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42 results on '"Lung, Maria L."'

3. Data from Monochromosome Transfer and Microarray Analysis Identify a Critical Tumor-Suppressive Region Mapping to Chromosome 13q14 and THSD1 in Esophageal Carcinoma

Author

Ko, Josephine M.Y., primary, Chan, Pui Ling, primary, Yau, Wing Lung, primary, Chan, Ho Kin, primary, Chan, King Chi, primary, Yu, Zhuo You, primary, Kwong, Fung Mei, primary, Miller, Lance D., primary, Liu, Edison T., primary, Yang, Li Chun, primary, Lo, Paulisally H.Y., primary, Stanbridge, Eric J., primary, Tang, Johnny C.O., primary, Srivastava, Gopesh, primary, Tsao, Sai Wah, primary, Law, Simon, primary, and Lung, Maria L., primary

Published
2023
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4. Supplementary Figures S1-S3 from Monochromosome Transfer and Microarray Analysis Identify a Critical Tumor-Suppressive Region Mapping to Chromosome 13q14 and THSD1 in Esophageal Carcinoma

Author

Ko, Josephine M.Y., primary, Chan, Pui Ling, primary, Yau, Wing Lung, primary, Chan, Ho Kin, primary, Chan, King Chi, primary, Yu, Zhuo You, primary, Kwong, Fung Mei, primary, Miller, Lance D., primary, Liu, Edison T., primary, Yang, Li Chun, primary, Lo, Paulisally H.Y., primary, Stanbridge, Eric J., primary, Tang, Johnny C.O., primary, Srivastava, Gopesh, primary, Tsao, Sai Wah, primary, Law, Simon, primary, and Lung, Maria L., primary

Published
2023
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5. Data from A CD90+ Tumor-Initiating Cell Population with an Aggressive Signature and Metastatic Capacity in Esophageal Cancer

Author

Tang, Kwan Ho, primary, Dai, Yong Dong, primary, Tong, Man, primary, Chan, Yuen Piu, primary, Kwan, Pak Shing, primary, Fu, Li, primary, Qin, Yan Ru, primary, Tsao, Sai Wah, primary, Lung, Hong Lok, primary, Lung, Maria L., primary, Tong, Daniel K., primary, Law, Simon, primary, Chan, Kwok Wah, primary, Ma, Stephanie, primary, and Guan, Xin Yuan, primary

Published
2023
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6. Supplementary Figure Legend and Table 1 - 5 from A CD90+ Tumor-Initiating Cell Population with an Aggressive Signature and Metastatic Capacity in Esophageal Cancer

Author

Tang, Kwan Ho, primary, Dai, Yong Dong, primary, Tong, Man, primary, Chan, Yuen Piu, primary, Kwan, Pak Shing, primary, Fu, Li, primary, Qin, Yan Ru, primary, Tsao, Sai Wah, primary, Lung, Hong Lok, primary, Lung, Maria L., primary, Tong, Daniel K., primary, Law, Simon, primary, Chan, Kwok Wah, primary, Ma, Stephanie, primary, and Guan, Xin Yuan, primary

Published
2023
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7. Supplementary Figure 2 from A CD90+ Tumor-Initiating Cell Population with an Aggressive Signature and Metastatic Capacity in Esophageal Cancer

Author

Tang, Kwan Ho, primary, Dai, Yong Dong, primary, Tong, Man, primary, Chan, Yuen Piu, primary, Kwan, Pak Shing, primary, Fu, Li, primary, Qin, Yan Ru, primary, Tsao, Sai Wah, primary, Lung, Hong Lok, primary, Lung, Maria L., primary, Tong, Daniel K., primary, Law, Simon, primary, Chan, Kwok Wah, primary, Ma, Stephanie, primary, and Guan, Xin Yuan, primary

Published
2023
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8. Supplementary Figure 1 from A CD90+ Tumor-Initiating Cell Population with an Aggressive Signature and Metastatic Capacity in Esophageal Cancer

Author

Tang, Kwan Ho, primary, Dai, Yong Dong, primary, Tong, Man, primary, Chan, Yuen Piu, primary, Kwan, Pak Shing, primary, Fu, Li, primary, Qin, Yan Ru, primary, Tsao, Sai Wah, primary, Lung, Hong Lok, primary, Lung, Maria L., primary, Tong, Daniel K., primary, Law, Simon, primary, Chan, Kwok Wah, primary, Ma, Stephanie, primary, and Guan, Xin Yuan, primary

Published
2023
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17. Germline Polymorphisms and Length of Survival of Nasopharyngeal Carcinoma: An Exome‐Wide Association Study in Multiple Cohorts

