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2. Prednisolone or tetracosactide depot for infantile epileptic spasms syndrome? A prospective analysis of data embedded within two randomised controlled trials

Author

Osborne, John P., Edwards, Stuart W., Alber, Fabienne Dietrich, Hancock, Eleanor, Johnson, Anthony L., Kennedy, Colin R., Likeman, Marcus, Lux, Andrew L., Mackay, Mark, Mallick, Andrew, Newton, Richard W., Nolan, Melinda, Pressler, Ronit, Rating, Dietz, Schmitt, Bernhard, Verity, Christopher M., and O'Callaghan, FinbarJ.K.

Published
2023
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5. Revised Guideline For Prescribing Vigabatrin In Children

Author

Vigabatrin Paediatric Advisory Group, Lux, Andrew L., Edwards, Stuart W., Osborne, John P., Hancock, Eleanor, Johnson, Anthony L., Kennedy, Colin R., O'Callaghan, Finbar J. K., Newton, Richard W., and Verity, Christopher M.

Published
2001

7. Infantile Spasms and Vigabatrin

Author

Osborne, John P., Edwards, Stuart W., Hancock, Eleanor, Lux, Andrew L., O'Callaghan, Finbar, Johnson, Tony, Kennedy, Colin R., Newton, Richard W., Verity, Christopher M., Lhatoo, S. D., and Sander, J. W. A. S.

Published
1999

9. Developmental and epilepsy outcomes at age 4 years in the UKISS trial comparing hormonal treatments to vigabatrin for infantile spasms: a multi-centre randomised trial

Author

Darke, Katrina, Edwards, Stuart W., Hancock, Eleanor, Johnson, Anthony L., Kennedy, Colin R., Lux, Andrew L., Newton, Richard W., O'Callaghan, Finbar J.K., Verity, Christopher M., and Osborne, John P.

Subjects
Spasms, Infantile -- Care and treatment, Spasms, Infantile -- Patient outcomes, Spasms, Infantile -- Research, Epilepsy in children -- Care and treatment, Epilepsy in children -- Patient outcomes, Epilepsy in children -- Research, Treatment outcome -- Research, Infants -- Development, Infants -- Research
Published
2010

10. An investigation into the relationship between vigabatrin, movement disorders, and brain magnetic resonance imaging abnormalities in children with infantile spasms

Author

Fong, Choong YI, Osborne, John P, Edwards, Stuart W, Hemingway, Cheryl, Hancock, Eleanor, Johnson, Anthony L, Kennedy, Colin R, Kneen, Rachel, Likeman, Marcus, Lux, Andrew L, Mordekar, Santosh R, Murugan, Velayutham, Newton, Richard W, Pike, Michael, Quinn, Michael, Spinty, Stefan, Vassallo, Grace, Verity, Christopher M, Whitney, Andrea, and OʼCallaghan, Finbar J K

Published
2013
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23. Vigabatrin with hormonal treatment versus hormonal treatment alone (ICISS) for infantile spasms: 18-month outcomes of an open-label, randomised controlled trial

