica), D'Anna, R. (Rosario), Duvekot, J.J. (Hans), Escribano, J. (Joaquin), Fanos, V. (Vassilios), Ferrazzi, E. (Enrico), Frusca, T. (Tiziana), Glassock, R.J. (Richard J.), Gyselaers, W.J. (Wilfried), Mecacci, F. (Federico), Montini, G. (Giovanni), Osmond, C. (Clive), Ramenghi, L., Romagnani, P. (Paola), Santoro, A. (Antonio), Simeoni, U. (Umberto), Steegers, E.A.P. (Eric), Vikse, B.E. (Bjorn Egil), Brenner, B.M. (Barry M.), Charlton, J. (Jennifer), Luyckx, V. (Valerie), Manfellotto, D. (Dario), Perico, N. (Norberto), Remuzzi, G. (Giuseppe), Somaschini, M. (Marco), Valensise, H. (Herbert), Adu, D. (Dwomoa), Allegaert, K.M. (Karel), Benedetto, C. (Chiara), Cetin, I. (Irene), Chevalier, R. (Robert), Cortinovis, M. (Monica), D'Anna, R. (Rosario), Duvekot, J.J. (Hans), Escribano, J. (Joaquin), Fanos, V. (Vassilios), Ferrazzi, E. (Enrico), Frusca, T. (Tiziana), Glassock, R.J. (Richard J.), Gyselaers, W.J. (Wilfried), Mecacci, F. (Federico), Montini, G. (Giovanni), Osmond, C. (Clive), Ramenghi, L., Romagnani, P. (Paola), Santoro, A. (Antonio), Simeoni, U. (Umberto), Steegers, E.A.P. (Eric), and Vikse, B.E. (Bjorn Egil)

Abstract

Hypertension and chronic kidney disease (CKD) have a significant impact on global morbidity and mortality. The Low Birth Weight and Nephron Number Working Group has prepared a consensus document aimed to address the relatively neglected issue for the developmental programming of hypertension and CKD. It emerged from a workshop held on April 2, 2016, including eminent internationally recognized experts in the field of obstetrics, neonatology, and nephrology. Through multidisciplinary engagement, the goal of the workshop was to highlight the association between fetal and childhood development and an increased risk of adult diseases, focusing on hypertension and CKD, and to suggest possible practical solutions for the future. The recommendations for action of the consensus workshop are the results of combined clinical experience, shared research expertise, and a review of the literature. They highlight the need to act early to prevent CKD and other related noncommunicable diseases later in life by reducing low birth weight, small for gestational age, prematurity, and low nephron numbers at birth through coordinated interventions. Meeting the current unmet needs would help to define the most cost-effective strategies and to optimize interventions to limit or interrupt the developmental programming cycle of CKD later in life, especially in the poorest part of the world.

Published
2017
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22. The Impact of Kidney Development on the Life Course: A Consensus Document for Action The Low Birth Weight and Nephron Number Working Group

Author

Universitat Rovira i Virgili, Brenner B.M., Charlton J., Luyckx V., Manfellotto D., Perico N., Remuzzi G., Somaschini M., Valensise H., Adu D., Allegaert K., Benedetto C., Cetin I., Chevalier R., Cortinovis M., D'Anna R., Duvekot J., Escribano J., Fanos V., Ferrazzi E., Frusca T., Glassock R.J., Gyselaers W., Mecacci F., Montini G., Osmond C., Ramenghi L., Romagnani P., Santoro A., Simeoni U., Steegers E.A.P., Vikse B.E., Universitat Rovira i Virgili, and Brenner B.M., Charlton J., Luyckx V., Manfellotto D., Perico N., Remuzzi G., Somaschini M., Valensise H., Adu D., Allegaert K., Benedetto C., Cetin I., Chevalier R., Cortinovis M., D'Anna R., Duvekot J., Escribano J., Fanos V., Ferrazzi E., Frusca T., Glassock R.J., Gyselaers W., Mecacci F., Montini G., Osmond C., Ramenghi L., Romagnani P., Santoro A., Simeoni U., Steegers E.A.P., Vikse B.E.

Abstract

Hypertension and chronic kidney disease (CKD) have a significant impact on global morbidity and mortality. The Low Birth Weight and Nephron Number Working Group has prepared a consensus document aimed to address the relatively neglected issue for the developmental programming of hypertension and CKD. It emerged from a workshop held on April 2, 2016, including eminent internationally recognized experts in the field of obstetrics, neonatology, and nephrology. Through multidisciplinary engagement, the goal of the workshop was to highlight the association between fetal and childhood development and an increased risk of adult diseases, focusing on hypertension and CKD, and to suggest possible practical solutions for the future. The recommendations for action of the consensus workshop are the results of combined clinical experience, shared research expertise, and a review of the literature. They highlight the need to act early to prevent CKD and other related noncommunicable diseases later in life by reducing low birth weight, small for gestational age, prematurity, and low nephron numbers at birth through coordinated interventions. Meeting the current unmet needs would help to define the most cost-effective strategies and to optimize interventions to limit or interrupt the developmental programming cycle of CKD later in life, especially in the poorest part of the world.

