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13. Autophagy in Muscle Regeneration: Mechanisms, Targets, and Therapeutic Perspective.

Author

Chu, Yun, Yuan, Xinrun, Tao, Yiming, Yang, Bin, and Luo, Jinlong

Subjects
SATELLITE cells, EUKARYOTIC cells, MUSCLE diseases, CELL differentiation, CELLULAR therapy, MUSCLE regeneration
Abstract

Autophagy maintains the stability of eukaryotic cells by degrading unwanted components and recycling nutrients and plays a pivotal role in muscle regeneration by regulating the quiescence, activation, and differentiation of satellite cells. Effective muscle regeneration is vital for maintaining muscle health and homeostasis. However, under certain disease conditions, such as aging, muscle regeneration can fail due to dysfunctional satellite cells. Dysregulated autophagy may limit satellite cell self-renewal, hinder differentiation, and increase susceptibility to apoptosis, thereby impeding muscle regeneration. This review explores the critical role of autophagy in muscle regeneration, emphasizing its interplay with apoptosis and recent advances in autophagy research related to diseases characterized by impaired muscle regeneration. Additionally, we discuss new approaches involving autophagy regulation to promote macrophage polarization, enhancing muscle regeneration. We suggest that utilizing cell therapy and biomaterials to modulate autophagy could be a promising strategy for supporting muscle regeneration. We hope that this review will provide new insights into the treatment of muscle diseases and promote muscle regeneration. [ABSTRACT FROM AUTHOR]

Published
2024
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14. Enhancement of the performance of Ge–air batteries under high temperatures using conductive MOF‐modified Ge anodes.

Author

Zhang, Yuhang, Han, Ya, Deng, Fengjun, Zhao, Tingyu, Liu, Ze, Wang, Dongxu, Luo, Jinlong, and Yu, Yingjian

Subjects
SURFACE passivation, POWER density, EXTREME environments, HIGH temperatures, PASSIVATION
Abstract

Germanium (Ge)–air batteries have gained significant attention from researchers owing to their high power density and excellent safety. However, self‐corrosion and surface passivation issues of Ge anode limit the development of high‐performance Ge–air batteries. In this study, conductive metal‐organic framework (MOF) Ni3(HITP)2 material was synthesized by the gas–liquid interface approach. The Ni3(HITP)2 material was deposited on the surface of the Ge anode to prevent corrosion and passivation reactions inside the battery. At 16°C, the discharge time of Ge anodes protected with MOFs was extended to 59 h at 195 μA cm−2, which was twice that of bare Ge anodes. The positive effect of MOFs on Ge–air batteries at high temperatures was observed for the first time. The Ge@Ni3(HITP)2 anodes discharged over 600 h at 65.0 μA cm−2. The experimental results confirmed that the two‐dimensional conductive MOF material effectively suppressed the self‐corrosion and passivation on Ge anodes. This work provides new ideas for improving the performance of batteries in extreme environments and a new strategy for anode protection in air batteries. [ABSTRACT FROM AUTHOR]

Published
2024
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20. Injectable Self‐Expanding/Self‐Propelling Hydrogel Adhesive with Procoagulant Activity and Rapid Gelation for Lethal Massive Hemorrhage Management (Adv. Mater. 15/2024)

Author

Zhao, Xin, primary, Huang, Ying, additional, Li, Zhenlong, additional, Chen, Jueying, additional, Luo, Jinlong, additional, Bai, Lang, additional, Huang, Heyuan, additional, Cao, Ertai, additional, Yin, Zhanhai, additional, Han, Yong, additional, and Guo, Baolin, additional

Published
2024
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23. N-Acetylcysteine Attenuates Sepsis-Induced Muscle Atrophy by Downregulating Endoplasmic Reticulum Stress.

