89 results on '"Lutiis, M. A."'
Search Results
2. The plasmatic and salivary levels of IL-1β, IL-18 and IL-6 are associated to emotional difference during stress in young male
- Author
-
La Fratta, I., primary, Tatangelo, R., additional, Campagna, G., additional, Rizzuto, A., additional, Franceschelli, S., additional, Ferrone, A., additional, Patruno, A., additional, Speranza, L., additional, De Lutiis, M. A., additional, Felaco, M., additional, Grilli, A., additional, and Pesce, M., additional
- Published
- 2018
- Full Text
- View/download PDF
3. Impact of RANTES, MCP-1 and IL-8 in mast cells
- Author
-
Castellani, M. L., Lutiis, M. A., Toniato, E., Conti, F., Felaco, P., Fulcheri, M., Theoharides, T. C., Caraffa, A., Pierluigi Antinolfi, Conti, P., Cuccurullo, C., Ciampoli, C., Felaco, M., Orso, C., Salini, V., Cerulli, G., Kempuraj, D., Tetè, S., Shaik, B., Castellani, M. L., De Lutiis, M. A., Toniato, E., Conti, F., Felaco, P., Fulcheri, M., Theoharides, T. C., Caraffa, A., Antinolfi, P., Conti, P., Cuccurullo, C., Ciampoli, C., Felaco, M., Orso, C., Salini, V., Cerulli, G., Kempuraj, D., Tetè, S., and Shaik, B.
- Subjects
Inflammation ,Serotonin ,IL-8 ,Interleukin-8 ,Histamine Release ,RANTES ,Animals ,Humans ,Mast Cells ,Inflammation Mediators ,IL-8, Mast cells, MCP-1, RANTES ,Chemokine CCL5 ,Chemokine CCL2 ,MCP-1 ,Signal Transduction - Abstract
Chemokines are cytokines with chemotactic properties on inflammatory cells and other cell types. RANTES, MCP-1 and related molecules, constitute the C-C class of chemokine supergene family and a group of cytokines produced by hematopoietic cells, while IL-8 constitute the C-X-C class. The roles of most of these chemokines are not well known, although members of the chemokine family are inflammatory agents. The C-C chemokine plays a role in regulating Th-cell cytokine production and leukocyte trafficking. In this study we clearly show that RANTES and MCP-1 are mediators of acute inflammatory responses. Our report describes additional biological activities for RANTES, MCP-1, and IL-8, suggesting that these chemokines play a fundamental role in histamine and serotonin generation and cell function in mast cells.
- Published
- 2010
4. Inflammatory compounds: neuropeptide substance P and cytokines
- Author
-
Castellani, M. L., Felaco, P., Pandolfi, F., Vincenzo Salini, Amicis, D., Vecchiet, J., Tetè, S., Ciampoli, C., Conti, F., Cerulli, G., Caraffa, A., Antinolfi, P., Cuccurullo, C., Perrella, A., Theoharides, T. C., Lutiis, M. A., Kempuraj, D., Shaik, Y. B., Castellani, M. l., Felaco, P., Pandolfi, F., Salini, V., De Amicis, D., Vecchiet, J., Tetè, S., Ciampoli, C., Conti, F., Cerulli, G., Carafa, A., Antinolfi, P., Cvuccurullo, C., Perrella, A., C: Theoharides, T., De Lutiis, M. A., Kempuraj, D., and Shaik, Y. B.
- Subjects
Inflammation ,Neuropeptide ,Chemokine ,Chemokine, Cytokine, Inflammation, Neuropeptide ,Cytokine - Published
- 2009
5. Tridimensional response of human dental follicular stem cells onto a synthetic hydroxyapatite scaffold
- Author
-
MASTRANGELO , FILIBERTO, Nargi E., Carone L., Dolci M., Caciagli F., Ciccarelli R., De Lutiis M. A., Karapanou V., Shaik B. Y., Conti P., Tetè S., Mastrangelo, Filiberto, Nargi, E., Carone, L., Dolci, M., Caciagli, F., Ciccarelli, R., De Lutiis, M. A., Karapanou, V., Shaik, B. Y., Conti, P., and Tetè, S.
- Published
- 2008
6. Anti-chemochine therapy for inflammatory diseases
- Author
-
CASTELLANI M.L, BHATTACHARYA K, TAGEN M, KEMPURA D, PERRELLA A, DE LUTIIS M, BOUCHER W, CONTI P, THEOHARIDES T.C, SALINI V, G. NERI, CASTELLANI M., L, Bhattacharya, K, Tagen, M, Kempura, D, Perrella, A, DE LUTIIS, M, Boucher, W, Conti, P, THEOHARIDES T., C, Salini, V, and G., Neri
- Abstract
Chemokines are inflammatory proteins acting via G-protein coupled chemokine receptors that trigger different signaling pathways. Monocyte chemoattractant protein-1 (CCL2/MCP-1) and regulated on activation, normal T expressed and secreted (CCL5/RANTES) are the two major members of the CC chemokine beta subfamily. The roles of RANTES and MCP-1 are emerging in regulating the recruitment of inflammatory cells into tissue during inflammation. The inhibition of MCP-1 and RANTES with corresponding antibodies or other inhibitors may provide benefits in different clinical scenarios including cancer, inflammation, CNS disorders, parasitic disease, autoimmune and heart diseases. RANTES and MCP-1 may represent targets for diagnostic procedures and therapeutic intervention, and may be useful as a prognostic factor in the above diseases.
- Published
- 2007
7. IL-35, an anti-inflammatory cytokine which expands CD4+CD25+ Treg Cells
- Author
-
Castellani, M. L., Anogeianaki, A., Felaco, P., Toniato, E., Lutiis, M. A., Shaik, B., Fulcheri, M., Vecchiet, J., Tetè, S., Salini, V., Theoharides, T. C., Caraffa, A., Pierluigi Antinolfi, Frydas, I., Conti, P., Cuccurullo, C., Ciampoli, C., Cerulli, G., Kempuraj, D., Castellani, Ml, Anogeianaki, A, Felaco, P, Toniato, E, De Lutiis, Ma, Shaik, B, Fulcheri, M, Vecchiet, J, Tetè, S, Salini, V, Theoharides, Tc, Caraffa, A, Antinolfi, P, Frydas, I, Conti, P, Cuccurullo, C, Ciampoli, C, Cerulli, G, and Kempuraj, D
- Subjects
CD4-Positive T-Lymphocytes ,Inflammation ,Anti-inflammatory cytokines, Autoimmunity, Interleukin 35, T cells, T helper cells ,Interleukins ,T cells ,Autoimmunity ,Cell Differentiation ,T-Lymphocytes, Helper-Inducer ,Interleukin-12 ,T-Lymphocytes, Regulatory ,Interleukin 35 ,T helper cells ,Cytokines ,Humans ,Anti-inflammatory cytokines ,Cell Division - Abstract
Interleukin 12 (IL 12) p35/p40 is a heterodimeric cytokine which plays a critical role in inflammation, immunity and tissue proliferation, and also plays a relevant function in T helper (Th) cell polarization and Th1 T-cell differentiation. IL-12 family members, IL-12p70, IL-23, IL-27 and IL-35, play an important role in influencing helper T-cell differentiation. EBV-induced gene 3 can be associated with the p35 subunit of IL-12 to form the EBI3/p35 heterodimer, also called IL-35. It has been shown that IL-35 has biological activity and able to expand CD4+CD25+ Treg cells, suppress the proliferation of CD4+CD25- effector cells and inhibit Th17 cell polarization. IL-35 has been shown to be constitutively expressed by regulatory T (Treg) cells CD4(+)CD25(+)Foxp3(+) and suggested to contribute to their suppressive activity. IL-35 is a crucial mediator which provokes CD4+CD25+ T cell proliferation and IL-10 generation, another well-known anti-inflammatory cytokine, along with TGFbeta cytokine. These studies suggest that IL-35, together with other successfully discovered cytokine inhibitors, represents a new potential therapeutic cytokine for chronic inflammation, autoimmunity and other immunological disorders.
