832 results on '"Lund, V."'
Search Results
2. EPOS2020/EUFOREA expert opinion on defining disease states and therapeutic goals in CRSwNP.
- Author
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Fokkens, W. J., De Corso, E., Backer, V., Bernal-Sprekelsen, M., Bjermer, L., von Buchwald, C., Chaker, A., Diamant, Z., Gevaert, P., Han, J., Hopkins, C., Hox, V., Klimek, L., Lund, V. J., Lee, S., Luong, A., Mullol, J., Peters, A., Pfaar, O., and Reitsma, S.
- Published
- 2024
- Full Text
- View/download PDF
3. Consensus criteria for chronic rhinosinusitis disease control: an international Delphi Study
- Author
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Sedaghat, A R, primary, Fokkens, W J, additional, Lund, V J, additional, Hellings, P W, additional, Kern, R C, additional, Reitsma, S, additional, Toppila-Salmi, S, additional, Bernal- Sprekelsen, M, additional, Mullol, J, additional, Gevaert, P, additional, Teeling, T, additional, Alobid, I, additional, Anselmo-Lima, W T, additional, Baroody, F M, additional, Cervin, A, additional, Cohen, N A, additional, Constantinidis, J, additional, De Gabory, L, additional, Desrosiers, M, additional, Harvey, R J, additional, Kalogjera, L, additional, Knill, A, additional, Landis, B N, additional, Meco, C, additional, Philpott, C M, additional, Ryan, D, additional, Schlosser, R J, additional, Senior, B A, additional, Smith, T L, additional, Tomazic, P V, additional, Zhang, L, additional, and Hopkins, C, additional
- Published
- 2023
- Full Text
- View/download PDF
4. Higgs Physics at LEP2
- Author
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Carena, M., Zerwas, P., Accomando, E., Bagnaia, P., Ballestrero, A., Bambade, P., Bardin, D., Berends, F., van der Bij, J., Binoth, T., Burkart, G., de Campos, F., Contri, R., Crosetti, G., Maestro, J. Cuevas, Dabelstein, A., de Boer, W., de StJean, C., Di Lodovico, F., Djouadi, A., Driesen, V., Dubinin, M., Duchovni, E., Eboli, O. J. P., Ehret, R., Ellwanger, U., Ernenwein, J. -P., Espinosa, J. -R., Faccini, R., Felcini, M., Folman, R., Genten, H., Grivaz, J. -F., Gross, E., Guy, J., Haber, H., Hajdu, Cs., Ham, S. W., Hempfling, R., Hoang, A., Hollik, W., Hoorelbeke, S., Hultqvist, K., Igo-Kemenes, P., Janot, P., de Jong, S., Jost, U., Kalinowski, J., Katsanevas, S., Keränen, R., Kilian, W., Kim, B. R., King, S. F., Kleiss, R., Kniehl, B. A., Krämer, M., Leike, A., Lund, E., Lund, V., Lutz, P., Marco, J., Mariotti, C., Martin, J. -P., Martinez-Rivero, C., Mikenberg, G., Monge, M. R., Montagna, G., Nicrosini, O., Oh, S. K., Ohmann, P., Passarino, G., Piccinini, F., Pittau, R., Plehn, T., Quiros, M., de Traubenberg, M. Rausch, Riemann, T., Rosiek, J., Ruhlmann-Kleider, V., Savoy, C. A., Sherwood, P., Shichanin, S., Silvestre, R., Sopczak, A., Spira, M., Valle, J. W. F., Vilanova, D., Wagner, C. E. M., White, P. L., Wlodek, T., Wolf, G., Yamashita, S., and Zwirner, F.
- Subjects
High Energy Physics - Phenomenology - Abstract
In this report we review the prospects for Higgs physics at LEP2. The theoretical aspects and the phenomenology of Higgs particles are discussed within the Standard Model (SM) and the Minimal Supersymmetric Standard Model (MSSM). The experimental search techniques are described and the discovery limits for Higgs bosons in the LEP2 energy range are summarized. In addition, opportunities of detecting Higgs particles in non-minimal extensions of the SM and the MSSM are investigated., Comment: 112 pages, latex file + figures (some bitmapped), to appear in Vol. 1, Report of the Workshop on Physics at LEP2, G. Altarelli, T. Sjostrand and F.Zwirner (eds), CERN 96-01. (Full postscript and uuencoded files, including full resolution figures are available at the www address http://surya11.cern.ch/surya_info/users/mcarena in finrep.ps, finrep.uu)
- Published
- 1996
5. Influence of nest box environment on kit survival
- Author
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Lund, V. H., Malmkvist, J., Larsen, P. F., editor, Møller, S. H., editor, Clausen, T., editor, Hammer, A. S., editor, Lássen, T. M., editor, Nielsen, V. H., editor, Tauson, A. H., editor, Jeppesen, L. L., editor, Hansen, S. W., editor, Elnif, J., editor, and Malmkvist, J., editor
- Published
- 2012
- Full Text
- View/download PDF
6. The Selective Role of Open and Endoscopic Approaches for Sinonasal Malignant Tumours
- Author
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Lopez, F, Shah, JP, Beitler, JJ, Snyderman, CH, Lund, V, Piazza, C, Makitie, AA, Guntinas-Lichius, O, Rodrigo, JP, Kowalski, LP, Quer, M, Shaha, A, Homma, A, Sanabria, A, Ferrarotto, R, Lee, AWM, Lee, VHF, Rinaldo, A, Ferlito, A, HUS Head and Neck Center, Clinicum, and Korva-, nenä- ja kurkkutautien klinikka
- Subjects
Skull Base ,MUCOSAL MELANOMA ,ORBITAL INVASION ,CRANIOFACIAL RESECTION ,Endoscopy ,ENDONASAL RESECTION ,Craniofacial Resection ,Paranasal Sinus Cancer ,NASAL CAVITY ,OLFACTORY NEUROBLASTOMA ,QUALITY-OF-LIFE ,Maxillectomy ,SQUAMOUS-CELL CARCINOMA ,3125 Otorhinolaryngology, ophthalmology ,Sinonasal Malignant Tumours ,SKULL BASE TUMORS ,PARANASAL SINUSES - Abstract
Endoscopic endonasal surgery has been demonstrated to be effective in the treatment of selected cases of sinonasal cancers. However, in cases of locally advanced neoplasms, as well as recurrences, the most appropriate approach is still debated. The present review aims to summarize the current state of knowledge on the utility of open approaches to resect sinonasal malignant tumours. Published comparative studies and meta-analyses suggest comparable oncological results with lower morbidity for the endoscopic approaches, but selection biases cannot be excluded. After a critical analysis of the available literature, it can be concluded that endoscopic surgery for selected lesions allows for oncologically safe resections with decreased morbidity. However, when endoscopic endonasal surgery is contraindicated and definitive chemoradiotherapy is not appropriate, craniofacial and transfacial approaches remain the best therapeutic option.
- Published
- 2022
7. Elective surgery cancellations due to the COVID-19 pandemic: global predictive modelling to inform surgical recovery plans
- Author
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Nepogodiev D., Omar O. M., Glasbey J. C., Li E., Simoes J. F. F., Abbott T. E. F., Ademuyiwa A. O., Biccard B. M., Chaudhry D., Davidson G. H., Di Saverio S., Gallo G., Ghosh D., Harrison E. M., Hutchinson P. J., Kamarajah S. K., Keller D. S., Lawani I., Minaya-Bravo A., Moore R., Morton D. G., Ntirenganya F., Pata F., Pearse R. M., la Medina A. R. -D., Tabiri S., Venn M. L., Omar A. B. O. M., Bhangu A., Siaw-Acheampong K., Adamina M., Agarwal A., Alameer E., Alderson D., Alakaloko F., Alser O., Arnaud A. P., Augestad K. M., Bankhead-Kendall B. K., Barlow E., Benson R. A., Blanco-Colino R., Brar A., Breen K. A., Buarque I. L., Caruana E. J., Chakrabortee S., Cox D., Cunha M. F., Dawson B. E., Desai A., Drake T. D., Edwards J. G., Elhadi M., Evans J. P., Farik S., Fiore M., Fitzgerald J. E., Ford S., Gomes G. M. A., Griffiths E. A., Gujjuri R. R., Halkias C., Heritage E., Isik A., Jenkinson M. D., Jones C. S., Khatri C., Keatley J. M., Kolias A., Lawday S., Lederhuber H., Leventoglu S., LAffler M. W., Martin J., Mashbari H. N., Mazingi D., Mckay S. C., Metallidis S., Mohan H. M., Moszkowicz D., Moug S., Ng-Kamstra J. S., Niquen M., Outani O., Pellino G., Pinkney T. D., Pockney P., Radenkovic D., Roberts K., Roslani A. C., Santos I., Schache A., Schnitzbauer A. A., Stewart G. D., Shaw R., Shu S., Soreide K., Spinelli A., Sundar S., Tiwari A., Townend P., Trout I. M., Tsoulfas G., van Ramshorst G. H., Vidya R., Vimalachandran D., Warren O., Wilkin R. J. W., Wright N., Hoste E., Huyghens L., Jacobs R., Opdenacker G., Poelaert J., Rijckaert D., De Decker K., Foubert L., De Neve N., Biston P., Piagnerelli M., Collin V., den Blauwen N., Clauwaert C., De Crop L., Verbeke A., Derumeaux P., Gardin C., Kindt S., Louage S., Verhamme B., DruwACopyright P., Lahaye I., Rosseel F., Rutsaert R., Vanlinthout L., De Kock M., Forget P., Kahn D., Lois F., Momeni M., Yemnga A. P. B., Jadoul J. -L., Malbrain M., Bosinceanu D., Collard E., Jorens P., Reyntiens D., Smitz C., Vercauteren M., Fagnoul D., Toplice K., OremuA¡ K., BeA¡lic G., Duzel V., Hauptman A., Peremin S., Aribar A., Aupcic M., Brod S., Mirkovic I., Bauer Z. A., Belavic M., BlaA¾anin B., KatuA¡in M. L., Krijan A. B., MiA¡kovic P., Aimic-Korac N., Topic J., Ailic A., Aunic J., Acan I., Adanic M., Ivanov N., Aaric J. P., Tomulic K., Viskovic N., BoA¡njak S., Drenjancevic I. H., Kristek G., Kvolik S., Markic S., Rakipovic A. S., Tot O. K., Fabris L. K., Bacak-Kocman I., Balenovic I., Bandic D., Deutsch P. A. J., Divjak L., Filipovic I. G., GuA¾vinec Z., Krznaric Z., Loncaric Y., MagaA¡ J. V., Mitrovic M., Okic M., Pavlek M., Ramov E., Rezek K., Sekulic A., Tomasevic B., Miric M., TomaA¡evic A., Mahecic T. T., Vrbanovic V., Bobinac M., BoA¾ic A., Debelic D., Frkovic V., Batinica I. M., Baranovic S., Gavranovic A., Kikec M., Maldini B., Maric S., Agnic I., Delic N., Dropulic N., GaA¡pic T. K., Ilic D., Ivancev B., Karanovic N., KuA¡cevic D., Marovic Z., Milic M., NeveA¡canin A., Petkovic T., Smoje M., Brozovic G., Goranovic T., Jelisavac M., Matolic M., Mazul-Sunko B., Oberhofer D., Pavicic A. M., Aakic K., Bozovic M. D., Krecek Z. K., Krobot R., Andabaka T., Bratanic M., Dzepina O., Kraljev M., Aeric J., Aimurina T., Grujic R., Nacevski-Bulaja B., BariA¾on M., Danira V., DraA¾en B., DuA¡anka K., HaluA¾an M. B., JoA¡ko A., Katica R., Labor M., Marinkovic T. G., Mihovilcevic D., Marija B., Srecko M., Drab M., Hudacek K., Krikava I., Stourac P., BrabcovA¡ M., KlozovA¡ R., Vajter J., Vymazal T., Toft P., Blichfeldt L., Hansen B. D., Moller K., Nielsen J. S., Frederiksen J., Andersen J. D., KA¼hne J. P., Leivdal S., Stendell L., Simonsen M., Zoltowski M. K., Ali Z. S., Freundlich M., Pilypaite J., Clausen N. G., Thorup L., Hansen F., Bestle M., Hansen C. S., Afshari A., Bille A. B., Lefort M., Secher E. L., Liboriussen L., Herodes V., HA¤rma E., Marvet K., Pool K., Kallas P., MA¤gi T. -K., SA¼tt J., Vijar K., Visk E., Vinnal M., Ellermaa J., Liibusk L., Hovilehto S., Kirsi A., Mustola S., Tiainen P., Toivonen J., Dabnell S., Kaminski T., Sysimetsa A., Kaukonen M., Silvasti P., Vainio K., Lund V., SjAvall S., Saarinen K., Viitanen M., Ahonen T., AlaspA¤A¤ A., Zittling R., Saarinen A., Moisander A., Wagner B., Laru-Sompa R., Elomaa E., Lavonen L., Nevantaus J., Geier K., Kavasmaa T., Koorits U., Kubjas M., Lauritsalo S., Ottelin L., Palve M., PynnAnen J., RA¤A¤bis I., Saarelainen M., HeikkilA¤ T., Kontula T., LehtimA¤ki M., Liimatainen J., Moilanen-Oikarinen M., Pakarinen M., Palanne R., SeppA¤nen H., Pulkkinen A., VA¤A¤rA¤niemi H., Kajaani, Paananen S., Koskenkari J., SA¤lkiA S., Vakkala M., Koskue T., Loisa P., Laitio R., HautamA¤ki R., Koivisto S. -P., Leon A., Bonnet F., Marret E., Spielvogel C., Papageorgiou C., Szymkiewicz O., Tounou-Akue F., Aubrun F., Bonnet A., Gazon M., Guiraud M., Laurent V., Tachon G., Demars N., Dumenil A. -S., Mercier F. J., Landais A., Mentec H., Bazin M., Futier E., Gonnu S., Petit A., Albaladejo P., Almeras L., Rossi-Blancher A. B. M., Lefrant J. Y., Barthel F., Hallel D., Sbai H., Khalifeh P., Lidzborski L., Jully M., Platon E., Pottecher J., Baumgarten R., Schultz C., ElMiloudi F., Lefebvre J., Waton K., Sprunck A., Steib A., Thibaud A., Thuet V., Kieffer V., Dubois-Vallaud D., Jacob L., Becanne X., Cherfaoui S., Gauzit R., Godier A., Lakhdari M., Samma C. M., Halchini C., Lacroix M., Pinna F., Barbes A., Just B., Mateu P., Benayoun L., Berger P., Granier