Author

O'Callaghan, Finbar J K, primary, Edwards, Stuart W, additional, Alber, Fabienne Dietrich, additional, Cortina Borja, Mario, additional, Hancock, Eleanor, additional, Johnson, Anthony L, additional, Kennedy, Colin R, additional, Likeman, Marcus, additional, Lux, Andrew L, additional, Mackay, Mark T, additional, Mallick, Andrew A, additional, Newton, Richard W, additional, Nolan, Melinda, additional, Pressler, Ronit, additional, Rating, Dietz, additional, Schmitt, Bernhard, additional, Verity, Christopher M, additional, Osborne, John P, additional, Abdel Aziz, Maysara, additional, Acharya, Triloknath, additional, Adcock, Carolyn, additional, Jones, Robert, additional, Howells, Rachel, additional, Marsh, Ben, additional, Adejare, Kemi, additional, Adiga, Rashmi, additional, Wheater, Mary, additional, Ahmed, Mansoor, additional, Sawal, Mohammad, additional, Goel, Chhavi, additional, Ahmed, MAS, additional, Alber, Michael, additional, Wolff, Markus, additional, Ruf, Susanne, additional, Al-Kharusi, Asya, additional, Al-Moasseb, Hassan, additional, Arora, Ruchi, additional, Beach, Richard, additional, Atkinson, Patricia, additional, Ayonrinde, Kunle, additional, Bala, Pronab, additional, Bamford, Nicola, additional, Barakat, Nagi, additional, Basheer, Nigel, additional, Baxter, Peter, additional, Mordekar, Santosh, additional, Rittey, Chris, additional, Borggraefe, Ingo, additional, Borusiak, Peter, additional, Cagnoli, Sabine, additional, Brown, Richard, additional, Calvert, Sophie, additional, Cameron, Duncan, additional, Chaniyil, Ramesh, additional, Chinthapalli, Ravi, additional, Chow, Gabriel, additional, Whitehouse, William, additional, Clarke, Vinodhini, additional, Cooper, Chris, additional, Datta, Alexane, additional, D'Costa, Selwyn, additional, de Goede, Christian, additional, Basu, Helen, additional, Deekollu, David, additional, Della Marina, Adela, additional, Dison, Penelope, additional, Dunkley, Colin, additional, Eaton, Megan, additional, Ellison, Julie, additional, Pugh, Robert, additional, Fallon, Penny, additional, Faza, Hani, additional, Choonara, Imti, additional, Morton, Richard, additional, Ratnayaka, Mal, additional, Ferrie, Colin, additional, Freeman, Amanda, additional, Warriner, Stephen, additional, Garcia, Maria, additional, Ghazavi, Malihe, additional, Gibbon, Frances, additional, Gibbs, John, additional, Ginbey, Des, additional, Guarino, Iolanda, additional, Gupta, Rajesh, additional, Hanlon, Mary, additional, Harris, Siân, additional, Munyard, Paul, additional, Hemingway, Cheryl, additional, Eltze, Christin, additional, Kaliakatsos, Marios, additional, Murugan, Velayutham, additional, Robinson, Robert, additional, Tan, Jeen, additional, Hindley, Daniel, additional, Hughes, Adrian, additional, Hussain, Akmal, additional, Boden, Greg, additional, Hussain, Munir, additional, Hussain, Nahin, additional, Dabydeen, Lyvia, additional, Irwin, Kate, additional, Jacobs, Julia, additional, Jauhari, Praveen, additional, Minchom, Philip, additional, Jones, Simon, additional, Karenfort, Michael, additional, Keimer, Reinhard, additional, Kennedy, Colin, additional, Kirkham, Fenella, additional, Whitney, Andrea, additional, Kirkpatrick, Martin, additional, Jollands, Alice, additional, Kneen, Rachel, additional, Iyer, Anand, additional, McTague, Amy, additional, Spinty, Stefan, additional, Kumar, Ramesh, additional, Kurlemann, Gerhard, additional, Lee, Matthew, additional, Jurges, Eman, additional, Levy, Robert, additional, Lewis, Helen, additional, Lewis, Hilary, additional, Lloyd Evans, Andrew, additional, Loh, Ne-Ron, additional, Osborne, John, additional, O'Callaghan, Finbar, additional, Maddicks, Hilary, additional, Luecke, Thomas, additional, Lux, Andrew, additional, Majumdar, Anirban, additional, Vijayakumar, Kayal, additional, MacKay, Mark, additional, Freeman, Jeremy, additional, Hayman, Michael, additional, Kornberg, Andrew, additional, Leventer, Rick, additional, Ryan, Monique, additional, Ware, Tyson, additional, Mancais, Penny, additional, Marinaki, Katina, additional, Massarano, Albert, additional, Mathew, Satheesh, additional, McLellan, Ailsa, additional, Melville, Colin, additional, Mewasingh, Leena, additional, Muhle, Hiltrud, additional, Nagmeldin, Eisawi, additional, Natarajan, Jeyashree, additional, Nelapatla, Suresh, additional, Gondwe, Jailosi, additional, Newton, Richard, additional, Hughes, Imelda, additional, Martland, Tim, additional, McCullagh, Gary, additional, Vassallo, Grace, additional, Nirmal, Stephen, additional, Davis, Suzanne, additional, Patel, Rakesh, additional, Sharpe, Cynthia, additional, Olabi, Anas, additional, O'Neill, Kevin, additional, Gould, Jim, additional, Panzer, Axel, additional, Theophil, Manuela, additional, Parepalli, Srinivas, additional, Hinde, Frank, additional, Smith, Martin, additional, Parker, Alasdair, additional, Chitre, Manali, additional, Philip, Sunny, additional, Gupta, Rajat, additional, Wassmer, Evangeline, additional, Pike, Mike, additional, McShane, Tony, additional, Prakash, Nandhini, additional, Padmakumar, Beena, additional, Pridmore, Clair, additional, Prietsch, Viola, additional, Krieg, Peter, additional, Quinlivan, Ros, additional, Quinn, Michael, additional, Collinson, Andrew, additional, Rajalingam, Usha, additional, Rakshi, Karl, additional, Rao, Tekki, additional, Ravi, Asha, additional, Rifkin, Rob, additional, Roper, Helen, additional, Rowlandson, Piers, additional, Sadleir, Lynette, additional, Sahi, Sanjay, additional, Saraswatula, Arun, additional, O'Sullivan, Siobhan, additional, Saravanan, Kethar, additional, Scammell, Alastair, additional, Rao, Sudhakar, additional, Schubert-Bast, Susanne, additional, Scott, David J, additional, Scott, Fraser, additional, Pye, Matthew, additional, Shah, Ayaz, additional, Stephen, Elma, additional, Shah, Shambhu, additional, Butterfill, Andrew, additional, Shute, Pauline, additional, Singh, Rajeeva, additional, Allogoa, Brigid, additional, Singh, Ravinder, additional, Sinha, Gyanranjan, additional, Sivakumar, Puthuval, additional, Smith, Robert, additional, Sriskandan, Sivaranjini, additional, Steinert, Martin, additional, Strassburg, Michael, additional, Strozzi, Susi, additional, Subramanian, Geeta, additional, and Tandy, Andrew, additional