- Published
- 2010
8. IL-32: a newly-discovered proinflammatory cytokine
- Author
-
Felaco, P., Castellani, M. L., Lutiis, M. A., Felaco, M., Pandolfi, F., Vincenzo Salini, Amicis, D., Vecchiet, J., Tetè, S., Ciampoli, C., Conti, F., Cerulli, G., Caraffa, A., Antinolfi, P., Cuccurullo, C., Perrella, A., Theoharides, T. C., Conti, P., Toniato, E., Kempuraj, D., Shaik, Y. B., Felaco, P, Castellani, Ml, De Lutiis, Ma, Felaco, M, Pandolfi, F, Salini, V, De Amicis, D, Vecchiet, J, Tete, S, Ciampoli, C, Conti, F, Cerulli, G, Caraffa, A, Antinolfi, P, Cuccurullo, C, Perrella, A, Theoharides, Tc, Conti, P, Toniato, E, Kempuraj, D, and Shaik, Yb
- Subjects
inflammation ,interleukin ,Interleukins ,IL-32 ,chemokine ,NF-kappa B ,cytokine ,Animals ,Humans ,Cell Differentiation ,Inflammation Mediators ,IL-32, inflammation, cytokine, chemokine, interleukin, immunity ,immunity - Abstract
IL-32, a newly-discovered proinflammatory cytokine that activates the p38MAPK and NF-kappaB pathways, is an important player in innate and adaptive immune response. IL-32, a cytokine produced mainly by T, natural killer, and epithelial cells induces significant amounts of TNFalpha and MIP-2 and increases the production of both cytokines in a dose-dependent manner. IL-32 has been implicated in inflammatory disorders, mycobacterium tuberculosis infections, inflammatory bowel disease, and influenza A virus infection, as well as in some autoimmune diseases, such as rheumatoid arthritis, ulcerative colitis and Crohn?s disease and in human stomach cancer, human lung cancer and breast cancer tissues. Moreover, it has been reported that IL-32 has pro-inflammatory effects on myeloid cells and causes the differentiation of osteoclast precursors into multinucleated cells expressing specific osteoclast markers. We recently found that human IL-32 has the capacity to provoke histamine release in human-derived cord blood mast cells (HDCBMC), but not in LAD 2 cells nor in rat peritoneal mast cells (RPMC), showing that IL-32 may be specie specific and act more in mature human mast cells (HDCBMC) than in transformed mast cells (LAD 2 cells). Certainly, IL-32 is another potent proinflammatory cytokine, however, the specific role of this newly-discovered protein in the network of cytokine biology remains to be determined.
- Published
- 2009
9. Capsaicin: an irritant anti-inflammatory compound
- Author
-
Anogianaki, A., Negrev, N. N., Shaik, Y. B., Castellani, M. L., Frydas, S., Vecchiet, J., Tetè, S., Vincenzo Salini, Amicis, D., Lutiis, M. A., Conti, F., Caraffa, A., Cerulli, G., Anogianaki, A, Negrev, Nn, Shaik, Yb, Castellani, Ml, Frydas, S, Vecchiet, J, S., Tete', Salini, V, DE AMICIS, D, DE LUTIIS, Ma, Conti, F, Caraffa, A, and Cerulli, G
- Subjects
Analgesics ,Nasal Decongestants ,Gastrointestinal Agents ,Heart Diseases ,Neoplasms ,Anti-Inflammatory Agents, Non-Steroidal ,Irritants ,Humans ,Nervous System Diseases ,capsaicin ,anti-inflammatory - Published
- 2007
10. Study on the effectiveness of a nifedipine gel for treatment of Raynaud's phenomenon
- Author
-
Foti, C., Quaranta, D., Pepe, M. L., Morea, G., Mastropasqua, D., D Amore, M., Mastrangelo, F., Tetè, S., Grassi, F. R., Andrea Ballini, Salini, V., Amicis, D., Scagliusi, P., Lutiis, M. A., Caraffa, A., Cerulli, G., Foti, C, Quaranta, D, Pepe, Ml, Morea, G, Mastropasqua, D, D'Amore, M, Mastrangelo, Filiberto, S., Tete', Grassi, Fr, Ballini, A, Salini, V, DE AMICIS, D, Scagliusi, P, DE LUTIIS, Ma, Caraffa, A, and Cerulli, G.
- Published
- 2006
11. Inducible nitric oxide synthase and heme oxygenase-1 in rat heart: direct effect of chronic exposure to hypoxia
- Author
-
alfredo grilli, Lutiis, M. A., Patruno, A., Speranza, L., Gizzi, F., Taccardi, A. A., Di Napoli, P., Caterina, R., Conti, P., and Felaco, M.
- Published
- 2003
12. Impact of IL-18 on inflammation
- Author
-
Tripodi, Domenico, Macauro, G, Anogeianaki, A, Castellani, M. L., Pandolfi, Franco, Felaco, P, Toniato, E, De Lutiis, M. A., Fulcheri, M., Tete, S., Galzio, R., Salini, V., Caraffa, A., Antinolfi, P., Frydas, I., Sabatino, G., Shaik Dasthagirisaheb, Y. B., Pandolfi, Franco (ORCID:0000-0001-8799-8173), Tripodi, Domenico, Macauro, G, Anogeianaki, A, Castellani, M. L., Pandolfi, Franco, Felaco, P, Toniato, E, De Lutiis, M. A., Fulcheri, M., Tete, S., Galzio, R., Salini, V., Caraffa, A., Antinolfi, P., Frydas, I., Sabatino, G., Shaik Dasthagirisaheb, Y. B., and Pandolfi, Franco (ORCID:0000-0001-8799-8173)
- Abstract
IL-18 is produced by many cell types, such as Kupffer cells, keratinocytes, macrophages, dendritic cells, and activated T cells stimulated by LPS. It is an important regulator of both innate and acquired immune responses. IL-18 plays a central role in rheumatoid arthritis since the T cells and macrophages that invade the synovial. These finding support a role for IL-18 in inflammation, allergy and immune diseases.
