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17 results on '"Lup, Andrew Ng Kay"'

11. Retraction notice to “Anti-inflammatory effect of functionalized sulfasalazine boron nitride nanocages on cardiovascular disease and breast cancer: An in-silico simulation” [J. Mol. Liquids 356 (2022) 119030]

Author

Hachem, Kadda, Opulencia, Maria Jade Catalan, Abdelbasset, Walid Kamal, Sevbitov, Andrey, Kuzichkin, Oleg R., Mohamed, Abdullah, Moazen Rad, Sahar, Salehi, Aref, Kaur, Jupinder, Kumar, Ravinder, Lup, Andrew Ng Kay, and Nia, Ali Arian

Published
2024
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12. The Effect of Curcumin and Cornstarch Biopolymers on the Shelf Life of Fresh Cheese: Physicomechanical and Antimicrobial Properties.

Author

Almajidi, Yasir Qasim, Lup, Andrew Ng Kay, Ramírez‐Coronel, Andrés Alexis, Almulla, Abbas F., Alsudani, Ali, Kadhm, Mustafa Salam, Alqurashi, Yaser E., and Obaid, Rasha Fadhel

Subjects
*EDIBLE coatings, *CORNSTARCH, *CURCUMIN, *BIOPOLYMERS, *ARRAIGNMENT, *CHEESE, *AQUEOUS solutions
Abstract

Natural polymers are used more frequently in packaging as alternatives to synthetic plastics. Cornstarch is one of the cheapest carbohydrate biopolymers that form films with suitable properties and appearance but considerably larger hydrophilicity and low mechanical characteristics compared to synthetic films. Incorporating curcumin into cornstarch films improves mechanical and antimicrobial properties and curcumin release into aqueous solutions of the films. The results show that the introduction of curcumin decreases the water solubility of the edible films from 3.58% to 1.49% and the moisture absorption from 2.87% to 1.94% (p < 0.05) and increases the length of films from 40% to 80% without changing their thickness. Examination of color properties shows that the increased curcumin concentration leads to a decrease in transparency and an increase in the redness and yellowness indices. These properties change from 72.2, 3.5, and 5.1 to 39.2, 21, and 13.7, respectively. The number of mold and yeast colonies in the cheese sample decreases during the storage period of 5 days. Generally, the findings indicate that the bioactive film of corn starch and curcumin (0.5%) can be used as a suitable coating for food products. [ABSTRACT FROM AUTHOR]

Published
2024
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15. Influence of the adsorption of toxic agents on the optical and electronic properties of B12N12 fullerene in the presence and absence of an external electric field.

Author

Soltani, Alireza, Ramezanitaghartapeh, Mohammad, Javan, Masoud Bezi, Baei, Mohammad T., Lup, Andrew Ng Kay, Mahon, Peter J., and Aghaei, Mehrdad

Subjects
ELECTRIC fields, FULLERENES, TIME-dependent density functional theory, OPTICAL properties, BINDING energy, DENSITY functional theory
Abstract

The interaction energies and optoelectronic properties, in the presence and absence of an electric field, have been studied for the interaction of B12N12 with the toxic agents sarin (SF) and chlorosarin (SC) using density functional theory (DFT) and time-dependent density functional theory (TDDFT) calculations. The results demonstrate that the P＝O group of SF and SC molecules can adsorb on the B12N12 with binding energies of −0.75 and −0.79 eV for the PBE functional, respectively. However, the binding energy of SC on B12N12 is slightly higher than that of SF. It was found that the electric field in the +Y direction increases the binding energies of the SF and SC molecules, while the electric field in the +X direction decreases the adsorption energy. Our computational results show the capability of B12N12 fullerene as a sensor for potential applications in the detection of toxic agents (SF and SC) under an external electric field. [ABSTRACT FROM AUTHOR]

Published
2020
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16. Penicillamine functionalized B12N12 and B12CaN12 nanocages act as potential inhibitors of proinflammatory cytokines: A combined DFT analysis, ADMET and molecular docking study

Author

Golestan University of Medical Science, Cao, Yan, Khan, Afrasyab, Balakheyli, Hanzaleh, Lup, Andrew Ng Kay, Taghartapeh, Mohammad Ramezani, Mirzaei, Hassan, Khandoozi, Seyed Reza, Soltani, Alireza, Aghaei, Mehrdad, Heidari, Fatemeh, Sarkar, Shaheen M., Albadarin, Ahmad B., Golestan University of Medical Science, Cao, Yan, Khan, Afrasyab, Balakheyli, Hanzaleh, Lup, Andrew Ng Kay, Taghartapeh, Mohammad Ramezani, Mirzaei, Hassan, Khandoozi, Seyed Reza, Soltani, Alireza, Aghaei, Mehrdad, Heidari, Fatemeh, Sarkar, Shaheen M., and Albadarin, Ahmad B.

Abstract

peer-reviewed, The adsorption of penicillamine (PCA) on pure B12N12 and B12CaN12 nanocages in aqueous and chloroform solvents has been evaluated using density functional theory (DFT) calculations. The interaction of PCA on B12N12 nanocages is chemisorption through its four nucleophilic sites: amine, carbonyl, hydroxyl and thiol. The most stable adsorption configuration was achieved when zwitterionic PCA adsorbs via its carbonyl group in water.

17. Spectroscopic, density functional theory, cytotoxicity and antioxidant activities of sulfasalazine and naproxen drugs combination

Author

Cao, Yan, Khan, Afrasyab, Soltani, Alireza, Erfani-Moghadam, Vahid, Lup, Andrew Ng Kay, Aghaei, Mehrdad, Abdolahi, Nafiseh, Khalili, Mohsen, Cordani, Marco, Balakheyli, Hanzaleh, Tavassoli, Samaneh, Albadarin, Ahmad B., Cao, Yan, Khan, Afrasyab, Soltani, Alireza, Erfani-Moghadam, Vahid, Lup, Andrew Ng Kay, Aghaei, Mehrdad, Abdolahi, Nafiseh, Khalili, Mohsen, Cordani, Marco, Balakheyli, Hanzaleh, Tavassoli, Samaneh, and Albadarin, Ahmad B.

Abstract

peer-reviewed, In this study, we reported preparation and characterization of a new nano product consisting of the combination of two anti-inflammatory drugs: naproxen and sulfasalazine (Sulfoxen) where both are currently used for the treatment of inflammatory disorders. The nano combination product and its structural characterization were obtained by the Fourier transform infrared (FT IR) spectroscopy, X-ray powder diffraction (XRPD), Thermogravimetric analysis (TGA) Differential scanning calorimetry (DSC), Dynamic light scattering (DLS), Atomic force microscopy (AFM), and Field emission scanning electron microscopy (FE-SEM), respectively. The hydrogen bonding between the COOH groups of naproxen (NPX) and sulfasalazine (SSZ) drugs were evaluated by the experimental and theoretical spectra. FESEM and AFM techniques represent that the most particles of Sulfoxen have a solid dense cubical or cuboidal structure and they also have size range of 50–100 nm. The objective was to prepare the nano-formulation of the Sulfoxen with improved antioxidant properties with respect to the two compounds administered separately. We have evaluated the anti-cancer effect of Sulfoxen in comparison to sulfasalazine and naproxen drugs on MCF-7 and KYSE30 cell lines. Interestingly, exposure of the zebrafishes to Sulfoxen (12.5 mM) did not exhibit lethal toxicity compared to the control groups. Therefore, Sulfoxen could contribute to more studies for the possible future clinical use.

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