Published
2018
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25. Safety and effectiveness of hormonal treatment versus hormonal treatment with vigabatrin for infantile spasms (ICISS): a randomised, multicentre, open-label trial

Author

O'Callaghan, Finbar J K, primary, Edwards, Stuart W, additional, Alber, Fabienne Dietrich, additional, Hancock, Eleanor, additional, Johnson, Anthony L, additional, Kennedy, Colin R, additional, Likeman, Marcus, additional, Lux, Andrew L, additional, Mackay, Mark, additional, Mallick, Andrew A, additional, Newton, Richard W, additional, Nolan, Melinda, additional, Pressler, Ronit, additional, Rating, Dietz, additional, Schmitt, Bernhard, additional, Verity, Christopher M, additional, and Osborne, John P, additional

Published
2017
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26. The underlying etiology of infantile spasms (West syndrome): Information from the International Collaborative Infantile Spasms Study (ICISS).

Author

Osborne, John P., Edwards, Stuart W., Dietrich Alber, Fabienne, Hancock, Eleanor, Johnson, Anthony L., Kennedy, Colin R., Likeman, Marcus, Lux, Andrew L., Mackay, Mark, Mallick, Andrew, Newton, Richard W., Nolan, Melinda, Pressler, Ronit, Rating, Dietz, Schmitt, Bernhard, Verity, Christopher M., and O'Callaghan, Finbar J. K.

