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2. A critical appraisal of the four systematic reviews and meta-analysis on stereotactic body radiation therapy versus external beam radiotherapy for painful bone metastases and where we go from here

Author

Wong, Henry C. Y., primary, Chan, Adrian Wai, additional, Johnstone, Peter, additional, Simone II, Charles B., additional, Navarro-Domenech, Inmaculada, additional, Hoskin, Peter, additional, Johnstone, Candice, additional, Recht, Abram, additional, Menten, Johan, additional, van der Linden, Yvette M., additional, van der Velden, Joanne M., additional, Nguyen, Quynh-Nhu, additional, Lutz, Stephen, additional, Andratschke, Nicolaus, additional, Wilmann, Jonas, additional, Kazmierska, Joanna, additional, Spalek, Mateusz, additional, Lim, Fiona, additional, Yu, H. Michael, additional, Perez, Brad, additional, Marta, Gustavo Nader, additional, Vassiliou, Vassilios, additional, Lee, Shing Fung, additional, Bonomo, Pierluigi, additional, Rembielak, Agata, additional, Chow, Edward, additional, Oldenburger, Eva, additional, and Raman, Srinivas, additional

Published
2023
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4. ACR Appropriateness Criteria® on Metastatic Bone Disease

Author

Roberts, Catherine C, Daffner, Richard H, Weissman, Barbara N, Bancroft, Laura, Bennett, D Lee, Blebea, Judy S, Bruno, Michael A, Fries, Ian Blair, Germano, Isabelle M, Holly, Langston, Jacobson, Jon A, Luchs, Jonathan S, Morrison, William B, Olson, Jeffrey J, Payne, William K, Resnik, Charles S, Schweitzer, Mark E, Seeger, Leanne L, Taljanovic, Mihra, Wise, James N, and Lutz, Stephen T

Subjects
Cancer, Breast Cancer, Clinical Research, Rare Diseases, Biomedical Imaging, 4.2 Evaluation of markers and technologies, Detection, screening and diagnosis, Musculoskeletal, Bone Neoplasms, Breast Neoplasms, Diagnostic Imaging, Evidence-Based Medicine, Female, Humans, Male, Neoplasm Staging, Practice Guidelines as Topic, Pregnancy, Pregnancy Complications, Neoplastic, Prostatic Neoplasms, United States, Appropriateness Criteria, metastatic disease, bone, imaging, screening, surveillance, staging, Clinical Sciences, Public Health and Health Services, Nuclear Medicine & Medical Imaging
Abstract

Appropriate imaging modalities for screening, staging, and surveillance of patients with suspected and documented metastatic disease to bone include (99m)Tc bone scanning, MRI, CT, radiography, and 2-[(18)F]fluoro-2-deoxyglucose-PET. Clinical scenarios reviewed include asymptomatic stage 1 breast carcinoma, symptomatic stage 2 breast carcinoma, abnormal bone scan results with breast carcinoma, pathologic fracture with known metastatic breast carcinoma, asymptomatic well-differentiated and poorly differentiated prostate carcinoma, vertebral fracture with history of malignancy, non-small-cell lung carcinoma staging, symptomatic multiple myeloma, osteosarcoma staging and surveillance, and suspected bone metastasis in a pregnant patient. No single imaging modality is consistently best for the assessment of metastatic bone disease across all tumor types and clinical situations. In some cases, no imaging is indicated. The recommendations contained herein are the result of evidence-based consensus by the ACR Appropriateness Criteria((R)) Expert Panel on Musculoskeletal Radiology.

Published
2010

9. Addressing concerns and uncertainties surrounding the application of palliative radiotherapy in cases with a 30-day expected mortality

Author

MS Radiotherapie, Navarro-Domenech, Inmaculada, Behroozian, Tara, Hoskin, Peter, Johnstone, Candice, Recht, Abram, Menten, Johan, Oldenburger, Eva, van der Linden, Yvette M, van der Velden, Joanne M, Nguyen, Quynh-Nhu, Simone, Charles B, Johnstone, Peter, Lutz, Stephen, Milton, Lauren, Andratschke, Nicolaus, Willmann, Jonas, Kazmierska, Joanna, Spałek, Mateusz, Marta, Gustavo N, Chow, Edward, Raman, Srinivas, MS Radiotherapie, Navarro-Domenech, Inmaculada, Behroozian, Tara, Hoskin, Peter, Johnstone, Candice, Recht, Abram, Menten, Johan, Oldenburger, Eva, van der Linden, Yvette M, van der Velden, Joanne M, Nguyen, Quynh-Nhu, Simone, Charles B, Johnstone, Peter, Lutz, Stephen, Milton, Lauren, Andratschke, Nicolaus, Willmann, Jonas, Kazmierska, Joanna, Spałek, Mateusz, Marta, Gustavo N, Chow, Edward, and Raman, Srinivas

