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136 results on '"Luo, Zhi-Hui"'

4. FPR1 signaling aberrantly regulates S100A8/A9 production by CD14+FCN1hi macrophages and aggravates pulmonary pathology in severe COVID-19.

Author

Wang, Zhongyi, Wang, Yi, Yan, Qing, Cai, Changlin, Feng, Ying, Huang, Qinghan, Li, Ting, Yuan, Shenzhen, Huang, Juan, Luo, Zhi-Hui, and Zhou, Jingjiao

Subjects
TRANSCRIPTION factors, PROTEIN microarrays, GENETIC transcription, EPITHELIAL cells, COMMUNICABLE diseases
Abstract

Excessive alarmins S100A8/A9 escalate the inflammation and even exacerbate immune-driven thrombosis and multi-organ damage. However, the regulatory mechanisms of S100A8/A9 expression in infectious diseases remain unclear. In this study, high-dimensional transcriptomic data analyses revealed a high proportion of CD14+FCN1hi macrophages within the pulmonary niche post-severe SARS-CoV-2 infection. By constructing the S100-coexpression gene list and supervised module scoring, we found that CD14+FCN1hi macrophages presented the highest scores of alarmin S100, and possibly served as the trigger and amplifier of inflammation in severe COVID-19. These CD14+FCN1hi cells lacked the positive regulatory activity of transcription factor PPARγ, and lost their differentiation ability towards mature macrophages. Ex vivo experiments further validated that the epithelial cells with high ORF-3a expression promoted the expression and secretion of S100A8/A9 through ANXA1/SAA1-FPR1 signaling. S100A8/A9 heterodimers, as well as the co-localization of S100A8/A9 with microtubules, were both diminished by the FPR1 inhibitor. Phospho-kinase protein array indicated that STAT3 promoted transcription, and PLC-γ and ERK1/2 pathways were involved in the hetero-dimerization and unconventional secretion of S100A8/A9. Our study highlights the pivotal role of FPR1 signaling in the excessive production of S100A8/A9 and provides a promising target for the prevention and control of severe COVID-19 and post-acute COVID-19 sequelae. CD14+FCN1hi macrophages highly express S100A8/S100A9, which is initiated by FPR1 signaling in severe COVID-19. An FPR1 inhibitor prevents the transcription, hetero-dimerization, and secretion of S100A8/A9 through STAT3/PLC-γ/ERK1/2 pathways. [ABSTRACT FROM AUTHOR]

Published
2024
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7. Research Progress and NMR Spectral Features of Natural C19-Diterpenoid Alkaloids

Author

YIN Tian-peng, LUO Zhi-hui, CAI Le, and DING Zhong-tao

Subjects
C19-diterpenoid alkaloids, nuclear magnetic resonance (NMR)spectroscopy, structural elucidation, Aconitum Delphinium, Electricity and magnetism, QC501-766
Abstract

Majority of diterpenoid alkaloids are C19-diterpenoid alkaloids found in the plants from the genera Aconitum, Delphinium and Consolida (Ranunculaceae). C19-diterpenoid alkaloids have attached lots of research interests due to their complex structures and remarkable pharmacological activities. This paper reviewed the structural features of natural C19-diterpenoid alkaloids reported in literature from 2010 to 2018, focusing on the NMR spectral characteristics of different subtypes of C19-diterpenoid alkaloids and how their structures could be elucidated from the NMR data. The work may provide a reference for the further research and development of C19-diterpenoid alkaloids.

