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Context:The mechanism of nickel-induced pathogenesis remains elusive. Objective:To examine effects of nickel exposure on plasma oxidative and anti-oxidative biomarkers. Materials and methods:Biomarker data were collected from 154 workers with various levels of nickel exposure and from 73 controls. Correlations between nickel exposure and oxidative and anti-oxidative biomarkers were determined using linear regression models. Results:Workers with a exposure to high nickel levels had significantly lower levels of anti-oxidants (glutathione and catalase) than those with a lower exposure to nickel; however, only glutathione showed an independent association after multivariable adjustment. Discussion and conclusion:Exposure to high levels of nickel may reduce serum anti-oxidative capacity. [ABSTRACT FROM AUTHOR]

Discusses a study that evaluated Asp 13-p21-Ki-ras in the sera of vinyl chloride (VC)-exposed workers in Taiwan using enhanced chemiluminescense Western blotting. How the study was conducted; Results of the study; Discussion of results.