Published
2017

24. Restoration of ovarian activity and pregnancy after transplantation of cryopreserved ovarian tissue: a review of 60 cases of reimplantation

Author

Donnez J, Dolmans MM, Pellicer A, Diaz-Garcia C, Sanchez Serrano M, Schmidt KT, Ernst E, Luyckx V, and Andersen CY

Abstract

Aggressive chemotherapy/radiotherapy and bone marrow transplantation can cure >90% of girls and young women affected by disorders requiring such treatment. However, the ovaries are very sensitive to cytotoxic drugs, especially to alkylating agents. Several options are currently available to preserve fertility in cancer patients. The present review reports the results of 60 orthotopic reimplantations of cryopreserved ovarian tissue performed by three teams, as well as 24 live births reported in the literature to date. Restoration of ovarian activity occurred in almost all cases in the three series. Among the 60 patients, eleven conceived and six of those had already delivered twelve healthy babies. In the future, we are looking to: 1) improve freezing techniques; and 2) enhance the "vascular bed" before reimplantation to increase pregnancy rates. On the other hand, cryopreservation of ovarian tissue may be combined with removal, via puncture, of small antral follicles, making it possible to freeze both ovarian tissue and isolated immature oocytes.

Published
2013

28. Clinical Nephrology - Lab methods and other markers

Author

Kleophas, W., primary, Bieber, B., additional, Robinson, B., additional, Duttlinger, J., additional, Fliser, D., additional, Lonneman, G., additional, Rump, L., additional, Pisoni, R., additional, Port, F., additional, Reichel, H., additional, Daniela, R., additional, Ciocalteu, A., additional, Checherita, I. A., additional, Peride, I., additional, Spataru, D. M., additional, Niculae, A., additional, Laetitia, K., additional, Amna, K., additional, Laurence, D., additional, Aoumeur, H.-A., additional, Flamant, M., additional, Haymann, J.-P., additional, Letavernier, E., additional, Vidal-Petiot, E., additional, Boffa, J.-J., additional, Vrtovsnik, F., additional, Bianco, F., additional, Pessolano, G., additional, Carraro, M., additional, Panzetta, G. O., additional, Ebert, N., additional, Gaedeke, J., additional, Jakob, O., additional, Kuhlmann, M., additional, Martus, P., additional, Van der Giet, M., additional, Scha  ner, E., additional, Khan, I., additional, Law, Y., additional, Turgutalp, K., additional, Ozhan, O., additional, Gok Oguz, E., additional, Kiykim, A., additional, Donadio, C., additional, Hatmi, Z. N., additional, Mahdavi-Mazdeh, M., additional, Morales, E., additional, Gutierrez-Millet, V., additional, Rojas-Rivera, J., additional, Huerta, A., additional, Gutierrez, E., additional, Gutierrez-Solis, E., additional, Polanco, N., additional, Caro, J., additional, Gonza z, E., additional, Praga, M., additional, Marco Mayayo, M., additional, Valdivielso, J., additional, Marti  z, M., additional, Fernaez Giraez, E., additional, Obrador, G., additional, Olvera, N., additional, Ortiz de la Pe, D., additional, Gutie ez, V., additional, Villa, A., additional, Redal-Baigorri, B., additional, Sombolos, K., additional, Tsakiris, D., additional, Boletis, J., additional, Vlahakos, D., additional, Siamopoulos, K., additional, Vargiemezis, V., additional, Nikolaidis, P., additional, Iatrou, C., additional, Dafnis, E., additional, Argyropoulos, C., additional, Xynos, K., additional, Schock-Kusch, D., additional, Shulhevich, Y., additional, Geraci, S., additional, Hesser, J., additional, Stsepankou, D., additional, Neudecker, S., additional, Koenig, S., additional, Hoecklin, F., additional, Pill, J., additional, Gretz, N., additional, Schweda, F., additional, Schreiber, A., additional, Kudo, K., additional, Konta, T., additional, Choi, S. O., additional, Kim, J. S., additional, Kim, M. K., additional, Yang, J. W., additional, Han, B. G., additional, Delanaye, P., additional, Cavalier, E., additional, Masson, I., additional, Mehdi, M., additional, Nicolas, M., additional, Lambermont, B., additional, Dubois, B., additional, Damas, P., additional, Krzesinski, J.