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379 results on '"Luo, Zewei"'

7. Highly Sensitive and Linear Vibration‐Based Flexible Modulus Sensing System for Human Modulus Monitoring and Disease Prevention (Adv. Sensor Res. 5/2024)

Author

Luo, Zewei, primary, Shen, Junhao, additional, Ran, Xu, additional, Huang, Zepeng, additional, Huang, Zaofeng, additional, Wang, Chaolun, additional, Cai, Chunhua, additional, Lyv, Liangjian, additional, Lin, Xin, additional, Sun, Litao, additional, Chu, Junhao, additional, Bi, Hengchang, additional, and Wu, Xing, additional

Published
2024
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28. Towards systems genetic analyses in barley: Integration of phenotypic, expression and genotype data into GeneNetwork

Author

Druka, Arnis, Druka, Ilze, Centeno, Arthur G, Li, Hongqiang, Sun, Zhaohui, Thomas, William TB, Bonar, Nicola, Steffenson, Brian J, Ullrich, Steven E, Kleinhofs, Andris, Wise, Roger P, Close, Timothy J, Potokina, Elena, Luo, Zewei, Wagner, Carola, Schweizer, Günther F, Marshall, David F, Kearsey, Michael J, Williams, Robert W, and Waugh, Robbie

Subjects
Biological Sciences, Genetics, Human Genome, Biotechnology, Chromosome Mapping, Database Management Systems, Databases, Genetic, Genome, Plant, Genotype, Hordeum, Phenotype, Genetics & Heredity
Abstract

BackgroundA typical genetical genomics experiment results in four separate data sets; genotype, gene expression, higher-order phenotypic data and metadata that describe the protocols, processing and the array platform. Used in concert, these data sets provide the opportunity to perform genetic analysis at a systems level. Their predictive power is largely determined by the gene expression dataset where tens of millions of data points can be generated using currently available mRNA profiling technologies. Such large, multidimensional data sets often have value beyond that extracted during their initial analysis and interpretation, particularly if conducted on widely distributed reference genetic materials. Besides quality and scale, access to the data is of primary importance as accessibility potentially allows the extraction of considerable added value from the same primary dataset by the wider research community. Although the number of genetical genomics experiments in different plant species is rapidly increasing, none to date has been presented in a form that allows quick and efficient on-line testing for possible associations between genes, loci and traits of interest by an entire research community.DescriptionUsing a reference population of 150 recombinant doubled haploid barley lines we generated novel phenotypic, mRNA abundance and SNP-based genotyping data sets, added them to a considerable volume of legacy trait data and entered them into the GeneNetwork http://www.genenetwork.org. GeneNetwork is a unified on-line analytical environment that enables the user to test genetic hypotheses about how component traits, such as mRNA abundance, may interact to condition more complex biological phenotypes (higher-order traits). Here we describe these barley data sets and demonstrate some of the functionalities GeneNetwork provides as an easily accessible and integrated analytical environment for exploring them.ConclusionBy integrating barley genotypic, phenotypic and mRNA abundance data sets directly within GeneNetwork's analytical environment we provide simple web access to the data for the research community. In this environment, a combination of correlation analysis and linkage mapping provides the potential to identify and substantiate gene targets for saturation mapping and positional cloning. By integrating datasets from an unsequenced crop plant (barley) in a database that has been designed for an animal model species (mouse) with a well established genome sequence, we prove the importance of the concept and practice of modular development and interoperability of software engineering for biological data sets.

Published
2008

32. T-Shaped Aptamer-Based LSPR Biosensor Using Ω-Shaped Fiber Optic for Rapid Detection of SARS-CoV-2

Author

Luo, Zewei, primary, Cheng, Yue, additional, He, Lu, additional, Feng, Yanting, additional, Tian, Yonghui, additional, Chen, Zhenhua, additional, Feng, Yaqiang, additional, Li, Yongxin, additional, Xie, Wenjun, additional, Huang, Weiwei, additional, Meng, Jiantong, additional, Li, Yu, additional, He, Fan, additional, Wang, Xu, additional, and Duan, Yixiang, additional

Published
2022
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41. Toehold-mediated strand displacement reaction formation of three-way junction DNA structure combined with nicking enzyme signal amplification for highly sensitive colorimetric detection of Salmonella Typhimurium

Author

Zhijun Huang, Qiyue Xie, Yixiang Duan, Luo Zewei, Mengfan Wu, and Xiaqing Wang

Subjects
Salmonella typhimurium, Deoxyribozyme, Biosensing Techniques, 02 engineering and technology, 01 natural sciences, Biochemistry, Signal, Analytical Chemistry, chemistry.chemical_compound, Limit of Detection, Environmental Chemistry, Single displacement reaction, Spectroscopy, Detection limit, Chemistry, 010401 analytical chemistry, DNA, DNA, Catalytic, Nicking enzyme, 021001 nanoscience & nanotechnology, 0104 chemical sciences, Nucleic acid, Colorimetry, 0210 nano-technology, Biological system, Nucleic Acid Amplification Techniques, Signal amplification
Abstract

The detection of Salmonella Typhimurium (S.typhimurium) is of great importance in food safety field. Colorimetric strategy is particularly appealing for S. typhimurium identification because of its user-friendliness and instrument-free. However, the existing colorimetric strategies still meet the challenges of low sensitivity, tedious nucleic acid extraction and expensive labeling processes. Herein, a high sensitivity and label-free colorimetric sensing strategy for S. typhimurium detection without nucleic acid extraction is constructed. Specifically, the proposed strategy is based on three-way junction (3WJ) DNA branched structure combined with nicking enzyme signal amplification (NESA). In the presence of target, cascaded signal amplification is initiated through a series of toehold-mediated strand displacement reactions (TSDRs) to recycle the trigger DNA causing formation of the numerous 3WJ DNA branched structures (3WJ-TSDRs). Then, the branches of 3WJ-TSDRs are fully utilized to hybridize with the DNAzyme signal probes to initiate NESA in the presence of Nt. BbvCI, which making every branch has a function of signal amplification. Finally, DNAzyme signal probes (green) were completely split into two fragments (colorless). The application of NESA in the branches of 3WJ-TSDRs offers a highly sensitive detection of S. typhimurium with a low limit of detection of 42 CFU mL−1. Besides, the colorimetric sensing strategy also shows strong anti-interference. The capability of the colorimetric sensing strategy in spiked samples was also investigated, showing a more intuitive results and fast detection in compare with the traditional plate counting method. With these characteristics, the proposed sensing strategy based on 3WJ-TSDRs and NESA is a promising tool for new point-of-care (POC) applications in food safety.

Published
2020

45. Genome-wide association mapping to candidate polymorphism resolution in the unsequenced barley genome

Author

The AGOUEB Consortium, Cockram, James, White, Jon, Zuluaga, Diana L., Smith, David, Comadran, Jordi, Macaulay, Malcolm, Luo, Zewei, Kearsey, Mike J., Werner, Peter, Harrap, David, Tapsell, Chris, Liu, Hui, Hedley, Peter E., Stein, Nils, Schulte, Daniela, Steuernagel, Burkhard, Marshall, David F., Thomas, William T. B., Ramsay, Luke, Mackay, Ian, Balding, David J., Waugh, Robbie, O'Sullivan, Donal M., and Doebley, John

Published
2010

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