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42 results on '"Luukkainen, Päivi"'

4. Length of Nutritional Transition Associates Negatively with Postnatal Growth in Very Low Birthweight Infants

Author

Immeli, Lotta, Sankilampi, Ulla, Mäkelä, Pauliina M., Leskinen, Markus, Sund, Reijo, Andersson, Sture, Luukkainen, Päivi, Clinicum, Helsinki University Hospital Area, HUS Children and Adolescents, and Children's Hospital

Subjects
Male, Parenteral Nutrition, Time Factors, growth, Nutritional Status, transition phase, Article, Eating, Enteral Nutrition, 3123 Gynaecology and paediatrics, Intensive Care Units, Neonatal, Humans, Infant, Very Low Birth Weight, TX341-641, preterm infants, Infant Nutritional Physiological Phenomena, Finland, Retrospective Studies, Nutrition. Foods and food supply, Malnutrition, Infant, Newborn, Infant, very low birthweight infant, nutrition, Female, 3143 Nutrition, Energy Intake, Infant, Premature
Abstract

Very low birthweight (VLBW, &lt, 1500 g) infants may be predisposed to undernutrition during the nutritional transition phase from parenteral to enteral nutrition. We studied the associations among the length of the transition phase, postnatal macronutrient intake, and growth from birth to term equivalent age in VLBW infants. This retrospective cohort study included 248 VLBW infants born before 32 weeks of gestation and admitted to the Children’s Hospital, Helsinki, Finland during 2005–2013. Daily nutrient intakes were obtained from computerized medication administration records. The length of the transition phase correlated negatively with cumulative energy, protein, fat, and carbohydrate intake at 28 days of age. It also associated negatively with weight and head circumference growth from birth to term equivalent age. For infants with a long transition phase (over 12 d), the estimates (95% CI) for weight and head circumference z-score change from birth to term equivalent age were −0.3 (−0.56, −0.04) and −0.44 (−0.81, −0.07), respectively, in comparison to those with a short transition phase (ad 7 d). For VLBW infants, rapid transition to full enteral feeding might be beneficial. However, if enteral nutrition cannot be advanced, well-planned parenteral nutrition during the transition phase is necessary to promote adequate growth.

Published
2021

6. Food consumption and risk of childhood asthma

Author

Lumia, Mirka, Takkinen, Hanna-Mari, Luukkainen, Päivi, Kaila, Minna, Lehtinen-Jacks, Susanna, Nwaru, Bright I., Tuokkola, Jetta, Niemelä, Onni, Haapala, Anna-Maija, Ilonen, Jorma, Simell, Olli, Knip, Mikael, Veijola, Riitta, and Virtanen, Suvi M.

Published
2015
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7. Blood pressure changes during the first 24 hours of life and the association with the persistence of a patent ductus arteriosus and occurrence of intraventricular haemorrhage

Author

Boldt, Robert, Mäkelä, Pauliina M., Immeli, Lotta, Sund, Reijo, Leskinen, Markus, Luukkainen, Päivi, Andersson, Sture, HUS Children and Adolescents, Children's Hospital, Clinicum, and Lastentautien yksikkö

Subjects
BIRTH-WEIGHT INFANTS, Male, FLOW, Science, Blood Pressure, Gestational Age, Hemorrhage, Surgical and Invasive Medical Procedures, Research and Analysis Methods, THERAPY, Vascular Medicine, Families, Pediatric Surgery, Signs and Symptoms, Mathematical and Statistical Techniques, Drug Therapy, 3123 Gynaecology and paediatrics, PRETERM INFANTS, HYPOTENSION, Sepsis, Medicine and Health Sciences, Humans, Infant, Very Low Birth Weight, Cluster Analysis, Ductus Arteriosus, Patent, Children, Retrospective Studies, Pharmaceutics, Infant, Newborn, C-REACTIVE PROTEIN, INDOMETHACIN, Age Groups, People and Places, RISK-FACTORS, UPDATE, Medicine, Female, Population Groupings, K Means Clustering, Clinical Medicine, Infants, Research Article
Abstract

Very low birthweight (VLBW) infants are at risk of intraventricular haemorrhage (IVH) and delayed closure of ductus arteriosus. We investigated mean arterially recorded blood pressure (MAP) changes during the first day of life in VLBW infants as potential risk factors for a patent ductus arteriosus (PDA) and IVH. This retrospective cohort study exploring MAP changes during adaption and risk factors for a PDA and IVH comprised 844 VLBW infants admitted to the Helsinki University Children's Hospital during 2005-2013. For each infant, we investigated 600 time-points of MAP recorded 4-24 hours after birth. Based on blood pressure patterns revealed by a data-driven method, we divided the infants into two groups. Group 1 (n = 327, mean birthweight = 1019 g, mean gestational age = 28 + (1/7) weeks) consisted of infants whose mean MAP was lower at 18-24 hours than at 4-10 hours after birth. Group 2 (n = 517, mean birthweight = 1070 g, mean gestational age = 28 + (5/7) weeks) included infants with a higher mean MAP at 18-24 hours than at 4-10 hours after birth. We used the group assignments, MAP, gestational age at birth, relative size for gestational age, surfactant administration, inotrope usage, invasive ventilation, presence of respiratory distress syndrome or sepsis, fluid intake, and administration of antenatal steroids to predict the occurrence of IVH and use of pharmacological or surgical therapy for a PDA before 42 weeks of gestational age. Infants whose mean MAP is lower at 18-24 hours than at 4-10 hours after birth are more likely to undergo surgical ligation of a PDA (odds ratio = 2.1; CI 1.14-3.89; p = 0.018) and to suffer from IVH (odds ratio = 1.83; CI 1.23-2.72; p = 0.003).