N., Perrigault P. F., Libert N., De Rudnicki S., Merat S., Bourdet B., FerrACopyright F., Minville V., Piriou V., Rague P., Wallet F., Lebuffe G., Desbordes J., Robin E., Ichai C., Orban J. -C., Gottschalk A., Piontek A., Unterberg M., Hilpert J., Kees M., Triltsch A., Wiegand-LAhnert C., GlAckner C., Hohn A., Rose E., SchrAder S., Wiese O., Awlakpui E., Hoeft A., Scheidemann M., Wittmann M., Ramminger A., Dresden C., de Abreu M. G., Heller A. R., Marx C., Neidel J., Goldmann A., von Heymann C., Laetsch B., Maahs E., Scholz L., Frenzel D., Massarat K., Lenhart F. -P., Reichle F., Rudlof K., Borchers F., Buettner C., Schmutzler M., Lucht A., Wagner J., Wuppertal H. K., Pilge S., Schneider G., Untergehrer G., Bis B., Krassler J., Dittmann J., Haberkorn J., Eberitsch J., Eberitsch K., Nippraschk T., Wepler U., Engelen W. -C., Nau C., Scholler A., SchA¼ttler J., Wintzheimer S., Bloos F., Braune A., Fergen D., Ludewig K., Paxian M., Reinhart K., Graf N., Schwarzkopf K., Berger K., Habicher M., Kasperiunaite R., Savelsberg S., Krep H., Reindl M., Bauer W., Bingold F., Christ S., Friederich P., Kaviani R., Auer P., BonnlA¤nder G., Drescher J., Braun R., Eichenauer T., Kerner J., Bierbaum K., BrA¼nner H., Grond S., Perez-Platz U., Andresen B., Linstedt U., Stegmann N., Erkens U., Kopcke J., Meyer A., Brestrich H., Ernst S., Merkel S., Krieger L., Luers F., Weyland A., Noeldge-Schomburg G., Wasmund C., Bredtmann R. -D., Erler I., Haumann C., MAllemann A., Oehmichen U., Sergejewa O., Lehning B., Czeslick E., Geyer M., Malcharek M., Sablotzki A., Stier M., Feld F., Marx G., Rossaint R., Simon V., Armaganidis A., Kotanidou A., Nanas S., Papastylianou A., Psevdi A., Stathopoulos A., Voulas A., Kanna E., Koutsikou A., Moustaka A., Chovas A., Komnos A., Zafiridis T., Franses J., Lavrentieva A., Koraki E., Katsenos C., Kasianidou M. F., Nasopoulou P., Spyropoulou E., Gousia C., Katsanoulas C., Lathyris D., Kyriazopoulos G., Sfyras D., Tsirogianni A., Kostopanagiotou G., Koulenti D., Lignos M., Matsota P., Christopoulos C., Mouratidou A., Vrettou E., Boufidis S., Moka E., Arnaoutoglou E., Koulouras V., Nakos G., Papathanakos G., Anthopoulos G., Choutas G., Karapanos D., Tzani V., Gkiokas G., Nastos K., Nikolakopoulos F., Dragoumanis C., Nikitidis N., Pneumatikos I., Theodorou V., Zacharouli D., Kandi S., Tasopoulos K., Arvaniti K., Matamis D., Mplougoura E., Petropoulou P., Soumpasis I., Amaniti E., Giannakou-Peftoulidou M., Gkeka E., Soultati I., Kokinou M., Papatheodorou L., Stafylaraki M., Giasnetsova T., Gritsi-Gerogianni N., Kydona C., Kiskira O., Koulentis I., Apsokardos A., Dimitropoulos K., Soldatou O., Nathanail C., Papazotos A., Tsakas P., Clouva-Molyvdas P. -M., Kolotoura A., Sartzi M., Papanikolaou S., Polakis P., Karatzas S., Kyparissi A., Papavasilopoulou T., Koukoubani T., Mastora E., Nyktari V., Malliotakis P., Papaioannou A., Bekos V., Maragkou E., Spring A., Ioakeimidou S. E. A., Noulas N., MolnA¡r Z., CsA¼llAg E., Elekes E., MolnA¡r T., Katona Z., Kremer I., Miko A., Budapest, Csomos A., Galambos Z., Szucs A., Szekeres G., Szabo E., Kranitz K., Simon M., Szigeti J., GaA¡l E., Havas A., Ille A., Miskolc, BrA¡z K., Nagy G., Hafeez P., Hanumanthaiah D., Brohan J., O'Chroinin D., Bailey K., Ramamoorthy K. G., Doyle Y., Freir N., O'Rourke J., Jonson P., Saeed S., Hayes I., Loughrey J., Frohlich S., McCauley N., Ryan D., Fitzpatrick G., Kevin L., Thomas J., Warde B., Woolhead A., Duggan M., Egan C., Crowley S., Lebese S., Bergin A., Westbrook A., Page R., Collins D., McKenny M., Bresciani A., Carmino L., Ghelfi S., Lorenzelli L., Novelli M. T., Pescarmona C., Roasio A., Gatta A., Nastasi M., Sanseverino M., Tinti C., Bianchin A., Tormena M. P., Franco A., Marini F., Di Mauro P., Rapido F., Tommasino C., Bellotti F., Boninsegna D., Castellani G., Sances D., Spano G., Tredici S., Vezzoli D., Fucecchio I., Bacci A., Coppini R., Dell'unto S., Mori E., Stanzani M. R., Tosi M., Collareta M., Forfori F., Franchi M., Mancino G., Battistella M., Baricocchi E., Bona F., Debernardi F., Giacoletto G., Iacobellis A., Massucco P., Moselli N., Muratore A., Palomba G., Sardo E., Suita L., Zocca E., Bucci B., Corte F. D., Piciucco T., Viarengo V., Cantarini E., Giampieri M., Tanfani A., Recchia E., Bignami E., Bruno G., Costagliola R., Gandolfi A., Greco M., Lembo R., Monti G., Nicelli E., Pasculli N., Turi S., Rocca G. D., Baroselli A., Brazzoni M., Buttazzoni M., Buttera S., Centonze C., Serena G., Spagnesi L., Toretti I., Vilardi A., Zearo E., Arpino I., Baraldi S., Guarnerio C., Molene V., Monea M. C., Vaccarisi E., Vicari L., Albante A., Aversano M., Loiacono C., Marandola M., Fusari M., Petrucci N., Galla A., Mascia A., Primieri P., Di Noto A., Gratarola A., Molin A., Pelosi P., Spagnolo L., Spena C., Calligaro P., Marchiotto S., Merlini A., Pedrazzoli E., Perina G., Visentin R., Fumagalli R., Garbagnati A., Manetti B., Snaier C., Somaini M., Farnia A., Nani R., Pierantonio N., Grasso S., Gazzanelli S., Pugliese F., Ruberto F., Bergamini E., Tassinati T., Capuzzo M., Cirillo V., Tufano R., Oggioni R., Parrini V., Brunori E., Capone M., Carbone L., Corradetti F., Elisei D., Fiorentino S., Francesconi M., Gattari D., Gorgoglione M., Iacobone E., Minnucci F., Montironi C., Riccioni G., Tappata G., Zompanti V., Verdenelli P., Cerutti E., Ranieri V. M., Grigorjevs S., Rikmane M., Rozkalne D., Stepanovs J., Suba O., Golubovska I., Kazune S., Miscuk A., Nemme J., Oss P., Sipylaite J., Macas A., Ragaisis V., Kontrimaviciute E., Tomkute G., Boerma E. C., Leeuwarden M. C., Kramer I. F., Poeze M., Maria J., Pelzer G., Nijsten M., Schoorl M., Spanjersberg R., Buhre W., Dieleman S., van Klei W. A., Bouw M., Pickkers P., Schreiner F., Zandvliet R., van den Berg R., De Wit E., Keijzer C., Hollmann M. W., Preckel B., van Acker G. J. D., Dennesen P. J. W., Kuijpers-Visser A. G., Inan T., Gemert A. W. M. M. K. -V., Ponssen H. H., Brouwer T., Koopmans M., van Bommel J., van Duijn D., van der Hoven B., Ormskerk P., Beck O., Schiere S., Reidinga A. C., Venema A., Jammer I., Dokka V., Monsen S. A., Ytrebo L. M., Noursadeghi M., Shahzad A., Boksasp O. D., Roiss C., Strietzel H. F., Berntsen A. G. S., Haugland H., Vingsnes S. O., Axelsson P., Risom Olsen T. C., Katre S., Aakeroey K., Tamowicz B., Bozilow D., Goch R., Grabowski P., Kupisiak J., Mallek M., Szyca R., Kostyrka W., Choma R., Jankowski G., Koscielniak W., Pietraszek P., Szarowar B., FranA§a C., Lacerda A. P., Ormonde L., Rosa R., Pereira I., Vitor P., Bento H. C., Carvalho M. R. L. M., Faria M., Almeida E., Mealha R., Vicente R., Monte R., Rua F., Barros N., Esteves F., Pinheiro C. M. G., Real V., Oliveira V. M., Oliveira M. F., Martins I., Saraiva J. P., AssunA§A£o J. P., BA¡rtolo A., Carvalho A., Correia C., Martins S., Milheiro R., Diaz A., GonA§alves M. I., Ribeiro R., Estilita J., GlAria C., de Almeida J., Barros F., Ramos A., Camara M., Maul E. R., Nobrega J., Langner A., Maia D. F., Afonso O., Faria F., Serra S., Botelho M. M., Ferreira P., MourA£o L., Oliveira A. V., Resende M., Aleman M., Fonseca J., Isidoro M., de Meneses H., PAªgas A., Pereira J., Pereira L., Ramos B., Matos F., Matos R., de Lurdes GonA§alves Castro M., Martins A., Ramos C., de Sousa M., Bento L., Botas C., Lopes V., Mendes R., Blaj M., Damian M., Lupusoru A., Ristescu I., Codreanu M., Diaconescu C., Nistor A., Stelian D. S., Streanga L., Berneanu M., Bordeianu C., Florenta C., Iacob A., Lupu M. N., Mocanu I., Moraru C., Meran C., Nicolae B., Sandu M., Turcanu R., Epure F., Grigore M., Hotaranu C., Popescu N., Baban O., Baciu M., Ciobanu A., Maftei I., Moldovan I., Ungureanu L., Bogdan P., Corneci D., Dinu M., Madalina D., Rely M., Silvius N., Tomescu D., Gabriela D., Dinescu S. A., Calin M., Ionescu D., Margarit S., Vasian H., Albu C., Balasa C., Cadrigati A., Dragulescu D., Gavra L., Hentia C., Macarie C., Manescu M., Nediglea I., Ocica D., Ovidiu B., Papurica M., Plavat C., Popa C., Ramneantu M., Sandesc D., Sandici Z., Sarandan M., Belciu I., Tincu E., Aignatoaie M., Huzuneanu M., Cocu S., Hagau N., Ciubotaru R., Copotoiu S. -M., Copotoiu R., Ioana G., Kovacs J., Leonard A., Szederjesi I., Genoveva V., Mosnegutu S., Djordjevic D., Djordjevic B., Grujic K., Jovanovic D., Obradovic J., Zeba S., Jevdjic J., Miletic M., Zunic F., Bulasevic A., Brko R., Gazibegovic N., Kendrisic M., Vojinovic R., CapkovA¡ J., Firment J., Grochova M., Trenkler S., Griger M., Zahorec R., Bakosova E., Kvasnica M., Saniova B., Sulaj M., Zacharovska A., Simkova A., CAkovA¡ A., Gebhardtova A., HanuljakovA¡ S., Koutun J., MartonovA¡ A., AilincA¡rovA¡ V., Galkova K., Krbila S., Sobona V., Ocenasova M., Novak-Jankovic V., Stecher A., Stivan F., Grynyuk A., Damjanovska M., Kostadinov I., Knezevic M., Malivojevic M., Borovsak Z., Kamenik M., MekiA¡ D., KapA¡ S. 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J., Williams S., Kaura V., Lanka P., Naylor C., Ahmed A., Myatt J., Shenoy R., Soon W.C., Tan J., Karadia S., Self J., Durant E., Tripathi S., Bullock C., Ghosh A., Bengeri S., Cowton A., Khalid M.S., Limb J., McAdam C., Porritt M., Shekar P., Harden C., Hollands H., King A., March L., Minto G., Patrick A., Waugh D., Kumara P., Simeson K., Yarwood J., Browning J., Julian H., Newton M., Pernu P.K., Wilson A., Commey T., Foot H., Glover L., Gupta A., Lancaster N., Levin J., Mackenzie F., Mestanza C., Nofal E., Pout L., Varden R., Wild J., Jones S., Davies C., Martin M., Thomas S., Burns K., McArthur C., Patel P., Lau G., Rich N., Davis F., Port B., Prout R., Smith C., Adelaja Y., Bennett V., Dumitrescu A., Murphy J.F., Keen A., Mguni N., Ong C., Adams G., Boshier P., Brown R., Butryn I., Chatterjee J., Freethy A., Tsakok M., Tsiligiannis S., Peat W., Stephenson L., Bradburn M., Pick S., Cunha P., Olagbaiye O., Tayeh S., Abernethy C., Balasubramaniam M., Bennett R., Bolton D., Martinson V., Bell S., Heather B., Kushakovsky V., Alcock L., Alexander H., Anderson C., Baker P., Brookes M., Cawthorn L., Cirstea E., Colling K., Coulter I., Das S., Haigh K., Hamdan A., Hugill K., Kottam L., Lisseter E., Mawdsley M., McGivern J., Padala K., Phelps V., Stewart K., Towse K., Tregonning J., Vahedi A., Walker A., Baines D., Bilolikar A., Chande S., Dunk N., Kulkarni R., Kumar P., Metodiev Y., Ncomanzi D., Raithatha B., Raymode P., Szafranski J., Twohey L., Watt P., Weatherall L., Weatherill J., Whitman Z., Wighton E., Abayasinghe C., Chan A., Darwish S., Gill J., Glasgow E., Harris C., Kochhar A., Mellis C., Pool A., Riozzi P., Selman A., Smith E.-J., Vele L., Gercek Y., Guy K., Holden D., Watson N., Whysall K., Andreou P., Hales D., Thompson J., Bowrey S., McDonald S., Gilmore J., Hills V., Kelly C., Kelly S., Lloyd G., Abbott T., Gall L., Torrance H., Vivian M., Berntsen E., Nolan T., Vohra A., Brown A., Clark R., Coughlan E., Daniel C., Patvardhan C., Pearson R., Predeep S., 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S.A., Chukkambotla S., Andrew A., Attrill E., Campbell G., Datson A., Fouracres A., Graterol J., Graves L., Hong B., Ishimaru A., Karthikeyan A., King H., Lawson T., Lee G., Lyons S., Hall A.M., Mathoulin S., Mcintyre E., Mclaughlin D., Mulcahy K., Robbins J., Sung W., Tayo A., Trembath L., Venugopal S., Wigmore G., Boereboom C., Downes C., Humphries R., Melbourne S., Tou S., Ullah S., Boxall L., Broomby R., Deen T., Hellewell A., Helliwell L., Hutchings M., Hutchins D., Keenan S., Mackie D., Potter A., Smith F., Stone L., Thorpe K., Wassall R., Woodgate A., Baillie S., Campbell T., James S., King C., de Araujo D.M., Martin D., Morkane C., Rajendram R., Burton M., James K., Keevil E., Minik O., Morgan J., Musgrave A., Rajanna H., Roberts T., Adamson M., Jumbe S., Kendall J., Muthuswamy M.B., Cruikshanks A., Wrench I., Zeidan L., Ardern D., Harris B., Hellstrom J., Varsani N., Brown C.W., Docherty P., Gillies M., McGregor E., Usher H., Bodger P., Creary T., Fowler A., Ijuo E., Jones T., Kantsedikas I., Lahiri S., McLean A.L., Phull M., Baldwin J., Doyle D., Mcmullan S., Oladapo M., Owen T., Williams A., Gregory P., Husain T., Mathers E., Montague L., Avis J., Cook T., Dali-Kemmery L., Kerslake I., Lambourne V., Pearson A., Boyd C., Lawson C., McCrossan R., Nesbitt V., O'connor L., Sinclair R., Farid N., Morgese C., Bhatia K., Karmarkar S., Ahmed J., Branagan G., Hutton M., Swain A., Brookes J., Cornell J., Dolan R., van Vuuren A.J., Jowitt T., Kalashetty G., Lloyd F., Patel K., Sherwood N., Chandler B., Deighton K., Emma T., Haunch K., Cheeseman M., Dent K., Gray C., Hood M., Jones D., Juj J., Rao R., Walker T., Cheah C., Cheing Y., Coutinho F., Gondo P., Hadebe B., Hove M.O., Krishnachetty B., Rhodes K., Sokhi J., Baker K.