-M., additional, Morel, J., additional, Lautrette, A., additional, Christophe, M., additional, Gagneux-Brunon, A., additional, Anne, F., additional, Fre (C)ric, L., additional, Bevc, S., additional, Ekart, R., additional, Hojs, R., additional, Gorenjak, M., additional, Puklavec, L., additional, Hashimoto, N., additional, Suzuki, A., additional, Mitsumoto, K., additional, Shimizu, M., additional, Niihata, K., additional, Kawabata, A., additional, Sakaguchi, Y., additional, Hayashi, T., additional, Shoji, T., additional, Okada, N., additional, Tsubakihara, Y., additional, Hamano, T., additional, Nakano, C., additional, Fujii, N., additional, Obi, Y., additional, Mikami, S., additional, Inoue, K., additional, Matsui, I., additional, Isaka, Y., additional, Rakugi, H., additional, Edvardsson, V., additional, Siguron, B., additional, Thorsteinsdottir, M., additional, Palsson, R., additional, Matsumoto, J., additional, Miyazaki, N., additional, Murata, I., additional, Yoshida, G., additional, Morishita, K., additional, Ushikoshi, H., additional, Nishigaki, K., additional, Ogura, S., additional, Minatoguchi, S., additional, Werneke, U., additional, Ott, M., additional, Salander-Renberg, E., additional, Taylor, D., additional, Stegmayr, B., additional, Surel, S., additional, Wenzlova, M., additional, Silva Junior, G., additional, Vieira, A. P., additional, Couto Bem, A., additional, Alves, M., additional, Torres, A., additional, Meneses, G., additional, Martins, A., additional, Liborio, A., additional, Daher, E., additional, Gluhovschi, G., additional, Modilca, M., additional, Daminescu, L., additional, Gluhovschi, C., additional, Velciov, S., additional, Petrica, L., additional, Gadalean, F., additional, Balgradean, C., additional, Schmeiser, H. H., additional, Kolesnyk, M., additional, Stepanova, N., additional, Surzhko, L., additional, Stashevska, N., additional, Filiopoulos, V., additional, Hadjiyannakos, D., additional, Arvanitis, D., additional, Panagiotopoulos, K., additional, Vlassopoulos, D., additional, Kaesler, N., additional, Schettgen, T., additional, Magdeleyns, E., additional, Brandenburg, V., additional, Vermeer, C., additional, Floege, J., additional, Kr, T., additional, Randone, O., additional, Ferraresi, M., additional, Aroasio, E., additional, Depascale, A., additional, Scognamiglio, S., additional, Consiglio, V., additional, Piccoli, G. B., additional, Jensen, L. V., additional, Lizakowski, S., additional, Rutkowski, P., additional, Tylicki, L., additional, Renke, M., additional, Sulikowska, B., additional, Donderski, R., additional, Bednarski, R., additional, Heleniak, Z., additional, Przybylska, M., additional, Manitius, J., additional, Rutkowski, B., additional, Bobrova, L., additional, Kozlovskaya, N., additional, Kanayama, K., additional, Hasegawa, M., additional, Kitagawa, F., additional, Ishii, J., additional, Yuzawa, Y., additional, Tanaka, K., additional, Sakai, K., additional, Hara, S., additional, Suzuki, Y., additional, Tanaka, Y., additional, Aikawa, A., additional, Hinoshita, F., additional, Hamano, N., additional, Sasaki, E., additional, Kato, A., additional, Katsuki, T., additional, Katsuma, A., additional, Imai, E., additional, Shibata, M., additional, Tada, M., additional, Shimbo, T., additional, Kikuchi, Y., additional, Oka, S., additional, Muramatsu, T., additional, Yanagisawa, N., additional, Fukutake, K., additional, Yamamoto, Y., additional, Ajisawa, A., additional, Tsuchiya, K., additional, Nitta, K., additional, Ando, M., additional, Liang, X., additional, Wang, P., additional, Liu, Z., additional, Zhao, Z., additional, Luyckx, V., additional, Bowker, S., additional, Miekle, A., additional, Toth, E., additional, Heguilen, R., additional, Malvar, A., additional, Hermes, R., additional, Cohen, L., additional