Published
2019
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8. Two new meroterpenoids from the bark of Cinnamomum cassia and their antioxidant activity

Author

Xie, Cai-Hong, Huang, Shang-Xiong, Li, Jin-Feng, Luo, Zhi-Hui, Huang, Geng-Feng, Yan, Bing-Bing, Fan, Hong-Xia, Zheng, Jun-Xia, Zhou, Zheng-Qun, and Gao, Hao

Subjects
Pharmacology, Complementary and alternative medicine, Organic Chemistry, Drug Discovery, Pharmaceutical Science, Molecular Medicine, General Medicine, Analytical Chemistry
Abstract

Two new (1 and 2) meroterpenoids were isolated from the bark of Cinnamomum cassia. Their structures were determined by spectroscopic analyses and chemical methods. Antioxidant activities of 1 and 2 were evaluated by the ORAC and DPPH radical scavenging assays, and the results revealed that compound 2 displayed oxygen radical absorbance capacity. The discovery of compounds 1 and 2 added new members of this kind of natural product.

Published
2023

12. Clinical efficacy observation of ‘Tong Du Yun Pi’ manipulation for infantile diarrhea in autumn

Author

Chen Song, Yan Peng, Tian Ling-ling, Luo Zhi-hui, Xu Chi-cheng, Wang Kun-xiu, and Chen Bo-lin

Subjects
medicine.medical_specialty, business.industry, Traditional Chinese medicine, Gastroenterology, Complementary and alternative medicine, Pediatric massage, Oral administration, Internal medicine, medicine, Acupuncture, Vomiting, Item score, Clinical efficacy, Infantile diarrhea, medicine.symptom, business
Abstract

To observe the clinical efficacy of ‘Tong Du Yun Pi’ (Governor Vessel-unblocking and spleen-promoting) manipulation in treating infantile diarrhea in autumn. Eighty-four kids were divided into a control group and an observation group using the random number table method, with 42 cases in each group. The control group was intervened by oral administration of montmorillonite powder, and the observation group was given additional ‘Tong Du Yun Pi’ pediatric massage (tuina) treatment. After treatment, the traditional Chinese medicine (TCM) symptoms scores, symptom improvement time, clinical efficacy and immune function indicators were compared between the two groups. After treatment, the total effective rate was 95.2% in the observation group versus 76.2% in the control group, and the between-group difference was statistically significant (P

Published
2021

16. Hepatoprotective Effect of Oplopanax elatus Nakai Adventitious Roots Extract by Regulating CYP450 and PPAR Signaling Pathway

Author

Jiang, Xiao-Long, primary, Luo, Pan-Yue, additional, Zhou, Yan-Ying, additional, Luo, Zhi-Hui, additional, Hao, Yue-Jun, additional, Fan, Ming-Zhi, additional, Wu, Xiao-Han, additional, Gao, Hao, additional, Bi, Hui-Chang, additional, Zhao, Zhi-Bin, additional, Lian, Mei-Lan, additional, and Lian, Zhe-Xiong, additional

Published
2022
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23. Cycloartane-type triterpenoids from the root of Astragalus membranaceus var. mongholicus

Author

Luo-Min Xiao, Cao, Pei-Hong, Luo, Zhi-Hui, Bao, Xue-Feng, Zheng-Qun Zhou, Li, Shuang, Sen-Sen Zhao, Zheng, Jun-Xia, Gao, Hao, and Zhi, Hui

Abstract

Three new (1–3) and 11 known (4–14) cycloartane-type triterpenoids were isolated from the root of Astragalus membranaceus var. mongholicus. Their structures were determined by spectroscopic analyses and chemical methods. Cycloartane-type triterpenoids are a class of major bioactive constituents in the root of A. membranaceus var. mongholicus, and the discovery of compounds 1–3 added new members of this kind of natural product.