-A., Bertram W., Looseley A., Arya S., Balfoussia D., Baxter L., Harris J., Jones C., Knaggs A., Markar S., Perera A., Scott A., Shida A., Sirha R., Wright S., Frost V., MacGregor M., Andrews E., Arrandale L., Barrett S., Cifra E., Cooper M., Dragnea D., Elna C., Maclean J., Meier S., Milliken D., Munns C., Ratanshi N., Salvana A., Watson A., Ali H., Critchley R., Hicks C., Liddle A., Pass M., Ritchie C., Thomas C., Too L., Welsh S., Gill T., Johnson J., Reed J., Davis E., Papadopoullos S., Attwood C., Biffen A., Boulton K., Gray S., Hay D., Mills S., Riddell R., Simpson J., Bhardwaj N., Paul E., Uwubamwen N., Alexander M., Arrich J., Arumugam S., Blackwood D., Boggiano V., Chatterjee D., Chhabra A., Christian R., Costelloe H., Matthewman M.C., Dalton E., Darko J., Davari M., Dave T., Deacon M., Deepak S., Edmond H., Ellis J., El-Sayed A., Eneje P., English R., Ewe R., Foers W., Franklin J., Gallego L., Garrett E., Goldberg O., Goss H., Greaves R., Harris R., Hennings C., Jones E., Kamali N., Kokkinos N., Lewis C., Lignos L., Malgapo E.V., Malik R., Milne A., Mulligan J.-P., Nicklin P., Palipane N., Parsons T., Piper R., Prakash R., Ramesh B., Rasip S., Reading J., Rela M., Reyes A., Robert S., Rooms M., Shah K., Simons H., Solanki S., Spowart E., Stevens A., Waggett H., Yassaee A., Kennedy A., Scott S., Somanath S., Berg A., Hernandez M., Nanda R., Tank G., Wilson N., Wilson D., Al-Soudaine Y., Baldwin M., Cornish J., Davies Z., Davies L., Edwards M., Frewer N., Gallard S., Glasbey J., Harries R., Hopkins L., Kim T., Koompirochana V., Lawson S., Lewis M., Makzal Z., Scourfield S., Ahmad Y., Bates S., Blackwell C., Bryant H., Coulter S., Cruickshank R., Daniel S., Daubeny T., Helen B., Hinxman H., Levett D., Skinner B., Walsgrove J., Dickson J., Constantin K., Karen M., O'Brien P., O'Donohoe L., Sundayi S., Brooke J., Cardy J., Humphreys S., Kessack L., Kubitzek C., Cotterill D., Hodzovic E., Hosdurga G., Miles E., Saunders G., Campbell M., Jemmett K., Raj A., Naik A., Ramamoorthy R., Shah N., Sylvan A., Blyth K., Johnson E., Lo P., Martin T., Plunkett E., Allison J., Carroll C., Craw N., Craw S., Pitt-Kerby T., Rowland-Axe R., Spurdle K., McDonald A., Simon D., Sinha V., Banner-Goodspeed V., Boone M., Campbell K., Lu F., Scannell J., Sobol J., Balajonda N., Clemmons K., Conde C., Funk B., Hopkins T., Olaleye O., Omer O., Pender M., Porto A., Waweru P., Yeh E., Bodansky D., Evans A., Kleopoulos S., Maril R., Mathney E., Sanchez A., Tinuoye E., Bateman B., Eng K., Jiang N., Ladha K., Needleman J., Chen L.-L., Lane R., Robinowitz D., Ghushe N., Irshad M., Takemoto S., Wallace A., Mazzeffi M., Rock P., Wallace K., Zhu X., Chua P., Mattera M., Sharar R., Thilen S., Treggiari M., Morgan A., Sofjan I., Subramaniam K., Avidan M., Maybrier H., Muench M., Wildes T., Elkhogia A.M., Omigbodun A.O., Antwi-Kusi A., Samateh A.L.S., Ndonga A., Basenero A., Mbwele B., Gordon C.S., Youssouf C., Ashebir D.Z., Munlemvo D.M., Zoumenou E., Madzimbamuto F., Ndayisaba G., Sama H.D., Ndasi H., Kluyts H.-L., Tumukunde J., Fawzy M., Mehyaoui R.M., Amanor-Boadu S.D., Rakotoarison S., Esterhuizen T.M., Patel U., Gobin V., Le Manach Y., Ngumi Z., Mehyaoui R., Kanoun H., Chelbi L., Alghazali A., Metali A., Mokretar R., Ouanes F., Imessaoudene Z., Khalfallah, Guenane M., Sadat S., Gadi B., Benali D., Chikh N., Laksari M., Boufas F., Akodjenou J., Gbehade O., Mewanou S., Djessouho E., Ahossi R., Abadagan H., Guegni A., Assoum G., Zomahoun L., Oscar K., Souhe R., Dewanou H., Nascimento R., Guezo M., Adjignon S.V., Anani F., Allaye T., Tchegnonsi C., Fanou L., Hadecon R., Atomabe A., Tchaou B., Horugavye E., Habimana L., Nkesha T., Manirimbere C., Ndikumana R., Niyondiko J.C., Minani P., Bigirimana F., Uwiteyimbabazi J., Konwuoh N.D., Ekwen G., Kaggya M., Constance N., Samuel N., Akanyun S., Freeman T., Royas L., Tchoupa M., Simo W.A.G., Ngouane D., Tanjong B.N., Bouya A.P., Carlos F., Gallou P.D., Prosper A., Athombo J.S., Sanduku D.K., Mampangula Y., Nziene V.N., Odia P.K., Mbombo W.D., Wms M., Mukuna P.M., Boloko P.M., Mvwama N.M., Jjn I., Manzombi J.K., Mvwala K.R., Ilunga J.P.M., Mawisa T., Kilembe A.M., Bikuelo C.J., Mwepu I.M., Mwaluka C.N., Sarah H.N., Kukembila A.M., Diyoyo M.P., Ngalala A.M., Kabango R., Kongolo M., Mbayabu M., Namegabe E.S., Bula Bula I.M., Likongo T.B., Pengemale G.N., Bingidimi S.S., Imposo D.H., Matondo P.M., Lelo S.N., Kamanda R.J., Kady N., Ntueba B., Christian M., Badianga E.K., Clc L., Mubeya F.K., Bahta M.T., Kassa S.K., Assefa S.B., Girmaye G.T., Samateh A.L., Janneh L., Sanyang L.N., Nyassi M.T., Grey-Johnson S.V., Villarreal R., Antunez O., Jallow C.S., Roberts C.A., Clegg-Lamptey J.N., Kutor Y.Y., Adu-Aryee N.A., Domoyyeri D.P., Atito-Narh E., Anabah T.W.A., Ndonga A.K.N., Ngumi Z.W.W., Bitta C., Nyawanda H.O., Oduor O.E.O., Okelo O.S., Ogendo S.W.O., Ngari N.B.M., Nyokabi N.N., Chokwe T.M., Gacii V.M., Githae B., Gatheru A.P., Maranga O., Muriithi J.M., Mwangi C.M., Mwiti T.M., Nabulindo S.M., Ndung'u C., Mugambi J., Mtongwe V.M., Kiprop B., Mbadi R., Wambugu P.K., Hersi S., Mutahi S., Aluvale J.S., Gitau S., Kariuki K., Ngatia E., Sitima S., Obadiah S., Mwenda V., Iraya A.M., Waweru E.N., Muturi A., Miima S., Ojujo M., Mossy P., Macharia I., Gakenia A., Mitema F., Manvinder M., Kipng'etich B., Njoroge M., Ndegwa D., Karanja J.K., Muchiri K., Makori O., Kibochi W., Mathangani W., Swaleh A., Wafula A., Maina S.N., Njenga P.W., Okonu N., Maghrabi M., Saed S.S., al Shams E.S., Shkirban A.S., Alakkari E.A., Gweder M.G., Baghni R.B., Alsabri S.A., Hebli S.H., Elghandouri M., Shanin S.H., Rokhsi S., Hensheri M.E.L., Eltaguri M., Elyasir I.E., Alwahedi H.W., Almoraid F., Anjar N., Alkilani A., Ghnain A., Senusi F.S., Elsaity R., Almajbery A., Abokris A., Montenegro L., Mohammed F.A.M., Hammouda M., Elsaadi G., Makhlouf N.M., Elzoway A.Z., Abuzalout T.S., Elmehdawi H., Alhendery A.A., Tarhuni A., Feituri A., Benamour A.S.B., Alkobty F.A., Azzaidey H.M.Z., Mohammed N.M., Elghazal Z.S.E., Alhoty F.F.H., Abugassa S.O.A., Al-Zubaidy K., Ilbarasi M.N., Alalem R., Swayeb E., Zubia N.Z., Mohamed P., Teeka M.O., Sohoub A., Abushnaf A., Mohamed A., Ramadan L., Shubba A., Huwidi O., Al-Serksi M., Eshtiwi M., Hadia E., Ahmed A.-J., Mansour I., Rian J.R., Yousef G., Mohamed S., Ahmed E.-Z., Ahmed B., Jamal Z., Abujanah S.A., Amer A.-A., Yousef O., Abozaid W., Elfagieh M.A., Ali A., Zoobei N.Z., Juwid A., Wafa A., Alatresh O.A., Alashhab M., Elzufri A.M., Aldarrat A.D., Matoug F., Alsellabi B., Alkesa T., Addanfour A., Badi H.B., Elfaghi I.E., Salaheddin E., Hamadi L., Hashmi H., Abd-rouf A., Ahmed M., Karar M., Zidan A., Alraheem A.A., Attia A., Yahya A.A., Otman F., Elmadany H., Gerbel G., Saleh M., Eurayet O., Almesmary R., Mostafa H., Abdurazig S., Dahim L., Jermi K., Koraz M.Y.K., Elghallal A.M., Eshwehdi A.A., Elwerfelli A., Elharati F.T., Elrafifi D., Algbali M., Abuhdema F., Elmadani L., Algedar H.A., Shefren I., Abdulrahman A., Najat N.Z., Elkhwildi R.M., Elgelany S., Abduljalil A., Hdud A., Zentuti H.Z., Khetrish S.B., Zeiton A.Z., Altagazi A.A., Almisslati S.H.A., Gandy Y.G., Jasim I., Alghafoud I.A., Hokoma M., Abusnina S.A., Gwila M., Yahya A.I., Mohammed M., Alqawi O.A., Hasan S.H., 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Z., Juwid, A., Wafa, A., Alatresh, O. A., Alashhab, M., Elzufri, A. M., Aldarrat, A. D., Matoug, F., Alsellabi, B., Alkesa, T., Addanfour, A., Badi, H. B., Elfaghi, I. E., Salaheddin, E., Hamadi, L., Hashmi, H., Abd-rouf, A., Ahmed, M., Karar, M., Zidan, A., Alraheem, A. A., Attia, A., Yahya, A. A., Otman, F., Elmadany, H., Gerbel, G., Saleh, M., Eurayet, O., Almesmary, R., Mostafa, H., Abdurazig, S., Dahim, L., Jermi, K., Koraz, M. Y. K., Elghallal, A. M., Eshwehdi, A. A., Elwerfelli, A., Elharati, F. T., Elrafifi, D., Algbali, M., Abuhdema, F., Elmadani, L., Algedar, H. A., Shefren, I., Abdulrahman, A., Najat, N. Z., Elkhwildi, R. M., Elgelany, S., Abduljalil, A., Hdud, A., Zentuti, H. Z., Khetrish, S. B., Zeiton, A. Z., Altagazi, A. A., Almisslati, S. H. A., Gandy, Y. G., Jasim, I., Alghafoud, I. A., Hokoma, M., Abusnina, S. A., Gwila, M., Yahya, A. I., Mohammed, M., Alqawi, O. A., Hasan, S. H., Rakotoarison, S. R., Albert, F., Hery, A. H., Mamy, R. M., Andriamampionona, A. G. 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C., Nakangombe, P., Musiba, V. E. M., Gama, G. G. N., Mwanga, H. A. M., Mgonja, L., Rink, B., Amisi, B. T., Bangure, L., Rois, W., Rois, I., Sabwa, H. K., Barongo, M. L., Tshisekedi, S. M., Mbuyi, T., Lyimo, T. S. K., Munyika, A. A., Kornilov, A. A., Rwehumbiza, S. S. R., Kumar, M., Makopa, E. K., Njuguna, W., Mavesere, H. P., Kabongo, A. N., Mutasiigwa, M. G. H., Yangazov, Y. M., Masiyambiri, A. T. M., Jannetjies, M. J., Dibwe, D. F., Manyere, D. V., Gorelyk, O., Kabangu, J. K., Gagara, M., Salaou, H., Moutari, M., Bori, I., Ogboli-Nwasor, E. O., Aghadi, K., Mohammed, I., Sarkin-Pawa, A., Yunus, A. A., Ibrahim, A. I., Edaigbini, S. A., Yakubu, Y., Sholadoye, T., Koledale, A. K., Anyanwu, L. J. C., Salisu-Kabara, H. M., Sheshe, A. A., Ekwunife, N. C., Ike, I. A. R., Anele, A., Isiguzo, M., Ihezie, O., Onyegbule, A., Enendu, E. O., Akhideno, I., Desalu, I. S., Bankole, O. B., Ojewola, R. W., Osinowo, A. O., Afolabi, B. B., Menkiti, I. D., Mofikoya, B. O., Osazuwa, M. O., Yusuf, A. S., Adamu, Y. B., Alatise, O. I., Arowolo, O. A., Adisa, A. O., Etuk, E. B., Eyelade, O. R., Ogunbode, O., Shittu, O. B., Idowu, O. K., Ayandipo, O. O., Lawal, T. A., Echem, R. C., Otokwala, J., Jamabo, S., Gueye, S., Allopi, K., Singh, U., Bester, J. J. A., Saaiman, C. R., Alli, A., Bischof, K. E., Hurri, H., Smith, O. I., Elghobashy, A. M., Omoshoro-Jones, J., Murray, R., Basson, C. H., de Wet, J. B., Skinner, G. C., Kransingh, S., Kuhn, W., Madsen, A. S. M., Matubatuba, J. T., Mayeza, S., Naidoo, L. C., Narain, S. J., Nkuebe, T. N., Nabela, L., Nkunjana, M., Mhatu, S., Thomas, B. P., Wynne, E. E., Davids, J. G., Gra¼newald, K. K., Kruger, S., Ras, W. A. P., Venter, P. J., Cacala, S. R. C., Kruse, C., Mahomva, O., Marais, L. C., Semenya, E. M., Rayne, S. R., Alphonsus, C. S., Mbuyisa, M. W., Torborg, A. M., De Lange, J. T., Drummond, L. W., Dullab, K. D., Enicker, B. C., Gigabhoy, R., Hardcastle, T. C., Maharaj, A., Majola, N., Moopanar, M., Mukama, I. F., Naicker, K., Ngcobo, G. K., Ramnarain, H., Rocher, A. G. L., Singh, S., Stoltenkamp, H. L., Alberts, A. N. J. D., Luthuli, L., Lumbamba, A. J. M., Anderson, P. G. R., du Plessis, W. M., Ellis, S., Ford, L. M., Rousseau, F. J., Rousseau, N., Steyn, G., Steyn, H. C., Weideman, M., Church, B., Holford, E. B., Szpytko, A. J., Brouckaert, N. T., Freeman, Y. B. M., Ehouni, A., Jithoo, S., Naidoo, L., Peter, A. M., Belhaj, S., Tun, M., Kapp, P., Bwambale, Y. B., Holder, H., Kasongo, K. J. P., Makhanya, V., Morapedi, M., Mahomedy, N. A., Pillay, V., Reddy, S. R., Mgoqo, N., Mrara, B., Nibe, Z., Ninise, E., Pahlana, S. M., Usenbo, A. O., Malongwe, S. M., Giles, D. G., Porrill, O. S., Reed, A. R., Visser, J., Davies, G. L., Koller, V. L., Moodie, Q. K., Spicer, J. M., Van Dyk, J. G., Diedericks, B. J. S., Esterhuizen, J. L., Mavhungu, R., Mhlari, T. M., Akhter, M., Baloyi, A. M., Bamuza, K. A., Bamuza, M. I., Bashiya, L., Blignaut, F., Machowski, A. Z., Madzivhe, L. J., Mafafo, S. C., Mashile, M. V., Masia, O. R., Masipa, J. N., Matenchi, M. W., Mathe, R. C., Mogale, J. O., Mohlala, M. P., Mongwe, K. N., Morulana, T. G., Motloutsi, S. P., Mphephu, P. E., Muroonga, M. P., Mzezewa, S. Z., Neil, M. C., Neluheni, E. V., Nesengani, D. S., Nesengani, N. T., Netshimboni, L. E., Notoane, I., Omoding, S., Orjiako, O., Perez, N., Pheeha, R. M., Pilusa, K. A., Pochana, M. P., Pupyshev, M., Rambau, M., Ramuntshi, R., Roura, H., Ryabchiy, B. B., Ryndine, V., Sebei, M. P., Moses, V. L., Mungherera, A. R. W., and Pansegrouw, J.