- Published
- 2011
13. VEGF, substance P and stress, new aspects: a revisited study.
- Author
-
Castellani, M. L., Galzio, R. J., Felaco, P., Tripodi, D., Toniato, E., De Lutiis, M. A., Conti, F., Fulcheri, M., Conti, C., Theoharides, T. C., Caraffa, A., Antinolfi, P., Felaco, M., Tete, S., Pandolfi, Franco, Shaik Dasthagirisaheb, Y. B., Pandolfi, Franco (ORCID:0000-0001-8799-8173), Castellani, M. L., Galzio, R. J., Felaco, P., Tripodi, D., Toniato, E., De Lutiis, M. A., Conti, F., Fulcheri, M., Conti, C., Theoharides, T. C., Caraffa, A., Antinolfi, P., Felaco, M., Tete, S., Pandolfi, Franco, Shaik Dasthagirisaheb, Y. B., and Pandolfi, Franco (ORCID:0000-0001-8799-8173)
- Abstract
Mast cells play an essential role in diverse physiological and pathological processes, such as atherosclerosis, malignancy, asthma, pulmonary fibrosis and arthritis, directly interact with bacteria, and appear to play a vital role in host defense against pathogens. Mast cells could be recruited in the inflammatory site, by MCP-1, RANTES and SCF, to selectively secrete proinflammatory molecules; these could include growth factors, histamine, which is mitogenic (H1) and an immunosuppressant (H2), neovascularization agents, such as heparin, IL-8, and VEGF, as well as proteases that could permit new blood vessel formation. Neurogenic inflammation involves vasodilation and plasma protein extravasation in response to neural stimulation. Upon stimulation, sensory neurons release Substance P and other neuropeptides and activate neurokinin-1 receptors leading to plasma protein extravasation from post-capillary venules. Substance P is a neuropeptide that is released from nerve endings in many tissues and plays an important role in immunological and inflammatory states, and it is also a mediator of tissue injury, asthma, arthritis, allergy and autoimmune diseases. SP-positive nerve fibers and mast cell contacts are increased by acute stress in mice leading to dermal mast cell degranulation. VEGF is produced by flammatory cells. IL-33 is the newest inflammatory member of the IL-1 cytokine family and we show here that SP can induce VEGF secretion from mast cells and IL-33 augments the effect of SP in VEGF transcription and translation protein.
- Published
- 2010
14. IL-31 a Th2 cytokine involved in immunity and inflammation.
- Author
-
Castellani, Ml, Felaco, P., Galzio, R. J., Tripodi, D., Toniato, E., De Lutiis, M. A., Fulcheri, M., Caraffa, A., Antinolfi, P., Tete, S., Felaco, M., Conti, F., Pandolfi, Franco, Theoharides, T. C., Shaiki Dathagirisaheb, Y. B., Pandolfi, Franco (ORCID:0000-0001-8799-8173), Castellani, Ml, Felaco, P., Galzio, R. J., Tripodi, D., Toniato, E., De Lutiis, M. A., Fulcheri, M., Caraffa, A., Antinolfi, P., Tete, S., Felaco, M., Conti, F., Pandolfi, Franco, Theoharides, T. C., Shaiki Dathagirisaheb, Y. B., and Pandolfi, Franco (ORCID:0000-0001-8799-8173)
- Abstract
Cytokines are immunal regulatory proteins, however they also play a relevant role in inflammatory diseases. IL-31 is a newly discovered cytokine expressed primarily in TH2 cells, introduced by activated CD4+ T cells. IL-31 is capable of inducing chemokines and other cytokines in several inflammatory diseases via its surface receptor. This cytokine is also produced by mast cells and mast cell line, suggesting a role in allergic diseases. In this editorial we revisit the biological role of IL-31 in immunity and inflammation.
- Published
- 2010
15. Vitamins and mast cells.
- Author
-
Anogeianaki, A., Castellani, M. L., Tripodi, D., Toniato, E., De Lutiis, M. A., Conti, F., Felaco, P., Fulcheri, M., Theoharides, T. C., Galzio, R., Caraffa, A., Antinolfi, P., Cuccurullo, C., Ciampoli, C., Felaco, M., Cerulli, Giuliano Giorgio, Pandolfi, Franco, Sabatino, G., Neri, G., Shaik Dathagirisaheb, Y. B., Cerulli, Giuliano Giorgio (ORCID:0000-0003-4990-1902), Pandolfi, Franco (ORCID:0000-0001-8799-8173), Anogeianaki, A., Castellani, M. L., Tripodi, D., Toniato, E., De Lutiis, M. A., Conti, F., Felaco, P., Fulcheri, M., Theoharides, T. C., Galzio, R., Caraffa, A., Antinolfi, P., Cuccurullo, C., Ciampoli, C., Felaco, M., Cerulli, Giuliano Giorgio, Pandolfi, Franco, Sabatino, G., Neri, G., Shaik Dathagirisaheb, Y. B., Cerulli, Giuliano Giorgio (ORCID:0000-0003-4990-1902), and Pandolfi, Franco (ORCID:0000-0001-8799-8173)
- Abstract
N/A
- Published
- 2010
16. Correlation between trace elements of serum and urine and immunological parameters in the population of rural and urban areas
- Author
-
Carmignani, Marco, Boscolo, P., Di Gioacchino, M., Di Giacomo, F., De Lutiis, M. A., Cervone, M., Grilli, A., and Felaco, M.
- Published
- 1995
17. Anti-Chemokine Therapy for Inflammatory Diseases
- Author
-
Castellani, M.L., primary, Bhattacharya, K., additional, Tagen, M., additional, Kempuraj, D., additional, Perrella, A., additional, De Lutiis, M., additional, Boucher, W., additional, Conti, P., additional, Theoharides, T.C., additional, Cerulli, G., additional, Salini, V., additional, and Neri, G., additional
- Published
- 2007
- Full Text
- View/download PDF
18. Interrelationship between Asthma and Functional Bowel Disease
- Author
-
Riccioni, G., primary, Della Vecchia, R., additional, Romano, F., additional, Staniscia, T., additional, Verna, N., additional, De Lutiis, M. A., additional, Comani, S., additional, Petrarca, C., additional, Castellani, M.L., additional, Di Ilio, C., additional, and D'Orazio, N., additional
- Published
- 2004
- Full Text
- View/download PDF
19. ALLERGIC INFLAMMATION: ROLE OF CYTOKINES WITH SPECIAL EMPHASIS ON IL-4.
- Author
-
SAGGINI, A., MACCAURO, G., TRIPODI, D., DE LUTIIS, M. A., CONTI, F., FELACO, P., FULCHERI, M., GALZIO, R., CARAFFA, A., ANTINOLFI, P., FELACO, M., PANDOLFI, F., SABATINO, G., NERI, G., and SHAIK-DASTHAGIRISAHEB, Y. B.
- Published
- 2011
- Full Text
- View/download PDF
20. PGD2, IL-1-FAMILY MEMBERS AND MAST CELLS.
- Author
-
Anogeianaki, A., Castellani, M. L., Tripodi, D., Felaco, P., Toniato, E., De Lutiis, M. A., Fulcheri, M., Tete, S., Galzio, R., Salini, V., Caraffa, A., Antinolfi, P., Frydas, I., Sabatino, G., and Shaik-Dasthagirisaheb, Y. B.
