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138 results on '"Luo, Jichang"'

1. An Effective Morphological Analysis Framework of Intracranial Artery in 3D Digital Subtraction Angiography

Author

Zhao, Haining, Wang, Tao, Liu, Shiqi, Xie, Xiaoliang, Zhou, Xiaohu, Hou, Zengguang, Jiao, Liqun, Ma, Yan, Li, Ye, Luo, Jichang, Dong, Jia, Zhang, Bairu, Filipe, Joaquim, Editorial Board Member, Ghosh, Ashish, Editorial Board Member, Prates, Raquel Oliveira, Editorial Board Member, Zhou, Lizhu, Editorial Board Member, Luo, Biao, editor, Cheng, Long, editor, Wu, Zheng-Guang, editor, Li, Hongyi, editor, and Li, Chaojie, editor

Published
2024
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9. Treatment of Intracranial Atherosclerotic Stenosis: Current Debates and Future Directions

Author

LUO Jichang, WANG Tao, and JIAO Liqun

Subjects
intracranial atherosclerotic stenosis, medical treatment, endovascular treatment, stroke, Medicine
Abstract

Intracranial atherosclerotic stenosis (ICAS) is a leading cause of ischemic stroke, especially in Asia. Since the publication of high-quality randomized controlled trials conducted by the United States in 2011, ICAS has been a subject of controversy and concerns. Recently, the results of a randomized controlled trial published in the leading international medical journal compare the effectiveness of endovascular treatment and medical treatment for ICAS in the Chinese population, which has reattracted public attention to this issue. Endovascular therapy is not inferior to medical treatment, and the benefits of endovascular therapy may be greater in drug-refractory patients with hemodynamic disorders.Therefore, this paper systematically discusses ICAS disease characteristics, treatment status, and future directions, suggesting that endovascular therapy may be of further benefit to drug-refractory patients with hemodynamic disorders, and stricter medical management and improved patient compliance will further reduce stroke recurrences and mortality.

Published
2022
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12. Incidence and predictors of restenosis following successful recanalization of non-acute internal carotid artery occlusion in 252 cases

Author

Lu, Guangdong, primary, Wang, Junqing, additional, Wang, Tao, additional, Xu, Xinjuan, additional, Li, Xin, additional, Sun, Xinyi, additional, Wang, Zhengyu, additional, Luo, Jichang, additional, Ma, Yan, additional, Yang, Bin, additional, Gao, Peng, additional, Wang, Yabing, additional, Chen, Yanfei, additional, Liu, Sheng, additional, and Jiao, Liqun, additional

Published
2024
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16. Comparison of drug-coated balloon angioplasty versus standard medical therapy on recurrent stroke and mortality rates among patients with symptomatic intracranial atherosclerotic stenosis: protocol for a systematic review and meta-analysis

Author

Sun, Yixin, primary, Luo, Jichang, additional, Gong, Haozhi, additional, Xu, Ran, additional, Zhang, Xiao, additional, Yang, Bin, additional, Ma, Yan, additional, Wang, Tao, additional, and Jiao, Liqun, additional

Published
2023
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22. PCSK9 increases vulnerability of carotid plaque by promoting mitochondrial dysfunction and apoptosis of vascular smooth muscle cells.

Author

Xu, Ran, Li, Tianhua, Luo, Jichang, Zhang, Xiao, Wang, Tao, Wang, Yabing, Ma, Yan, Yang, Bin, Jia, Jinzhu, Dmytriw, Adam A., Li, Wenjing, and Jiao, Liqun

Subjects
ATHEROSCLEROTIC plaque, VASCULAR smooth muscle, MUSCLE cells, MITOCHONDRIA, APOPTOSIS
Abstract

