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3. Application progress and challenges of artificial intelligence in organoid research

Author

WU Hongji, WANG Haixia, WANG Ling, LUO Xiaogang, ZOU Dongling

Subjects
organoids, artificial intelligence, machine learning, precision medicine, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282
Abstract

Organoids, recognized as invaluable models in tumor and stem cell research, assume a pivotal role in the meticulous analysis of diverse datasets pertaining to their growth dynamics, drug screening processes and related phenomena. However, the manual scrutiny and conventional statistical methodologies employed in handling organoid data often grapple with challenges such as diminished precision and efficiency, heightened complexity, escalated human resource requirements, and a degree of subjectivity. Acknowledging the remarkable efficacy of artificial intelligence (AI) in the realms of biology and medicine, the incorporation of AI into organoid research stands poised to enhance the objectivity, precision and expediency of analyses. This integration empowers organoids to more effectively fulfill objectives such as disease modeling, drug screening and precision medicine. Notably, significant strides have been made in AI-driven analyses of organoid image data. The amalgamation of deep learning into image analysis facilitates a more meticulous delineation of the microstructural intricacies and nuanced changes within organoids, achieving a level of accuracy akin to that of experts. This not only elevates the precision of organoid morphology and growth recognition, but also contributes to substantial time and cost savings in research endeavors. Furthermore, the infusion of AI technology has yielded breakthroughs in the processing of organoid omics data, resulting in heightened efficiency in data processing and the identification of latent gene expression patterns. This furnishes novel tools for comprehending cellular development and unraveling the intricate mechanisms underlying various diseases. In addition to image data, AI techniques applied to diverse organoid datasets, encompassing electrical signals and spectra, have realized an unbiased classification of organoid types and states, embarking on a comprehensive journey towards characterizing organoids holistically. In the pivotal domain of drug screening for organoids, AI emerges as a stalwart companion, providing robust support for real-time process monitoring and result prediction. Leveraging high-content microscopy images and sophisticated deep learning models, researchers can dynamically monitor organoid responses to drugs, effecting non-invasive detection of drug impacts and amplifying the precision and efficiency of drug screening processes. Despite the significant strides made by AI in organoid research, challenges persist, encompassing hurdles in data acquisition, constraints in sample quality and quantity, and quandaries associated with model interpretability. Overcoming these challenges necessitates dedicated future research efforts aimed at enhancing data consistency, fortifying model interpretability, and exploring methodologies for the seamless fusion of multimodal data. Such endeavors are poised to usher in a more comprehensive and dependable application of AI in organoid research. In summation, the integration of AI technology introduces unparalleled opportunities to organoid research, resulting in noteworthy advancements. Nevertheless, interdisciplinary research and collaborative efforts remain imperative to navigate challenges and propel the more profound integration of AI into organoid research. The future holds promise for AI to assume an even more prominent role in advancing organoid research toward clinical translation and precision medicine.

Published
2024
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4. Development and Commissioning of a Compact Cosmic Ray Muon Imaging Prototype

Author

Luo, Xujia, Wang, Quanxiao, Qin, Kemian, Tian, Heng, Fu, Zhiqiang, Zhao, Yanwei, Shen, Zhongtao, Liu, Hao, Fu, Yuanyong, Liu, Guorui, Yao, Kaiqiang, Qian, Xiangping, Rong, Jian, Zhang, Weixiong, Luo, Xiaogang, Liu, Chunxian, Tian, Xiangsheng, Yu, Minghai, Wu, Feng, Chen, Jingjing, Liu, Juntao, and Liu, Zhiyi

Subjects
Physics - Instrumentation and Detectors, Physics - Applied Physics
Abstract

Due to the muon tomography's capability of imaging high Z materials, some potential applications have been reported on inspecting smuggled nuclear materials in customs. A compact Cosmic Ray Muons (CRM) imaging prototype, Lanzhou University Muon Imaging System (LUMIS), is comprehensively introduced in this paper including the structure design, assembly, data acquisition and analysis, detector performance test, and material imaging commissioning etc. Casted triangular prism plastic scintillators (PS) were coupled with Si-PMs for sensitive detector components in system. LUMIS's experimental results show that the detection efficiency of an individual detector layer is about 98%, the position resolution for vertical incident muons is 2.5 mm and the angle resolution is 8.73 mrad given a separation distance of 40.5 cm. Moreover, the image reconstruction software was developed based on the Point of Closest Approach (PoCA) to detect lead bricks as our target. The reconstructed images indicate that the profile of the lead bricks in the image is highly consistent with the target. Subsequently, the capability of LUMIS to distinguish different materials, such as Pb, Cu, Fe, and Al, was investigated as well. The lower limit of response time for rapidly alarming high-Z materials is also given and discussed. The successful development and commissioning of the LUMIS prototype have provided a new solution option in technology and craftsmanship for developing compact CRM imaging systems that can be used in many applications.

Published
2022
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