Author

Chen, Renyu, Zheng, Yingfang, Zhou, Chenchen, Dai, Hongkai, Wang, Yurou, Chu, Yun, and Luo, Jinlong

Subjects
MUSCULAR atrophy, ENDOPLASMIC reticulum, MUSCLE mass, UBIQUITIN ligases, ACETYLCYSTEINE, SKELETAL muscle
Abstract

(1) Background: Sepsis-induced muscle atrophy is characterized by a loss of muscle mass and function which leads to decreased quality of life and worsens the long-term prognosis of patients. N-acetylcysteine (NAC) has powerful antioxidant and anti-inflammatory properties, and it relieves muscle wasting caused by several diseases, whereas its effect on sepsis-induced muscle atrophy has not been reported. The present study investigated the effect of NAC on sepsis-induced muscle atrophy and its possible mechanisms. (2) Methods: The effect of NAC on sepsis-induced muscle atrophy was assessed in vivo and in vitro using cecal ligation and puncture-operated (CLP) C57BL/6 mice and LPS-treated C2C12 myotubes. We used immunofluorescence staining to analyze changes in the cross-sectional area (CSA) of myofibers in mice and the myotube diameter of C2C12. Protein expressions were analyzed by Western blotting. (3) Results: In the septic mice, the atrophic response manifested as a reduction in skeletal muscle weight and myofiber cross-sectional area, which is mediated by muscle-specific ubiquitin ligases—muscle atrophy F-box (MAFbx)/Atrogin-1 and muscle ring finger 1 (MuRF1). NAC alleviated sepsis-induced skeletal muscle wasting and LPS-induced C2C12 myotube atrophy. Meanwhile, NAC inhibited the sepsis-induced activation of the endoplasmic reticulum (ER) stress signaling pathway. Furthermore, using 4-Phenylbutyric acid (4-PBA) to inhibit ER stress in LPS-treated C2C12 myotubes could partly abrogate the anti-muscle-atrophy effect of NAC. Finally, NAC alleviated myotube atrophy induced by the ER stress agonist Thapsigargin (Thap). (4) Conclusions: NAC can attenuate sepsis-induced muscle atrophy, which may be related to downregulating ER stress. [ABSTRACT FROM AUTHOR]

Published
2024
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35. Injectable Antiswelling and High-Strength Bioactive Hydrogels with a Wet Adhesion and Rapid Gelling Process to Promote Sutureless Wound Closure and Scar-free Repair of Infectious Wounds

Author

Zhao, Xin, Luo, Jinlong, Huang, Ying, Mu, Lei, Chen, Jueying, Liang, Zhen, Yin, Zhanhai, Chu, Dake, Han, Yong, and Guo, Baolin

Abstract

Developing injectable antiswelling and high-strength bioactive hydrogels with wet tissue adhesiveness and a rapid gelling process to meet the requirements for rapid hemostasis, sutureless wound closure, and scar-free repair of infected skin wounds continues to have ongoing challenges. Herein, injectable, antibacterial, and antioxidant hydrogel adhesives based on poly(citric acid-co-polyethylene glycol)-g-dopamine and amino-terminated Pluronic F127 (APF) micelles loaded with astragaloside IV (AS) are prepared. The H2O2/horseradish peroxidase (HRP) system is used to cause cross-linking of the hydrogel network through oxidative coupling between catechol groups and chemical cross-linking between the catechol group and the amino group. The hydrogels exhibit a rapid gelling process, high mechanical strength, an antiswelling effect, good antioxidant property, H2O2release behavior, and degradability. In addition, the hydrogels present good wet tissue adhesiveness, high bursting pressure, excellent antibacterial activity, long-term sustained release of AS, and good biocompatibility. The hydrogels perform good hemostasis on mouse liver, rat liver, and rabbit femoral vein bleeding models and achieve much better closure and healing of skin incisions than biomedical glue and surgical sutures. Furthermore, the hydrogel dressing significantly improved the scar-free repair of MRSA-infected full thickness skin defect wounds by modulating inflammation, regulating the ratio of collagen I/III, and improving the vascularization and granulation tissue formation. Thus, AS-loaded hydrogels show huge potential as multifunctional dressings for in vivo hemostasis, sutureless wound closure, and scar-free repair of infected skin wounds.

