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Background As a common geriatric chronic disease, sarcopenia has a high prevalence in patients with coronary heart disease (CHD), which increases the risk of adverse events such as falls and fractures, calf circumference, upper arm circumference, and Ishii score have been shown to be valuable in screening for sarcopenia, but are less commonly used in CHD patients. Objective To evaluate the accuracy and consistency of calf circumference, upper arm circumference, and Ishii score in screening for combined sarcopenia in hospitalized elderly patients with CHD. Methods A total of 213 CHD patients treated at the Department of Cardiology, Affiliated Hospital of North Sichuan Medical College from January 1, 2023 to May 31, 2023, were selected for the study, the body composition test instrument was used to detect indicators such as muscle mass and upper arm circumference, the measurement of calf circumference was performed, and Ishii score was calculated simultaneously. Spearman's rank correlation analysis was used to explore the correlation of upper arm circumference, calf circumference and Ishii score with indicators such as muscle mass, the diagnostic effect of upper arm circumference, calf circumference and Ishii score on sarcopenia in different people was analyzed by plotting receiver operating characteristic (ROC) curves, and the optimal diagnostic cut-off values were determined, which were calculated as Kappa values to determine the consistency of the upper arm circumference, calf circumference and Ishii score with the diagnostic criteria of sarcopenia according to the Chinese Expert Consensus (2023) Criteria for the Prevention and Treatment of Sarcopenia in the elderly. Results The prevalence of combined sarcopenia in CHD patients was 27.2% (58/213). In the whole population, upper arm circumference and calf circumference was positively correlated with appendicular skeletal muscle mass, appendicular skeletal muscle mass index, and grip strength (P

Objective: This study aimed to make full use of walnut by-products. Methods: Ultrasonic-assisted ethanol extraction method was used to extract the antioxidant components of walnut shell and distraction wood. The changes of antioxidant components (total phenols and total flavonoids) and antioxidant activities (DPPH, ABTS, hydroxyl radical scavenging ability, Iron reduction antioxidant capacity-FRAP and ferrous ion chelating activity) of walnut by-products extract during the simulated digestion were studied in vitro, and their correlation was analyzed. Results: The total phenols(TPC), total flavonoids(TFC) content, and antioxidant activity of distraction wood were always higher than those of walnut shells (P＜0.05). After simulated in vitro digestion, the TPC and TFC of both walnut shell and distraction wood decreased gradually (Pstomach>intestine (P2+ chelating activity, the antioxidant capacity of the digestive juices showed a significant positive correlation with TPC and TFC (P

Chronic thromboembolic pulmonary hypertension (CTEPH) is a chronic life-threatening disease caused by organized blood clots that narrow or block the pulmonary arteries, leading to redistributions of blood flow and remodeling of the pulmonary microvascular bed. This progressive increase in pulmonary vascular resistance and pulmonary arterial pressure eventually results in right heart failure or even death. Pulmonary endarterectomy (PEA) is considered the preferred treatment for CTEPH. However, approximately 40% of patients are unable to undergo PEA surgery due to distal lesions or complications. Balloon pulmonary angioplasty (BPA) is an angiographically guided catheter intervention that uses appropriately sized balloons to dilate and open narrowed or occluded pulmonary vessels step by step. BPA holds great promise for offering a new treatment option for these patients. This article reviews the clinical efficacy and predictability of postoperative complications of BPA in treating CTEPH, as well as the advances in combined treatment of BPA with PEA or with riociguat, with the aim to provide reference for clinicians in selecting treatment options for CTEPH patients.

The optimization analysis of gears in a hybrid transmission is carried out using the micro-modification module in the simulation platform of system analysis software MASTA，aiming at the vibration and noise problems of gear meshing in hybrid transmission. By comparing the transmission error between gears before and after modification and the contact stress nephogram of the tooth surface, the effectiveness of micro-modification based on system analysis software MASTA is verified, which provides a reliable theoretical basis for actual modification. The analysis results show that the transmission error of the gear is obviously reduced after micro-modification, and the contact stress nephogram of the tooth surface has been improved to a great extent, which plays an active role in reducing the vibration and noise of the gear. Finally, the data collection and comparative analysis of vibration and noise of gears in transmission are carried out. The results show that the corresponding box vibration acceleration and gear noise will be significantly improved after the micro-modification of the gear pair.

Prognosis in pulmonary hypertension is closely associated with right heart function. In the early stage of pulmonary hypertension, the right ventricle can maintain the normal blood flow of the pulmonary circulation by increasing its contractility. As the disease progresses, the right ventricular afterload rises persistently, the right ventricle is gradually decompensated, even right heart failure occurs. Right ventricular-pulmonary arterial coupling refers to a matching between right ventricular contractility and afterload. The impairment of this coupling may be an early marker of right ventricular dysfunction. This article reviews the research progress of its assessment and application in pulmonary hypertension.

