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550 results on '"Lundbye-Christensen, Søren"'

16. Intake of marine n-3 polyunsaturated fatty acids and the risk of incident peripheral artery disease

Author

Tram, Linda, Bork, Christian S., Venø, Stine K., Lasota, Anne N., Lundbye-Christensen, Søren, Schmidt, Erik B., and Overvad, Kim

Subjects
Unsaturated fatty acids -- Health aspects, Food/cooking/nutrition, Health
Abstract

Background A high intake of marine n-3 polyunsaturated fatty acids (PUFAs) may lower the risk of coronary heart disease and ischemic stroke. The association between intake of marine n-3 PUFAs and development of peripheral artery disease (PAD), however, remains unexplored. We hypothesised that intake of marine n-3 PUFAs, eicosapentaenoic acid (EPA), docosahexaenoic acid (DHA) and the sum of EPA + DHA was associated with a lower risk of incident PAD. Methods We used data from the Danish Diet, Cancer and Health cohort and investigated the associations between intake of EPA, DHA and EPA + DHA and development of PAD. Information on intake of n-3 PUFAs was obtained through a validated food frequency questionnaire. Potential PAD cases were identified through linkage to the Danish National Patient Register and subsequently, all cases were validated. Results Data were available from 55,248 participants and during a median of 13.6 years of follow-up, 950 cases of PAD were identified. Multivariate Cox regression analyses with adjustments for established risk factors showed no statistically significant associations between intake of EPA (p = 0.255), DHA (p = 0.071) or EPA + DHA (p = 0.168) and the rate of incident PAD. Conclusions We did not confirm our hypothesis that intake of EPA, DHA or EPA + DHA was associated with a lower risk of incident PAD., Author(s): Linda Tram [sup.1] , Christian S. Bork [sup.1] , Stine K. Venø [sup.1] [sup.2] , Anne N. Lasota [sup.3] , Søren Lundbye-Christensen [sup.4] , Erik B. Schmidt [sup.1] [sup.2] [...]

Published
2021
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17. Are Gamers Prone to eThrombosis during Long Gaming Sessions?

Author

Krarup, Kasper Bygum, primary, Krarup, Henrik Bygum, additional, Moerk, Morten, additional, Lundbye-Christensen, Søren, additional, Handberg, Aase, additional, Nguyen, Hien Thi Thu, additional, Pedersen, Inge Søkilde, additional, and Kristensen, Søren Risom, additional

Published
2024
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20. Are Gamers Prone to eThrombosis during Long Gaming Sessions?

Author

Krarup, Kasper B., Krarup, Henrik B., Mørk, Morten, Lundbye-Christensen, Søren, Handberg, Aase, Nguyen, Hien T. T., Pedersen, Inge S., and Kristensen, Søren R.

Subjects
THROMBIN, VENOUS thrombosis, VIRTUAL reality, LOCAL area networks, PROTHROMBIN, PHYSICAL activity, CALORIC content of foods
Abstract

During the last two decades, several cases of venous thrombosis (VTE) after a prolonged period at a computer have been described, denominated as "eThrombosis". Video gaming on a computer has become very popular and can be a social activity where several players gather to play against each other or in a virtual environment for several days ("LAN (i.e., Local Area Network) parties") where the participants are sedentary and consuming calorie-rich food items. The aim of this study was to investigate potential coagulation activation during a 42 h LAN party. Nine male gamers volunteered for the LAN party. Citrated blood was sampled before and every 6 h, and plasma was analyzed for thrombin generation, thrombin–antithrombin complexes (TAT), prothrombin fragment 1 + 2 (F1 + 2), and D-dimer. Thrombin generation increased slightly but not significantly during the LAN party, whereas the coagulation activation markers were unchanged. These results do not indicate that the coagulation system is activated significantly during 42 h of gaming with minimal physical activity. Although increased activity cannot be excluded, it does not directly indicate a risk of VTE in general. [ABSTRACT FROM AUTHOR]

Published
2024
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32. Promoter hypermethylation of SFRP1 as a prognostic and potentially predictive blood-based biomarker in patients with localized pancreatic ductal adenocarcinoma

Author

Stubbe, Benjamin Emil, primary, Larsen, Anders Christian, additional, Madsen, Poul Henning, additional, Krarup, Henrik Bygum, additional, Pedersen, Inge Søkilde, additional, Lundbye-Christensen, Søren, additional, Hansen, Carsten Palnæs, additional, Hasselby, Jane Preuss, additional, Johansen, Astrid Zedlitz, additional, Thorlacius-Ussing, Ole, additional, Johansen, Julia Sidenius, additional, and Henriksen, Stine Dam, additional

Published
2023
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40. Long-term risk of cardiovascular implantable electronic device re-interventions following external cardioversion of atrial fibrillation and flutter – a nationwide cohort study

Author

Elgaard, Anders Fyhn, primary, Dinesen, Pia Thisted, additional, Riahi, Sam, additional, Hansen, John, additional, Lundbye-Christensen, Søren, additional, Johansen, Jens Brock, additional, Nielsen, Jens Cosedis, additional, Lip, Gregory Y.H., additional, and Larsen, Jacob Moesgaard, additional

Published
2023
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45. Exploring I-FABP, endothelin-1 and L-lactate as biomarkers of acute intestinal necrosis: a case-control study

Author

Straarup, David, Gotschalck, Kåre A., Christensen, Peter A., Krarup, Henrik, Lundbye-Christensen, Søren, Handberg, Aase, and Thorlacius-Ussing, Ole

Abstract

Objective: Acute intestinal necrosis (AIN) is a disease with devastating high mortality. AIN due to obstructed arterial blood flow has a blurred clinical presentation. Timely diagnosis is paramount, and a blood-based biomarker is warranted to increase patient survival. We aimed to assess intestinal fatty acid binding protein (I-FABP) and endothelin-1 as diagnostic biomarkers for AIN. To our knowledge, this is the first study exploring endothelin-1 in AIN patients from a general surgical population. Design: We conducted a single-centre nested case–control study comparing acutely admitted AIN patients to age- and sex-matched non-AIN patients during 2015–2016. I-FABP and endothelin-1 were analysed using an enzyme-linked immunosorbent assay. L-lactate levels were also measured in all patients. Cut-offs were estimated using receiver operator characteristic curves, and the diagnostic performance was estimated using the area under the receiver operator characteristic curve (AUC). Results: We identified 43 AIN patients and included 225 matched control patients. Median levels of I-FABP, endothelin-1 and L-lactate were 3550 (IQR: 1746–9235) pg/ml, 3.91 (IQR: 3.33–5.19) pg/ml and 0.92 (IQR: 0.74–1.45) mM in AIN patients and 1731 (IQR: 1124–2848) pg/ml, 2.94 (IQR: 2.32–3.82) pg/ml and 0.85 (IQR: 0.64-1.21) mM in control patients, respectively. The diagnostic performances of endothelin-1 and of I-FABP + endothelin-1 combined were moderate. Endothelin-1 alone revealed an AUC of 0.74 (0.67; 0.82). The sensitivity and specificity of endothelin-1 were 0.81 and 0.64, respectively. Conclusion: I-FABP and endothelin-1 are promising biomarkers for AIN, with moderate diagnostic performance compared with the commonly used biomarker L-lactate. Preregistration: ClinicalTrials.gov: NCT05665946.

Published
2023
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