- Subjects
PROSTAGLANDINS ,MAST cells ,CYTOKINES ,IMMUNOMODULATORS ,INTERLEUKINS ,INFLAMMATION ,HISTAMINE ,BASOPHILS ,IMMUNOGLOBULIN E - Abstract
Cytokines are immunomodulatory and inflammatory compounds produced by many different cell types. The IL-1 family consists of at least eleven cytokines including IL-18 and IL-13 and are essential to the host defence against severe infections and mediate inflammation. IL-18 also enhances tumour rejection and has high capacity to augment the cytotoxicity of NK cells and T cells. IL-33 stimulates basophils and mast cells to produce cytokines and histamine independently of IgE. Mast cells play a crucial role in the development of allergy through the cross-linking of their surface receptors for IgE leading to degranulation and inflammation. Activated mast cells induce the generation of PGD2, detectable in 2-15 minutes after challenge, and LTC4. Here we review the interrelationship between PGD2, IL-1 family members and mast cells. [ABSTRACT FROM AUTHOR]
- Published
- 2010
- Full Text
- View/download PDF
21. IL-31 A TH2 CYTOKINE INVOLVED IN IMMUNITY AND INFLAMMATION.
- Author
-
Castellani, M. L., Felaco, P., Galzio, R. J., Tripodi, D., Toniato, E., De Lutiis, M. A., Fulcheri, M., Caraffa, A., Antinolfi, P., Tetè, S., Felaco, M., Conti, F., Pandolfi, F., Theoharides, T. C., and Shaik-Dasthagirisaheb, Y. B.
- Published
- 2010
- Full Text
- View/download PDF
22. IL-34 A NEWLY DISCOVERED CYTOKINE.
- Author
-
Castellani, M. L., Anogetanaki, A., Felaco, P., Toniato, E., De Lutiis, M. A., Shaik, B., Fulcheri, M., Vecchiet, J., Tete, S., Salini, V., Theoharides, T. C., Caraffa, A., Antinolfi, P., Frydas, S., Conti, P., Cuccurullo, C., Ciampoli, C., and Cerulli, G.
- Subjects
THERAPEUTIC use of cytokines ,MONOCYTES ,CELL growth ,LABORATORY rats ,OSTEOPOROSIS treatment ,ENZYME inhibitors - Abstract
In this study we describe some biological effects of IL-34, a newly discovered cytokine. We show that Il-34 stimulates monocyte cell viability and directly modulates the number and function of monocytes and regulates myeloid cell growth and differentiation. Moreover, since IL-34 in mice is involved in osteoporosis, an antagonist of this cytokine could be beneficial for the treatment of this disease. [ABSTRACT FROM AUTHOR]
- Published
- 2010
- Full Text
- View/download PDF
23. INTER-RELATIONSHIP BETWEEN CHEMOKINES AND MAST CELLS.
- Author
-
Castellani, M. L., Anogeianaki, A., Toniato, B., De Lutiis, M. A., Felaco, P., Fulcheri, M., Vecchiet, J., Tetè, S., Salini, V., Caraffa, A., Antinolfi, P., Theoharides, T. C., Conti, F., Cuccurullo, C., Ciampoli, C., Felaco, M., Orso, C., Cerulli, G., Frydas, I., and Shaik, B.
- Subjects
CHEMOKINES ,MAST cells ,HISTAMINE ,SEROTONIN ,ARACHIDONIC acid ,CYTOKINES ,IMMUNE response ,IMMUNOMODULATORS ,CLINICAL trials - Abstract
The inflammatory response is mediated by immunological and chemotactic factors, proteins of the complement system, histamine, serotonin, arachidonic acid products and cytokines. All these compounds, including cytokines/chemokines, are major contributors to the symptoms of inflammation. Cytokines/chemokines, commonly referred to as "biological response modifiers", are relatively new compounds for possible use in stimulation of the immune response, and display a number of overlapping abilities to stimulate cells of various lineages and differentiation stages; nonetheless, most of these compounds are potent inflammatory mediators. Mast cell mediators are either contained within secretory granules or can be synthesized de novo and can be released upon activation by either a massive degranulation, or by a selective release of specific molecules. These cells accumulate in the stroma of a variety of inflamed and transformed tissues in response to locally produced chemotactic factors for immune-cells, such as RANTES and MCP-1. Here we describe some connections between mast cells and chemokines. [ABSTRACT FROM AUTHOR]
- Published
- 2010
- Full Text
- View/download PDF
24. Nitric Oxide Synthase in Healthy and Inflamed Human Dental Pulp.
- Author
-
Di Nardo Di Maio, F., Lohinai, Z., D'Arcangelo, C., De Fazio, P. Esposito, Speranza, L., De Lutiis, M. A., Patruno, A., Grilli, A., and Felaco, M.
- Subjects
NITRIC oxide ,DENTAL pulp ,IMMUNOHISTOCHEMISTRY ,POLYMERASE chain reaction ,PULPITIS ,HYPEREMIA - Abstract
Nitric oxide synthase (NOS) plays a significant role in the pathogenesis of pulpitis. In this study, we hypothesized the existence of endothelial (eNOS) and inducible (iNOS) enzyme isoforms in human dental pulp. Extracted third molar pulps were divided into groups based on clinical diagnosis: healthy, hyperemic, and irreversible pulpitis. We have localized the eNOS and iNOS by immunohistochemistry and have tested their mRNA expression by RT-PCR and protein levels by Western blots. eNOS is present in the endothelial cells and odontoblasts of the healthy pulp, but an elevation of eNOS mRNA and protein levels with a concomitant dilation of vessels was characteristic under pathological conditions. Healthy pulp tissue failed to exhibit any iNOS; however, acute inflammation enhanced the mRNA and protein levels of iNOS, mainly in the leukocytes. There are differences in localization and expression between eNOS and iNOS in healthy and inflamed dental pulp. [ABSTRACT FROM AUTHOR]
- Published
- 2004
- Full Text
- View/download PDF
25. Renal and plasma enzymatic activities in Wistar rats with arterial hypertension induced by chronic exposure to inorganic mercury
- Author
-
Carmignani, Marco, Grilli, A., Boscolo, P., De Lutiis, M. A., Di Sante, O., and Felaco, M.
- Published
- 1989
26. Histochemical modifications in the kidney of rats by chronic Hg exposure resulted in hypertension
- Author
-
Grilli, A., De Lutiis, M. A., Soldano, G., Artese, L., Volpe, ANNA RITA, and Felaco, M.
- Published
- 1989
27. iNOS activity in the aged rat liver tissue
- Author
-
Patruno, A., Speranza, L., Tete, S., Filiberto MASTRANGELO, Lutiis, M. A., Pesce, M., Franceschelli, S., Vinciguerra, I., Felaco, M., Grilli, A., Patruno, A, Speranza, L, S., Tete', Mastrangelo, Filiberto, DE LUTIIS, Ma, Pesce, M, Franceschelli, S, Vinciguerra, I, Felaco, M, and Grilli, A.
28. Negative feeedback interaction of HO-1/iNOS in PBMC of ACHF patients
- Author
-
Speranza, L., Franceschelli, S., Pesce, M., Ferrone, A., Patruno, A., Riccioni, G., Lutiis, M. A., Felaco, M., and alfredo grilli
29. Impact of extremely low frequency electromagnetic fields on CD4 expression in peripheral blood mononuclear cells
- Author
-
Felaco, M., Marcella Reale, Grilli, A., Lutiis, M. A., Barbacane, R. C., Di Luzio, S., and Conti, P.