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Adult ,Global Health ,SARS‐CoV‐2 ,Health Services Accessibility ,NO ,cancellation ,Models ,COVID‐19 ,Humans ,Pandemics ,Bayes Theorem ,COVID-19 ,Elective Surgical Procedures ,Health Care Rationing ,Health Policy ,Infection Control ,Models, Statistical ,health care economics and organizations ,Elective Surgical Procedure ,Original Articles ,Statistical ,elective surgery ,Original Article ,human activities ,Human - Abstract
The COVID-19 pandemic has disrupted routine hospital services globally. This study estimated the total number of adult elective operations that would be cancelled worldwide during the 12 weeks of peak disruption due to COVID-19.A global expert response study was conducted to elicit projections for the proportion of elective surgery that would be cancelled or postponed during the 12 weeks of peak disruption. A Bayesian β-regression model was used to estimate 12-week cancellation rates for 190 countries. Elective surgical case-mix data, stratified by specialty and indication (surgery for cancer versus benign disease), were determined. This case mix was applied to country-level surgical volumes. The 12-week cancellation rates were then applied to these figures to calculate the total number of cancelled operations.The best estimate was that 28 404 603 operations would be cancelled or postponed during the peak 12 weeks of disruption due to COVID-19 (2 367 050 operations per week). Most would be operations for benign disease (90·2 per cent, 25 638 922 of 28 404 603). The overall 12-week cancellation rate would be 72·3 per cent. Globally, 81·7 per cent of operations for benign conditions (25 638 922 of 31 378 062), 37·7 per cent of cancer operations (2 324 070 of 6 162 311) and 25·4 per cent of elective caesarean sections (441 611 of 1 735 483) would be cancelled or postponed. If countries increased their normal surgical volume by 20 per cent after the pandemic, it would take a median of 45 weeks to clear the backlog of operations resulting from COVID-19 disruption.A very large number of operations will be cancelled or postponed owing to disruption caused by COVID-19. Governments should mitigate against this major burden on patients by developing recovery plans and implementing strategies to restore surgical activity safely.La pandemia de COVID-19 ha interrumpido los servicios hospitalarios habituales a nivel mundial. En este estudio se calculó el número total de operaciones electivas para adultos que se cancelarían en todo el mundo durante las 12 semanas de interrupción máxima debido a COVID’19. MÉTODOS: Se realizó un estudio global de respuestas de expertos para obtener proyecciones sobre la proporción de cirugía electiva que se cancelaría o pospondría durante las 12 semanas del pico máximo de disrupción. Se usó un modelo bayesiano de regresión beta para estimar las tasas de cancelación durante 12 semanas en 190 países. Se determinaron los datos de la casuística de casos quirúrgicos electivos, estratificados por especialidad e indicación (cáncer versus cirugía benigna). Esta casuística de casos se aplicó a volúmenes quirúrgicos a nivel de país. Las tasas de cancelación de las 12 semanas se aplicaron a estas cifras para calcular el total de operaciones suspendidas.La mejor estimación fue que 28.404.603 operaciones hubieran sido canceladas o pospuestas durante las 12 semanas del pico de disrupción por COVID-19 (2.367.050 operaciones por semana). La mayoría hubieran sido operaciones por enfermedad benigna (90,2%, 25.638.922/28. 404. 603). La tasa de cancelación general en 12 semanas sería del 72,3%. A nivel mundial, el 81,7% (25.638.921/31.378.062) de la cirugía benigna, el 37,7% (2. 324.069/6.162.311) de la cirugía por cáncer y el 25,4% (441.611/1.735.483) de las cesáreas electivas hubieran sido canceladas o pospuestas. Si los países aumentan su volumen quirúrgico normal en un 20% después de la pandemia, se tardaría una mediana de 45 semanas para eliminar la acumulación de operaciones resultantes de la disrupción por COVID’19. CONCLUSIÓN: Se cancelará o pospondrá un número muy grande de operaciones debido a la disrupción causada por COVID-19. Los gobiernos deberían mitigar esta importante carga para los pacientes mediante el desarrollo de planes de recuperación e implementando estrategias para reiniciar de manera segura la actividad quirúrgica.
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- 2020
8. Positioning the principles of precision medicine in care pathways for allergic rhinitis and chronic rhinosinusitis – A EUFOREA‐ARIA‐EPOS‐AIRWAYS ICP statement
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Hellings, P. W., Fokkens, W. J., Bachert, C., Akdis, C. A., Bieber, T., Agache, I., Bernal‐Sprekelsen, M., Canonica, G. W., Gevaert, P., Joos, G., Lund, V., Muraro, A., Onerci, M., Zuberbier, T., Pugin, B., Seys, S. F., Bousquet, J., Aberer, W, Agache, I, Akdis, CA, Akdis, M, Alobid, I, Ankri, J, Annesi‐Maesano, I, Ansotegui, IJ, Anto, JM, Arnavielhe, S, Arshad, H, Asarnoj, A, Avolio, F, Bachert, C, Bachert, C, Baiardini, I, Barbagallo, M, Barbara, C, Baroody, F, Bateman, ED, Bedbrook, A, Beghé, B, Bel, EH, Bennoor, KS, Benson, M, Bergmann, KC, Bewick, M, Bialoszewski, AZ, Bieber, T, Bindslev‐Jensen, C, Bjermer, L, Blain, H, Blasi, F, Boner, AL, Bonini, M, Bonini, S, Bosnic‐Anticevich, S, Bosse, I, Bouchard, J, Boulet, LP, Bourret, R, Bousquet, J, Bousquet, PJ, Braido, F, Briggs, AH, Brightling, CE, Brozek, J, Bucca, C, Buhl, R, Bunu, C, Burte, E, Bush, A, Caballero‐Fonseca, F, Caimmi, DP, Calderon, MA, Camargos, PA, Camuzat, T, Canonica, GW, Cardona, V, Carlsen, KH, Carr, W, Carreiro‐Martins, P, Carriazo, AM, Casale, T, Cepeda Sarabia, AM, Cervin, A, Cesari, M, Chatzi, L, Chavannes, NH, Chiron, R, Chivato, T, Chkhartishvili, E, Chuchalin, AG, Chung, KF, Ciprandi, G, Cohen, N, Conzález Diaz, S, Cox, L, Crooks, G, Cruz, AA, Custovic, A, Dahl, R, Dahlen, SE, Darsow, U, De Carlo, G, De Manuel Keenoy, E, de Sousa, JC, De Vries, G, Dedeu, T, Deleanu, D, Demoly, P, Denburg, JA, Devillier, P, Didier, A, Dinh‐Xuan, AT, Dokic, D, Douagui, H, Douglas, R, Dray, G, Du Toit, G, Dubakiene, R, Durham, SR, Dykewicz, MS, Eklund, P, El‐Gamal, Y, Ellers, E, Emuzyte, R, Farrell, J, Fink Wagner, A, Fiocchi, A, Fletcher, M, Fokkens, WJ, Fonseca, J, Forastiere, F, Gaga, M, Gamkrelidze, A, Gemicioğlu, B, Georgalas, C, Gereda, JE, Gevaert, P, Goossens, H, Grisle, I, Guldemond, NA, Gutter, Z, Guzmán, MA, Haahtela, T, Harvey, R, Heinrich, J, Hellings, PW, Hellings, PW, Hellquist‐Dahl, B, Hopkins, C, Horak, F, Hourihane, JO, Humbert, M, Hyland, M, Iaccarino, G, Illario, M, Jares, EJ, Jeandel, C, Johnston, SL, Jonquet, O, Joos, G, Joos, G, Jung, KS, Just, J, Jutel, M, Kaidashev, I, Kalayci, O, Kalogjera, L, Kalyoncu, AF, Kardas, P, Keil, T, Keith, PK, Kerkhof, M, Kern, B, Kerstjens, HA, Khaitov, M, Khaltaev, N, Klimek, L, Kogevinas, M, Kolek, V, Koppelman, GH, Kowalski, M, Kowalski, ML, Kuitunen, M, Kull, I, Kuna, P, Kvedariene, V, Lambrecht, B, Larenas‐Linnemann, D, Lau, S, Laune, D, Le, LT, Li, J, Lieberman, P, Lipworth, B, Lodrup Carlsen, KC, Louis, R, Lund, VJ, Lupinek, C, MacNee, W, Magar, Y, Magnan, A, Mahboub, B, Maier, D, Majer, I, Malva, J, Manning, P, Marshall, GD, Masjedi, MR, Mathieu‐Dupas, E, Maurer, M, Mavale‐Manuel, S, Melén, E, Melo‐Gomes, E, Meltzer, EO, Mercier, J, Merk, H, Miculinic, N, Mihaltan, F, Milenkovic, B, Millot‐Keurinck, J, Mohammad, Y, Momas, I, Morais‐Almeida, M, Mösges, R, Mullol, J, Mullol, J, Muraro, A, Murray, R, Naclerio, R, Nadif, R, Namazova‐Baranova, L, Neffen, H, Nekam, K, Nieto, A, Niggemann, B, Nogueira‐Silva, L, Nogues, M, Nyembue, TD, OʼHehir, RE, Ohta, K, Okamoto, Y, Okubo, K, Olive‐Elias, M, Ouedraogo, S, Paggiaro, P, Pali‐Schöll, I, Palkonen, S, Panzner, P, Papadopoulos, NG, Papi, A, Park, HS, Passalacqua, G, Pawankar, R, Pedersen, S, Pereira, AM, Pfaar, O, Picard, R, Pigearias, B, Pin, I, Plavec, D, Pohl, W, Popov, TA, Portejoie, F, Postma, D, Potter, P, Poulsen, LK, Price, D, Price, D, Rabe, KF, Raciborski, F, Riechelmann, H, Robalo‐Cordeiro, C, Roberts, G, Rodenas, F, Rodriguez‐Mañas, L, Rolland, C, Roman Rodriguez, M, Romano, A, Rosado‐Pinto, J, Rosario, N, Rottem, M, Ryan, D, Samolinski, B, Sanchez‐Borges, M, Sastre‐Dominguez, J, Scadding, GK, Schlosser, R, Schmid‐Grendelmeier, P, Schunemann, HJ, Scichilone, N, Senior, B, Serrano, E, Sheikh, A, Shields, M, Simons, FER, Siroux, V, Sisul, JC, Skrindo, I, Smit, HA, Solé, D, Sooronbaev, T, Spranger, O, Stellato, C, Stelmach, R, Sterk, PJ, Strandberg, T, Sunyer, J, Thijs, C, Thomas, M, Todo‐Bom, A, Tomazic, PV, Toskala, E, Triggiani, M, Valenta, R, Valero, A, Valiulis, A, Valovirta, E, van Eerd, M, van Ganse, E, van Hage, M, van Wick, RG, Vandenplas, O, Varona, LL, Vazankari, T, Vellas, B, Ventura, MT, Vezzani, G, Viegi, G, Voegels, R, Vontetsianos, T, Wagenmann, M, Wahn, U, Walker, S, Wang, DY, Wang, Y, Werfel, T, Whalley, B, Wickman, M, Williams, DM, Williams, S, Wilson, N, Wormald, PJ, Wright, J, Yawn, BP, Yiallouros, PK, Yorgancioglu, A, Young, I, Yusuf, OM, Zaidi, A, Zar, HJ, Zernotti, ME, Zhang, L, Zhong, N, Zidarn, M, and Zuberbier, T
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- 2017
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9. Impacts of climate change on drinking water quality in Norway
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Skaland, R. G., primary, Herrador, B. G., additional, Hisdal, H., additional, Hygen, H. O., additional, Hyllestad, S., additional, Lund, V., additional, White, R., additional, Wong, W. K., additional, and Nygård, K., additional
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- 2022
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10. Sarcoidosis
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Lund, V. J., Whaley, K., editor, and Scadding, G. K., editor
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- 1994
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11. Wegener’s Disease
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Lund, V. J., Whaley, K., editor, and Scadding, G. K., editor
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- 1994
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12. European Symposium on Precision Medicine in Allergy and Airways Diseases: Report of the European Union Parliament Symposium (October 14, 2015)
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Muraro, A., Fokkens, W. J., Pietikainen, S., Borrelli, D., Agache, I., Bousquet, J., Costigliola, V., Joos, G., Lund, V. J., Poulsen, L. K., Price, D., Rolland, C., Zuberbier, T., and Hellings, P. W.
