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The main goal of this study was to update the Finnish smoke-diving drill (FSDD) and to measure the physical strain of and recovery from the drill. Furthermore, the aim was to compare the physical strain of contract and professional firefighters and effect of floor materials. The associations between aerobic capacity and physical strain were also studied. The updates made included an added hose pull task and updating the equipment used. Heart rate (HR), oxygen consumption (V̇O2), and blood lactate concentration ([La-]) of 32 professional and 5 contract firefighters were measured before, during, and 10 and 30 min after the updated drill. The mean HR during the drill was 78% and V̇O2 59% of maximum. HR and [La-] had not recovered to baseline levels after 30-minute recovery period. Physical strain was higher among contract firefighters and [La-] accumulation on rough floor surfaces. Better aerobic capacity was associated with reduced physical strain. Practitioner summary: The purpose of this study was to update the Finnish smoke-diving drill. This paper describes the process of updating the drill, and the experimental measurements regarding the metabolic demands of the updated drill. The updates made included adding a hose pull task and updating the equipment used during the drill. [ABSTRACT FROM AUTHOR]

Background Faster recovery from work may help to prevent work-related ill health. Aims To provide a preliminary assessment of the range and nature of interventions that aim to improve recovery from cognitive and physical work. Methods A scoping review to examine the range and nature of the evidence, to identify gaps in the evidence base and to provide input for systematic reviews. We searched for workplace intervention studies that aimed at enhancing recovery. We used an iterative method common in qualitative research to obtain an overview of study elements, including intervention content, design, theory, measurements, effects and cost-effectiveness. Results We found 28 studies evaluating seven types of interventions mostly using a randomized controlled study design. For person-directed interventions, we found relaxation techniques, training of recovery experiences, promotion of physical activity and stress management. For work-directed interventions, there were participatory changes, work–break schedules and task variation. Most interventions were based on the conservation of resources and affect-regulation theories, none were based on the effort–recovery theory. The need for recovery (NfR) and the recovery experiences questionnaires (REQ) were used most often. Study authors reported a beneficial effect of the intervention in 14 of 26 published studies. None of the studies that used the NfR scale found a beneficial effect, whereas studies that used the REQ showed beneficial effects. Three studies indicated that interventions were not cost-effective. Conclusions Feasible and possibly effective interventions are available for improving recovery from cognitive and physical workload. Systematic reviews are needed to determine their effectiveness. [ABSTRACT FROM AUTHOR]

Aims : The potential benefits of workplace physical activity (PA) interventions are in improving both health and important workplace outcomes. Despite the differences in PA level between physically strenuous and inactive work, the literature reporting the effectiveness of the interventions does not usually differentiate physically active and inactive jobs. The aim of the current study was therefore to collect and synthesise research evidence on workplace PA interventions to promote work ability specifically among workers in physically strenuous jobs by means of a scoping review. Methods : The databases Medline, Cochrane Central and Scopus were used to identify interventions to promote work ability by increasing PA among workers in physically strenuous jobs. An iterative method was used to obtain an overview of the study elements and to extract details on the study design, sample, intervention, outcomes and effectiveness. Results : A total of 47 studies evaluating eight categories of interventions were found. Out of these, 18 reported significant effects on work ability. Positive results came from a range of different interventions, including aerobic exercise, strength training, combined aerobic exercise and strength training, stretching, yoga, consultation and tailored physical exercise programmes. Conclusions : Few interventions were effective in promoting work ability by increasing PA among workers in physically strenuous jobs. In particular, trials based on the demands of work, multimodal interventions and applying wearable technology are needed .

Although worksite interventions increase physical activity, little is known about their effects on work ability. The objective of this scoping review was to examine the extent, range and nature of interventions to promote work ability by increasing the physical activity or decreasing the sedentary time of sedentary workers in order to identify implications for health promotion at workplaces. We searched Medline, Cochrane Central, and Scopus and identified 29 intervention studies. Using an iterative method, we provided an overview of the study elements and extracted details on study sample, design, intervention content, outcomes, and beneficial effects. Most of the studies (N = 25) were RCTs. Thirteen studies reported beneficial effects on work ability. Tailored and group-based interventions and interventions including environmental actions were often beneficial (9/13). We identified features of feasible and effective interventions for promoting work ability by increasing the physical activity or decreasing the sedentary time of sedentary workers. However, more studies are needed on the sustainability of these effects, and versatile interventions tailored to workers and work demands., (Copyright © 2019 Elsevier Ltd. All rights reserved.)

Urotensin-II (UT-II) and its receptor (UTR) are involved in the occurrence of different epithelial cancers. In particular, UTR was found overexpressed on colon, bladder, and prostate cancer cells. The conjugation of ligands, able to specifically bind receptors that are overexpressed on cancer cells, to liposome surface represents an efficient active targeting strategy to enhance selectivity and efficiency of drug delivery systems. The aim of this study was to develop liposomes conjugated with UT-II (LipoUT) for efficient targeting of cancer cells that overexpress UTR. The liposomes had a mean diameter between 150 nm and 160 nm with a narrow size distribution (PI ≤ 0.1) and a doxo encapsulation efficiency of 96%. Moreover, the conjugation of UT-II to liposomes weakly reduced the zeta potential. We evaluated UTR expression on prostate (DU145, PC3, and LNCaP) and colon (WIDR and LoVo) cancer cells by FACS and western blotting analysis. UTR protein was expressed in all the tested cell lines; the level of expression was higher in WIDR, PC3, and LNCaP cells compared with LoVo and DU145. MTT cell viability assay showed that LipoUT-doxo was more active than Lipo-doxo on the growth inhibition of cells that overexpressed UTR (PC3, LNCaP, and WIDR) while in LoVo and DU145 cell lines, the activity was similar to or lower than that one of Lipo-doxo, respectively. Moreover, we found that cell uptake of Bodipy-labeled liposomes in PC3 and DU145 was higher for LipoUT than the not-armed counterparts but at higher extent in UTR overexpressing PC3 cells (about 2-fold higher), as evaluated by both confocal and FACS. In conclusion, the encapsulation of doxo in UT-II-targeted liposomes potentiated its delivery in UTR-overexpressing cells and could represent a new tool for the targeting of prostate and colon cancer., Competing Interests: The authors declare that they have no conflicts of interest., (Copyright © 2019 Silvia Zappavigna et al.)