Published
2023

10. A critical appraisal of the four systematic reviews and meta-analysis on stereotactic body radiation therapy versus external beam radiotherapy for painful bone metastases and where we go from here

Author

MS Radiotherapie, Wong, Henry C Y, Chan, Adrian Wai, Johnstone, Peter, Simone, Charles B, Navarro-Domenech, Inmaculada, Hoskin, Peter, Johnstone, Candice, Recht, Abram, Menten, Johan, van der Linden, Yvette M, van der Velden, Joanne M, Nguyen, Quynh-Nhu, Lutz, Stephen, Andratschke, Nicolaus, Wilmann, Jonas, Kazmierska, Joanna, Spalek, Mateusz, Lim, Fiona, Yu, H Michael, Perez, Brad, Marta, Gustavo Nader, Vassiliou, Vassilios, Lee, Shing Fung, Bonomo, Pierluigi, Rembielak, Agata, Chow, Edward, Oldenburger, Eva, Raman, Srinivas, MS Radiotherapie, Wong, Henry C Y, Chan, Adrian Wai, Johnstone, Peter, Simone, Charles B, Navarro-Domenech, Inmaculada, Hoskin, Peter, Johnstone, Candice, Recht, Abram, Menten, Johan, van der Linden, Yvette M, van der Velden, Joanne M, Nguyen, Quynh-Nhu, Lutz, Stephen, Andratschke, Nicolaus, Wilmann, Jonas, Kazmierska, Joanna, Spalek, Mateusz, Lim, Fiona, Yu, H Michael, Perez, Brad, Marta, Gustavo Nader, Vassiliou, Vassilios, Lee, Shing Fung, Bonomo, Pierluigi, Rembielak, Agata, Chow, Edward, Oldenburger, Eva, and Raman, Srinivas

Published
2023

11. Appropriateness of the 30-day expected mortality metric in palliative radiation treatment: a narrative review

Author

Arts-assistenten Radiotherapie, Navarro-Domenech, Inmaculada, Behroozian, Tara, Hoskin, Peter, Johnstone, Candice, Recht, Abram, Menten, Johan, Oldenburger, Eva, van der Linden, Yvette M., van der Velden, Joanne M., Nguyen, Quynh Nhu, Simone, Charles B., Johnstone, Peter, Lutz, Stephen, Milton, Lauren, Andratschke, Nicolaus, Willmann, Jonas, Kazmierska, Joanna, Spałek, Mateusz, Marta, Gustavo N., Chow, Edward, Raman, Srinivas, Arts-assistenten Radiotherapie, Navarro-Domenech, Inmaculada, Behroozian, Tara, Hoskin, Peter, Johnstone, Candice, Recht, Abram, Menten, Johan, Oldenburger, Eva, van der Linden, Yvette M., van der Velden, Joanne M., Nguyen, Quynh Nhu, Simone, Charles B., Johnstone, Peter, Lutz, Stephen, Milton, Lauren, Andratschke, Nicolaus, Willmann, Jonas, Kazmierska, Joanna, Spałek, Mateusz, Marta, Gustavo N., Chow, Edward, and Raman, Srinivas

Published
2023

12. Addressing concerns and uncertainties surrounding the application of palliative radiotherapy in cases with a 30-day expected mortality