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- 2016
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13. Malignant Melanoma of the Nasal Cavity and Upper Jaw
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Lund, V. J., Waclawiczek, Hans Werner, Gebhart, W., Manfreda, D., and Schlag, P.
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- 1991
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14. Eustachian tube dysfunction: consensus statement on definition, types, clinical presentation and diagnosis
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Schilder, A. G.M., Bhutta, M. F., Butler, C. C., Holy, C., Levine, L. H., Kvaerner, K. J., Norman, G., Pennings, R. J., Poe, D., Silvola, J. T., Sudhoff, H., and Lund, V. J.
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- 2015
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15. Maintained superiority of chronotherapeutics vs. exercise in a 20-week randomized follow-up trial in major depression
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Martiny, K., Refsgaard, E., Lund, V., Lunde, M., Thougaard, B., Lindberg, L., and Bech, P.
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- 2015
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16. Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)
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Klionsky D, Abdel-Aziz A, Abdelfatah S, Abdellatif M, Abdoli A, Abel S, Abeliovich H, Abildgaard M, Abudu Y, Acevedo-Arozena A, Adamopoulos I, Adeli K, Adolph T, Adornetto A, Aflaki E, Agam G, Agarwal A, Aggarwal B, Agnello M, Agostinis P, Agrewala J, Agrotis A, Aguilar P, Ahmad S, Ahmed Z, Ahumada-Castro U, Aits S, Aizawa S, Akkoc Y, Akoumianaki T, Akpinar H, Al-Abd A, Al-Akra L, Al-Gharaibeh A, Alaoui-Jamali M, Alberti S, Alcocer-Gomez E, Alessandri C, Ali M, Al-Bari M, Aliwaini S, Alizadeh J, Almacellas E, Almasan A, Alonso A, Alonso G, Altan-Bonnet N, Altieri D, Alves S, da Costa C, Alzaharna M, Amadio M, Amantini C, Amaral C, Ambrosio S, Amer A, Ammanathan V, An Z, Andersen S, Andrabi S, Andrade-Silva M, Andres A, Angelini S, Ann D, Anozie U, Ansari M, Antas P, Antebi A, Anton Z, Anwar T, Apetoh L, Apostolova N, Araki T, Araki Y, Arasaki K, Araujo W, Araya J, Arden C, Arevalo M, Arguelles S, Arias E, Arikkath J, Arimoto H, Ariosa A, Armstrong-James D, Arnaune-Pelloquin L, Aroca A, Arroyo D, Arsov I, Artero R, Asaro D, Aschner M, Ashrafizadeh M, Ashur-Fabian O, Atanasov A, Au A, Auberger P, Auner H, Aurelian L, Autelli R, Avagliano L, Avalos Y, Aveic S, Aveleira C, AvinWittenberg T, Aydin Y, Ayton S, Ayyadevara S, Azzopardi M, Baba M, Backer J, Backues S, Bae D, Bae O, Bae S, Baehrecke E, Baek A, Baek S, Bagetta G, Bagniewska-Zadworna A, Bai H, Bai J, Bai X, Bai Y, Bairagi N, Baksi S, Balbi T, Baldari C, Balduini W, Ballabio A, Ballester M, Balazadeh S, Balzan R, Bandopadhyay R, Banerjee S, Bao Y, Baptista M, Baracca A, Barbati C, Bargiela A, Barila D, Barlow P, Barmada S, Barreiro E, Barreto G, Bartek J, Bartel B, Bartolome A, Barve G, Basagoudanavar S, Bassham D, Jr R, Basu A, Batoko H, Batten I, Baulieu E, Baumgarner B, Bayry J, Beale R, Beau I, Beaumatin F, Bechara L, Beck G, Beers M, Begun J, Behrends C, Behrens G, Bei R, Bejarano E, Bel S, Behl C, Belaid A, Belgareh-Touze N, Bellarosa C, Belleudi F, Perez M, Bello-Morales R, Beltran J, Beltran S, Benbrook D, Bendorius M, Benitez B, Benito-Cuesta I, Bensalem J, Berchtold M, Berezowska S, Bergamaschi D, Bergami M, Bergmann A, Berliocchi L, Berlioz-Torrent C, Bernard A, Berthoux L, Besirli C, Besteiro S, Betin V, Beyaert R, Bezbradica J, Bhaskar K, Bhatia-Kissova I, Bhattacharya R, Bhattacharya S, Bhattacharyya S, Bhuiyan M, Bhutia S, Bi L, Bi X, Biden T, Bijian K, Billes V, Binart N, Bincoletto C, Birgisdottir A, Bjorkoy G, Blanco G, Blas-Garcia A, Blasiak J, Blomgran R, Blomgren K, Blum J, Boada-Romero E, Boban M, BoeszeBattaglia K, Boeuf P, Boland B, Bomont P, Bonaldo P, Bonam S, Bonfili L, Bonifacino J, Boone B, Bootman M, Bordi M, Borner C, Bornhauser B, Borthakur G, Bosch J, Bose S, Botana L, Botas J, Boulanger C, Boulton M, Bourdenx M, Bourgeois B, Bourke N, Bousquet G, Boya P, Bozhkov P, Bozi L, Bozkurt T, Brackney D, Brandts C, Braun R, Braus G, Bravo-Sagua R, Bravo-San Pedro J, Brest P, Bringer M, Briones-Herrera A, Broaddus V, Brodersen P, Alvarez E, Brodsky J, Brody S, Bronson P, Bronstein J, Brown C, Brown R, Brum P, Brumell J, Brunetti-Pierri N, Bruno D, Bryson-Richardson R, Bucci C, Buchrieser C, Bueno M, Buitrago-Molina L, Buraschi S, Buch S, Buchan J, Buckingham E, Budak H, Budini M, Bultynck G, Burada F, Burgoyne J, Buron M, Bustos V, Buttner S, Butturini E, Byrd A, Cabas I, Cabrera-Benitez S, Cadwell K, Cai J, Cai L, Cai Q, Cairo M, Calbet J, Caldwell G, Caldwell K, Call J, Calvani R, Calvo A, Barrera M, Camara N, Camonis J, Camougrand N, Campanella M, Campbell E, Campbell-Valois F, Campello S, Campesi I, Campos J, Camuzard O, Cancino J, de Almeida D, Canesi L, Caniggia I, Canonico B, Canti C, Cao B, Caraglia M, Carames B, Carchman E, Cardenal-Munoz E, Cardenas C, Cardenas L, Cardoso S, Carew J, Carle G, Carleton G, Carloni S, Carmona-Gutierrez D, Carneiro L, Carnevali O, Carosi J, Carra S, Carrier A, Carrier L, Carroll B, Carter A, Carvalho A, Casanova M, Casas C, Casas J, Cassioli C, Castillo E, Castillo K, Castillo-Lluva S, Castoldi F, Castori M, Castro A, Castro-Caldas M, Castro-Hernandez J, Castro-Obregon S, Catz S, Cavadas C, Cavaliere F, Cavallini G, Cavinato M, Cayuela M, Rica P, Cecarini V, Cecconi F, Cechowska-Pasko M, Cenci S, Ceperuelo-Mallafre V, Cerqueira J, Cerutti J, Cervia D, Cetintas V, Cetrullo S, Chae H, Chagin A, Chai C, Chakrabarti G, Chakrabarti O, Chakraborty T, Chami M, Chamilos G, Chan D, Chan E, Chan H, Chan M, Chan Y, Chandra P, Chang C, Chang H, Chang K, Chao J, Chapman T, Charlet-Berguerand N, Chatterjee S, Chaube S, Chaudhary A, Chauhan S, Chaum E, Checler F, Cheetham M, Chen C, Chen G, Chen J, Chen L, Chen M, Chen N, Chen Q, Chen R, Chen S, Chen W, Chen X, Chen Y, Chen Z, Cheng H, Cheng J, Cheng S, Cheng W, Cheng X, Cheng Y, Cheng Z, Cheong H, Cheong J, Chernyak B, Cherry S, Cheung C, Cheung K, Chevet E, Chi R, Chiang A, Chiaradonna F, Chiarelli R, Chiariello M, Chica N, Chiocca S, Chiong M, Chiou S, Chiramel A, Chiurchiu V, Cho D, Choe S, Choi A, Choi M, Choudhury K, Chow N, Chu C, Chua J, Chung H, 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Clair D, Stagni V, Staiano L, Stalnecker C, Stankov M, Stathopulos P, Stefan K, Stefan S, Stefanis L, Steffan J, Steinkasserer A, Stenmark H, Sterneckert J, Stevens C, Stoka V, Storch S, Stork B, Strappazzon F, Strohecker A, Stupack D, Su H, Su L, SuarezFontes A, Subauste C, Subbian S, Subirada P, Sudhandiran G, Sue C, Sui X, Summers C, Sun G, Sun J, Sun K, Sun M, Sun Q, Sun Y, Sun Z, Sunahara K, Sundberg E, Susztak K, Sutovsky P, Suzuki H, Sweeney G, Symons J, Sze S, Szewczyk N, Tabolacci C, Tacke F, Taegtmeyer H, Tafani M, Tagaya M, Tai H, Tait S, Takahashi Y, Takats S, Talwar P, Tam C, Tam S, Tampellini D, Tamura A, Tan C, Tan E, Tan Y, Tanaka M, Tang D, Tang J, Tang T, Tanida I, Tao Z, Taouis M, Tatenhorst L, Tavernarakis N, Taylor A, Taylor G, Taylor J, Tchetina E, Tee A, Tegeder I, Teis D, Teixeira N, Teixeira-Clerc F, Tekirdag K, Tencomnao T, Tenreiro S, Tepikin A, Testillano P, Tettamanti G, Tharaux P, Thedieck K, Thekkinghat A, Thellung S, Thinwa J, Thirumalaikumar V, Thomas S, Thomes P, Thorburn A, Thukral L, Thum T, Thumm M, Tian L, Tichy A, Till A, Timmerman V, Titorenko V, Todi S, Todorova K, Toivonen J, Tomaipitinca L, Tomar D, Tomas-Zapico C, Tong B, Tong C, Tong X, Tooze S, Torgersen M, Torii S, Torres-Lopez L, Torriglia A, Towers C, Towns R, Toyokuni S, Trajkovic V, Tramontano D, Tran Q, Travassos L, Trelford C, Tremel S, Trougakos I, Tsao B, Tschan M, Tse H, Tse T, Tsugawa H, Tsvetkov A, Tumbarello D, Tumtas Y, Tunon M, Turcotte S, Turk B, Turk V, Turner B, Tuxworth R, Tyler J, Tyutereva E, Uchiyama Y, UgunKlusek A, Uhlig H, Ulasov I, Umekawa M, Ungermann C, Unno R, Urbe S, Uribe-Carretero E, Ustun S, Uversky V, Vaccari T, Vaccaro M, Vahsen B, Vakifahmetoglu-Norberg H, Valdor R, Valente M, Valko A, Vallee R, Valverde A, Van den Berghe G, van Der Veen S, Van Kaer L, van Loosdregt J, van Wijk S, Vandenberghe W, Vanhorebeek I, Vannier-Santos M, Vannini N, Vanrell M, Vantaggiato C, Varano G, Varela-Nieto I, Varga M, Vasconcelos M, Vats S, Vavvas D, VegaNaredo I, Vega-Rubin-de-Celis S, Velasco G, Velazquez A, Vellai T, Vellenga E, Velotti F, Verdier M, Verginis P, Vergne I, Verkade P, Verma M, Verstreken P, Vervliet T, Vervoorts J, Vessoni A, Victor V, Vidal M, Vidoni C, Vieira O, Vierstra R, Vigano S, Vihinen H, Vijayan V, Vila M, Vilar M, Villalba J, Villalobo A, Villarejo-Zori B, Villarroya F, Villarroya J, Vincent O, Vindis C, Viret C, Viscomi M, Visnjic D, Vitale I, Vocadlo D, Voitsekhovskaja O, Volonte C, Volta M, Vomero M, Von Haefen C, Vooijs M, Voos W, Vucicevic L, Wade-Martins R, Waguri S, Waite K, Wakatsuki S, Walker D, Walker M, Walker S, Walter J, Wandosell F, Wang B, Wang C, Wang D, Wang F, Wang G, Wang H, Wang J, Wang K, Wang L, Wang M, Wang N, Wang P, Wang Q, Wang W, Wang X, Wang Y, Wang Z, Warnes G, Warnsmann V, Watada H, Watanabe E, Watchon M, Weaver T, Wegrzyn G, Wehman A, Wei H, Wei L, Wei T, Wei Y, Weiergraber O, Weihl C, Weindl G, Weiskirchen R, Wells A, Wen R, Wen X, Werner A, Weykopf B, Wheatley S, Whitton J, Whitworth A, Wiktorska K, Wildenberg M, Wileman T, Wilkinson S, Willbold D, Williams B, Williams R, Williamson P, Wilson R, Winner B, Winsor N, Witkin S, Wodrich H, Woehlbier U, Wollert T, Wong E, Wong J, Wong R, Wong V, Wong W, Wu A, Wu C, Wu J, Wu K, Wu M, Wu S, Wu W, Wu X, Wu Y, Xavier R, Xia H, Xia L, Xia Z, Xiang G, Xiang J, Xiang M, Xiang W, Xiao B, Xiao G, Xiao H, Xiao J, Xiao L, Xiao S, Xiao Y, Xie B, Xie C, Xie M, Xie Y, Xie Z, Xilouri M, Xu C, Xu E, Xu H, Xu J, Xu L, Xu W, Xu X, Xue Y, Yakhine-Diop S, Yamaguchi M, Yamaguchi O, Yamamoto A, Yamashina S, Yan S, Yan Z, Yanagi Y, Yang C, Yang D, Yang H, Yang J, Yang L, Yang M, Yang P, Yang Q, Yang S, Yang W, Yang X, Yang Y, Yao H, Yao S, Yao X, Yao Y, Yasui T, Yazdankhah M, Yen P, Yi C, Yin X, Yin Y, Yin Z, Ying M, Ying Z, Yip C, Yiu S, Yoo Y, Yoshida K, Yoshii S, Yoshimori T, Yousefi B, Yu B, Yu H, Yu J, Yu L, Yu M, Yu S, Yu V, Yu W, Yu Z, Yuan J, Yuan L, Yuan S, Yuan Y, Yuan Z, Yue J, Yue Z, Yun J, Yung R, Zacks D, Zaffagnini G, Zambelli V, Zanella I, Zang Q, Zanivan S, Zappavigna S, Zaragoza P, Zarbalis K, Zarebkohan A, Zarrouk A, Zeitlin S, Zeng J, Zerovnik E, Zhan L, Zhang B, Zhang D, Zhang H, Zhang J, Zhang K, Zhang L, Zhang M, Zhang P, Zhang S, Zhang W, Zhang X, Zhang Y, Zhang Z, Zhao H, Zhao L, Zhao S, Zhao T, Zhao X, Zhao Y, Zheng G, Zheng K, Zheng L, Zheng S, Zheng X, Zheng Y, Zheng Z, Zhivotovsky B, Zhong Q, Zhou A, Zhou B, Zhou C, Zhou G, Zhou H, Zhou J, Zhou K, Zhou R, Zhou X, Zhou Y, Zhou Z, Zhu B, Zhu C, Zhu G, Zhu H, Zhu W, Zhu Y, Zhuang H, Zhuang X, Zientara-Rytter K, Zimmermann C, Ziviani E, Zoladek T, Zong W, Zorov D, Zorzano A, Zou W, Zou Z, Zuryn S, Zwerschke W, Brand-Saberi B, Kenchappa C, Oshima S, Rong Y, Sluimer J, and Stallings C