Author

Guo, Yun‐Miao, primary, Chen, Jie‐Rong, additional, Feng, Yan‐Chun, additional, Chua, Melvin L. K., additional, Zeng, Yanni, additional, Hui, Edwin Pun, additional, Chan, Allen K. C., additional, Tang, Lin‐Quan, additional, Wang, Lin, additional, Cui, Qian, additional, Han, Hui‐Qiong, additional, Luo, Chun‐Ling, additional, Lin, Guo‐Wang, additional, Liang, Yan, additional, Liu, Yang, additional, He, Zhong‐Lian, additional, Liu, Yu‐Xiang, additional, Wei, Pan‐Pan, additional, Liu, Chu‐Jun, additional, Peng, Wan, additional, Han, Bo‐Wei, additional, Zuo, Xiao‐Yu, additional, Ong, Enya H. W., additional, Yeo, Eugenia L. L., additional, Low, Kar Perng, additional, Tan, Gek San, additional, Lim, Tony K. H., additional, Hwang, Jacqueline S. G., additional, Li, Bo, additional, Feng, Qi‐Sheng, additional, Xia, Xiaojun, additional, Xia, Yun‐Fei, additional, Ko, Josephine, additional, Dai, Wei, additional, Lung, Maria L., additional, Chan, Anthony T. C., additional, Lo, Dennis Y. M., additional, Zeng, Mu‐Sheng, additional, Mai, Hai‐Qiang, additional, Liu, Jianjun, additional, Zeng, Yi‐Xin, additional, and Bei, Jin‐Xin, additional

Published
2020
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20. Prospective, Multicenter, Phase 2 Trial of Induction Chemotherapy Followed by Bio-Chemoradiotherapy for Locally Advanced Recurrent Nasopharyngeal Carcinoma

Author

Ng, Wai-Tong, primary, Ngan, Roger K.C., additional, Kwong, Dora L.W., additional, Tung, Stewart Y., additional, Yuen, Kam-Tong, additional, Kam, Michael K.M., additional, Sze, Henry C.K., additional, Yiu, Harry H.Y., additional, Chan, Lucy L.K., additional, Lung, Maria L., additional, and Lee, Anne W.M., additional

Published
2018
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23. Abstract 2298: Methylated gene markers discovered in nasopharyngeal carcinoma by differential methylation hybridization (DMH) in high density CpG island DNA chips

Author

Cheng, Wai Wai, primary, Ngan, Roger K.C., additional, Kwong, Dora L.W., additional, Huang, Tim H.M., additional, Ma, Victor W.S., additional, Law, Stephen C.K., additional, Tse, Loretta, additional, Busson, Pierre, additional, Tsao, George S.W., additional, Lung, Maria L., additional, and Yip, Timothy T.C., additional

Published
2014
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26. Role of p38 MAPKs in Hypericin Photodynamic Therapy-induced Apoptosis of Nasopharyngeal Carcinoma Cells

Author

Chan, Pui S., Koon, Ho K., Wu, Zhen G., Wong, Ricky N.S., Lung, Maria L., Chang, Chi K., Mak, Nai K., Chan, Pui S., Koon, Ho K., Wu, Zhen G., Wong, Ricky N.S., Lung, Maria L., Chang, Chi K., and Mak, Nai K.

Abstract

The present study aims to determine the role of mitogen-activated protein kinases (MAPKs) in hypericin-mediated photodynamic therapy (HY-PDT)-induced apoptosis of the HK-1 nasopharyngeal carcinoma (NPC) cells. HY-PDT was found to induce proteolytic cleavage of procaspase-9 and -3 in HK-1 cells. Apoptotic nuclei were observed at 6 h after PDT whereas B-cell leukemia/lymphoma-2-associated-X-protein (Bax) translocation and formation of Bax channel is responsible for the cell death. Increase in phosphorylation of p38 MAPKs and c-Jun N-terminal kinase 1/2 (JNK1/2) was detected at 15-30 min after HY-PDT. The appearance of phosphorylated form of p38 MAPKs and JNK1/2 was inhibited by the singlet oxygen scavenger l-histidine. HY-PDT-induced cell death was enhanced by the chemical inhibitors for p38 MAPKs (SB202190 and SB203580), but not by the JNKs inhibitor SP600125. Knockdown of the p38 alpha and p38 beta MAPK isoforms by small interfering RNA (siRNA) are more effective than the p38 delta in enhancing PDT-induced cell death. Augmentation of apoptosis by p38 alpha or p38 beta knockdown is also correlated with the increased proteolytic cleavage of procaspase-9 after HY-PDT treatment. Our results suggested that HY-PDT activated p38 MAPKs through the production of singlet oxygen. Inhibition of p38 MAPKs with chemical inhibitors or siRNA enhances HY-PDT-induced apoptosis of the HK-1 NPC cells.