Author

Navarro-Domenech, Inmaculada, Behroozian, Tara, Hoskin, Peter, Johnstone, Candice, Recht, Abram, Menten, Johan, Oldenburger, Eva, van der Linden, Yvette M, van der Velden, Joanne M, Nguyen, Quynh-Nhu, Simone, Charles B, Johnstone, Peter, Lutz, Stephen, Milton, Lauren, Andratschke, Nicolaus; https://orcid.org/0000-0003-3647-5916, Willmann, Jonas, Kazmierska, Joanna, Spałek, Mateusz, Marta, Gustavo N, Chow, Edward, Raman, Srinivas, Navarro-Domenech, Inmaculada, Behroozian, Tara, Hoskin, Peter, Johnstone, Candice, Recht, Abram, Menten, Johan, Oldenburger, Eva, van der Linden, Yvette M, van der Velden, Joanne M, Nguyen, Quynh-Nhu, Simone, Charles B, Johnstone, Peter, Lutz, Stephen, Milton, Lauren, Andratschke, Nicolaus; https://orcid.org/0000-0003-3647-5916, Willmann, Jonas, Kazmierska, Joanna, Spałek, Mateusz, Marta, Gustavo N, Chow, Edward, and Raman, Srinivas

Published
2023

13. Appropriateness of the 30-day expected mortality metric in palliative radiation treatment: a narrative review

Author

Navarro-Domenech, Inmaculada, Behroozian, Tara, Hoskin, Peter, Johnstone, Candice, Recht, Abram, Menten, Johan, Oldenburger, Eva, van der Linden, Yvette M, van der Velden, Joanne M, Nguyen, Quynh-Nhu, Simone, Charles B, Johnstone, Peter, Lutz, Stephen, Milton, Lauren, Andratschke, Nicolaus; https://orcid.org/0000-0003-3647-5916, Willmann, Jonas; https://orcid.org/0000-0002-2531-3551, Kazmierska, Joanna, Spałek, Mateusz, Marta, Gustavo N, Chow, Edward, Raman, Srinivas, Navarro-Domenech, Inmaculada, Behroozian, Tara, Hoskin, Peter, Johnstone, Candice, Recht, Abram, Menten, Johan, Oldenburger, Eva, van der Linden, Yvette M, van der Velden, Joanne M, Nguyen, Quynh-Nhu, Simone, Charles B, Johnstone, Peter, Lutz, Stephen, Milton, Lauren, Andratschke, Nicolaus; https://orcid.org/0000-0003-3647-5916, Willmann, Jonas; https://orcid.org/0000-0002-2531-3551, Kazmierska, Joanna, Spałek, Mateusz, Marta, Gustavo N, Chow, Edward, and Raman, Srinivas

Abstract

BACKGROUND AND OBJECTIVE The 30-day expected mortality rate is frequently used as a metric to determine which patients benefit from palliative radiation treatment (RT). We conducted a narrative review to examine whether its use as a metric might be appropriate for patient selection. METHODS A literature review was conducted to identify relevant studies that highlight the benefits of palliative RT in timely symptom management among patients with a poor performance status, the accuracy of predicting survival near the end of life and ways to speed up the process of RT administration through rapid response clinics. KEY CONTENT AND FINDINGS Several trials have demonstrated substantial response rates for pain and/or bleeding by four weeks and sometimes within the first two weeks after RT. Models of patient survival have limited accuracy, particularly for predicting whether patients will die within the next 30 days. Dedicated Rapid Access Palliative RT (RAPRT) clinics, in which patients are assessed, simulated and treated on the same day, reduce the number of patient visits to the radiation oncology department and hence the burden on the patient as well as costs. CONCLUSIONS Single-fraction palliative RT should be offered to eligible patients if they are able to attend treatment and could potentially benefit from symptom palliation, irrespective of predicted life expectancy. We discourage the routine use of the 30-day mortality as the only metric to decide whether to offer RT. More common implementation of RAPRT clinics could result in a significant benefit for patients of all life expectancies, but particularly those having short ones.

Published
2023

14. A critical appraisal of the four systematic reviews and meta- analysis on stereotactic body radiation therapy versus external beam radiotherapy for painful bone metastases and where we go from here