30. Interrelationship between vitamins and cytokines in immunity
- Author
-
Castellani, M. L., Shaik-Dasthagirisaheb, Y. B., Tripodi, D., Anogeianaki, A., Felaco, P., Toniato, E., Lutiis, M. A., Fulcheri, M., Tetè, S., Galzio, R., Vincenzo Salini, Caraffa, A., Antinolfi, P., Frydas, I., Sabatino, G., Kempuraj, D., Castellani, Ml, Shaik-Dasthagirisaheb, Yb, Tripodi, D, Anogeianaki, A, Felaco, P, Toniato, E, De Lutiis, Ma, Fulcheri, M, Tetè, S, Galzio, R, Salini, V, Caraffa, A, Antinolfi, P, Frydas, I, Sabatino, G, and Kempuraj, D
- Subjects
Inflammation ,Cytokines, Immunity, Inflammation, Treg cells, Vitamins ,Immunity ,Animals ,Humans ,Cytokines ,Avitaminosis ,Vitamins ,Infections ,Immunity, Innate ,Treg cells - Abstract
Cytokines are important proteins that modulate immunity and inflammation. Vitamins are also involved in immunity and inflammation. They are found to restore the ability of some cells to produce certain cytokines. Vitamin deficiency appears to affect the mechanism of immune cells, though the impact of reduced cytokine response in vitamin malnutrition is not clear. Vitamin D is involved in many medical conditions, such as infections and inflammation, and mediates innate immunity. Deficiency of vitamin D increases the risk of infectious and inflammatory diseases. In addition, this vitamin modulates Treg function and IL-10 production which is important for therapeutic treatment. Vitamin A increases inflammatory response and is involved in tissue damage; moreover, vitamin A is a key modulator of TGFbeta which can suppress several cytokines. Vitamin E, an anti-ageing compound, is associated with a defect of naive T cells and may inhibit some inflammatory compounds such as prostaglandin generation.
31. Infections and mast cells
- Author
-
Felaco, P., Toniato, E., Castellani, M. L., Ciampoli, C., Amicis, D., Orso, C., Cuccurullo, C., Lutiis, M. A., Patruno, A., Speranza, L., Felaco, M., Caraffa, A., Pandolfi, F., Antinolfi, P. L., Cerulli, G., Conti, F., Mario Fulcheri, Sabatino, G., Conti, P., and Shaik, Y.
- Subjects
Receptors, IgE ,infection, mast cells, inflammation, cytokines ,inflammation ,Animals ,Humans ,mast cells ,Immunoglobulin E ,Inflammation Mediators ,Infections ,infection ,cytokines - Abstract
Mast cells play a role in various physiological functions: innate and acquired immunity, epithelium remodelling and proliferation, angiogenesis, cancer, inflammation and infections. Mast cells are activated by cross-linking of FcERI molecules, which are involved in the binding of multivalent antigens to the attached IgE molecules, resulting in a variety of responses including the immediate release of potent inflammatory mediators. In addition, mast cell biology consists in the capability to secrete preformed mediators which include biogenic amines and newly synthetized mediators, which include lipid-derived mediators and cytokines. It has been reported that parasite infections induce a systemic immunomodulatory network, including regulatory T cells, pro-inflammatory and anti-inflammatory cytokines, which might play a key role in the allergic phenotype. Here, in this article, we revisited the relationship between mast cells and infections.
32. Effects of 50 Hz sinusoidal electromagnetic fields on MCP-1 and rantes generated from activated human macrophages
- Author
-
Di Luzio, S., Felaco, S. M., Barbacane, R. C., Frydas, S., Grilli, A., Castellani, M. L., Macrì, M. A., Di Gioacchino, M., DANIELE MERLITTI, Lutiis, M. A., Masci, S., Di Giulio, C., Cacchio, M., and Reale, M.
33. Biological role of interleukin-1β in defensive aggressive behavior
- Author
-
Mirko Pesce, Speranza, L., Franceschelli, S., Ialenti, V., Patruno, A., Febo, M. A., Lutiis, M. A., Felaco, M., and Grilli, A.
34. Role of quercetin (a natural herbal compound) in allergy and inflammation
- Author
-
Shaik, Y. B., Castellani, M. L., Alessandro Perrella, Conti, F., Salini, V., Tetè, S., Madhappan, B., Vecchiet, J., Lutiis, M. A., Caraffa, A., and Cerulli, G.
- Subjects
QUERCETIN ,HERBAL AGENTS ,ANTI-INFLAMMATORY ,ANTI-OXIDANT ,BIOFLAVONOIDS
35. Anti-inflammatory properties of the plant Verbascum Mallophorum
- Author
-
Speranza, L., Franceschelli, S., Pesce, M., LUIGI MENGHINI, Patruno, A., Vinciguerra, I., Lutiis, M. A., Felaco, M., Felaco, P., and Grilli, A.
36. Endothelial nitric oxide synthase (eNOS) expression and localization in healthy and diabetic rat hearts
- Author
-
Felaco, M., Grilli, A., Lutiis, M. A., Patruno, A., Libertini, N., Taccardi, A. A., Di Napoli, P., Camillo DI GIULIO, Barbacane, R., and Conti, P.
37. Plasmatic markers of muscular stress in isokinetic exercise
- Author
-
Speranza, L., alfredo grilli, Patruno, A., Franceschelli, S., Felzani, G., Pesce, M., Vinciguerra, I., Lutiis, M. A., and Felaco, M.
38. Impact of IL-18 on inflammation
- Author
-
Domenico Tripodi, Anogeianaki Antonia, Castellani Maria Luisa, Felaco Paolo, Toniato E, De Lutiis M.A, Fulcheri M, Tete' Stefano, Salini Vincenzo, Frydas I, Sabatino Giuseppe, Shaik-Dasthagirisaheb Y.B, Domenico, Tripodi, Anogeianaki, Antonia, Castellani Maria, Luisa, Felaco, Paolo, Toniato, E, De Lutiis M., A, Fulcheri, M, Tete', Stefano, Salini, Vincenzo, Frydas, I, Sabatino, Giuseppe, and Shaik-Dasthagirisaheb Y., B
- Subjects
Inflammation ,Interleukin-18 ,Immunoregulation ,Autoimmunity ,Lymphocytes - Abstract
IL-18 is produced by many cell types, such as Kupffer cells, keratinocytes, macrophages, dendritic cells, and activated T cells stimulated by LPS. It is an important regulator of both innate and acquired immune responses. IL-18 plays a central role in rheumatoid arthritis because of the T cells and macrophages that invade the synovial fluid. These finding support a role for IL-18 in inflammation, allergy and immune diseases.