, Muguerza, G., additional, Lococo, B., additional, Bernasconi, A., additional, Loboda, O., additional, Dudar, I., additional, Krot, V., additional, Alekseeva, V., additional, Ichinose, M., additional, Sasagawa, N., additional, Toyama, K., additional, Saito, A., additional, Kayamori, Y., additional, Kang, D., additional, Kim, H. W., additional, Yoshioka, K., additional, Hara, M., additional, Ohashi, K., additional, Maksudova, A., additional, Khalfina, T., additional, Cuoghi, A., additional, Bellei, E., additional, Caiazzo, M., additional, Bergamini, S., additional, Palladino, G., additional, Monari, E., additional, Tomasi, A., additional, Loiacono, E., additional, Camilla, R., additional, Dapr, V., additional, Morando, L., additional, Gallo, R., additional, Peruzzi, L., additional, Conrieri, M., additional, Bianciotto, M., additional, Bosetti, F. M., additional, Coppo, R., additional, DI Lullo, L., additional, Floccari, F., additional, Rivera, R., additional, Granata, A., additional, Faiola, R., additional, Feliziani, C., additional, Villani, A., additional, Malaguti, M., additional, Santoboni, A., additional, Kyriaki, K., additional, Droulias, J., additional, Bogdanova, M., additional, Rameev, V. V., additional, Simonyan, A. H., additional, Kozlovskaya, L. V., additional, Altiparmak, M. R., additional, Trabulus, S., additional, Akalin, N., additional, Yalin, A. S., additional, Esenkaya, A., additional, Yalin, S. F., additional, Serdengeae(C), K., additional, Arita, D., additional, Cunha, T., additional, Perez, J., additional, Sakata, M., additional, Arita, L., additional, Nogueira, M., additional, Jara, Z., additional, Souza, N., additional, Casarini, D., additional, Metzger, M., additional, Vallet, M., additional, Karras, A., additional, Froissart, M., additional, Stengel, B., additional, Houillier, P., additional, Paul, K., additional, Kretzschmar, D., additional, Yilmaz, A., additional, Ba hlein, B., additional, Titze, S., additional, Figulla, H.-R., additional, Wolf, G., additional, Busch, M., additional, Korotchaeva, Y., additional, Gordovskaya, N., additional, Kozlovskaya, L., additional, Ng, K. P., additional, Sharma, P., additional, Stringer, S., additional, Jesky, M., additional, Dutton, M., additional, Ferro, C., additional, Cockwell, P., additional, Moon, S. J., additional, Lee, S. C., additional, Yoon, S. Y., additional, Lee, J. E., additional, Han, S. J., additional, Anna, B., additional, Kirsch, T., additional, Svjetlana, L., additional, Joon-Keun, P., additional, Jan, B., additional, Johanna, K., additional, Haller, H., additional, Haubitz, M., additional, Smirnov, A., additional, Kayukov, I., additional, Rafrafi, N., additional, Degtereva, O., additional, Dobronravov, V., additional, Koch, M., additional, Stefan, H., additional, Dika, G., additional, Antoine, M.-H., additional, Husson, C., additional, Kos, J., additional, Milic, M., additional, Fucek, M., additional, Cvoriocec, D., additional, Bourgeade, M.-F., additional, Nortier, J. L., additional, Jelakovic, B., additional, Nawal, E. H., additional, Naoufal, M., additional, Nabila, M., additional, Fadwa, E. M., additional, Salma, E. K., additional, Nisrine, B., additional, Mohamed, Z., additional, Guislaine, M., additional, Mohamed Gharbi, B., additional, Benyounes, R., additional, Sotila, G. G., additional, Sorin, R., additional, Irina Magdalena, D., additional, Roxana, C., additional, Claudia, R., additional, Correa Barcellos, F., additional, Hallal, P. H., additional, Bohlke, M., additional, Boscolo Del Vechio, F., additional, Reges, A., additional, Santos, I., additional, Mielke, G., additional, Fortes, M., additional, Antunez, B., additional, Laganovic, M., additional, Vukovic Lela, I., additional, Karanovic, S., additional, Seric, J., additional, Premuic, V., additional, Fitrek, M., additional, Fodor, L., additional, Meljkovic Vrkic, T., additional, Bansal, V., additional, Hoppensteadt, D., additional, and Fareed, J., additional