Published
2009

27. Monochromosome transfer and microarray analysis identify a critical tumor-suppressive region mapping to chromosome 13q14 and THSD1 in esophageal carcinoma

Author

Ko, Josephine M.Y., Chan, Pui Ling, Yau, Wing Lung, Chan, Ho Kin, Chan, King Chi, Yu, Zhuo You, Kwong, Fung Mei, Miller, Lance D., Liu, Edison T., Yang, Li Chun, Lo, Paulisally H.Y., Stanbridge, Eric J., Tang, Johnny C.O., Srivastava, Gopesh, Tsao, Sai Wah, Law, Simon, Lung, Maria L., Ko, Josephine M.Y., Chan, Pui Ling, Yau, Wing Lung, Chan, Ho Kin, Chan, King Chi, Yu, Zhuo You, Kwong, Fung Mei, Miller, Lance D., Liu, Edison T., Yang, Li Chun, Lo, Paulisally H.Y., Stanbridge, Eric J., Tang, Johnny C.O., Srivastava, Gopesh, Tsao, Sai Wah, Law, Simon, and Lung, Maria L.

Abstract

Loss of chromosome 13q regions in esophageal squamous cell carcinoma (ESCC) is a frequent event. Monochromosome transfer approaches provide direct functional evidence for tumor suppression by chromosome 13 in SLMT-1, an ESCC cell line, and identify critical regions at 13q12.3, 13q14.11, and 13q14.3. Differential gene expression profiles of three tumor-suppressing microcell hybrids (MCH) and their tumorigenic parental SLMT-1 cell line were revealed by competitive hybridization using 19k cDNA oligonucleolide microarrays. Nine candidate 13q14 tumor-suppressor genes (TSG), including RB1, showed down-regulation in SLMT-1, compared with NE1, an immortalized normal esophageal epithelial cell line; their average gene expression was restored in MCHs compared with SLMT-1. Reverse transcription-PCR validated gene expression levels in MCHs and a panel of ESCC cell lines. Results suggest that the tumor-suppressing effect is not attributed to RB1, but instead likely involves thrombospondin type I domain-containing 1 (THSD1), a novel candidate TSG mapping to 13q14. Quantitative reverse transcription-PCR detected down-regulation of THSD1 expression in 100\% of ESCC and other cancer cell lines. Mechanisms for THSD1 silencing in ESCC involved loss of heterozygosity and promoter hypermethylation, as analyzed by methylation-specific PCR and clonal bisulfite sequencing. Transfection of wild-type THSD1 into SLMT-1 resulted in significant reduction of colony-forming ability, hence providing functional evidence for its growth-suppressive activity. These findings suggest that THSD1 is a good candidate TSG.

Published
2008

28. A CD90+ Tumor-Initiating Cell Population with an Aggressive Signature and Metastatic Capacity in Esophageal Cancer

Author

Tang, Kwan Ho, primary, Dai, Yong Dong, additional, Tong, Man, additional, Chan, Yuen Piu, additional, Kwan, Pak Shing, additional, Fu, Li, additional, Qin, Yan Ru, additional, Tsao, Sai Wah, additional, Lung, Hong Lok, additional, Lung, Maria L., additional, Tong, Daniel K., additional, Law, Simon, additional, Chan, Kwok Wah, additional, Ma, Stephanie, additional, and Guan, Xin Yuan, additional

Published
2013
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34. Monochromosome Transfer and Microarray Analysis Identify a Critical Tumor-Suppressive Region Mapping to Chromosome 13q14 and THSD1 in Esophageal Carcinoma

Author

Ko, Josephine M.Y., primary, Chan, Pui Ling, additional, Yau, Wing Lung, additional, Chan, Ho Kin, additional, Chan, King Chi, additional, Yu, Zhuo You, additional, Kwong, Fung Mei, additional, Miller, Lance D., additional, Liu, Edison T., additional, Yang, Li Chun, additional, Lo, Paulisally H.Y., additional, Stanbridge, Eric J., additional, Tang, Johnny C.O., additional, Srivastava, Gopesh, additional, Tsao, Sai Wah, additional, Law, Simon, additional, and Lung, Maria L., additional

Published
2008
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35. Tumor suppressive role of a 2.4 Mb 9q33–q34 critical region and DEC1 in esophageal squamous cell carcinoma

Author

Yang, Lichun, primary, Leung, Alfred C C, additional, Ko, Josephine M Y, additional, Lo, Paulisally H Y, additional, Tang, Johnny C O, additional, Srivastava, Gopesh, additional, Oshimura, Mitsuo, additional, Stanbridge, Eric J, additional, Daigo, Yataro, additional, Nakamura, Yusuke, additional, Tang, Cecilia M C, additional, Lau, Kwok W, additional, Law, Simon, additional, and Lung, Maria L, additional

Published
2004
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39. Tumor suppressive role of a 2.4?Mb 9q33-q34 critical region and DEC1 in esophageal squamous cell carcinoma.

