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At present, to settle the question of excessive noise in the speech signal during the call of mobile devices in China, the research proposes that the Wiener filter and the generative adversarial network are combined into the IGAN algorithm. Firstly, the Wiener filter regularization algorithm is introduced to construct the preprocessing model of the speech signal; then the preprocessing model is fused with the generative adversarial network algorithm to construct the denoising model. Finally, the performance analysis and simulation experiments of the application effect of the model are carried out. The results show that in the experiment comparing IGAN with five traditional algorithms, when the SNR ratio is increased to 17.5 dB, the MOS and PESQ scores under the IGAN method can reach 4.9 and 3.5 respectively, and the DNN effect is second only to IGAN. Other algorithms perform poorly. Then compare the number of iterations and the loss value between the two. When the network voice signal begins to converge, the loss value corresponding to DNN is 1.132; while the loss value of IGAN is about 0.573, it can be found that the loss value of IGAN has dropped by half, which shows that IGAN Build the model with a smaller loss value. And IGAN tends to converge when iteratively is performed for about 200 times, and the average peak SNR can reach up to 33.85 dB, an increase of nearly 1.02 dB, and the effect is remarkable. This all shows that the IGAN algorithm has the best denoising performance for network speech signals, improves the denoising efficiency, and is conducive to obtaining a denoising signal with a higher fit with the clean signal, so that mobile devices can better serve the people. [ABSTRACT FROM AUTHOR]

Introduction: Hutchinson-Gilford progeria syndrome is a rare pediatric genetic syndrome with an incidence of one per eight million live births. The disorder is characterized by premature aging, generally leading to death due to myocardial infarction or stroke at approximately 13.4 years of age. The genetic diagnosis and special clinical manifestation in two Han Chinese siblings observed at our clinic for genetic counseling are described in this report. We screened the LMNA gene in these two siblings as well as in their unaffected parents. A homozygous mutation R527C was identified in the affected siblings, and both parents were heterozygous for this variant.Case Presentation: In case 1, the elder 10-year-old female sibling showed the classic physical and radiological changes of Hutchinson-Gilford progeria syndrome in addition to a considerable overlap with the phenotype of mandibuloacral dysplasia.In case 2, the younger male sibling had begun to show some early physical changes at age six months.Conclusion: The phenotypic findings in the patients we describe here widen the clinical spectrum of Hutchinson-Gilford progeria syndrome symptoms, providing further recognition of the phenotypic range of LMNA-associated diseases. [ABSTRACT FROM AUTHOR]