Published
2020
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25. Additional file 1 of pyMeSHSim: an integrative python package for biomedical named entity recognition, normalization, and comparison of MeSH terms

Author

Luo, Zhi-Hui, Shi, Meng-Wei, Yang, Zhuang, Zhang, Hong-Yu, and Chen, Zhen-Xia

Abstract

Additional file 1 : Supplementary figure 1. Determination of the parameter weight ω for Wang’s algorithm based on the semantic similarity between the 40 MeSH term pairs in the evaluation with GWAS phenotypes. A. Violin plot of the semantic similarity calculated by pyMeSHSim with Jiang and Conrath’s (jiang), Lin’s (lin), Resnik’s (res), Schlicker’s (rel), and) and Wang’s (wang) algorithms. The effect of weight ω for Wang’s algorithm was test by tuning it from 0 to 1 (weight_0.0 to weight_1.0). B. The Pearson’s correlation between the results of pyMeSHSim (Y axis) and meshes (X axis). The 40 MeSH pairs with semantic similarity between 0 ~ 1 were shown in Supplementary Table 2. The weight ω was set to be 0.6 when pyMeSHSim had the highest correlation with meshes for all the algorithms.

Published
2020
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27. Astramalabaricosides A–T, Highly Oxygenated Malabaricane Triterpenoids with Migratory Inhibitory Activity from Astragalus membranaceusvar. mongholicus

Author

Luo, Zhi-Hui, Zeng, Jin, Yu, Hai-Yang, Huang, Hui-Yun, Bao, Xue-Feng, Qin, Sheng-Ying, Chen, Guo-Dong, Zhou, Zheng-Qun, Zhi, Hui, Yao, Xin-Sheng, and Gao, Hao

Abstract

Twenty new malabaricane triterpenoids, astramalabaricosides A–T (1–20), were isolated from the roots of Astragalus membranaceusvar. mongholicus(Astragali Radix). Their structures were determined by spectroscopic analysis, and the use of the circular dichroism exciton chirality method, quantum chemical calculations, and chemical methods. Malabaricane triterpenoids, an unusual group with the 6-6-5-tricyclic core, are distributed in plants (e.g., Simaroubaceae, Polypodiaceae, and Fabaceae), a marine sponge, and fungi, and their number obtained to date is limited. Compounds 1–20were characterized as glycosides with a highly oxygenated side chain, and 13–20were the first cyclic carbonate derivatives among the malabaricane triterpenoids. The stereocluster formed from the continuous hydroxylated chiral carbons in each highly oxygenated side chain and the 6-6-5-tricyclic core system were entirely segregated, and the independent identification of their stereoconfigurations required considerable effort. The migratory inhibitory and antiproliferative activities of 1–20were evaluated by wound-healing and cell-viability assays, respectively. Most compounds showed significant migratory inhibitory activity, and a preliminary structure–activity relationship was developed. Malabaricane triterpenoids are being reported in the genus Astragalusfor the first time.

Published
2022
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40. A new diterpenoid alkaloid from Aconitum hemsleyanum.

Author

Luo, Zhi-Hui, Chen, Yang, Sun, Xin-Yi, Fan, Hua, Li, Wei, Deng, Liang, and Yin, Tian-Peng

Subjects
MONKSHOODS, ALKALOIDS, HERBAL medicine, RANUNCULACEAE
Abstract

A new C19-diterpenoid alkaloid named hemsleyaline (1), along with fourteen known alkaloids (2-15), were isolated from the roots of Aconitum hemsleyanum Pritz. (Ranunculaceae), a herbal medicine in southwest China. Their structures were established on the basis of extensive spectroscopic analyses. Compound 1 showed mild cholinesterase inhibitory effect with IC50 value of 471 ± 9 μM. [ABSTRACT FROM AUTHOR]

Published
2020
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48. On the inefficiency of the quasi-gradient screening algorithm

Author

Sun Xing-ming, Wei Ling-de, and Luo Zhi-hui

Subjects
Mathematical optimization, Partial differential equation, Development (topology), Mechanics of Materials, Applied Mathematics, Mechanical Engineering, Water energy, Inefficiency, Screening algorithm, Mathematics
Abstract

In this paper, the well-knwon quasi-gradient screening algorithm on optimal sequencing cascaded development of water energy resources will be introduced. Then we will given a contraexample in practice and prove the inefficiency of the algorithm in theory.

Published
1992

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