Background: Proprotein convertase subtilisin/kexin type 9 (PCSK9) has been recognized as a novel lipid‐lowing target. Recent clinical studies suggested the value of inhibiting PCSK9 in decreasing the vulnerability of coronary plaques. However, the evidence of PCSK9‐regulated evolution of unstable carotid plaques is unclear, which has limited the use of PCSK9 inhibitor in carotid plaques. This study aimed to determine the effect and molecular mechanisms of PCSK9 on vulnerability of carotid plaques, to provide potential therapeutic targets for stabilizing carotid plaques. Methods: The expression of PCSK9 in stable and unstable carotid plaques were examined in tissue and plasma. Human aortic vascular smooth muscle cells (VSMCs) and carotid VSMCs were employed to transfect lentivirus for overexpression and knockdown of PCSK9, respectively. Morphological and functional changes of mitochondria were observed by live‐cell imaging. Cell apoptosis was evaluated by propidium iodide staining. RNA‐sequencing and biological examinations were performed to explore and validate the underlying mechanisms. Truncated plasmids were employed to identify the functional domain of PCSK9 in regulation of VSMCs' mitochondrial morphology, function and apoptosis. Results: Clinically, PCSK9 was closely related with vulnerability of human carotid plaques. Increased expression of PCSK9 in human VSMCs was accompanied by higher level of apoptosis. At subcellular level of VSMCs, the morphology of mitochondria was shifted toward the fission state, followed by mitochondrial dysfunction. Inhibition of p38 MAPK activation partially rescued the above morphological and behavioral changes caused by PCSK9. Furthermore, inhibiting of dynamin‐related protein 1 (DRP1) attenuated PCSK9‐related mitochondrial dysfunction and cell apoptosis. The 1‐149aa domain of PCSK9 protein was essential to achieve functional regulation to VSMCs. Conclusion: Our findings demonstrated that PCSK9 induced morphology‐related mitochondrial dysfunction and apoptosis of VSMCs, which may be related to increased vulnerability of carotid plaque. [ABSTRACT FROM AUTHOR]

Published
2024
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25. Patterns and implications of artery remodeling based on high-resolution vessel wall imaging in symptomatic severe basilar artery stenosis

Author

Luo, Jichang, primary, Bai, Xuesong, additional, Tian, Qiuyue, additional, Li, Long, additional, Wang, Tao, additional, Xu, Ran, additional, Gong, Haozhi, additional, Wang, Yabing, additional, Chen, Yanfei, additional, Gao, Peng, additional, Chen, Jian, additional, Yang, Bin, additional, Ma, Yan, additional, Dmytriw, Adam A., additional, and Jiao, Liqun, additional

Published
2023
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26. Correlations between intravascular pressure gradients and cerebral blood flow in patients with symptomatic, medically refractory, anterior circulation artery stenosis: an exploratory study

Author

Li, Long, Yang, Bin, Dmytriw, Adam A, Li, Yanling, Gong, Haozhi, Bai, Xuesong, Zhang, Chao, Chen, Jian, Dong, Jia, Wang, Yabing, Gao, Peng, Wang, Tao, Luo, Jichang, Xu, Xin, Feng, Yao, Zhang, Xiao, Yang, Renjie, Ma, Yan, and Jiao, Liqun

Abstract

BackgroundFractional flow reserve is widely used in coronary disease management, with a threshold of 0.80. However, similar thresholds are unclear in functional assessment of intracranial atherosclerotic stenosis (ICAS).ObjectiveTo investigate the potential threshold values in functional assessment of ICAS by studying the relation between pressure-derived indexes and perfusion parameters derived from arterial spin labeling (ASL).MethodsPatients were consecutively screened between June 2019 and December 2020. The translesional gradient indices were measured by pressure guidewire under resting-state conditions and recorded as mean distal/proximal pressure ratios (Pd/Pa) and translesional pressure difference (Pa−Pd). Preoperative and postoperative cerebral blood flow (CBF) bilaterally and the relative cerebral blood flow ratio (rCBF) were measured and recorded by ASL imaging. Patients were defined as having reversible hemodynamic insufficiency only if the preoperative rCBF was <0.9 and the postoperative rCBF≥0.9. Preoperative and postoperative Pd/Pa or Pa−Pd values of those patients were used to calculate the threshold.ResultsTwenty-five patients (19 men, 6 women) with a mean age of 56.7±9.4 years were analyzed. Seventeen patients (68%) had lesions at the M1 segment of the middle cerebral artery, eight patients (32%) had lesions in the intracranial internal carotid artery. In 14 of the 25 patients, the preoperative rCBF was <0.9 and the postoperative rCBF≥0.9. Cut-off values of Pd/Pa=0.81 and Pa−Pd=8 mm Hg were suggested to be associated with hemodynamic insufficiency.ConclusionsIn a highly selected subgroup with ICAS, cut-off values of translesional pressure gradients (Pd/Pa=0.81 or Pa−Pd=8 mm Hg) were preliminarily established, which may facilitate clinical decision-making in the management of ICAS.