Published
2012
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31. POSTER VIEWING SESSION - MALE AND FEMALE FERTILITY PRESERVATION

Author

Akakubo, N., primary, Kagawa, N., additional, Yabuuchi, A., additional, Silber, S. J., additional, Yamaguchi, S., additional, Nagumo, Y., additional, Takai, Y., additional, Ishihara, S., additional, Takehara, Y., additional, Kato, O., additional, Kocent, J., additional, Hu, J. C. Y., additional, Neri, Q. V., additional, Rosenwaks, Z., additional, Palermo, G. D., additional, Armuand, G., additional, Rodriguez-Wallberg, K., additional, Wettergren, L., additional, Lampic, C., additional, Martinez-Soto, J. C., additional, Domingo, J. C., additional, Cordovilla, B., additional, Gadea, J., additional, Landeras, J., additional, Sadri-Ardekani, H., additional, Akhondi, M. M., additional, van der Veen, F., additional, de Rooij, D. G., additional, Repping, S., additional, van Pelt, A. M. M., additional, Vanacker, J., additional, Luyckx, V., additional, Dolmans, M. M., additional, Amorim, C. A., additional, Van Langendonckt, A., additional, Donnez, J., additional, Camboni, A., additional, Gavella, M., additional, Lipovac, V., additional, Siftar, Z., additional, Garaj-Vrhovac, V., additional, Gajski, G., additional, Gook, D., additional, Borg, J., additional, Edgar, D. H., additional, Brink-van der Vlugt, J. J., additional, Van der Velden, V. H. J., additional, Noordijk, A., additional, Timmer-Bosscha, H., additional, Tissing, W. J. E., additional, Land, J. A., additional, Hollema, H., additional, Van Echten-Arends, J., additional, Alvarez, J. G., additional, Gosalvez, A., additional, Velilla, E., additional, Lopez-Teijon, M., additional, Lopez-Fernandez, C., additional, Gosalvez, J., additional, Kristensen, S. G., additional, Rasmussen, A., additional, Yding Andersen, C., additional, Raziel, A., additional, Friedler, S., additional, Gidoni, Y., additional, Ben Ami, I., additional, Kaufman, S., additional, Omansky, A., additional, Strassburger, D., additional, Komarovsky, D., additional, Bern, O., additional, Kasterstein, E., additional, Komsky, A., additional, Maslansky, B., additional, Ron-El, R., additional, Fujimoto, A., additional, Osuga, Y., additional, Ichinose, M., additional, Oishi, H., additional, Harada, M., additional, Koizumi, M., additional, Takemura, Y., additional, Yano, T., additional, Taketani, Y., additional, Molnar, Z., additional, Mokanszki, A., additional, Benyo, M., additional, Bazsane Kassai, Z., additional, Olah, E., additional, Jakab, A., additional, Rodriguez-Wallberg, K. A., additional, Vonheim, E., additional, Gumus, E., additional, Persson, I., additional, Lundqvist, M., additional, Karlstrom, P. O., additional, Hovatta, O., additional, Pasqualotto, F. F., additional, Teixeira, R., additional, Medeiros, G. S., additional, Canabarro, C., additional, Tonezer, J., additional, Grando, A. P. C., additional, Borges Jr., E., additional, Pasqualotto, E. B., additional, Westphal, J. R., additional, Bastings, L., additional, Beerendonk, C. C. M., additional, Braat, D. D. M., additional, Peek, R., additional, Courbiere, B., additional, Berthelot-Ricou, A., additional, Di Giorgio, C., additional, De Meo, M., additional, Roustan, A., additional, Botta, A., additional, Perrin, J., additional, Abir, R., additional, Orvieto, R., additional, Friedman, O., additional, Ben-Haroush, A., additional, Fisch, B., additional, Lawrenz, B., additional, Henes, J., additional, Henes, M., additional, Neunhoeffer, E., additional, Schmalzing, M., additional, Fehm, T., additional, and Koetter, I., additional

Published
2011
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36. Reply

Author

Luyckx, V. A., primary and Mardigan, T. A., additional

Published
2005
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38. Birth weight predicts both proteinuria and overweight/obesity in a rural population of Aboriginal and non-Aboriginal Canadians.

Author

Oster, R. T., Luyckx, V. A., and Toth, E. L.

Abstract

The risk for many chronic diseases appears to be mediated in part by birth weight. Among Aboriginal Canadians, the prevalence of end-stage renal disease and cardiovascular disease risk is disproportionately high, largely because of elevated diabetes prevalence. The relationships between birth weight (and other potential risk factors) and diabetes, hypertension, proteinuria and overweight/obesity were explored in 1439 rural Albertans (Canada), of whom 67.3% were Aboriginal. At voluntary outreach screening programs, demographic and clinical data were measured and recalled birth weights recorded. Statistical modeling using logistic regression was used to evaluate the relationships. In the final adjusted models, associations remained for low birth weight and proteinuria [odds ratio (OR) 2.36; 95% CI 1.24–4.49], as well as for high birth weight and overweight/obesity (OR 1.58; 95% CI 1.00–2.53). These findings emphasize the need to strive for healthy pregnancies, with appropriate weight gains in these and other disadvantaged populations around the world. [ABSTRACT FROM PUBLISHER]

Published
2013
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44. When the Earth Trembles in the Americas: The Experience of Haiti and Chile 2010.