Introduction: Different kinds of shared and activity-based offices are common today and employees' experiences, perceived health, well-being, satisfaction, and productivity have been studied in different types and sizes of environments. Objectives: In this study we aimed to determine employee satisfaction with a multi-space office. We also aimed to find associations between satisfaction with working space and both individual and social well-being. Methods: A total of 91 employees from a multi-space office shared by six municipality-owned companies answered a self-administered questionnaire. Frequencies, percentages, averages, and minimum and maximum values are used to describe the results. We used cross-tabulation and Pearson's Chi-Square test to study the associations and linear regression analysis to create a model describing the variability of workspace satisfaction. Results: The employees were most satisfied with the workspace furniture (82% of respondents) and most dissatisfied with workspace acoustics (44%). Workspace satisfaction was associated with self-satisfaction, good self-perceived future work ability, and good recovery. As regards social factors, workspace satisfaction was associated with good atmosphere among colleagues and good social capital. Satisfaction with acoustics was also associated with good self-perceived future work ability, recovery, and good social capital. Social capital best explained the general variation in workplace satisfaction. Conclusions: Many individual- and social-related well-being outcomes, and especially social capital, were associated with workspace satisfaction. To maintain workplace satisfaction and well-being, attention should be paid to the design, functionality, and management of the used workspaces., (Copyright © 2019 Lusa, Käpykangas, Ansio, Houni and Uitti.)

Purpose: To investigate the association between personal meaning of work and perceived work ability among middle-aged workers with physically strenuous or light work. We evaluated the course of perceived work ability from 31 to 46 years and examined the possible differences in the association between personal meaning of work and perceived work ability at the age of 46 depending on physical workload., Methods: The study population consisted of participants of the Northern Finland Birth Cohort 1966 (n = 4420). Data were collected through questionnaires at 31 and 46 years. The main outcome was perceived work ability (0-7 = poor, 8-10 = good) and the main explanatory measures were physically strenuous work and personal meaning of work. Multivariate logistic regression analyses were adjusted for unhealthy habits, number of diseases, job strain, social support at work, employment history and gender. They were also stratified for the strenuousness of work., Results: Perceived work ability decreased during the 15-year follow-up in both the strenuous and light work groups, and was lowest among workers with strenuous work. Perceived work ability remained poor or decreased in 22% of men and 21% of women in the strenuous work group vs. 14% and 13% in the light work group, respectively. After adjusting for confounders, the participants in both groups who reported low personal meaning of work were at approximately a twofold risk of having poor perceived work ability at 46 years compared to the participants who reported high personal meaning of work., Conclusions: Perceived work ability was significantly lower and deteriorated more during the follow-up among participants with strenuous work. High personal meaning of work was important for good work ability, irrespective of the strenuousness of work.

Hybrid self-assembling nanoparticles (hsaNPs) encapsulating bisphosphonates (BPs) recently showed very promising results in preclinic experiments for the treatment of brain tumor. However, the poor knowledge on the architecture of hybrid nanovectors is certainly one of the main reasons hampering further clinical and industrial development of these technologies. Here we propose to combine different techniques, that is, small angle neutron scattering (SANS) and X-ray Sscattering (SAXS), with cryo-electron transmission microscopy (cryo-TEM) to study the architecture of the final hsaNPs as well as of the four components before the assembling process. Data analysis based on SANS and SAXS experiments suggested a multiple compartment architecture of the final product, consisting of two bilayers sourrounding a core. Structures consisting of two shells surrounding an internal core were also observed in the cryo-TEM analysis. Such high resolution insight, also combined with size distribution and zeta potential of the NPs, provides exhaustive characterization of hsaNPs encapsulating BPs, and it is aimed at supporting further their clinical and industrial development.

Sedentary behavior is defined as sitting or lying with low energy expenditure. Humans in industrialized societies spend an increasing amount of time in sedentary behaviors every day. This has been associated with detrimental health outcomes. Despite a growing interest in the health effects of sedentary behavior at work, associations remain unclear, plausibly due to poor and diverse methods for assessing sedentary behavior. Thus, good practice guidance for researchers and practitioners on how to assess occupational sedentary behavior are needed. The aim of this paper is to provide a practical guidance for practitioners and researchers on how to assess occupational sedentary behavior. Ambulatory systems for use in field applications (wearables) are a promising approach for sedentary behavior assessment. Many different small-size consumer wearables, with long battery life and high data storage capacity are commercially available today. However, no stand-alone commercial system is able to assess sedentary behavior in accordance with its definition. The present paper offers decision support for practitioners and researchers in selecting wearables and data collection strategies for their purpose of study on sedentary behavior. Valid and reliable assessment of occupational sedentary behavior is currently not easy. Several aspects need to be considered in the decision process on how to assess sedentary behavior. There is a need for development of a cheap and easily useable wearable for assessment of occupational sedentary behavior by researchers and practitioners., (Copyright © 2017 Elsevier Ltd. All rights reserved.)