- Published
- 2011
39. Inter-relationship between chemokines and mast cells
- Author
-
Stefano Tetè, Chiara Cuccurullo, Elena Toniato, Mario Fulcheri, Mario Felaco, Pierluigi Antinolfi, Paolo Felaco, Jacopo Vecchiet, Giuliano Giorgio Cerulli, M.L. Castellani, F. Conti, T.C. Theoharides, I Frydas, Antonia Anogeianaki, C. Orso, Alessandro Caraffa, C. Ciampoli, B. Shaik, M.A. De Lutiis, Vincenzo Salini, Castellani, M. L., Anogeianaki, A., Toniato, E., De Lutiis, M. A., Felaco, P., Fulcheri, M., Vecchiet, J., Tetè, S., Salini, V., Caraffa, A., Antinolfi, P., Theorides, T. C., Conti, F., Cuccurullo, C., Ciampoli, C., Felaco, M., Orso, C., Cerulli, G., Frydas, I., and Shaik, B.
- Subjects
Inflammation ,Chemokine ,biology ,Immunology ,lcsh:R ,lcsh:Medicine ,Chemotaxis ,Complement system ,Interleukin 33 ,chemistry.chemical_compound ,chemistry ,medicine ,biology.protein ,Mast cells ,Immunology and Allergy ,Cytokines ,Arachidonic acid ,Serotonin ,medicine.symptom ,Chemokines ,Chemokines, Cytokines, Inflammation, Mast cells ,Histamine - Abstract
The inflammatory response is mediated by immunological and chemotactic factors, proteins of the complement system, histamine, serotonin, arachidonic acid products and cytokines. All these compounds, including cytokines/chemokines, are major contributors to the symptoms of inflammation. Cytokines/chemokines, commonly referred to as “biological response modifiers”, are relatively new compounds for possible use in stimulation of the immune response, and display a number of overlapping abilities to stimulate cells of various lineages and differentiation stages; nonetheless, most of these compounds are potent inflammatory mediators. Mast cell mediators are either contained within secretory granules or can be synthesized de novo and can be released upon activation by either a massive degranulation, or by a selective release of specific molecules. These cells accumulate in the stroma of a variety of inflamed and transformed tissues in response to locally produced chemotactic factors for immune-cells, such as RANTES and MCP-1. Here we describe some connections between mast cells and chemokines.
- Published
- 2010
40. Vascular Endothelial growth factor (VEGF) in Human tooth germ center
- Author
-
Federico Gizzi, M Piccirilli, M Dolci, Stefano Tetè, Luciano Artese, Mario Felaco, Antonia Patruno, Lorenza Speranza, M.A. De Lutiis, Filiberto Mastrangelo, Mastrangelo, Filiberto, Piccirilli, M, Dolci, M, Tete', S, Speranza, L, Patruno, A, Gizzi, F, M., Felaco, Artese, L, and DE LUTIIS, M. A.
- Subjects
Adult ,Male ,Vascular Endothelial Growth Factor A ,0301 basic medicine ,Pathology ,medicine.medical_specialty ,Adolescent ,Endothelium ,Angiogenesis ,Blotting, Western ,Immunology ,Neovascularization, Physiologic ,Biology ,03 medical and health sciences ,chemistry.chemical_compound ,0302 clinical medicine ,Ameloblasts ,Image Processing, Computer-Assisted ,medicine ,Humans ,Immunology and Allergy ,RNA, Messenger ,Child ,Stellate reticulum ,Pharmacology ,Odontoblasts ,Reverse Transcriptase Polymerase Chain Reaction ,Antibodies, Monoclonal ,Tooth Germ ,030206 dentistry ,Immunohistochemistry ,Vascular endothelial growth factor B ,Vascular endothelial growth factor ,Vascular endothelial growth factor A ,030104 developmental biology ,medicine.anatomical_structure ,Vascular endothelial growth factor C ,chemistry ,Female ,Endothelium, Vascular ,Densitometry - Abstract
Many oncogenis and tumour suppressor genes found inside normal and pathological cells are fundamental for the processes of development, proliferation and tissue differentiation. The purpose of our study is to show the presence and a possible relationship of the VEGF protein during different phases of the development of human dental germ centers. After cephalometric investigation in 8 orthodontic patients with a mean age of 13 years, (4 females and 4 males), hyperdivergence of the third molars were extracted. The 40 surgical samples were tested with monoclonal human anti-VEGFs antibodies carrying out a semi-quantitative analysis to look for a positive reaction. Reaction for anti-VEGF antibodies was detected in normal embryological tissues and in microvessels near odontogenic cells. During different phases of embryologic development of the dental bud our search showed intracytoplasmatic positive immunoreactions both in the ameloblastic and odontoblastic cells. Additionally, a positive reaction was observed for the VEGF protein in the cells of the stellate reticulum and in those endothelial tissue surrounding the microvessels in all the samples examined.
- Published
- 2005
41. Super-oxide anion production and antioxidant enzymatic activities associated with the executive functions in peripheral blood mononuclear cells of healthy adult samples.
- Author
-
Pesce M, Rizzuto A, La Fratta I, Tatangelo R, Campagna G, Iannasso M, Ferrone A, Franceschelli S, Speranza L, Patruno A, De Lutiis MA, Felaco M, and Grilli A
- Subjects
- Adult, Catalase blood, Female, Glutathione Peroxidase blood, Glutathione Reductase blood, Humans, Leukocytes, Mononuclear enzymology, Male, Superoxide Dismutase blood, Young Adult, Antioxidants metabolism, Executive Function, Leukocytes, Mononuclear metabolism, Superoxides metabolism
- Abstract
Executive Functions (EFs) involve a set of high cognitive abilities impairment which have been successfully related to a redox omeostasis imbalance in several psychiatric disorders. Firstly, we aimed to investigate the relationship between executive functioning and some oxidative metabolism parameters in Peripheral Blood Mononuclear Cells (PBMCs) from healthy adult samples. The Brown Attention-Deficit Disorder Scales were administered to assess five specific facets of executive functioning. Total superoxide anion production, Super Oxide Dismutase (SOD), Catalase (CAT), Glutathione Reductase (GR) and Glutathione Peroxidase (GPx) activities were evaluated on proteins extracted from the PBMCs. We found significant positive correlations between superoxide anion production and the total score of the 'Brown' Scale and some of its clusters. The GPx and CAT activities were negatively associated with the total score and some clusters. In a linear regression analysis, these biological variables were indicated as the most salient predictors of the total score, explaining the 24% variance (adjusted R(2)=0.24, ANOVA, p<.001). This study provides novel evidence that Executive Functions have underpinnings in the oxidative metabolism, as ascertained in healthy subjects., (Copyright © 2015 Elsevier Ireland Ltd and the Japan Neuroscience Society. All rights reserved.)