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flux ,macroautophagy ,phagophore ,stress ,vacuole ,Autophagosome ,LC3 ,lysosome ,neurodegeneration ,cancer - Abstract
In 2008, we published the first set of guidelines for standardizing research in autophagy. Since then, this topic has received increasing attention, and many scientists have entered the field. Our knowledge base and relevant new technologies have also been expanding. Thus, it is important to formulate on a regular basis updated guidelines for monitoring autophagy in different organisms. Despite numerous reviews, there continues to be confusion regarding acceptable methods to evaluate autophagy, especially in multicellular eukaryotes. Here, we present a set of guidelines for investigators to select and interpret methods to examine autophagy and related processes, and for reviewers to provide realistic and reasonable critiques of reports that are focused on these processes. These guidelines are not meant to be a dogmatic set of rules, because the appropriateness of any assay largely depends on the question being asked and the system being used. Moreover, no individual assay is perfect for every situation, calling for the use of multiple techniques to properly monitor autophagy in each experimental setting. Finally, several core components of the autophagy machinery have been implicated in distinct autophagic processes (canonical and noncanonical autophagy), implying that genetic approaches to block autophagy should rely on targeting two or more autophagy-related genes that ideally participate in distinct steps of the pathway. Along similar lines, because multiple proteins involved in autophagy also regulate other cellular pathways including apoptosis, not all of them can be used as a specific marker for bona fide autophagic responses. Here, we critically discuss current methods of assessing autophagy and the information they can, or cannot, provide. Our ultimate goal is to encourage intellectual and technical innovation in the field.
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- 2021
17. Efficacy and safety of treatment with biologicals for severe chronic rhinosinusitis with nasal polyps: A systematic review for the EAACI guidelines
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Agache, I, Song, Y, Alonso-Coello, P, Vogel, Y, Rocha, C, Sola, I, Santero, M, Akdis, C, Akdis, M, Canonica, GW, Chivato, T, del Giacco, S, Eiwegger, T, Fokkens, W, Georgalas, C, Gevaert, P, Hopkins, C, Klimek, L, Lund, V, Naclerio, R, O'Mahony, L, Palkonen, S, Pfaar, O, Schwarze, J, Soyka, MB, Wang, DY, Zhang, L, Canelo-Aybar, C, Palomares, O, and Jutel, M
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chronic rhinosinusitis ,dupilumab ,mepolizumab ,omalizumab ,reslizumab - Abstract
This systematic review evaluates the efficacy and safety of biologicals for chronic rhinosinusitis with nasal polyps (CRSwNP) compared with the standard of care. PubMed, Embase, and Cochrane Library were searched for RCTs. Critical and important CRSwNP-related outcomes were considered. The risk of bias and the certainty of the evidence were assessed using GRADE. RCTs evaluated (dupilumab-2, omalizumab-4, mepolizumab-2, and reslizumab-1) included 1236 adults, with follow-up of 20-64 weeks. Dupilumab reduces the need for surgery (NFS) or oral corticosteroid (OCS) use (RR 0.28; 95% CI 0.20-0.39, moderate certainty) and improves with high certainty smell evaluated with UPSIT score (mean difference (MD) +10.54; 95% CI +9.24 to +11.84) and quality of life (QoL) evaluated with SNOT-22 (MD -19.14; 95% CI -22.80 to -15.47), with fewer treatment-related adverse events (TAEs) (RR 0.95; 95% CI 0.89-1.02, moderate certainty). Omalizumab reduces NFS (RR 0.85; 95% CI 0.78-0.92, high certainty), decreases OCS use (RR 0.38; 95% CI 0.10-1.38, moderate certainty), and improves high certainty smell (MD +3.84; 95% CI +3.64 to +4.04) and QoL (MD -15.65; 95% CI -16.16 to -15.13), with increased TAE (RR 1.73; 95% CI 0.60-5.03, moderate certainty). There is low certainty for mepolizumab reducing NFS (RR 0.78; 95% CI 0.64-0.94) and improving QoL (MD -13.3; 95% CI -23.93 to -2.67) and smell (MD +0.7; 95% CI -0.48 to +1.88), with increased TAEs (RR 1.64; 95% CI 0.41-6.50). The evidence for reslizumab is very uncertain.
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- 2021
18. EPOS 4 Patients.
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UCL - SSS/IREC/PNEU - Pôle de Pneumologie, ORL et Dermatologie, UCL - (SLuc) Service d'oto-rhino-laryngologie, Hopkins, C, Surda, P, Walker, A, Wolf, A, Speth, M M, Jacques, T, Hox, V, Van Gerven, L, Santamaria-Gadea, A, Segboer, C, Lourijsen, E, Turri-Zanoni, M, Huart, C, Rennie, C, Green, R, The Samter's Society, The Samter's Society, Kelly, C E, Knill, A, Lund, V J, Fokkens, W J, UCL - SSS/IREC/PNEU - Pôle de Pneumologie, ORL et Dermatologie, UCL - (SLuc) Service d'oto-rhino-laryngologie, Hopkins, C, Surda, P, Walker, A, Wolf, A, Speth, M M, Jacques, T, Hox, V, Van Gerven, L, Santamaria-Gadea, A, Segboer, C, Lourijsen, E, Turri-Zanoni, M, Huart, C, Rennie, C, Green, R, The Samter's Society, The Samter's Society, Kelly, C E, Knill, A, Lund, V J, and Fokkens, W J
- Abstract
EPOS2020 is the 4th and most recent version of the European Position Paper on Rhinosinusitis and Nasal Polyps which was first published in 2005. It aims to provide the most up to date scientifically robust information on the topic published in the literature which has been critically analysed by an international group of clinicians drawn from all disciplines dealing with these problems together with patients. The guidelines offer evidence-based recommendations and care pathways for acute and chronic rhinosinusitis in both adults and children. Management of these diseases from the patients' perspective is an important part of EPOS2020. Not only is this included in the main document but, for the first time, we have produced a separate supplement dedicated to and in collaboration with patients, EPOS4Patients, which aims to provide information in an accessible format, to answer frequently asked questions about these diseases and their treatment options as well as including useful patient resources and websites. It has never been more important for patients to be actively involved in their care. Being well informed helps you to make the best decisions together with your doctor.
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- 2021
19. EPOS 4 Patients.
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UCL - SSS/IONS/NEUR - Clinical Neuroscience, UCL - (SLuc) Service d'oto-rhino-laryngologie, Hopkins, C, Surda, P, Walker, A, Wolf, A, Speth, M M, Jacques, T, Hox, V, Van Gerven, L, Santamaria-Gadea, A, Segboer, C, Lourijsen, E, Turri-Zanoni, M, Huart, C, Rennie, C, Green, R, The Samter's Society, The Samter's Society, Kelly, C E, Knill, A, Lund, V J, Fokkens, W J, UCL - SSS/IONS/NEUR - Clinical Neuroscience, UCL - (SLuc) Service d'oto-rhino-laryngologie, Hopkins, C, Surda, P, Walker, A, Wolf, A, Speth, M M, Jacques, T, Hox, V, Van Gerven, L, Santamaria-Gadea, A, Segboer, C, Lourijsen, E, Turri-Zanoni, M, Huart, C, Rennie, C, Green, R, The Samter's Society, The Samter's Society, Kelly, C E, Knill, A, Lund, V J, and Fokkens, W J
- Abstract
EPOS2020 is the 4th and most recent version of the European Position Paper on Rhinosinusitis and Nasal Polyps which was first published in 2005. It aims to provide the most up to date scientifically robust information on the topic published in the literature which has been critically analysed by an international group of clinicians drawn from all disciplines dealing with these problems together with patients. The guidelines offer evidence-based recommendations and care pathways for acute and chronic rhinosinusitis in both adults and children. Management of these diseases from the patients' perspective is an important part of EPOS2020. Not only is this included in the main document but, for the first time, we have produced a separate supplement dedicated to and in collaboration with patients, EPOS4Patients, which aims to provide information in an accessible format, to answer frequently asked questions about these diseases and their treatment options as well as including useful patient resources and websites. It has never been more important for patients to be actively involved in their care. Being well informed helps you to make the best decisions together with your doctor.
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- 2021
20. EPOS 4 Patients.
- Author
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UCL - (SLuc) Service d'oto-rhino-laryngologie, Hopkins, C, Surda, P, Walker, A, Wolf, A, Speth, M M, Jacques, T, Hox, V, Van Gerven, L, Santamaria-Gadea, A, Segboer, C, Lourijsen, E, Turri-Zanoni, M, Huart, C, Rennie, C, Green, R, The Samter's Society, The Samter's Society, Kelly, C E, Knill, A, Lund, V J, Fokkens, W J, UCL - (SLuc) Service d'oto-rhino-laryngologie, Hopkins, C, Surda, P, Walker, A, Wolf, A, Speth, M M, Jacques, T, Hox, V, Van Gerven, L, Santamaria-Gadea, A, Segboer, C, Lourijsen, E, Turri-Zanoni, M, Huart, C, Rennie, C, Green, R, The Samter's Society, The Samter's Society, Kelly, C E, Knill, A, Lund, V J, and Fokkens, W J
- Abstract
EPOS2020 is the 4th and most recent version of the European Position Paper on Rhinosinusitis and Nasal Polyps which was first published in 2005. It aims to provide the most up to date scientifically robust information on the topic published in the literature which has been critically analysed by an international group of clinicians drawn from all disciplines dealing with these problems together with patients. The guidelines offer evidence-based recommendations and care pathways for acute and chronic rhinosinusitis in both adults and children. Management of these diseases from the patients' perspective is an important part of EPOS2020. Not only is this included in the main document but, for the first time, we have produced a separate supplement dedicated to and in collaboration with patients, EPOS4Patients, which aims to provide information in an accessible format, to answer frequently asked questions about these diseases and their treatment options as well as including useful patient resources and websites. It has never been more important for patients to be actively involved in their care. Being well informed helps you to make the best decisions together with your doctor.