Author

Vanholder, R., Borniche, D., Claus, S., Correa-Rotter, R., Crestani, R., Ferir, M. C., Gibney, N., Hurtado, A., Luyckx, V. A., Portilla, D., Rodriguez, S., Sever, M. S., Vanmassenhove, J., and Wainstein, R.

Subjects
MEDICAL assistance, HUMANITARIAN assistance, NEPHROLOGY, HAITI Earthquake, Haiti, 2010, CHILE Earthquake, Chile, 2010 (February 27)
Abstract

The response of the nephrological community to the Haiti and Chile earthquakes which occurred in the first months of 2010 is described. In Haiti, renal support was organized by the Renal Disaster Relief Task Force (RDRTF) of the International Society of Nephrology (ISN) in close collaboration with Médecins Sans Frontières (MSF), and covered both patients with acute kidney injury (AKI) and patients with chronic kidney disease (CKD). The majority of AKI patients (19/27) suffered from crush syndrome and recovered their kidney function. The remaining 8 patients with AKI showed acute-to-chronic renal failure with very low recovery rates. The intervention of the RDRTF-ISN involved 25 volunteers of 9 nationalities, lasted exactly 2 months, and was characterized by major organizational difficulties and problems to create awareness among other rescue teams regarding the availability of dialysis possibilities. Part of the Haitian patients with AKI reached the Dominican Republic (DR) and received their therapy there. The nephrological community in the DR was able to cope with this extra patient load. In both Haiti and the DR, dialysis treatment was able to be prevented in at least 40 patients by screening and adequate fluid administration. Since laboratory facilities were destroyed in Port-au-Prince and were thus lacking during the first weeks of the intervention, the use from the very beginning on of a point-of-care device (i-STAT®) was very efficient for the detection of aberrant kidney function and electrolyte parameters. In Chile, nephrological problems were essentially related to difficulties delivering dialysis treatment to CKD patients, due to the damage to several units. This necessitated the reallocation of patients and the adaptation of their schedules. The problems could be handled by the local nephrologists. These observations illustrate that local and international preparedness might be life-saving if renal problems occur in earthquake circumstances. Copyright © 2010 S. Karger AG, Basel [ABSTRACT FROM AUTHOR]

Published
2011
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46. Lessons learned during the war in Ukraine: a report from the Renal Disaster Relief Task Force of the ERA

Author

Serhan Tuğlular, Valerie Luyckx, Raymond Vanholder, Andrej Skoberne, Andrzej Wiecek, İonut Nistor, Ewa Pawlowicz-Szlarska, Rukshana Shroff, Dmytro Ivanov, Kai-Uwe Eckardt, Edita Noruisiene, Daniel Gallego, Olena Loboda, Mehmet S Sever, and Tuğlular S., Luyckx V., Vanholder R., Skoberne A., Wiecek A., Nistor İ., Pawlowicz-Szlarska E., Shroff R., Ivanov D., Eckardt K., et al.

Subjects
kidney patients, Transplantation, conflicts, Nephrology, dialysis, war, disasters
Abstract

People living with kidney disease are among the most vulnerable at times of natural or man-made disasters. In addition to their unpredictable course, armed conflicts impose a major threat given the disruption of infrastructure, sanitation and access to food, water and medical care. The ongoing war in Ukraine has once more demonstrated the importance of preparedness, organization, coordination and solidarity during disasters. People living with kidney disease face serious challenges given their dependence on life-sustaining treatment, irrespective of whether they remain in the war zone or are displaced internally or externally. This especially affects those requiring kidney replacement therapy, dialysis or transplantation, but also patients with other kidney diseases and the medical staff who care for them. Soon after the war started, the European Renal Association assigned a Renal Disaster Relief Task Force dedicated to support the people living with kidney disease and the nephrology community in Ukraine. This report summarizes the major challenges faced, actions taken and lessons learned by this task force. We anticipate that the experience will help to increase preparedness and mitigate the devastating effects of armed conflicts on the kidney community in the future and propose to establish an international collaboration to extend this effort to other parts of the world facing similar challenges.

