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29 results on '"Luo, Jizhuang"'

13. Risk stratification model for patients with stage I invasive lung adenocarcinoma based on clinical and pathological predictors

Author

Wang, Yiyang, Zheng, Difan, Luo, Jizhuang, Zhang, Jie, Pompili, Cecilia, Ujiie, Hideki, Matsuura, Natsumi, Chen, Haiquan, Yao, Feng, Wang, Yiyang, Zheng, Difan, Luo, Jizhuang, Zhang, Jie, Pompili, Cecilia, Ujiie, Hideki, Matsuura, Natsumi, Chen, Haiquan, and Yao, Feng

Abstract

Background: The aim of this study was to propose a new kind of pathological classification and further establish a prognostic model for resected stage I invasive adenocarcinoma (IADC). Methods: Clinicopathological data were collected from 2 hospitals. The new proposed pathological reclassification was defined according to certain subtype instead of a predominant one. Survival curves were plotted by Kaplan-Meier analysis. Cox regressions were analyzed for recurrence-free survival (RFS) and overall survival (OS), through which prognostic scores and stratification models were established. The comparison between risk models and the eighth edition of tumor, node, metastasis (TNM) classification was conducted through receiver operating characteristic curves (ROC), as identified by the area under the curve (AUC) and z test. Results: In all, 1,196 patients were enrolled. At multivariable analysis, solid and micropapillary of the new pathological reclassification, along with stage IA3 and IB were independent predictors for poorer RFS. Stage IB and smoking status significantly indicated worse OS. After normalization and standardization of log-hazard ratio (HR), personalized scores were calculated and the risk stratifications with 3 risk groups were generated. Compared with TNM classification, the risk model of RFS showed advantage over early-recurrence prediction (1-year: 0.653 vs. 0.556, P=0.033; 3-year: 0.663 vs. 0.076, P=0.008). No marked difference was observed in long-term RFS or OS. Conclusions: Considering the harboring of certain patterns may be a new concept in adenocarcinoma classification. The risk stratification model based on this pathological classification and the eighth TNM classification showed remarkable superiority over TNM alone in predicting early recurrence of stage I adenocarcinoma. However, TNM classification remained valuable for long-term recurrence and survival prediction.

Published
2021

15. Genetic analyses of differences between solid and nonsolid predominant lung adenocarcinomas

Author

Luo, Jizhuang, Ma, Ke, Shi, Yu, Chen, Zongwei, Zhao, Mengnan, Huang, Yiwei, Wang, Shuai, Xi, Junjie, Zhan, Cheng, Xu, Songtao, and Wang, Qun

Subjects
Gene Expression Profiling, Computational Biology, High-Throughput Nucleotide Sequencing, Adenocarcinoma of Lung, Original Articles, Differentially expressed gene, DNA Methylation, lung adenocarcinoma, Prognosis, solid subtype, Gene Expression Regulation, Neoplastic, differentially mutated gene, Gene Ontology, Mutation, Biomarkers, Tumor, Humans, Original Article, Gene Regulatory Networks, Transcriptome, Genetic Association Studies, Neoplasm Staging
Abstract

Background Solid predominant lung adenocarcinomas (LUAD) have distinct histopathological and clinical characteristics compared with nonsolid subtypes. A comprehensive comparison of altered genes found in solid and nonsolid subtypes has not previously been performed. In this study, we analyzed differences in gene expression, genetic mutations, and DNA methylation to better understand the risk factors for these two subtypes of LUAD. Methods Differentially expressed genes (DEGs) and differentially mutated genes (DMGs) were analyzed from RNA‐seq data downloaded from The Cancer Genome Atlas (TCGA) and Broad Institute database. To understand the functional significance of molecular changes, we examined the DEGs and DMGs with Gene Ontology and Kyoto Encyclopedia of Genes and Genomes pathway analysis. Results A total of 184 patients in the TCGA cohort and 140 patients in the Broad Institute cohort were included in this study. We identified 75 DEGs, of which 15 were upregulated and 56 downregulated in the solid group relative to the nonsolid group. The DEGs were mainly involved in the regulation of water and fluid transport. We discovered 38 significantly differentially expressed genes that overlapped in the two groups. The DMGs were mainly enriched for pathways involved in cell–cell adhesion, cell adhesion, biological adhesion, and hemophilic cell adhesion. We additionally discovered nine significantly methylated genes between solid and nonsolid LUAD. Conclusions Our study identified distinct DEGs, DMGs, and methylation genes for solid and nonsolid LUAD subtypes. These findings improve our understanding of the different carcinogenesis mechanisms in LUAD and will help to develop new therapeutic strategies.

Published
2018

17. 2018 annual report of thoracic surgery service at Shanghai Chest Hospital

Author

Wang, Yiyang, primary, Luo, Jizhuang, additional, Yang, Yu, additional, Cheng, Xinghua, additional, Chen, Tianxiang, additional, Yao, Feng, additional, Gu, Zhitao, additional, Sun, Yifeng, additional, Luo, Qingqian, additional, Li, Zhigang, additional, Yang, Jun, additional, Mao, Teng, additional, Fu, Shijie, additional, Wang, Rui, additional, Zhang, Jie, additional, Zhao, Heng, additional, Yu, Yongchun, additional, Pan, Changqing, additional, and Fang, Wentao, additional

Published
2019
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22. Analysis of the clinicopathological characteristics, genetic phenotypes, and prognostic of pure mucinous adenocarcinoma.