Author

Wong, Henry C Y, Chan, Adrian Wai, Johnstone, Peter, Simone, Charles B, Navarro-Domenech, Inmaculada, Hoskin, Peter, Johnstone, Candice, Recht, Abram, Menten, Johan, van der Linden, Yvette M, van der Velden, Joanne M, Nguyen, Quynh-Nhu, Lutz, Stephen, Andratschke, Nicolaus; https://orcid.org/0000-0003-3647-5916, Wilmann, Jonas, Kazmierska, Joanna, Spalek, Mateusz, Lim, Fiona, Yu, H Michael, Perez, Brad, Marta, Gustavo Nader, Vassiliou, Vassilios, Lee, Shing Fung, Bonomo, Pierluigi, Rembielak, Agata, Chow, Edward, Oldenburger, Eva, Raman, Srinivas, Wong, Henry C Y, Chan, Adrian Wai, Johnstone, Peter, Simone, Charles B, Navarro-Domenech, Inmaculada, Hoskin, Peter, Johnstone, Candice, Recht, Abram, Menten, Johan, van der Linden, Yvette M, van der Velden, Joanne M, Nguyen, Quynh-Nhu, Lutz, Stephen, Andratschke, Nicolaus; https://orcid.org/0000-0003-3647-5916, Wilmann, Jonas, Kazmierska, Joanna, Spalek, Mateusz, Lim, Fiona, Yu, H Michael, Perez, Brad, Marta, Gustavo Nader, Vassiliou, Vassilios, Lee, Shing Fung, Bonomo, Pierluigi, Rembielak, Agata, Chow, Edward, Oldenburger, Eva, and Raman, Srinivas

Abstract

Radiotherapy is an important treatment modality for pain control in patients with bone metastases. Stereotactic body radiation therapy (SBRT), which allows delivering a much higher dose per fraction while sparing critical structures compared to conventional external beam radiotherapy (cEBRT), has become more widely used, especially in the oligometastatic setting. Randomized controlled trials (RCTs) comparing the pain response rate of SBRT and cEBRT for bone metastases have shown conflicting results, as have four recent systematic reviews with meta-analyses of these trials. Possible reasons for the different outcomes between these reviews include differences in methodology, which trials were included, and the endpoints examined and how they were defined. We suggest ways to improve analysis of these RCTs, particularly performing an individual patient-level meta-analysis since the trials included heterogeneous populations. The results of such studies will help guide future investigations needed to validate patient selection criteria, optimize SBRT dose schedules, include additional endpoints (such as the time to onset of pain response, durability of pain response, quality of life (QOL), and side effects of SBRT), and better assess the cost-effectiveness and trade-offs of SBRT compared to cEBRT. An international Delphi consensus to guide selection of optimal candidates for SBRT is warranted before more prospective data is available.

Published
2023

17. Appropriateness of the 30-day expected mortality metric in palliative radiation treatment: a narrative review

Author

Navarro-Domenech, Inmaculada, primary, Behroozian, Tara, additional, Hoskin, Peter, additional, Johnstone, Candice, additional, Recht, Abram, additional, Menten, Johan, additional, Oldenburger, Eva, additional, van der Linden, Yvette M., additional, van der Velden, Joanne M., additional, Nguyen, Quynh-Nhu, additional, Simone II, Charles B., additional, Johnstone, Peter, additional, Lutz, Stephen, additional, Milton, Lauren, additional, Andratschke, Nicolaus, additional, Willmann, Jonas, additional, Kazmierska, Joanna, additional, Spałek, Mateusz, additional, Marta, Gustavo N., additional, Chow, Edward, additional, and Raman, Srinivas, additional

Published
2023
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18. Addressing concerns and uncertainties surrounding the application of palliative radiotherapy in cases with a 30-day expected mortality

Author

Navarro-Domenech, Inmaculada, primary, Behroozian, Tara, additional, Hoskin, Peter, additional, Johnstone, Candice, additional, Recht, Abram, additional, Menten, Johan, additional, Oldenburger, Eva, additional, van der Linden, Yvette M., additional, van der Velden, Joanne M., additional, Nguyen, Quynh-Nhu, additional, Simone II, Charles B., additional, Johnstone, Peter, additional, Lutz, Stephen, additional, Milton, Lauren, additional, Andratschke, Nicolaus, additional, Willmann, Jonas, additional, Kazmierska, Joanna, additional, Spałek, Mateusz, additional, Marta, Gustavo N., additional, Chow, Edward, additional, and Raman, Srinivas, additional

Published
2023
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19. Definitive radiation therapy in locally advanced non-small cell lung cancer: Executive summary of an American Society for Radiation Oncology (ASTRO) evidence-based clinical practice guideline

Author

Rodrigues, George, Choy, Hak, Bradley, Jeffrey, Rosenzweig, Kenneth E., Bogart, Jeffrey, Curran, Walter J., Jr., Gore, Elizabeth, Langer, Corey, Louie, Alexander V., Lutz, Stephen, Machtay, Mitchell, Puri, Varun, Werner-Wasik, Maria, and Videtic, Gregory M.M.