Subjects
INFANTILE spasms, ETIOLOGY of diseases, DOWN syndrome, STROKE, TIME management, NOSOLOGY
Abstract

Objective: To determine the underlying etiologies in a contemporary cohort of infants with infantile spasms and to examine response to treatment. Methods: Identification of the underlying etiology and response to treatment in 377 infants enrolled in a clinical trial of the treatment of infantile spasms between 2007 and 2014 using a systematic review of history, examination, and investigations. They were classified using the pediatric adaptation of International Classification of Diseases, Tenth Revision (ICD‐10). Results: A total of 219 of 377 (58%) had a proven etiology, of whom 128 (58%) responded, 58 of 108 (54%) were allocated hormonal treatment, and 70 of 111 (63%) had combination therapy. Fourteen of 17 (82%, 95% confidence interval [CI] 59% to 94%) infants with stroke and infarct responded (compared to 114 of 202 for the rest of the proven etiology group (56%, 95% CI 48% to 62%, chi‐square 4.3, P = .037): the better response remains when treatment allocation and lead time are taken into account (odds ratio 5.1, 95% CI 1.1 to 23.6, P = .037). Twenty of 37 (54%, 95% CI 38% to 70%) infants with Down syndrome had cessation of spasms compared to 108 of 182 (59%, 95% CI 52% to 66%, chi‐square 0.35, P = .55) for the rest of the proven etiology group. The lack of a significant difference remains after taking treatment modality and lead‐time into account (odds ratio 0.8, 95% CI 0.4 to 1.7, P = .62). In Down syndrome infants, treatment modality did not appear to affect response: 11 of 20 (55%) allocated hormonal therapy responded, compared to 9 of 17 (53%) allocated combination therapy. Significance: This classification allows easy comparison with other classifications and with our earlier reports. Stroke and infarct have a better outcome than other etiologies, whereas Down syndrome might not respond to the addition of vigabatrin to hormonal treatment. [ABSTRACT FROM AUTHOR]

Published
2019
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27. Consensus paper on post-operative pediatric cerebellar mutism syndrome:the Iceland Delphi results

Author

Gudrunardottir, Thora, Morgan, Angela T, Lux, Andrew L, Walker, David A, Walsh, Karin S, Wells, Elizabeth M, Wisoff, Jeffrey H, Juhler, Marianne, Schmahmann, Jeremy D, Keating, Robert F, Catsman-Berrevoets, Coriene, Gudrunardottir, Thora, Morgan, Angela T, Lux, Andrew L, Walker, David A, Walsh, Karin S, Wells, Elizabeth M, Wisoff, Jeffrey H, Juhler, Marianne, Schmahmann, Jeremy D, Keating, Robert F, and Catsman-Berrevoets, Coriene

Abstract

INTRODUCTION: Confusion has surrounded the description of post-operative mutism and associated morbidity in pediatric patients with cerebellar tumors for years. The heterogeneity of definitions and diagnostic features has hampered research progress within the field, and to date, no international guidelines exist on diagnosis, prevention, treatment, or follow-up of this debilitating condition. An international group of clinicians and researchers from multiple relevant disciplines recently formed a cohesive panel to formulate a new working definition and agree upon standardized methods for diagnosis and follow-up.METHODS: Consensus was obtained using the modified nominal group technique, involving four rounds of online Delphi questionnaires interspersed with a structured consensus conference with lectures, group work, and open discussion sessions.RESULTS: A new, proposed definition of "post-operative pediatric CMS" was formed, preliminary recommendations for diagnostic and follow-up procedures were created, two working groups on a new scoring scale and risk prediction and prevention were established, and areas were identified where further information is needed.DISCUSSION: The consensus process was motivated by desire to further research and improve quality of life for pediatric brain tumor patients. The Delphi rounds identified relevant topics and established basic agreement, while face-to-face engagement helped resolve matters of conflict and refine terminology. The new definition is intended to provide a more solid foundation for future clinical and research work. It is thought as a consensus for moving forward and hopefully paves the way to developing a standard approach to this challenging problem with the advent of better scoring methods and ultimate goal of reducing the risk of CMS.