Published
2021

8. Turvallisen lääkehoidon erityispiirteitä lapsilla

Author

Kuitunen, Sini, Luukkainen, Päivi, HUS Apteekki, and HUS Lasten ja nuorten sairaudet

Subjects
Drug-Related Side Effects and Adverse Reactions, Medication Therapy Management, 317 Farmasia, Documentation, Drug Prescriptions, Medical Records, 3123 Naisten- ja lastentaudit, Drug Therapy, Pharmaceutical Preparations, Risk Factors, Polypharmacy, Medication Errors, Patient Safety, +prevention & control, Drug Monitoring, Child, +administration & dosage
Abstract

Teema : turvallinen lääkehoito. Vertaisarvioitu. Lapsiin liittyy potilasryhmänä useita lääkityspoikkeamille altistavia erityispiirteitä. Sekä sairaalassa että perusterveydenhuollossa joudutaan usein käyttämään lääkkeitä, joilta puuttuu myyntilupa tai käyttöaihe lapsille, kyseiselle ikäryhmälle tai hoidettavaan tilaan. Tutkimustietoa erityisesti monilääkityksen haitta- ja interaktioriskeistä, tehosta sekä pitkäaikaisvaikutuksista lapsen kasvuun ja kehitykseen on saatavilla vähän. Lääkeannos määräytyy yksilöllisesti potilaan koon ja iän mukaan, mikä monimutkaistaa lääkehoitoprosessia ja lisää inhimillisten erehdysten riskiä. Lapsilla lääkityspoikkeamat liittyvät usein väärään annokseen, joka voi pilkkuvirheen seurauksena olla jopa kymmenkertainen. Lääkityspoikkeamien seuraukset voivat olla vakavia erityisesti silloin, kun kyseessä on suuren riskin lääke. Lasten lääkitysturvallisuutta voidaan parantaa yhtenäistämällä lääkkeiden käyttöä ja ottamalla käyttöön lääkityspoikkeamia ehkäiseviä suojauksia prosessin tunnistettuihin riskikohtiin.

Published
2021

16. Maahanmuuttajalapset terveydenhuollossa - monta taustaa, yhteinen terveys

Author

Madanat-Harjuoja, Laura, Salmi, Heli, Luukkainen, Päivi, Kaila, Minna, Lastenklinikka, Clinicum, HUS Lasten ja nuorten sairaudet, Kansanterveystieteen osasto, Helsingin yliopisto, and HUS Psykiatria

Subjects
3123 Naisten- ja lastentaudit, 3142 Kansanterveystiede, ympäristö ja työterveys
Published
2017

17. Hidden sources like saline flushes make a significant contribution to the fluid intake of very low birthweight infants during the first postnatal week.

Author

Mäkelä, Pauliina M., Immeli, Lotta, Leskinen, Markus, Rinta‐Koski, Olli‐Pekka, Sund, Reijo, Andersson, Sture, Luukkainen, Päivi, and Rinta-Koski, Olli-Pekka

Subjects
INFANTS, CHILDREN'S hospitals, INTENSIVE care units, NEONATAL intensive care, DRUG administration, RESEARCH, RESEARCH methodology, VERY low birth weight, RETROSPECTIVE studies, NEONATAL intensive care units, MEDICAL cooperation, EVALUATION research, COMPARATIVE studies, RESEARCH funding
Abstract

Aim: We examined actual fluid intake, and routes of administration, in very low birthweight (VLBW) infants during the first week of life in a neonatal intensive care unit.Methods: This retrospective cohort study comprised 953 infants born at <32 weeks and 1500 g and treated at Helsinki University Children's Hospital from 2005 to 2013. All parenterally and enterally administered fluids, and their sources, were obtained from our patient information system. Infants were divided into three groups according to their gestational age: 23-26, 27-29 and 30-31 weeks.Results: Fluid intake exceeded European guidelines during the first 3 days. On days 1-7, total fluid intake was highest in the most premature group (P < .001) and the median total fluid intake in this group peaked at 177 mL/kg/d (IQR 154-209) on day three. Intravascular flushes provided a considerable source of fluids, with the median intake in the most preterm group peaking at 26.4 mL/kg/d, which represented 15.6% of total fluid intake.Conclusion: During the first 3 days of life, our VLBW infants had a higher total fluid intake than the European guidelines. A considerable percentage came from hidden sources, such as saline flushes, which should be taken into account when prescribing fluids. [ABSTRACT FROM AUTHOR]

Published
2020
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19. Improved postnatal growth of extremely low-birthweight boys over the last two decades.