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- 2021
21. Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)
- Author
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Klionsky, D, Abdel-Aziz, A, Abdelfatah, S, Abdellatif, M, Abdoli, A, Abel, S, Abeliovich, H, Abildgaard, M, Abudu, Y, Acevedo-Arozena, A, Adamopoulos, I, Adeli, K, Adolph, T, Adornetto, A, Aflaki, E, Agam, G, Agarwal, A, Aggarwal, B, Agnello, M, Agostinis, P, Agrewala, J, Agrotis, A, Aguilar, P, Ahmad, S, Ahmed, Z, Ahumada-Castro, U, Aits, S, Aizawa, S, Akkoc, Y, Akoumianaki, T, Akpinar, H, Al-Abd, A, Al-Akra, L, Al-Gharaibeh, A, Alaoui-Jamali, M, Alberti, S, Alcocer-Gómez, E, Alessandri, C, Ali, M, Alim Al-Bari, M, Aliwaini, S, Alizadeh, J, Almacellas, E, Almasan, A, Alonso, A, Alonso, G, Altan-Bonnet, N, Altieri, D, Álvarez, É, Alves, S, Alves da Costa, C, Alzaharna, M, Amadio, M, Amantini, C, Amaral, C, Ambrosio, S, Amer, A, Ammanathan, V, An, Z, Andersen, S, Andrabi, S, Andrade-Silva, M, Andres, A, Angelini, S, Ann, D, Anozie, U, Ansari, M, Antas, P, Antebi, A, Antón, Z, Anwar, T, Apetoh, L, Apostolova, N, Araki, T, Araki, Y, Arasaki, K, Araújo, W, Araya, J, Arden, C, Arévalo, M, Arguelles, S, Arias, E, Arikkath, J, Arimoto, H, Ariosa, A, Armstrong-James, D, Arnauné-Pelloquin, L, Aroca, A, Arroyo, D, Arsov, I, Artero, R, Asaro, D, Aschner, M, Ashrafizadeh, M, Ashur-Fabian, O, Atanasov, A, Au, A, Auberger, P, Auner, H, Aurelian, L, Autelli, R, Avagliano, L, Ávalos, Y, Aveic, S, Aveleira, C, Avin-Wittenberg, T, Aydin, Y, Ayton, S, Ayyadevara, S, Azzopardi, M, Baba, M, Backer, J, Backues, S, Bae, D, Bae, O, Bae, S, Baehrecke, E, Baek, A, Baek, S, Bagetta, G, Bagniewska-Zadworna, A, Bai, H, Bai, J, Bai, X, Bai, Y, Bairagi, N, Baksi, S, Balbi, T, Baldari, C, Balduini, W, Ballabio, A, Ballester, M, Balazadeh, S, Balzan, R, Bandopadhyay, R, Banerjee, S, Bánréti, Á, Bao, Y, Baptista, M, Baracca, A, Barbati, C, Bargiela, A, Barilà, D, Barlow, P, Barmada, S, Barreiro, E, Barreto, G, Bartek, J, Bartel, B, Bartolome, A, Barve, G, Basagoudanavar, S, Bassham, D, Bast, R, Basu, A, Batoko, H, Batten, I, Baulieu, E, Baumgarner, B, Bayry, J, Beale, R, Beau, I, Beaumatin, F, Bechara, L, Beck, G, Beers, M, Begun, J, Behrends, C, Behrens, G, Bei, R, Bejarano, E, Bel, S, Behl, C, Belaid, A, Belgareh-Touzé, N, Bellarosa, C, Belleudi, F, Belló Pérez, M, Bello-Morales, R, Beltran, J, Beltran, S, Benbrook, D, Bendorius, M, Benitez, B, Benito-Cuesta, I, Bensalem, J, Berchtold, M, Berezowska, S, Bergamaschi, D, Bergami, M, Bergmann, A, Berliocchi, L, Berlioz-Torrent, C, Bernard, A, Berthoux, L, Besirli, C, Besteiro, S, Betin, V, Beyaert, R, Bezbradica, J, Bhaskar, K, Bhatia-Kissova, I, Bhattacharya, R, Bhattacharya, S, Bhattacharyya, S, Bhuiyan, M, Bhutia, S, Bi, L, Bi, X, Biden, T, Bijian, K, Billes, V, Binart, N, Bincoletto, C, Birgisdottir, A, Bjorkoy, G, Blanco, G, Blas-Garcia, A, Blasiak, J, Blomgran, R, Blomgren, K, Blum, J, Boada-Romero, E, Boban, M, Boesze-Battaglia, K, Boeuf, P, Boland, B, Bomont, P, Bonaldo, P, Bonam, S, Bonfili, L, Bonifacino, J, Boone, B, Bootman, M, Bordi, M, Borner, C, Bornhauser, B, Borthakur, G, Bosch, J, Bose, S, Botana, L, Botas, 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Werner, Brand-Saberi, Beate, Dong, X Charlie, Kenchappa, Chandra Shekar, Li, Zuguo, Lin, Yong, Oshima, Shigeru, Rong, Yueguang, Sluimer, Judith C, Stallings, Christina L, and Tong, Chun-Kit
- Abstract
In 2008, we published the first set of guidelines for standardizing research in autophagy. Since then, this topic has received increasing attention, and many scientists have entered the field. Our knowledge base and relevant new technologies have also been expanding. Thus, it is important to formulate on a regular basis updated guidelines for monitoring autophagy in different organisms. Despite numerous reviews, there continues to be confusion regarding acceptable methods to evaluate autophagy, especially in multicellular eukaryotes. Here, we present a set of guidelines for investigators to select and interpret methods to examine autophagy and related processes, and for reviewers to provide realistic and reasonable critiques of reports that are focused on these processes. These guidelines are not meant to be a dogmatic set of rules, because the appropriateness of any assay largely depends on the question being asked and the system being used. Moreover, no individual assay is perfect for every situation, calling for the use of multiple techniques to properly monitor autophagy in each experimental setting. Finally, several core components of the autophagy machinery have been implicated in distinct autophagic processes (canonical and noncanonical autophagy), implying that genetic approaches to block autophagy should rely on targeting two or more autophagy-related genes that ideally participate in distinct steps of the pathway. Along similar lines, because multiple proteins involved in autophagy also regulate other cellular pathways including apoptosis, not all of them can be used as a specific marker for bona fide autophagic responses. Here, we critically discuss current methods of assessing autophagy and the information they can, or cannot, provide. Our ultimate goal is to encourage intellectual and technical innovation in the field.
- Published
- 2021
22. Setting the research agenda for ENT, hearing and balance: the GENERATE project
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Bohm, N., Schilder, A., and Lund, V.
- Published
- 2014
- Full Text
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23. EUFOREA treatment algorithm for allergic rhinitis
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Hellings, P. W., Scadding, G., Bachert, C., Bjermer, L., Canonica, G. W., Cardell, L. O., Carney, A. S., Constantinidis, J., Deneyer, L., Diamant, Z., Durham, S., Gevaert, P., Harvey, R., Hopkins, C., Kjeldsen, A., Klimek, L., Lund, V. J., Price, D., Rimmer, J., Ryan, D., Roberts, G., Sahlstrand-Johnson, P., Salmi, S., Samji, M., Scadding, Guy, Smith, P., Steinsvik, A., Wagenmann, M., Seys, S., Wahn, U., Fokkens, W. J., Ear, Nose and Throat, and AII - Inflammatory diseases
- Subjects
Otorhinolaryngology ,Humans ,General Medicine ,Rhinitis, Allergic ,Algorithms ,Asthma - Abstract
Allergic rhinitis (AR) is the most common chronic inflammatory disease, affecting an estimated 100 million Europeans (1). Despite a substantial burden on individuals, society and health economies (2), AR remains under-diagnosed, under-estimated (in terms of severity), and under-treated (3). Although effective and safe treatments exist, patients wait too long to seek medical advice, often preferring to self-manage at drug stores and at the pharmacy (4).
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- 2020
24. European Position Paper on Rhinosinusitis and Nasal Polyps 2020
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Fokkens, W J, Lund, V J, Hopkins, C, Hellings, P W, Kern, R, Reitsma, S, Toppila-Salmi, S, Bernal-Sprekelsen, M, Mullol, J, Alobid, I, Terezinha Anselmo-Lima, W, Bachert, C, Baroody, F, von Buchwald, C, Cervin, A, Cohen, N, Constantinidis, J, De Gabory, L, Desrosiers, M, Diamant, Z, Douglas, R G, Gevaert, P H, Hafner, A, Harvey, R J, Joos, G F, Kalogjera, L, Knill, A, Kocks, J H, Landis, B N, Limpens, J, Lebeer, S, Lourenco, O, Meco, C, Matricardi, P M, O'Mahony, L, Philpott, C M, Ryan, D, Schlosser, R, Senior, B, Smith, T L, Teeling, T, Tomazic, P V, Wang, D, Zhang, L, Agius, A M, Ahlstrom-Emanuelsson, C, Alabri, R, Albu, S, Alhabash, S, Aleksic, A, Aloulah, M, Al-Qudah, M, Alsaleh, S, Baban, M A, Baudoin, T, Balvers, T, Battaglia, P, Bedoya, J D, Beule, A, Bofares, K M, Braverman, I, Brozek-Madry, E, Richard, B, Callejas, C, Carrie, S, Caulley, L, Chussi, D, de Corso, E, Coste, A, El Hadi, U, Elfarouk, A, Eloy, P H, Farrokhi, S, Felisati, G, Ferrari, M D, Fishchuk, R, Grayson, W, Goncalves, P M, Grdinic, B, Grgic, V, Hamizan, A W, Heinichen, J V, Husain, S, Ping, T I, Ivaska, J, Jakimovska, F, Jovancevic, L, Kakande, E, Kamel, R, Karpischenko, S, Kariyawasam, H H, Kawauchi, H, Kjeldsen, A, Klimek, L, Krzeski, A, Kopacheva Barsova, G, Kim, S W, Lal, D, Letort, J J, Lopatin, A, Mahdjoubi, A, Mesbahi, A, Netkovski, J, Nyenbue Tshipukane, D, Obando-Valverde, A, Okano, M, Onerci, M, Ong, Y K, Orlandi, R, Otori, N, Ouennoughy, K, Ozkan, M, Peric, A, Plzak, J, Prokopakis, E, Prepageran, N, Psaltis, A, Pugin, B, Raftopulos, M, Rombaux, P, Riechelmann, H, Sahtout, S, Sarafoleanu, C-C, Searyoh, K, Rhee, C-S, Shi, J, Shkoukani, M, Shukuryan, A K, Sicak, M, Smyth, D, Sindvongs, K, Soklic Kosak, T, Stjarne, P, Sutikno, B, Steinsvag, S, Tantilipikorn, P, Thanaviratananich, S, Tran, T, Urbancic, J, Valiulius, A, Vasquez de Aparicio, C, Vicheva, D, Virkkula, P M, Vicente, G, Voegels, R, Wagenmann, M M, Wardani, R S, Welge-Lussen, A, Witterick, I, Wright, E, Zabolotniy, D, Zsolt, B, Zwetsloot, C P, Fokkens, W J, Lund, V J, Hopkins, C, Hellings, P W, Kern, R, Reitsma, S, Toppila-Salmi, S, Bernal-Sprekelsen, M, Mullol, J, Alobid, I, Terezinha Anselmo-Lima, W, Bachert, C, Baroody, F, von Buchwald, C, Cervin, A, Cohen, N, Constantinidis, J, De Gabory, L, Desrosiers, M, Diamant, Z, Douglas, R G, Gevaert, P H, Hafner, A, Harvey, R J, Joos, G F, Kalogjera, L, Knill, A, Kocks, J H, Landis, B N, Limpens, J, Lebeer, S, Lourenco, O, Meco, C, Matricardi, P M, O'Mahony, L, Philpott, C M, Ryan, D, Schlosser, R, Senior, B, Smith, T L, Teeling, T, Tomazic, P V, Wang, D, Zhang, L, Agius, A M, Ahlstrom-Emanuelsson, C, Alabri, R, Albu, S, Alhabash, S, Aleksic, A, Aloulah, M, Al-Qudah, M, Alsaleh, S, Baban, M A, Baudoin, T, Balvers, T, Battaglia, P, Bedoya, J D, Beule, A, Bofares, K M, Braverman, I, Brozek-Madry, E, Richard, B, Callejas, C, Carrie, S, Caulley, L, Chussi, D, de Corso, E, Coste, A, El Hadi, U, Elfarouk, A, Eloy, P H, Farrokhi, S, Felisati, G, Ferrari, M D, Fishchuk, R, Grayson, W, Goncalves, P M, Grdinic, B, Grgic, V, Hamizan, A W, Heinichen, J V, Husain, S, Ping, T I, Ivaska, J, Jakimovska, F, Jovancevic, L, Kakande, E, Kamel, R, Karpischenko, S, Kariyawasam, H H, Kawauchi, H, Kjeldsen, A, Klimek, L, Krzeski, A, Kopacheva Barsova, G, Kim, S W, Lal, D, Letort, J J, Lopatin, A, Mahdjoubi, A, Mesbahi, A, Netkovski, J, Nyenbue Tshipukane, D, Obando-Valverde, A, Okano, M, Onerci, M, Ong, Y K, Orlandi, R, Otori, N, Ouennoughy, K, Ozkan, M, Peric, A, Plzak, J, Prokopakis, E, Prepageran, N, Psaltis, A, Pugin, B, Raftopulos, M, Rombaux, P, Riechelmann, H, Sahtout, S, Sarafoleanu, C-C, Searyoh, K, Rhee, C-S, Shi, J, Shkoukani, M, Shukuryan, A K, Sicak, M, Smyth, D, Sindvongs, K, Soklic Kosak, T, Stjarne, P, Sutikno, B, Steinsvag, S, Tantilipikorn, P, Thanaviratananich, S, Tran, T, Urbancic, J, Valiulius, A, Vasquez de Aparicio, C, Vicheva, D, Virkkula, P M, Vicente, G, Voegels, R, Wagenmann, M M, Wardani, R S, Welge-Lussen, A, Witterick, I, Wright, E, Zabolotniy, D, Zsolt, B, and Zwetsloot, C P
- Abstract
The European Position Paper on Rhinosinusitis and Nasal Polyps 2020 is the update of similar evidence based position papers published in 2005 and 2007 and 2012. The core objective of the EPOS2020 guideline is to provide revised, up-to-date and clear evidence-based recommendations and integrated care pathways in ARS and CRS. EPOS2020 provides an update on the literature published and studies undertaken in the eight years since the EPOS2012 position paper was published and addresses areas not extensively covered in EPOS2012 such as paediatric CRS and sinus surgery. EPOS2020 also involves new stakeholders, including pharmacists and patients, and addresses new target users who have become more involved in the management and treatment of rhinosinusitis since the publication of the last EPOS document, including pharmacists, nurses, specialised care givers and indeed patients themselves, who employ increasing self-management of their condition using over the counter treatments. The document provides suggestions for future research in this area and offers updated guidance for definitions and outcome measurements in research in different settings. EPOS2020 contains chapters on definitions and classification where we have defined a large number of terms and indicated preferred terms. A new classification of CRS into primary and secondary CRS and further division into localized and diffuse disease, based on anatomic distribution is proposed. There are extensive chapters on epidemiology and predisposing factors, inflammatory mechanisms, (differential) diagnosis of facial pain, allergic rhinitis, genetics, cystic fibrosis, aspirin exacerbated respiratory disease, immunodeficiencies, allergic fungal rhinosinusitis and the relationship between upper and lower airways. The chapters on paediatric acute and chronic rhinosinusitis are totally rewritten. All available evidence for the management of acute rhinosinusitis and chronic rhinosinusitis with or without nasal polyps in adult
- Published
- 2020
25. Acute kidney injury in patients with severe sepsis in Finnish Intensive Care Units
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Poukkanen, M., Vaara, S. T., PETTILÄ, V., Kaukonen, K.-M., Korhonen, A.-M., Hovilehto, S., Inkinen, O., LARU-SOMPA, R., Kaminski, T., Reinikainen, M., Lund, V., and Karlsson, S.