Published
2016

28. Shaken impact syndrome

Author

Miller, Marvin, Greeley, Christopher S, O'Callaghan, Finbar J K, Walker, Stephen G, and Lux, Andrew L

Subjects
Shaken baby syndrome -- Diagnosis, Infants -- Injuries
Published
2001

31. The effect of lead time to treatment and of age of onset on developmental outcome at 4 years in infantile spasms: Evidence from the United Kingdom Infantile Spasms Study

Author

O’Callaghan, Finbar J. K., primary, Lux, Andrew L., additional, Darke, Katrina, additional, Edwards, Stuart W., additional, Hancock, Eleanor, additional, Johnson, Anthony L., additional, Kennedy, Colin R., additional, Newton, Richard W., additional, Verity, Christopher M., additional, and Osborne, John P., additional

Published
2011
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33. Shaken Impact Syndrome

Author

Lux, Andrew L., Walker, Stephen G., O'Callaghan, Finbar J. K., Greeley, Christopher S., Lux, Andrew L., Walker, Stephen G., O'Callaghan, Finbar J. K., and Greeley, Christopher S.

Abstract

Karen Barlow and Robert Minns1 report a one in 4065 chance of a child in Scotland having NAHI by age 1 year. They give the annual incidence of shaken impact syndrome as being 24·6 per 100 000. Even though the study sample size and data structure were not described in detail, these risks are clearly the same. Their analysis treats NAHI and shaken impact syndrome as identical, even though part of their report defines shaken impact syndrome as a subgroup of NAHIs. Intuitively, the syndrome that includes an acute encephalopathy with subdural haemorrhages, cerebral oedema, retinal haemorrhages, and fractures, occurring in the context of an inappropriate or inconsistent history, commonly with evidence of other impact or malicious injuries, is an extreme form of non-accidental head injury. We think that the risk estimates should be different. The effects of variation in the data are not described adequately by the cited binomial CI. In their earlier, retrospective study of children younger than 5 years, Barlow and Minns showed appreciable variation beyond that which would be explained by a binomial model.2 For example, in 1990 they identified four cases of NAHI and, in 1994, 26 cases. With such variation, and even with fuller reporting, it is difficult to justify basing an annual incidence on a study of 18 months' duration. We are not convinced that the new term shaken impact syndrome is required. Caffey3 used the term whiplash shaken baby syndrome, and Duhaime and colleagues4 the simpler term shaken baby syndrome. We think that the best term would be one that makes few or no assumptions about mechanisms of injury, which are contentious. Barlow and Minns did not assess how many children had injuries with these clinical features that were classified as accidental. This information is essential to study regional variations in incidence and to decide whether these arise because of differences in diagnostic classification. Changes in classification might be affected by time tr

Published
2001

35. Shaken impact syndrome

Author

Lux, Andrew L, primary, Walker, Stephen G, additional, O'Callaghan, Finbar JK, additional, and Greeley, Christopher S, additional

Published
2001
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36. The effect of lead time to treatment and of age of onset on developmental outcome at 4 years in infantile spasms: Evidence from the United Kingdom Infantile Spasms Study.

Author

O'Callaghan, Finbar J. K., Lux, Andrew L., Darke, Katrina, Edwards, Stuart W., Hancock, Eleanor, Johnson, Anthony L., Kennedy, Colin R., Newton, Richard W., Verity, Christopher M., and Osborne, John P.

Subjects
*INFANTILE spasms, *TREATMENT of encephalomyelitis, *INFANT disease treatment, *SEIZURES (Medicine), *SPASM treatment
Abstract

Summary [ABSTRACT FROM AUTHOR]

Published
2011
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37. Responses of local research ethics committees to a study with approval from a multicentre research ethics committee.

Author

Alberti, K G M M and Lux, Andrew L

Subjects
*ETHICS committees, *RESEARCH ethics
Abstract

Provides information on a study which assessed the impact of the guidelines on the practice of local research ethics committees in Great Britain. How submissions are classified as approved; Response times, numbers of copies of documents required and decisions of local research ethics committees for submission made between September 1998 and September 1999; Comment about the system of ethical approval of multicenter research.

Published
2000

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