- Published
- 2016
- Full Text
- View/download PDF
42. Negative feedback interaction of HO-1/INOS in PBMC of acute congestive heart failure patients.
- Author
-
Speranza L, Franceschelli S, Pesce M, Ferrone A, Patruno A, Riccioni G, De Lutiis MA, Felaco M, and Grilli A
- Subjects
- Acute Disease, Aged, Feedback, Physiological, Female, Humans, Male, Middle Aged, NF-kappa B metabolism, Ventricular Function, Left, Heart Failure physiopathology, Heme Oxygenase-1 physiology, Leukocytes, Mononuclear metabolism, Nitric Oxide Synthase Type II physiology
- Abstract
Heart failure (HF) is a common clinical syndrome with frequent exacerbations requiring hospitalization. Among the various mechanisms that underlie the pathogenesis of HF, the activation of the immune system leads to a progressive and redundant release of proinflammatory cytokines responsible for a variety of deleterious effects in heart failure, such as endothelial dysfunction, apoptosis of myocytes, activation of MMPs (Matrix Metallo Proteinases) and oxidative stress, with the result of decreased inotropism and clinical syndrome such as pulmonary edema,. The condition of oxidative stress induces the expression of genes coding for the proteins inducible nitric oxide synthase (iNOS) and heme oxygenase-1 (HO-1). Twenty-five hospitalized cardiology patients with symptomatic acute congestive HF (NYHA Class III-IV) and impaired left ventricular (LV) function (ejection fraction less than 35 percent) were included in the study. The aim of this study was to evaluate the cytokines plasma concentrations and the expression and activity of iNOS and HO-1 proteins in peripheral blood mononuclear cell (PBMC) extracted from patients in comparison to control group. In ACHF; left ventricular ejection fraction (LVEF) percent was reduced. Furthermore; iNOS and HO-1 expression and cytokines plasma levels were significantly higher in patients with ACHF as compared to controls group. Moreover the enzyme activity presents an opposite trend compared to that obtained in the analysis of the transcript and proteins. Our studies suggest a negative feedback interaction between iNOS and HO-1 important in the physiopathology of heart failure that could be considered a good candidate as a future therapeutic target for the development of new drugs.
- Published
- 2013
43. Biological role of interleukin-1beta in defensive-aggressive behaviour.
- Author
-
Pesce M, Speranza L, Franceschelli S, Ialenti V, Patruno A, Febo MA, De Lutiis MA, Felaco M, and Grilli A
- Subjects
- Humans, Hypothalamus metabolism, Interleukin-1beta metabolism, Receptors, Interleukin-1 Type I metabolism, Serotonin metabolism, Aggression, Defense Mechanisms, Hypothalamus immunology, Interleukin-1beta immunology, Receptors, Interleukin-1 Type I immunology, Serotonin immunology, Synaptic Transmission immunology
- Abstract
During the past decade, a great deal of data has accumulated supporting the notion that cytokines interact to regulate several aspects of social and emotional behaviour. There are reports of a positive correlation between cytokine levels and aggressive behaviour in healthy populations, and clinical reports describe an increase of aggressive traits in patients who receive cytokine immunotherapy. Interleukin-1beta released during an immune response acts as messenger that helps to modulate behaviour by influencing relevant neurotransmitter systems, and in some cases, by directly acting within the brain. In this site, IL-1beta exerts its actions by acting through 5-HT2 and IL-1 Type I receptors in hypothalamus or by potentially indirect routes, including activation of sensory afferents, and stimulation of cytokine release by brain endothelial cells. This review reports research investigating the relationship between IL-1beta, and the immune and central nervous systems involving or potentially involving defensive aggressive behaviour.
- Published
- 2011
44. Impact of IL-18 on inflammation.
- Author
-
Tripodi D, Maccauro G, Anogeianaki A, Castellani ML, Pandolfi F, Felaco P, Toniato E, De Lutiis MA, Fulcheri M, Tetè S, Galzio R, Salini V, Caraffa A, Antinolfi P, Frydas I, Sabatino G, and Shaik-Dasthagirisaheb YB
- Subjects
- Animals, Dendritic Cells immunology, Humans, Inflammation immunology, Keratinocytes immunology, Kupffer Cells immunology, Lipopolysaccharides pharmacology, Lymphocyte Activation drug effects, Lymphocyte Activation immunology, Arthritis, Rheumatoid immunology, Hypersensitivity immunology, Interleukin-18 immunology
- Abstract
IL-18 is produced by many cell types, such as Kupffer cells, keratinocytes, macrophages, dendritic cells, and activated T cells stimulated by LPS. It is an important regulator of both innate and acquired immune responses. IL-18 plays a central role in rheumatoid arthritis since the T cells and macrophages that invade the synovial. These finding support a role for IL-18 in inflammation, allergy and immune diseases.
- Published
- 2011
45. Vitamins and mast cells.
- Author
-
Anogeianaki A, Castellani ML, Tripodi D, Toniato E, De Lutiis MA, Conti F, Felaco P, Fulcheri M, Theoharides TC, Galzio R, Caraffa A, Antinolfi P, Cuccurullo C, Ciampoli C, Felaco M, Cerulli G, Pandolfi F, Sabatino G, Neri G, and Shaik-Dasthagirisaheb YB
- Subjects
- Animals, Humans, Mast Cells physiology, Vitamin B 6 pharmacology, Vitamin D pharmacology, Vitamin E pharmacology, Immune System drug effects, Mast Cells drug effects, Vitamins pharmacology
- Abstract
The immune system is a highly complex, intricately regulated group of cells whose integrated function is essential to health. The mast cell inflammatory response is characterized by an early phase with massive discharge of mediators stored in cytoplasmic secretory granules. Through multigranular/compound exocytosis and a late phase that involves generation of arachidonic acid metabolites and de novo synthesis of cytokines/chemokines and growth factors. Vitamins have been shown to have a protective effect on the body's immune cells. Vitamin C and E are necessary in allergic disease treatment where mast cells are involved. In addition, ascorbic acid and pyridoxine are useful compounds for the treatment of inflammatory disorder of the respiratory airways. Here we revisited the inter-relationship between vitamins and mast cells.
- Published
- 2010
- Full Text
- View/download PDF
46. Interrelationship between vitamins and cytokines in immunity.
- Author
-
Castellani ML, Shaik-Dasthagirisaheb YB, Tripodi D, Anogeianaki A, Felaco P, Toniato E, De Lutiis MA, Fulcheri M, Tetè S, Galzio R, Salini V, Caraffa A, Antinolfi P, Frydas I, Sabatino G, and Kempuraj D
- Subjects
- Animals, Avitaminosis immunology, Humans, Immunity, Innate, Infections immunology, Inflammation immunology, Cytokines immunology, Vitamins immunology
- Abstract
Cytokines are important proteins that modulate immunity and inflammation. Vitamins are also involved in immunity and inflammation. They are found to restore the ability of some cells to produce certain cytokines. Vitamin deficiency appears to affect the mechanism of immune cells, though the impact of reduced cytokine response in vitamin malnutrition is not clear. Vitamin D is involved in many medical conditions, such as infections and inflammation, and mediates innate immunity. Deficiency of vitamin D increases the risk of infectious and inflammatory diseases. In addition, this vitamin modulates Treg function and IL-10 production which is important for therapeutic treatment. Vitamin A increases inflammatory response and is involved in tissue damage; moreover, vitamin A is a key modulator of TGFbeta which can suppress several cytokines. Vitamin E, an anti-ageing compound, is associated with a defect of naive T cells and may inhibit some inflammatory compounds such as prostaglandin generation.