Published
2015
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20. Adjuvant radiation therapy in locally advanced non-small cell lung cancer: Executive summary of an American Society for Radiation Oncology (ASTRO) evidence-based clinical practice guideline

Author

Rodrigues, George, Choy, Hak, Bradley, Jeffrey, Rosenzweig, Kenneth E., Bogart, Jeffrey, Curran, Walter J., Jr., Gore, Elizabeth, Langer, Corey, Louie, Alexander V., Lutz, Stephen, Machtay, Mitchell, Puri, Varun, Werner-Wasik, Maria, and Videtic, Gregory M.M.

Published
2015
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25. Update on the systematic review/meta-analysis of uncomplicated bone metastases treated with external beam radiation

Author

Behroozian, Tara, primary, Navarro, Inmaculada, additional, Hoskin, Peter, additional, Johnstone, Candice, additional, Recht, Abram, additional, Menten, Johan, additional, Oldenburger, Eva, additional, van der Linden, Yvette, additional, van der Velden, Joanne M., additional, Nguyen, Quynh-Nhu, additional, Simone, Charles B., additional, Johnstone, Peter, additional, Lutz, Stephen, additional, Milton, Lauren, additional, Andratschke, Nicolaus, additional, Willmann, Jonas, additional, Kazmierska, Joanna, additional, Spałek, Mateusz, additional, Chow, Edward, additional, and Raman, Srinivas, additional

Published
2022
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29. List of Contributors

Author

Anscher, Mitchell S., primary, Chiu, Nicholas, additional, Chow, Edward, additional, DeAngelis, Carlo, additional, Dharmarajan, Kavita, additional, Fields, Emma C., additional, Frakes, Jessica M., additional, Hertan, Lauren, additional, Hoffe, Sarah E., additional, Jimenez, Rachel B., additional, Johnstone, Candice C., additional, Johnstone, C.A., additional, Jones, Joshua, additional, Koranteng, Lauren, additional, Krishnan, Monica S., additional, Leard, Lorriana E., additional, Lutz, Stephen, additional, Maranzano, Ernest, additional, Moryl, Natalie, additional, Pulenzas, Natalie, additional, Racsa, Margarita, additional, Rades, Dirk, additional, Rhome, Ryan, additional, Schoenfeld, Jonathan D., additional, Shih, Helen A., additional, Taylor, Allison, additional, Urdaneta, Alfredo I., additional, Venkat, Puja, additional, Wei, Randy L., additional, Wilhite, Tyler J., additional, Yu, Hsiang-Hsuan Michael, additional, and Zhang, Na, additional

Published
2017
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31. Transiting Exoplanet Survey Satellite (TESS) Flight Dynamics Commissioning Results and Experiences

Author

Parker, Joel J. K, Lebois, Ryan L, Lutz, Stephen, Nickel, Craig, Ferrant, Kevin, and Michaels, Adam

Subjects
Astronautics (General)
Abstract

The Transiting Exoplanet Survey Satellite (TESS) will perform the first-ever spaceborne all-sky exoplanet transit survey and is the first primary-mission application of a lunar-resonant orbit. Launched on April 18, 2018, TESS completed a two-month commissioning phase consisting of three phasing loops followed by a lunar flyby and a final maneuver to achieve resonance. During the mission orbit, no further station-keeping maneuvers are planned or required. NASA Goddard Space Flight Center is performing flight dynamics operations for the mission. This paper covers the design, implementation, and results from TESS commissioning, including the projected performance of the final mission orbit.