BackgroundDirectly or indirectly, individual psychosocial characteristics, motivation, and health consciousness factors help to maintain physical and psychological health through maintaining physical activity.ObjectiveIn the current study, we investigated how fitness apps moderate the links among COVID-19 preventive strategies, virtual reality exercise, physical health, and psychological health in Chinese society.MethodA nationwide online survey across China was conducted under a snowball sampling design from February to June 2022. A total of 3,000 questionnaires were distributed across China via online platforms. A total of 2,795 complete detailed replies were included in the final analysis. Structural equation modeling techniques were employed to analyze the collected data through Smart-PLS 3.0.ResultsIt has been statically proved that all the scales used in this inquiry to determine the mean scores, standard deviation, excess kurtosis, and skewness values were reliable and produced satisfactory results. The overall results (H1: β = 0.385, t = 15.699, p = 0.000; H2: β = 0.159, t = 7.405, p = 0.000; H3: β = 0.122, t = 5.435, p = 0.000; H4: β = 0.143, t = 6.493, p = 0.000; H5: β = 0.157, t = 6.444, p = 0.000; H6: β = 0.184, t = 9.071, p = 0.000; H7: β = 0.192, t = 9.319, p = 0.000; H8: β = 0.235, t = 11.899, p = 0.000; H9: β = −0.114, t = 4.872, p = 0.000; H10: β = 0.042, t = 2.872, p = 0.004; H11: β = 0.041, t = 2.699, p = 0.007) supported our hypothetical model and explained that using fitness apps and virtual reality exercise benefits physical and psychological health.ConclusionThe fitness app’s primary purpose during and after the pandemic is to motivate users to keep up with their regular at-home workouts. Exercise and active living are helpful in the prevention of risk factors associated with physical inactivity.

Oral anticoagulants can effectively reduce the risk of stroke in patients with atrial fibrillation. However, patients with atrial fibrillation and chronic renal insufficiency have an increased risk in both stroke and bleeding, making anticoagulant therapy challenging. Compared with traditional anticoagulant warfarin, non-vitamin K antagonist oral anticoagulants are non-inferior to warfarin in efficacy and safety. They don't require routine monitoring of the international normalized ratio and have better patient compliance. However, all the non-vitamin K antagonist oral anticoagulants are partially metabolized through kidneys to a varying degree, and thus their administration in patients with atrial fibrillation and chronic renal insufficiency is controversial. This review summarizes the administration of oral anticoagulants in these patients to guide clinical practice.

Pulmonary thromboembolism(PTE)is the third most common cause of cardiovascular death. However, only about 20% to 30% of patients with high-risk PTE received systemic thrombolysis in real world, due to concerns about the risks such as major bleeding. Although systemic thrombolysis could decrease all-cause mortality of patients with intermediate-risk PTE, the risk of bleeding outweighs the benefits. Ultrasound-assisted catheter-directed thrombolysis (UA-CDT) could directly deliver thrombolytic drugs to the thrombus with lower doses needed. Meanwhile, ultrasound waves could also enhance thrombolysis. Therefore, UA-CDT is emerging as a new tool, with good efficacy and safety records, for the treatment of PTE. In the present review article, we introduce the mechanism, required device, common protocol, efficacy and safety of UA-CDT and discuss directions for future studies.

C30H48O4, orthorhombic, P212121 (no. 19), a = 12.34133(14) Å, b = 16.50759(15) Å, c = 26.8804(2) Å, V = 5476.23(9) Å3, Z = 8, Rgt(F) = 0.0422, wRref(F2) = 0.0990, T = 293 K.

In the context of China’s dual-carbon goals, energy efficiency in public buildings has become a focal point of public concern. As large-scale public transportation buildings, the indoor thermal comfort and the current state of energy consumption of coach stations are increasingly being emphasized. This research used existing coach stations in the Xi’an region as the object; through on-site investigations and field tests of indoor thermal environments in winter and summer seasons, it was found that the coach stations had energy waste and high energy consumption; the enclosure structures had poor thermal performance; and the stations lacked effective energy-saving measures. Energy-saving transformation strategies were proposed from two aspects: enclosure structures and renewable energy utilization. Using DeST-C for energy consumption, the external walls, roofs, insulation materials, and glass materials were simulated, and nine different combinations of energy-saving schemes were simulated using orthogonal experiments. The optimal scheme was selected based on the comprehensive energy-saving rate and economic analysis results, which included using 80 mm XPS external insulation for the external walls, low-e hollow glass for the windows (low transmittance type), and an 80 mm PUR board for the roof insulation. The energy-saving rate of this scheme was 26.84%. The use of rooftop solar photovoltaic power generation and fresh air heat recovery devices can effectively reduce building energy consumption, and the investment payback period is less than 5 years. The research applications have practical significance for improving the indoor environment of existing coach stations and saving energy consumption.