Published
2023
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47. Armed conflicts and kidney patients: A consensus statement from the renal disaster relief task force of the ERA

Author

Mehmet S Sever, Raymond Vanholder, Valerie Luyckx, Kai-Uwe Eckardt, Mykola Kolesnyk, Andrzej Wiecek, Ewa Pawlowicz-Szlarska, Daniel Gallego, Rukshana Shroff, Andrej Škoberne, Ionut Nistor, Mohamed Sekkarie, Dmytro Ivanov, Edita Noruišiene, Serhan Tuglular, Sever M. S. , Vanholder R., Luyckx V., Eckardt K., Kolesnyk M., Wiecek A., Pawlowicz-Szlarska E., Gallego D., Shroff R., Skoberne A., et al., and University of Zurich

Subjects
Internal Diseases, Urology, 610 Medicine & health, Sağlık Bilimleri, İç Hastalıkları, Clinical Medicine (MED), disasters, Transplantasyon, conflicts, UROLOGY & NEPHROLOGY, Health Sciences, Klinik Tıp (MED), ÜROLOJİ VE NEFROLOJİ, wars, kidney patients, Transplantation, Internal Medicine Sciences, Klinik Tıp, 10060 Epidemiology, Biostatistics and Prevention Institute (EBPI), Dahili Tıp Bilimleri, CLINICAL MEDICINE, Tıp, Nefroloji, 10036 Medical Clinic, Nephrology, Üroloji, Medicine, dialysis
Abstract

During conflicts, people with kidney disease, either those remaining in the affected zones or those who are displaced, may be exposed to additional threats because of medical and logistical challenges. Acute kidney injury developing on the battlefield, in field hospitals or in higher-level hospital settings is characterized by poor outcomes. People with chronic kidney disease may experience treatment interruptions, contributing to worsening kidney function. Patients living on dialysis or with a functioning graft may experience limitations of dialysis possibilities or availability of immunosuppressive medications, increasing the risk of severe complications including death. When patients must flee, these threats are compounded by unhealthy and insecure conditions both during displacement and/or at their destination. Measures to attenuate these risks may only be partially effective. Local preparedness for overall and medical/kidney-related disaster response is essential. Due to limitations in supply, adjustments in dialysis frequency or dose, switching between hemodialysis and peritoneal dialysis and changes in immunosuppressive regimens may be required. Telemedicine (if possible) may be useful to support inexperienced local physicians in managing medical and logistical challenges. Limited treatment possibilities during warfare may necessitate referral of patients to distant higher-level hospitals, once urgent care has been initiated. Preparation for disasters should occur ahead of time. Inclusion of disaster nephrology in medical and nursing curricula and training of patients, families and others on self-care and medical practice in austere settings may enhance awareness and preparedness, support best practices adapted to the demanding circumstances and prepare non-professionals to lend support.

Published
2023
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48. Hemodialysis.

Author

Dreyer G, Gonani A, Luyckx V, Dreyer, Gavin, Gonani, Andrew, and Luyckx, Valerie

Published
2011
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49. Ethical considerations on the use of big Data and Artificial Intelligence in kidney research from the ERA ethics committee.

Author

Van Biesen W, Ponikvar JB, Fontana M, Heering P, Sever MS, Sawhney S, and Luyckx V

Abstract

In the current paper, we will focus on requirements to ensure big data can advance the outcomes of our patients suffering from kidney disease. The associated ethical question is whether and how we as a nephrology community can and should encourage the collection of big data of our patients. We identify some ethical reflections on the use of big data, and their importance and relevance. Furthermore, we balance advantages and pitfalls and discuss requirements to make legitimate and ethical use of big data possible. The collection, organization and curation of data come upfront in the pipeline prior to any analyses. Great care must therefore be taken to ensure quality of the data at this stage, to avoid the garbage in garbage out problem and suboptimal patient care as a consequence of such analyses. Access to the data should be organized so that correct and efficient use of data is possible. This means that data must be stored safely, so that only those entitled to do so can access them. At the same time, those who are entitled to access the data should be able to do so in an efficient way, so as not to hinder relevant research. Analysis of observational data is itself prone to many errors and biases. Each of these biases can finally result in provision of low-quality medical care. Secure platforms should therefore also ensure correct methodology is used to interpret the available data. This requires close collaboration of a skilled workforce of experts in medical research and data scientists. Only then will our patients be able to benefit fully from the potential of AI and big data., (© The Author(s) 2024. Published by Oxford University Press on behalf of the ERA.)

Published
2024
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50. Progress of nations in the organisation of, and structures for, kidney care delivery between 2019 and 2023: cross sectional survey in 148 countries.