Published
2018

33. Update on the systematic review/meta-analysis of uncomplicated bone metastases treated with external beam radiation

Author

Arts-assistenten Radiotherapie, Behroozian, Tara, Navarro, Inmaculada, Hoskin, Peter, Johnstone, Candice, Recht, Abram, Menten, Johan, Oldenburger, Eva, van der Linden, Yvette, van der Velden, Joanne M., Nguyen, Quynh Nhu, Simone, Charles B., Johnstone, Peter, Lutz, Stephen, Milton, Lauren, Andratschke, Nicolaus, Willmann, Jonas, Kazmierska, Joanna, Spałek, Mateusz, Chow, Edward, Raman, Srinivas, Arts-assistenten Radiotherapie, Behroozian, Tara, Navarro, Inmaculada, Hoskin, Peter, Johnstone, Candice, Recht, Abram, Menten, Johan, Oldenburger, Eva, van der Linden, Yvette, van der Velden, Joanne M., Nguyen, Quynh Nhu, Simone, Charles B., Johnstone, Peter, Lutz, Stephen, Milton, Lauren, Andratschke, Nicolaus, Willmann, Jonas, Kazmierska, Joanna, Spałek, Mateusz, Chow, Edward, and Raman, Srinivas

Published
2022

39. Monte Carlo Analysis as a Trajectory Design Driver for the Transiting Exoplanet Survey Satellite (TESS) Mission

Author

Nickel, Craig, Parker, Joel, Dichmann, Don, Lebois, Ryan, and Lutz, Stephen

Subjects
Lunar And Planetary Science And Exploration, Astrodynamics
Abstract

The Transiting Exoplanet Survey Satellite (TESS) will be injected into a highly eccentric Earth orbit and fly 3.5 phasing loops followed by a lunar flyby to enter a mission orbit with lunar 2:1 resonance. Through the phasing loops and mission orbit, the trajectory is significantly affected by lunar and solar gravity. We have developed a trajectory design to achieve the mission orbit and meet mission constraints, including eclipse avoidance and a 30-year geostationary orbit avoidance requirement. A parallelized Monte Carlo simulation was performed to validate the trajectory after injecting common perturbations, including launch dispersions, orbit determination errors, and maneuver execution errors. The Monte Carlo analysis helped identify mission risks and is used in the trajectory selection process.

Published
2016

40. Monte Carlo Analysis as a Trajectory Design Driver for the TESS Mission

Author

Nickel, Craig, Lebois, Ryan, Lutz, Stephen, Dichmann, Donald, and Parker, Joel

Subjects
Astrodynamics
Abstract

The Transiting Exoplanet Survey Satellite (TESS) will be injected into a highly eccentric Earth orbit and fly 3.5 phasing loops followed by a lunar flyby to enter a mission orbit with lunar 2:1 resonance. Through the phasing loops and mission orbit, the trajectory is significantly affected by lunar and solar gravity. We have developed a trajectory design to achieve the mission orbit and meet mission constraints, including eclipse avoidance and a 30-year geostationary orbit avoidance requirement. A parallelized Monte Carlo simulation was performed to validate the trajectory after injecting common perturbations, including launch dispersions, orbit determination errors, and maneuver execution errors. The Monte Carlo analysis helped identify mission risks and is used in the trajectory selection process.

Published
2016

41. Trajectory Design Enhancements to Mitigate Risk for the Transiting Exoplanet Survey Satellite (TESS)

Author

Dichmann, Donald, Parker, Joel, Nickel, Craig, and Lutz, Stephen

Subjects
Astrodynamics
Abstract

The Transiting Exoplanet Survey Satellite (TESS) will employ a highly eccentric Earth orbit, in 2:1 lunar resonance, which will be reached with a lunar flyby preceded by 3.5 phasing loops. The TESS mission has limited propellant and several constraints on the science orbit and on the phasing loops. Based on analysis and simulation, we have designed the phasing loops to reduce delta-V (DV) and to mitigate risk due to maneuver execution errors. We have automated the trajectory design process and use distributed processing to generate and optimal nominal trajectories; to check constraint satisfaction; and finally to model the effects of maneuver errors to identify trajectories that best meet the mission requirements.

Published
2016

42. ACR Appropriateness Criteria ® on Metastatic Bone Disease

Author

Roberts, Catherine C., Daffner, Richard H., Weissman, Barbara N., Bancroft, Laura, Bennett, D. Lee, Blebea, Judy S., Bruno, Michael A., Fries, Ian Blair, Germano, Isabelle M., Holly, Langston, Jacobson, Jon A., Luchs, Jonathan S., Morrison, William B., Olson, Jeffrey J., Payne, William K., Resnik, Charles S., Schweitzer, Mark E., Seeger, Leanne L., Taljanovic, Mihra, Wise, James N., and Lutz, Stephen T.

Published
2010
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