Published
2024
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27. Explore the role of long noncoding RNAs and mRNAs in intracranial atherosclerotic stenosis: From the perspective of neutrophils.

Author

Wang, Yilin, Wang, Tao, Han, Ziping, Wang, Rongliang, Hu, Yue, Yang, Zhenhong, Shen, Tong, Zheng, Yangmin, Luo, Jichang, Ma, Yan, Luo, Yumin, and Jiao, Liqun

Subjects
NON-coding RNA, ATHEROSCLEROSIS, STENOSIS, NEUTROPHILS, MESSENGER RNA
Abstract

CONTEXT: Circulating neutrophils and long noncoding RNAs (lncRNAs) play various roles in intracranial atherosclerotic stenosis (ICAS). OBJECTIVE: Our study aimed to detect differentially expressed (DE) lncRNAs and mRNAs in circulating neutrophils and explore the pathogenesis of atherosclerosis from the perspective of neutrophils. METHODS: Nineteen patients with ICAS and 15 healthy controls were enrolled. The peripheral blood of the participants was collected, and neutrophils were separated. The expression profiles of lncRNAs and mRNAs in neutrophils from five patients and five healthy controls were obtained, and DE lncRNAs and mRNAs were selected. Six lncRNAs were selected and validated using quantitative reverse transcription–polymerase chain reaction (qRT‑PCR), and ceRNA and lncRNA‑RNA binding protein (RBP)‑mRNA networks were constructed. Correlation analysis between lncRNAs and mRNAs was performed. Functional enrichment annotations were also performed. RESULTS: Volcano plots and heat maps displayed the expression profiles and DE lncRNAs and mRNAs, respectively. The qRT‑PCR results revealed that the four lncRNAs showed a tendency consistent with the expression profile, with statistical significance. The ceRNA network revealed three pairs of regulatory networks: lncRNA RP3‑406A7.3‑NAGLU, lncRNA HOTAIRM1‑MVK/IL‑25/ GBF1/CNOT4/ANKK1/PLEKHG6, and lncRNA RP11‑701H16.4‑ZNF416. The lncRNA‑RBP‑mRNA network showed five pairs of regulatory networks: lncRNA RP11‑701H16.4‑TEK, lncRNA RP11‑701H16.4‑MED17, lncRNA SNHG19‑NADH‑ubiquinone oxidoreductase core subunit V1, lncRNA RP3‑406A7.3‑Angel1, and lncRNA HOTAIRM1‑CARD16. CONCLUSIONS: Our study identified and verified four lncRNAs in neutrophils derived from peripheral blood, which may explain the transcriptional alteration of neutrophils during the pathophysiological process of ICAS. Our results provide insights for research related to the pathogenic mechanisms and drug design of ICAS. [ABSTRACT FROM AUTHOR]

Published
2023
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29. Spatial metabolomics identifies lipid profiles of human carotid atherosclerosis