Author

Okpechi IG, Levin A, Tungsanga S, Arruebo S, Caskey FJ, Chukwuonye II, Damster S, Donner JA, Ekrikpo UE, Ghimire A, Jha V, Luyckx V, Nangaku M, Saad S, Tannor EK, Tonelli M, Ye F, Bello AK, and Johnson DW

Subjects
Humans, Cross-Sectional Studies, Global Health, Kidney Transplantation statistics & numerical data, Health Policy, Nephrology organization & administration, Registries, Oceania, Healthcare Financing, Caribbean Region, Africa, Asia, Renal Dialysis statistics & numerical data, Middle East, North America, Latin America, Europe, Russia, Health Services Accessibility statistics & numerical data, Renal Replacement Therapy statistics & numerical data, Delivery of Health Care organization & administration
Abstract

Objective: To assess changes in key measures of kidney care using data reported in 2019 and 2023., Design: Cross sectional survey in 148 countries., Setting: Surveys from International Society of Nephrology Global Kidney Health Atlas between 2019 and 2023 that included participants from countries in Africa (n=36), Eastern and Central Europe (n=16), Latin America (n=18), the Middle East (n=11), Newly Independent States and Russia (n=10), North America and the Caribbean (n=8), North and East Asia (n=6), Oceania and South East Asia (n=15), South Asia (n=7), and Western Europe (n=21)., Participants: Countries that participated in both surveys (2019 and 2023)., Main Outcome Measures: Comparison of 2019 and 2023 data for availability of kidney replacement treatment services, access, health financing, workforce, registries, and policies for kidney care. Data for countries that participated in both surveys (2019 and 2023) were included in our analysis. Country data were aggregated by International Society of Nephrology regions and World Bank income levels. Proportionate changes in the status of these measures across both periods were reported., Results: Data for 148 countries that participated in both surveys were available for analysis. The proportions of countries that provided public funding (free at point of delivery) increased from 27% in 2019 to 28% in 2023 for haemodialysis, 23% to 28% for peritoneal dialysis, and 31% to 36% for kidney transplantation services. Centres for these treatments increased from 4.4 per million population (pmp) to 4.8 pmp (P<0.001) for haemodialysis, 1.4 pmp to 1.6 pmp for peritoneal dialysis, and 0.43 pmp to 0.46 pmp for kidney transplantation services. Overall, access to haemodialysis and peritoneal dialysis improved, however, access to kidney transplantation decreased from 30 pmp to 29 pmp. The global median prevalence of nephrologists increased from 9.5 pmp to 12.4 pmp (P<0.001). Changes in the availability of kidney registries and in national policies and strategies for kidney care were variable across regions and country income levels. The reporting of specific barriers to optimal kidney care by countries increased from 55% to 59% for geographical factors, 58% to 68% (P=0.043) for availability of nephrologists, and 46% to 52% for political factors., Conclusions: Important changes in key areas of kidney care delivery were noted across both periods globally. These changes effected the availability of, and access to, kidney transplantation services. Countries and regions need to enact enabling strategies for preserving access to kidney care services, particularly kidney transplantation., Competing Interests: Competing interests: All authors have completed the ICMJE uniform disclosure form at www.icmje.org/disclosure-of-interest/ and declare: funding support for this project from the International Society of Nephrology (grant RES0033080 to the University of Alberta); ST reports fellowship grants from the International Society of Nephrology-Salmasi Family and the Kidney Foundation of Thailand, outside the submitted work. SA reports personal fees from The International Society of Nephrology, outside the submitted work. SD reports personal fees from The International Society of Nephrology, outside the submitted work. JD reports personal fees from The International Society of Nephrology, outside the submitted work. VJ reports personal fees from GSK, Astra Zeneca, Baxter Healthcare, Visterra, Biocryst, Chinook, Vera, and Bayer, paid to his institution, outside the submitted work. VAL reports royalties from Elsevier, consulting fees from the World Health Organization, travel support from the European Renal Association and International Society of Nephrology, and leadership role in Advocacy Working Group of the International Society of Nephrology, outside the submitted work. MN reports grants and personal fees from KyowaKirin, Boehringer Ingelheim, Chugai, Daiichi Sankyo, Torii, Japan Tobacco, Mitsubishi Tanabe, grants from Takeda and Bayer, and personal fees from Astellas, Akebia, AstraZeneca, and GSK, outside the submitted work. AKB reports other (consultancy and honoraria) from AMGEN Incorporated and Otsuka, other (consultancy) from Bayer and GSK, and grants from Canadian Institute of Health Research and Heart and Stroke Foundation of Canada, outside the submitted work; he is also Associate Editor of the Canadian Journal of Kidney Health and Disease and Co-chair of the ISN-Global Kidney Health Atlas. DWJ reports consultancy fees, research grants, speaker’s honoraria and travel sponsorships from Baxter Healthcare and Fresenius Medical Care, consultancy fees from Astra Zeneca, Bayer, and AWAK, speaker’s honoraria from ONO and Boehringer Ingelheim & Lilly, and travel sponsorships from ONO and Amgen, outside the submitted work. He is also a current recipient of an Australian National Health and Medical Research Council Leadership Investigator Grant, outside the submitted work. All other authors have nothing to declare., (© Author(s) (or their employer(s)) 2019. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ.)

Published
2024
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