Author

Chen, Zhencong, Li, Ming, Ma, Ke, Shang, Guoguo, Liang, Jiaqi, Yin, Jiacheng, Luo, Jizhuang, Zhan, Cheng, Shi, Yu, and Wang, Qun

Subjects
MUCINOUS adenocarcinoma, PHENOTYPES, THORACIC surgery, GENE ontology, MULTIVARIATE analysis, UNIVARIATE analysis
Abstract

Background: Primary pure mucinous adenocarcinoma of the lung (PMA) is a rare subtype. However, correlations between clinicopathological features and genetic phenotypes with survival have not been described comprehensively. Methods: Pure mucinous adenocarcinoma patient information collected from the Surveillance, Epidemiology, and End Results (SEER) database, the Department of Thoracic Surgery, Zhongshan Hospital, Fudan University (FDZSH), and the Cancer Genome Atlas (TCGA) were extracted, evaluated, and compared with other lung adenocarcinomas (LUAD) patient data. Gene Ontology and Kyoto Encyclopedia of Genes and Genomes pathway analyses were performed to explore the functional importance of underlying molecular changes. Overall survival (OS) was evaluated with the Kaplan‐Meier method. Univariate and multivariate analysis through Cox proportional hazard regression identified risk factors that predicted OS, and the results were used to construct a nomogram to predict OS for PMA patients. Results: Overall, 3622 patients, 41 patients, and 15 patients with PMA were identified from the SEER, FDZSH, and TCGA databases, respectively. There were 345 differentially expressed genes, 30 differentially mutated genes and 72 differentially methylated genes were identified between PMA and other LUAD samples. In the SEER database, PMA had a better prognosis compared to other LUAD. Compared with patients with other LUAD, patients with PMA exhibited unique clinicopathological features, including fewer grade III/IV tumors, less pleural invasion, more early‐stage cancer, and more lower lobe carcinomas. Multivariate analyses showed that age, race, T stage, N stage, surgery, and chemotherapy were independent risk factors. The nomogram had a calibration index of 0.724. Conclusions: Our research identified unique clinicopathological characteristics and genetic phenotypes for PMA and other LUAD. The nomogram accurately predicted OS. [ABSTRACT FROM AUTHOR]

Published
2020
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28. Solid predominant histologic subtype and early recurrence predict poor postrecurrence survival in patients with stage I lung adenocarcinoma

Author

Luo, Jizhuang, primary, Wang, Rui, additional, Han, Baohui, additional, Zhang, Jie, additional, Zhao, Heng, additional, Fang, Wentao, additional, Luo, Qingquan, additional, Yang, Jun, additional, Yang, Yunhai, additional, Zhu, Lei, additional, Chen, Tianxiang, additional, Cheng, Xinghua, additional, Huang, Qingyuan, additional, Wang, Yiyang, additional, Zheng, Jiajie, additional, and Chen, Haiquan, additional

Published
2016
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29. Solid predominant histologic subtype and early recurrence predict poor postrecurrence survival in patients with stage I lung adenocarcinoma.

Author

Luo J, Wang R, Han B, Zhang J, Zhao H, Fang W, Luo Q, Yang J, Yang Y, Zhu L, Chen T, Cheng X, Huang Q, Wang Y, Zheng J, and Chen H

Subjects
Adenocarcinoma of Lung, Aged, Female, Humans, Male, Middle Aged, Neoplasm Metastasis, Neoplasm Staging, Prognosis, Proportional Hazards Models, Retrospective Studies, Survival Analysis, Adenocarcinoma pathology, Lung Neoplasms pathology, Neoplasm Recurrence, Local pathology
Abstract

Introduction: This study investigated the correlation between histologic predominant pattern and postrecurrence survival (PRS), and identified the clinicopathologic factors influencing PRS in patients with completely resected stage I lung adenocarcinoma., Methods: A total of 136 stage I lung adenocarcinoma patients who experienced tumor recurrence after completely resection were included in this study. To analysis the association between histologic predominant pattern and PRS, invasive adenocarcinomas with mixed histologic components were divided into 2 groups: solid and nonsolid group (including lepidic, acinar, papillary, micropapillary) based on the histologic predominant pattern. PRS was analyzed to identify the prognostic predictors using the Kaplan-Meier approach and multivariable Cox models., Results: For all stage I invasive adenocarcinoma patients, the majority of postsurgical recurrences occurred within 2 years. Patients with solid predominant histological pattern were associated with unfavorable PRS (HR, 2.40; 95%CI 1.13-5.08, p=.022). There was a significant difference for poor PRS for patients who diagnosed tumor recurrence shorter than 12 months after surgery (HR, 2.34; 95%CI 1.12-4.90, p=.024). Extrathoracic metastasis was associated with poor media PRS in univariable analysis (p =.011), however, there was no significant PRS difference in multivariable analysis (HR, 1.56; 95%CI 0.65-3.73, p=.322) compared with intrathoracic metastasis., Conclusions: Solid predominant histologic subtype and recurrence free interval less than 12 months predict worse PRS in patients with stage I lung adenocarcinoma.

Published
2017
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