- Published
- 2010
47. VEGF, substance P and stress, new aspects: a revisited study.
- Author
-
Castellani ML, Galzio RJ, Felaco P, Tripodi D, Toniato E, De Lutiis MA, Conti F, Fulcheri M, Conti C, Theoharides TC, Caraffa A, Antinolfi P, Felaco M, Tete S, Pandolfi F, and Shaik-Dasthagirisaheb YB
- Subjects
- Animals, Cytokines biosynthesis, Humans, Stress, Psychological metabolism, Mast Cells physiology, Stress, Psychological immunology, Substance P physiology, Vascular Endothelial Growth Factor A physiology
- Abstract
Mast cells play an essential role in diverse physiological and pathological processes, such as atherosclerosis, malignancy, asthma, pulmonary fibrosis and arthritis, directly interact with bacteria, and appear to play a vital role in host defense against pathogens. Mast cells could be recruited in the inflammatory site, by MCP-1, RANTES and SCF, to selectively secrete proinflammatory molecules; these could include growth factors, histamine, which is mitogenic (H1) and an immunosuppressant (H2), neovascularization agents, such as heparin, IL-8, and VEGF, as well as proteases that could permit new blood vessel formation. Neurogenic inflammation involves vasodilation and plasma protein extravasation in response to neural stimulation. Upon stimulation, sensory neurons release Substance P and other neuropeptides and activate neurokinin-1 receptors leading to plasma protein extravasation from post-capillary venules. Substance P is a neuropeptide that is released from nerve endings in many tissues and plays an important role in immunological and inflammatory states, and it is also a mediator of tissue injury, asthma, arthritis, allergy and autoimmune diseases. SP-positive nerve fibers and mast cell contacts are increased by acute stress in mice leading to dermal mast cell degranulation. VEGF is produced by flammatory cells. IL-33 is the newest inflammatory member of the IL-1 cytokine family and we show here that SP can induce VEGF secretion from mast cells and IL-33 augments the effect of SP in VEGF transcription and translation protein.
- Published
- 2010
48. IL-35, an anti-inflammatory cytokine which expands CD4+CD25+ Treg Cells.
- Author
-
Castellani ML, Anogeianaki A, Felaco P, Toniato E, De Lutiis MA, Shaik B, Fulcheri M, Vecchiet J, Tetè S, Salini V, Theoharides TC, Caraffa A, Antinolfi P, Frydas I, Conti P, Cuccurullo C, Ciampoli C, Cerulli G, and Kempuraj D
- Subjects
- CD4-Positive T-Lymphocytes cytology, CD4-Positive T-Lymphocytes drug effects, Cell Differentiation, Cell Division drug effects, Cytokines drug effects, Cytokines physiology, Humans, Inflammation physiopathology, Interleukin-12 pharmacology, T-Lymphocytes, Helper-Inducer cytology, T-Lymphocytes, Helper-Inducer physiology, T-Lymphocytes, Regulatory cytology, T-Lymphocytes, Regulatory drug effects, CD4-Positive T-Lymphocytes immunology, Interleukins pharmacology, Interleukins physiology, T-Lymphocytes, Regulatory immunology
- Abstract
Interleukin 12 (IL 12) p35/p40 is a heterodimeric cytokine which plays a critical role in inflammation, immunity and tissue proliferation, and also plays a relevant function in T helper (Th) cell polarization and Th1 T-cell differentiation. IL-12 family members, IL-12p70, IL-23, IL-27 and IL-35, play an important role in influencing helper T-cell differentiation. EBV-induced gene 3 can be associated with the p35 subunit of IL-12 to form the EBI3/p35 heterodimer, also called IL-35. It has been shown that IL-35 has biological activity and able to expand CD4+CD25+ Treg cells, suppress the proliferation of CD4+CD25- effector cells and inhibit Th17 cell polarization. IL-35 has been shown to be constitutively expressed by regulatory T (Treg) cells CD4(+)CD25(+)Foxp3(+) and suggested to contribute to their suppressive activity. IL-35 is a crucial mediator which provokes CD4+CD25+ T cell proliferation and IL-10 generation, another well-known anti-inflammatory cytokine, along with TGFbeta cytokine. These studies suggest that IL-35, together with other successfully discovered cytokine inhibitors, represents a new potential therapeutic cytokine for chronic inflammation, autoimmunity and other immunological disorders.
- Published
- 2010
49. Impact of RANTES, MCP-1 and IL-8 in mast cells.
- Author
-
Castellani ML, De Lutiis MA, Toniato E, Conti F, Felaco P, Fulcheri M, Theoharides TC, Caraffa A, Antinolfi P, Conti P, Cuccurullo C, Ciampoli C, Felaco M, Orso C, Salini V, Cerulli G, Kempuraj D, Tetè S, and Shaik B
- Subjects
- Animals, Histamine Release physiology, Humans, Inflammation etiology, Inflammation physiopathology, Inflammation Mediators physiology, Serotonin physiology, Signal Transduction, Chemokine CCL2 physiology, Chemokine CCL5 physiology, Interleukin-8 physiology, Mast Cells physiology
- Abstract
Chemokines are cytokines with chemotactic properties on inflammatory cells and other cell types. RANTES, MCP-1 and related molecules, constitute the C-C class of chemokine supergene family and a group of cytokines produced by hematopoietic cells, while IL-8 constitute the C-X-C class. The roles of most of these chemokines are not well known, although members of the chemokine family are inflammatory agents. The C-C chemokine plays a role in regulating Th-cell cytokine production and leukocyte trafficking. In this study we clearly show that RANTES and MCP-1 are mediators of acute inflammatory responses. Our report describes additional biological activities for RANTES, MCP-1, and IL-8, suggesting that these chemokines play a fundamental role in histamine and serotonin generation and cell function in mast cells.
- Published
- 2010
50. Infections and mast cells.
- Author
-
Felaco P, Toniato E, Castellani ML, Ciampoli C, De Amicis D, Orso C, Cuccurullo C, De Lutiis MA, Patruno A, Speranza L, Felaco M, Caraffa A, Pandolfi F, Antinolfi PL, Cerulli G, Conti F, Fulcheri M, Sabatino G, Conti P, and Shaik Y
- Subjects
- Animals, Humans, Immunoglobulin E metabolism, Infections metabolism, Infections parasitology, Inflammation Mediators metabolism, Mast Cells metabolism, Receptors, IgE metabolism, Immunoglobulin E immunology, Infections immunology, Inflammation Mediators immunology, Mast Cells immunology, Receptors, IgE immunology
- Abstract
Mast cells play a role in various physiological functions: innate and acquired immunity, epithelium remodelling and proliferation, angiogenesis, cancer, inflammation and infections. Mast cells are activated by cross-linking of FcERI molecules, which are involved in the binding of multivalent antigens to the attached IgE molecules, resulting in a variety of responses including the immediate release of potent inflammatory mediators. In addition, mast cell biology consists in the capability to secrete preformed mediators which include biogenic amines and newly synthetized mediators, which include lipid-derived mediators and cytokines. It has been reported that parasite infections induce a systemic immunomodulatory network, including regulatory T cells, pro-inflammatory and anti-inflammatory cytokines, which might play a key role in the allergic phenotype. Here, in this article, we revisited the relationship between mast cells and infections.
- Published
- 2009
Catalog
Discovery Service for Jio Institute Digital Library
For full access to our library's resources, please sign in.