Author

Immeli, Lotta, Andersson, Sture, Leskinen, Markus, Vuorinen, Emmi, Rinta‐Koski, Olli‐Pekka, Luukkainen, Päivi, Rinta-Koski, Olli-Pekka, and Luukkainen, Päivi

Subjects
POSTNATAL care, BIRTH weight, ADRENOCORTICAL hormones, STEROID hormones, PARENTERAL feeding, BIRTH size, LOW birth weight, PREMATURE infants, LONGITUDINAL method, SEX distribution, SURVIVAL
Abstract

The survival rate of extremely low birth weight (ELBW) infants has risen over the last two decades. However, the incidence of neurodevelopmental problems in these children remains high (1,2). Postnatal growth restriction is common among ELBW infants and it has been associated with poor long-term outcomes (3). It is widely recognised that an optimal nutrient supply is essential (4) to simulate postnatal intrauterine growth and, therefore, nutritional recommendations for preterm infants have changed substantially over the last 15 years (5,6). This article is protected by copyright. All rights reserved. [ABSTRACT FROM AUTHOR]

Published
2017
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21. Maternal dietary folate, folic acid and vitamin D intakes during pregnancy and lactation and the risk of cows’ milk allergy in the offspring

Author

Tuokkola, Jetta, primary, Luukkainen, Päivi, additional, Kaila, Minna, additional, Takkinen, Hanna-Mari, additional, Niinistö, Sari, additional, Veijola, Riitta, additional, Virta, Lauri J., additional, Knip, Mikael, additional, Simell, Olli, additional, Ilonen, Jorma, additional, and Virtanen, Suvi M., additional

Published
2016
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23. Validation of the Finnish ISAAC questionnaire on asthma against anti-asthmatic medication reimbursement database in 5-year-old children

Author

Nwaru, Bright Ibeabughichi, primary, Lumia, Mirka, additional, Kaila, Minna, additional, Luukkainen, Päivi, additional, Tapanainen, Heli, additional, Erkkola, Maijaliisa, additional, Ahonen, Suvi, additional, Pekkanen, Juha, additional, Klaukka, Timo, additional, Veijola, Riitta, additional, Simell, Olli, additional, Knip, Mikael, additional, and Virtanen, Suvi Mirjami, additional

Published
2010
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37. Clustering of Serratia marcescensInfections in a Neonatal Intensive Care Unit

Author

Sarvikivi, Emmi, Lyytikäinen, Outi, Salmenlinna, Saara, Vuopio-Varkila, Jaana, Luukkainen, Päivi, Tarkka, Eveliina, and Saxén, Harri

Abstract

AbstractObjectives:To study clusters of infections caused by Serratia marcescensin a neonatal intensive care unit (NICU) and to determine risk factors for S. marcescensinfection or colonization.Design:Genotyping of S. marcescensisolates was performed by pulsed-field gel electrophoresis (PFGE). A retrospective case-control study was conducted.Setting:A tertiary-care pediatric hospital with a 16-bed NICU.Patients:All neonates with at least one culture positive for S. marcescensin the NICU during December 1999 to July 2002. Case-patients (n = 11) treated in the NICU during December 1999 to February 2000 were included in the case-control study. Neonates treated in the NICU for at least 72 hours during the same period with cultures negative for S. marcescenswere used as control-patients (n = 27).Results:S. marcescenswas cultured from 19 neonates; 9 were infected and 10 were colonized. PFGE analysis identified three epidemic strains; each cluster consisted of identical isolates, except one isolate in the first cluster that was different. The risk factors identified were low birth weight, prematurity, prolonged respiratory therapy, prolonged use of antibiotics, and maternal infection prior to delivery. Overcrowding and understaffing were recorded simultaneously with the clusters.Conclusions:PFGE analysis showed three independent clusters. Several factors contributed to spread of the epidemic strains: (1) there were many severely premature and susceptible neonates, (2) the NICU was overcrowded during the clusters, and (3) transmission was likely to occur via the hands of staff. Cohorting and improvement of routine infection control measures led to the cessation of each cluster.

Published
2004
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41. The effect of elimination diet on the growth of a child with milk allergy - a systematic review.

Author

Piekkala A, Kaila M, Virtanen S, and Luukkainen P

Subjects
Animals, Body Weight, Cattle, Humans, Infant, Infant, Newborn, Child Development, Growth Disorders physiopathology, Milk Hypersensitivity physiopathology
Abstract

Background: Cow's milk is the most common food allergen in children under 3 years of age. Milk allergy is treated by eliminating milk from the diet., Methods: The present study was conducted according to international guidelines for systematic reviews., Results: In all three articles included in the current study, children with milk allergy were of lower weight than the controls. Furthermore, in one of the studies included, growth of the children with mild allergy was stunted., Discussion: The current review shows that milk allergy is associated with stunted growth in childhood. The reasons for this growth retardation are unclear.

Published
2016

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