Search

Objective: To detect the relationship between CTGF in the bone marrow of MM patients and osteolytic lesion of myeloma, moreover, to investigate the clinical significance of CTGF in MM., Methods: Fifity-four MM patients treated in our hospital from March 2019 to April 2020 were enrolled, and 28 healthy volunteers were selected as the control group. The plasma in bone marrow of the patients was collected, and the ELISA was used to detect the level of CTGF in bone marrow plasma and the relationship between its and clinical characteristics were statistically analyzed., Results: The CTGF level of MM patients was significantly higher than those in the healthy control group (P<0.001); the CTGF level in male patients was higher than that in female patients (P=0.007); the CTGF level in MM patients with osteolytic lesions was significantly higher than patients without osteolytic lesions and controls (P=0.007, P=0.001). The CTGF level in MM patients was positively correlated with the number of bone lesions (P<0.001, r=0.52). CTGF levels in patients with ≥3 bone lesions were significantly higher than those with <3 bone lesions and without bone lesions (P=0.014, P=0.002). ROC curve result showed that CTGF expression level shows a significant diagnostic value for MM bone disease (P<0.001)., Conclusion: The abnormally high expression of CTGF level in MM patients is related to the degree of myelomas osteolytic lesions and can reflect the progress of MM.

Objective: To compare the curative effect of arthroscopic and open surgeries for retrograde intramedullary interlocking nails(RIIN) in the treatment of femoral supracondylar fracture., Methods: A total of 40 patients with femoral supracondylar fracture underwent either arthroscopic (n=20) or open surgeries (n=20) for rRIIN., Results: The operation time, surgical blood loss and bone union time in arthroscopic group was less than that in the open surgery group (P<0.05). Follow-up of the patients for 10.3+/-3.6 months revealed excellent results in 15 cases, good in 3 cases, and acceptable in 1 case in the arthroscopic group, according to the Kolmert criteria, while excellent in 7, good in 14, acceptable in 4 and poor in 2 cases in the open surgery group, without statistically significances in the rate of good or excellent outcomes between the two groups (90.0% vs 75.0%, P=0.246)., Conclusion: Compared with open surgery, RIIN shortens the operation time, reduces intraoperative blood loss and accelerates bone union, thus benefiting the recovery of knee joint functions.