Author

Yang, Lichun, Leung, Alfred C C, Ko, Josephine M Y, Lo, Paulisally H Y, Tang, Johnny C O, Srivastava, Gopesh, Oshimura, Mitsuo, Stanbridge, Eric J, Daigo, Yataro, Nakamura, Yusuke, Tang, Cecilia M C, Lau, Kwok W, Law, Simon, and Lung, Maria L

Subjects
SQUAMOUS cell carcinoma, ESOPHAGEAL cancer, RODENTS, MICE, GENETICS, EMBRYOLOGY
Abstract

The key genes involved in the development of esophageal squamous cell carcinoma (ESCC) remain to be elucidated. Previous studies indicate extensive genomic alterations occur on chromosome 9 in ESCC. Using a monochromosome transfer approach, this study provides functional evidence and narrows down the critical region (CR) responsible for chromosome 9 tumor suppressing activity to a 2.4?Mb region mapping to 9q33-q34 between markers D9S1798 and D9S61. Interestingly, a high prevalence of allelic loss in this CR is also observed in primary ESCC tumors by microsatellite typing. Allelic loss is found in 30/34 (88%) tumors and the loss of heterozygosity (LOH) frequency ranges from 67 to 86%. Absent to low expression of a 9q32 candidate tumor suppressor gene (TSG), DEC1 (deleted in esophageal cancer 1), is detected in four Asian ESCC cell lines. Stably expressing DEC1 transfectants provide functional evidence for inhibition of tumor growth in nude mice and DEC1 expression is decreased in tumor segregants arising after long-term selection in vivo. There is 74%LOH in the DEC1 region of ESCC primary tumors. This study provides the first functional evidence for the presence of critical tumor suppressive regions on 9q33-q34. DEC1 is a candidate TSG that may be involved in ESCC development.Oncogene (2005) 24, 697-705. doi:10.1038/sj.onc.1208179 Published online 6 December 2004 [ABSTRACT FROM AUTHOR]

Published
2005
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41. A CD90+ Tumor-Initiating Cell Population with an Aggressive Signature and Metastatic Capacity in Esophageal Cancer.

Author

Kwan Ho Tang, Yong Dong Dai, Man Tong, Yuen Piu Chan, Pak Shing Kwan, Li Fu, Yan Ru Qin, Sai Wah Tsao, Hong Lok Lung, Lung, Maria L., Tong, Daniel K., Law, Simon, Kwok Wah Chan, Ma, Stephanie, and Xin Yuan Guan

Subjects
*CANCER cells, *ESOPHAGEAL cancer, *TUMOR growth, *LYMPH node diseases, *METASTASIS
Abstract

Tumor-initiating cells (TIC), also known as cancer stem cells, are regarded widely as a specific subpopulation of cells needed for cancer initiation and progression. TICs have yet to be identified in esophageal tumors that have an increasing incidence in developed countries. Here, we report a CD90+ cell population found in esophageal squamous cell carcinoma (ESCC), which is endowed with stem cell--like properties and high tumorigenic and metastatic potential. mRNA profiling of these cells suggested pathways through which they drive tumor growth and metastasis, with deregulation of an Ets-1/MMP signaling pathway and epithelial--mesenchymal transition figuring prominently. These cells possessed higher self-renewal activity and were sufficient for tumor growth, differentiation, metastasis, and chemotherapeutic resistance. CD90+ TICs were isolated and characterized from ESCC clinical specimens as well as ESCC cell lines. In freshly resected clinical specimens, they represented a rare cell population, the levels of which correlated with strong family histories and lymph node metastasis. Our results prompt further study of this CD90+ population of esophageal TICs as potential therapeutic targets. [ABSTRACT FROM AUTHOR]

Published
2013
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42. Orthotopic Xenograft Mouse Model in Esophageal Squamous Cell Carcinoma.

Author

Yu VZ, Ip JCY, Ko JMY, Tao L, Lam AK, and Lung ML

Subjects
Animals, Carcinoma, Squamous Cell pathology, Cell Line, Tumor, Disease Models, Animal, Esophageal Neoplasms pathology, Esophageal Squamous Cell Carcinoma classification, Esophagus pathology, Heterografts, Humans, Mice, Mice, Nude, Mouth Neoplasms pathology, Transplantation, Heterologous, Tumor Microenvironment, Esophageal Squamous Cell Carcinoma pathology, Xenograft Model Antitumor Assays methods
Abstract

Orthotopic xenograft model recapitulates the faithful organ-specific microenvironment and facilitates analyses involving tumor-stromal interactions that are crucial for developing new-generation cancer therapy. Herein, we describe the detailed rationales and protocols of a versatile orthotopic xenograft model for esophageal squamous cell carcinoma.

Published
2020
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