Published
2023
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39. Development and Validation of a Nomogram for Predicting 28-Day Mortality on Admission in Elderly Patients with Severe Community-Acquired Pneumonia

Author

Song,Yansha, Wang,Xiaocen, Lang,Ke, Wei,Tingting, Luo,Jinlong, Song,Yuanlin, Yang,Dong, Song,Yansha, Wang,Xiaocen, Lang,Ke, Wei,Tingting, Luo,Jinlong, Song,Yuanlin, and Yang,Dong

Abstract

Yansha Song,1,* Xiaocen Wang,1,* Ke Lang,1,* Tingting Wei,1 Jinlong Luo,1 Yuanlin Song,1,2 Dong Yang1,2 1Department of Pulmonary and Critical Care Medicine, Zhongshan Hospital, Fudan University, Shanghai, People’s Republic of China; 2Shanghai Key Laboratory of Lung Inflammation and Injury, Shanghai, People’s Republic of China*These authors contributed equally to this workCorrespondence: Dong Yang; Yuanlin Song, Department of Pulmonary and Critical Care Medicine, Zhongshan Hospital, Fudan University, 180 Fenglin Road, Shanghai, People’s Republic of China, Tel +86 21 64041990, Email yang.dong@zs-hospital.sh.cn; song.yuanlin@zs-hospital.sh.cnIntroduction: There were few studies on the mortality of severe community-acquired pneumonia (SCAP) in elderly people. Early prediction of 28-day mortality of hospitalized patients will help in the clinical management of elderly patients (age ≥ 65 years) with SCAP, but a prediction model that is reliable and valid is still lacking.Methods: The 292 elderly patients with SCAP met the criteria defined by the American Thoracic Society from 33 hospitals in China. Clinical parameters were analyzed by the use of univariable and multivariable logistic regression analysis. A nomogram to predict the 28-day mortality in elderly patients with SCAP was constructed and evaluated using the area under the receiver operating characteristic curve (AUC) and internally verified using the Bootstrap method.Results: A total of 292 elderly patients (227 surviving and 65 died within 28 days) were included in the analysis. Age, Glasgow score, blood platelet, and blood urea nitrogen values were found to be significantly associated with 28-day mortality in elderly patients with SCAP. The AUC of the nomogram was 0.713 and the calibration curve for 28-day mortality also showed high coherence between the predicted and actual probability of mortality.Conclusion: This study provides a nomogram containing age, Glasgow score

Published
2022

40. Low Eosinophil Phenotype Predicts Noninvasive Mechanical Ventilation Use in Patients with Hospitalized Exacerbations of COPD [Corrigendum]

Author

Wei,Tingting, Wang,Xiaocen, Lang,Ke, Chen,Cuicui, Song,Yansha, Luo,Jinlong, Gu,Zhaolin, Hu,Xianglin, Yang,Dong, Wei,Tingting, Wang,Xiaocen, Lang,Ke, Chen,Cuicui, Song,Yansha, Luo,Jinlong, Gu,Zhaolin, Hu,Xianglin, and Yang,Dong

Abstract

Wei T, Wang X, Lang K, et al. J Inflamm Res. 2022;15:1259–1271. The authors have advised that the funding statement on page 1270 is incorrect. An additional funding source was inadvertently omitted by the authors. The text “This work was supported, in part, by National Natural Science Foundation of China (project number 81970069;82170091); Smart Healthcare Project of Zhongshan Hospital, Fudan University (project number 2020ZHZS18)” should read “This work was supported, in part, by State’s Key Project of Research and Development Plan (2017YFC1310602, 2017YFC1310600); National Natural Science Foundation of China (project number 81970069; 82170091); and Smart Healthcare Project of Zhongshan Hospital, Fudan University (project number 2020ZHZS18)”. The authors apologize for this omission. Read the original article