Author

Li, Wei, primary, Luo, Jichang, additional, Peng, Fangda, additional, Liu, Ruiting, additional, Bai, Xuesong, additional, Wang, Tao, additional, Zhang, Xiao, additional, Zhu, Junge, additional, Li, Xu-Ying, additional, Wang, Zhanjun, additional, Liu, Wubin, additional, Wang, Jiyue, additional, Zhang, Liyong, additional, Chen, Xianyang, additional, Xue, Teng, additional, Ding, Chunguang, additional, Wang, Chaodong, additional, and Jiao, Liqun, additional

Published
2023
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33. eIF2α mediated integrated stress response connects multiple intracellular signaling to reprogram vascular smooth muscle cell fate in carotid plaques

Author

Luo, Jichang, primary, Zhang, Xiao, additional, Li, Wenjing, additional, Wang, Tao, additional, Wu, Yujie, additional, Li, Tianhua, additional, Wang, Yilin, additional, Xu, Wenlong, additional, Ma, Yan, additional, Yang, Bin, additional, Luo, Yumin, additional, Yang, Ge, additional, Xu, Ran, additional, and Jiao, Liqun, additional

Published
2022
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35. Impact of conventional lipid-lowering therapy on circulating levels of PCSK9: protocol for a systematic review and meta-analysis of randomised controlled trials

Author

Luo, Jichang, primary, Huang, Tianze, additional, Xu, Ran, additional, Wang, Xue, additional, Yang, Yutong, additional, Li, Long, additional, Zhang, Xiao, additional, Zhang, Yinhang, additional, Yang, Renjie, additional, Wang, Jie, additional, Yang, Hai, additional, Ma, Yan, additional, Yang, Bin, additional, Wang, Tao, additional, and Jiao, Liqun, additional

Published
2022
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37. High-Risk Intracranial Atherosclerotic Stenosis Despite Aggressive Medical Treatment: Protocol for a Prospective Nested Case-Control Study

Author

Wang, Tao, primary, Luo, Jichang, additional, Liu, Changyi, additional, Yang, Bin, additional, Xu, Ran, additional, Li, Long, additional, Yang, Kun, additional, Zhang, Chao, additional, Wang, Yabing, additional, Chen, Yanfei, additional, Gao, Peng, additional, Chen, Jian, additional, Jiao, Liqun, additional, and Ma, Yan, additional

Published
2022
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39. Hemodynamic Versus Anatomic Assessment of Symptomatic Atherosclerotic Middle Cerebral Artery Stenosis: the Relationship Between Pressure Wire Translesional Gradient and Angiographic Lesion Geometry

Author

Li, Long, primary, Yang, Bin, additional, Dmytriw, Adam A., additional, Wang, Tao, additional, Luo, Jichang, additional, Li, Yanling, additional, Ma, Yan, additional, Chen, Jian, additional, Wang, Yabing, additional, Gao, Peng, additional, Feng, Yao, additional, Bai, Xuesong, additional, Zhang, Xiao, additional, Dong, Jia, additional, Yang, Renjie, additional, Jiao, Liqun, additional, and Ling, Feng, additional

Published
2021
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43. Cognitive rehabilitation interventions after stroke: protocol for a systematic review and meta-analysis of randomized controlled trials

Author

Zhao, Qing, primary, Wang, Xue, additional, Wang, Tao, additional, Dmytriw, Adam A., additional, Zhang, Xiao, additional, Yang, Kun, additional, Luo, Jichang, additional, Bai, Xuesong, additional, Jiang, Nan, additional, Yang, Bin, additional, Ma, Yan, additional, Jiao, Liqun, additional, and Xie, Yunyan, additional

Published
2021
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46. Cognitive Rehabilitation Interventions After Stroke: Protocol for a Systematic Review and Meta-analysis of Randomized Controlled Trials

Author

Zhao, Qing, primary, Wang, Xue, additional, Wang, Tao, additional, Dmytriw, Adam A., additional, Zhang, Xiao, additional, Yang, Kun, additional, Luo, Jichang, additional, Bai, Xuesong, additional, Jiang, Nan, additional, Yang, Bin, additional, Ma, Yan, additional, Jiao, Liqun, additional, and Xie, Yunyan, additional

Published
2020
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