Published
2022

41. Low Eosinophil Phenotype Predicts Noninvasive Mechanical Ventilation Use in Patients with Hospitalized Exacerbations of COPD

Author

Wei,Tingting, Wang,Xiaocen, Lang,Ke, Chen,Cuicui, Song,Yansha, Luo,Jinlong, Gu,Zhaolin, Hu,Xianglin, Yang,Dong, Wei,Tingting, Wang,Xiaocen, Lang,Ke, Chen,Cuicui, Song,Yansha, Luo,Jinlong, Gu,Zhaolin, Hu,Xianglin, and Yang,Dong

Abstract

Tingting Wei,* Xiaocen Wang,* Ke Lang,* Cuicui Chen, Yansha Song, Jinlong Luo, Zhaolin Gu, Xianglin Hu, Dong Yang Department of Pulmonary and Critical Care Medicine, Zhongshan Hospital, Fudan University, Shanghai, People’s Republic of China*These authors contributed equally to this workCorrespondence: Dong Yang; Xianglin Hu, Email yang.dong@zs-hospital.sh.cn; xianglinhero@163.comRationale: Eosinophilic inflammation is related to the progression and outcomes of acute exacerbation of chronic obstructive pulmonary disease (AECOPD). Till now, few studies have focused on low EOS in AECOPD.Objective: To reveal the clinical characteristics, therapeutic responses and prognosis of patients hospitalized of AECOPD with low EOS.Methods: The electronic database of Zhongshan Hospital, Fudan University was used. Cohort 1 included 608 patients with hospitalized AECOPD. Study population 2 consisted of 166 patients with AECOPD admission at least twice. Impact of low EOS on NIMV treatment, length of hospital stays and 12-month AECOPD-related readmission were analyzed with multivariable logistic regression model. Thirty-five hospitalized AECOPD patients were prospectively recruited as cohort 3 to explore the association between EOS and other immune cells using Spearman correlation coefficient for ranked data.Results: EOS level was suppressed on admission in AECOPD patients, and significantly improved after hospitalized treatment (P < 0.05). For inflammatory markers, leucocytes, neutrophils and lactate dehydrogenase levels were higher, while lymphocytes, monocytes and interleukin-6 levels were lower in the low-EOS group than those in the non-low EOS group (P < 0.05). Low EOS (EOS < 50 cells/μL) was an independent risk factor of NIMV use (OR = 1.86, 95% CI = 1.26 ∼ 2.73). The EOS percentage was positively correlated with the T cell percentage (r = 0.46, P < 0.05) and negatively correlated with the natural killer cell percentage (r = &a

Published
2022

48. Preparation, thermal response mechanisms and biomedical applications of thermosensitive hydrogels for drug delivery

Author

Luo, Jinlong, Zhao, Xin, Guo, Baolin, and Han, Yong

Abstract

ABSTRACTIntroductionDrug treatment is one of the main ways of coping with disease today. For the disadvantages of drug management, thermosensitive hydrogel is used as a countermeasure, which can realize the simple sustained release of drugs and the controlled release of drugs in complex physiological environments.Areas coveredThis paper talks about thermosensitive hydrogels that can be used as drug carriers. The common preparation materials, material forms, thermal response mechanisms, characteristics of thermosensitive hydrogels for drug release and main disease treatment applications are reviewed.Expert opinionWhen thermosensitive hydrogels are used as drug loading and delivery platforms, desired drug release patterns and release profiles can be tailored by selecting raw materials, thermal response mechanisms, and material forms. The properties of hydrogels prepared from synthetic polymers will be more stable than natural polymers. Integrating multiple thermosensitive mechanisms or different kinds of thermosensitive mechanisms on the same hydrogel is expected to realize the spatiotemporal differential delivery of multiple drugs under temperature stimulation. The industrial transformation of thermosensitive hydrogels as drug delivery platforms needs to meet some important conditions.

Published
2023
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