- Published
- 2013
- Full Text
- View/download PDF
26. Re: Inferior turbinate mucosal graft combined with radiofrequency for the treatment of nasal hereditary haemorrhagic telangiectasia: Our experience in sixteen patients
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Rimmer, J. and Lund, V. J.
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- 2013
- Full Text
- View/download PDF
27. Uncontrolled allergic rhinitis and chronic rhinosinusitis: where do we stand today?
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Hellings, P. W., Fokkens, W. J., Akdis, C., Bachert, C., Cingi, C., Dietz de Loos, D., Gevaert, P., Hox, V., Kalogjera, L., Lund, V., Mullol, J., Papadopoulos, N. G., Passalacqua, G., Rondón, C., Scadding, G., Timmermans, M., Toskala, E., Zhang, N., and Bousquet, J.
- Published
- 2013
- Full Text
- View/download PDF
28. Beauchamp and Childress’ four principles applied to animal ethics issues
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Lund, V., primary and Forsberg, E.M., additional
- Published
- 2009
- Full Text
- View/download PDF
29. Positioning the principles of precision medicine in care pathways for allergic rhinitis and chronic rhinosinusitis â A EUFOREA-ARIA-EPOS-AIRWAYS ICP statement
- Author
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Hellings, P. W., Fokkens, W. J., Bachert, C., Akdis, C. A., Bieber, T., Agache, I., Bernal-Sprekelsen, M., Canonica, G. W., Gevaert, P., Joos, G., Lund, V. J., Muraro, A., Onerci, M., Zuberbier, T., Pugin, B., Seys, S. F., Bousquet, Jean, ARIA and EPOS working groups, Akdis, M., Alobid, I., Ankri, J., Annesi-Maesano, I., Ansotegui, I. J., Anto, Josep M., Arnavielhe, S., Arshad, S. H., Asarnoj, A., Avolio, F., Baiardini, I., Barbagallo, Carlo M., Barbara, Cristina, Baroody, F., Bateman, E. D., Bedbrook, Anna, Beghé, B., Bel, E. H., Bennoor, K. S., Benson, M., Bergmann, K. C., Bewick, M., Białoszewski, A. Z., Bindslev-Jensen, C., Bjermer, L., Blain, Hubert, Blasi, F., Boner, A. L., Bonini, M., Bonini, S., Bosnic-Anticevitch, S., Bosse, I., Bouchard, J., Boulet, L. P., Bourret, Rodolphe, Braido, F., Briggs, A. H., Brightling, C. E., Brozek, J. L., Bucca, C., Buhl, R., Bunu, C., Burte, E., Bush, A., Caballero-Fonseca, F., Caimmi, D. P., Calderon, M. A., Camargos, P. A. M., Camuzat, Thierry, Cardona, V., Carlsen, K. H., Carr, W., Carreiro-Martins, P., Carriazo, A. M., Casale, T. B., A.M, Cepeda Sarabia, Cervin, A., Cesari, M., Chatzi, L., Chavannes, Niels H., Chiron, R., Pérez, T. Chivato, Chkhartishvili, E., Chuchalin, Alexander G., Chung, K. F., Ciprandi, G., Cohen, N., Diaz, S. Conzález, Cox, L., Crooks, George, Cruz, A. A., Custovic, Adnan, Dahl, R., Dahlen, S. E., Darsow, U., Carlo, G. De, Keenoy, E. De Manuel, Sousa, J. Correia de, Vries, Elisabeth G. E. de, Dedeu, Antoni, Deleanu, D., Demoly, Pascal, Denburg, J. A., Devillier, P., Didier, A., Dinh-Xuan, A. T., Dokic, D., Douagui, H. B., Douglas, R., Dray, G., Toit, G. Du, Dubakiene, R., Durham, S. R., Dykewicz, M. S., Eklund, P., El-Gamal, Y., Ellers, E., Emuzyte, R., Farrell, J., Fink-Wagner, A., Fiocchi, A., Fletcher, M., Fonseca, J. A., Forastiere, F., Gaga, M., Gamkrelidze, A., Gemicioǧlu, B., Georgalas, C., Gereda, J. E., Goossens, H., Grisle, I., Guldemond, N. A., Gutter, Z., Guzmán, M. A., Haahtela, T., Harvey, R., Heinrich, J., Hellquist-Dahl, B., Hopkins, C., Horak, F., Hourihane, J. O. B., Humbert, M., Hyland, M. E., Iaccarino, G., Illario, M., Jares, E. J., Jeandel, Claude, Johnston, S. L., Jonquet, Olivier, Jung, K. S., Just, J., Jutel, M., Kaidashev, I. P., Kalayci, O., Kalogjera, L., Kalyoncu, A. F., Kardas, P., Keil, T., Keith, P. K., Kerkhof, M., Kern, B., Kerstjens, H. A. M., Khaitov, M. R., Khaltaev, N., Klimek, L., Kogevinas, M., Kolek, V., Koppelman, G. H., Kowalski, M. L., Kuitunen, M., Kull, I., Kuna, P., Kvedariene, V., Lambrecht, B., Larenas-Linnemann, D., Lau, S., Laune, D., Le, Tuyen D., Li, J., Lieberman, P., Lipworth, B. J., Carlsen, K. C. Lodrup, Louis, R., Lupinek, C., MacNee, W., Magard, Y., Magnan, A., Mahboub, B., Maier, D., Majer, I., Malva, J., Manning, P. J., Marshall, G. D., Masjedi, M. R., Mathieu-Dupas, E., Maurer, M., Mavale-Manuel, S., Melén, E., Gomes, Elisabete Melo, Meltzer, E. O., Mercier, Jacques, Merk, H., Miculinic, N., Mihaltan, F., Milenkovic, B., Millot-Keurinck, J., Mohammad, Y., Momas, I., Almeida, M. Morais, Mosges, R., Mullol, J., Murray, R., Naclerio, R. N., Nadif, R., Namazova-Baranova, L., Neffen, H., Nekam, K., Nieto, A., Niggemann, B., Nogueira-Silva, L., Nogues, M., Nyembue, T. D., O'Hehir, R. E., Ohta, K., Okamoto, Y., Okubo, K., Olive-Elias, M., Ouedraogo, S., Paggiaro, P. L., Pali-Schöll, I., Palkonen, S., Panzner, P., Papadopoulos, N. G., Papi, A., Park, H. S., Passalacqua, G., Pawankar, R., Pedersen, S., Pereira, A. M., Pfaar, O., Picard, R., Pigearias, B., Pin, I., Plavec, D., Pohl, W., Popov, T. A., Portejoie, F., Postma, D. S., Potter, P., Poulsen, L. K., Price, D., Rabe, K. F., Raciborski, F., Riechelmann, H., Robalo-Cordeiro, C., Roberts, G., Rodenas, F., Rodriguez-Mañas, L., Rolland, C., Rodriguez, M. Roman, Romano, A., Rosado-Pinto, J., Rosario, N. A., Rottem, M., Ryan, D., Samolinski, B., Sanchez-Borges, M., Sastre-Dominguez, J., Scadding, G. K., Schlosser, R., Schmid-Grendelmeier, P., Schunemann, H. J., Scichilone, N., Senior, B., Serrano, E., Sheikh, A., Shields, K. M., Simons, F. E. R., Siroux, V., Sisul, J. C., Skrindo, I., Smit, H. A., Sole, D., Sooronbaev, T., Spranger, O., Stellato, C., Stelmach, R., Sterk, P. J., Strandberg, T., Sunyer, Jordi, Thijs, C., Thomas, M., Todo-Bom, A., Tomazic, P. V., Toskala, E., Triggiani, M., Valenta, R., Valero, A. L., Valiulis, A., Valovirta, E., Eerd, M. van, Ganse, E. van, Hage, M. van, Wick, R. G. van, Vandenplas, O., Varona, L. L., Vazankari, T., Vellas, B., Ventura, M. T., Vezzani, G., Viegi, Giovanni, Voegels, R., Vontetsianos, T., Wagenmann, M., Wahn, U., Walker, S., Wang, D. Y., Wang, Ya Xing, Werfel, T., Whalley, B., Wickman, M., Williams, D. M., Williams, S., Wilson, N., Wormald, P. J., Wright, J., Yawn, B. P., Yiallouros, Panayiotis K., Yorgancioglu, A., Young, I., Yusuf, O. M., Zaidi, A., Zar, H. J., Zernotti, M. E., Zhang, L., Zhong, N., Zidarn, M., Adult Psychiatry, Ear, Nose and Throat, AII - Inflammatory diseases, AII - Amsterdam institute for Infection and Immunity, Pulmonology, Other departments, Hellings, P. W., Fokkens, W. J., Bachert, C., Akdis, C. A., Bieber, T., Agache, I., Bernal-Sprekelsen, M., Canonica, G. W., Gevaert, P., Joos, G., Lund, V., Muraro, A., Onerci, M., Zuberbier, T., Pugin, B., Seys, S. F., Bousquet, J., Aberer, W., Akdis, M., Alobid, I., Ankri, J., Annesi-Maesano, I., Ansotegui, I. J., Anto, J. M., Arnavielhe, S., Arshad, H., Asarnoj, A., Avolio, F., Baiardini, I., Barbagallo, M., Barbara, C., Baroody, F., Bateman, E. D., Bedbrook, A., Beghe, B., Bel, E. H., Bennoor, K. S., Benson, M., Bergmann, K. C., Bewick, M., Bialoszewski, A. Z., Bindslev-Jensen, C., Bjermer, L., Blain, H., Blasi, F., Boner, A. L., Bonini, M., Bonini, S., Bosnic-Anticevich, S., Bosse, I., Bouchard, J., Boulet, L. P., Bourret, R., Bousquet, P. J., Braido, F., Briggs, A. H., Brightling, C. E., Brozek, J., Bucca, C., Buhl, R., Bunu, C., Burte, E., Bush, A., Caballero-Fonseca, F., Caimmi, D. P., Calderon, M. A., Camargos, P. A., Camuzat, T., Cardona, V., Carlsen, K. H., Carr, W., Carreiro-Martins, P., Carriazo, A. M., Casale, T., Cepeda Sarabia, A. M., Cervin, A., Cesari, M., Chatzi, L., Chavannes, N. H., Chiron, R., Chivato, T., Chkhartishvili, E., Chuchalin, A. G., Chung, K. F., Ciprandi, G., Cohen, N., Conzalez Diaz, S., Cox, L., Crooks, G., Cruz, A. A., Custovic, A., Dahl, R., Dahlen, S. E., Darsow, U., De Carlo, G., De Manuel Keenoy, E., de Sousa, J. C., De Vries, G., Dedeu, T., Deleanu, D., Demoly, P., Denburg, J. A., Devillier, P., Didier, A., Dinh-Xuan, A. T., Dokic, D., Douagui, H., Douglas, R., Dray, G., Du Toit, G., Dubakiene, R., Durham, S. R., Dykewicz, M. S., Eklund, P., El-Gamal, Y., Ellers, E., Emuzyte, R., Farrell, J., Fink Wagner, A., Fiocchi, A., Fletcher, M., Fonseca, J., Forastiere, F., Gaga, M., Gamkrelidze, A., Gemicioglu, B., Georgalas, C., Gereda, J. E., Goossens, H., Grisle, I., Guldemond, N. A., Gutter, Z., Guzman, M. A., Haahtela, T., Harvey, R., Heinrich, J., Hellquist-Dahl, B., Hopkins, C., Horak, F., Hourihane, J. O., Humbert, M., Hyland, M., Iaccarino, G., Illario, M., Jares, E. J., Jeandel, C., Johnston, S. L., Jonquet, O., Jung, K. S., Just, J., Jutel, M., Kaidashev, I. P., Kalayci, O., Kalogjera, L., Kalyoncu, A. F., Kardas, P., Keil, T., Keith, P. K., Kerkhof, M., Kern, B., Kerstjens, H. A., Khaitov, M., Khaltaev, N., Klimek, L., Kogevinas, M., Kolek, V., Koppelman, G. H., Kowalski, M., Kowalski, M. L., Kuitunen, M., Kull, I., Kuna, P., Kvedariene, V., Lambrecht, B., Larenas-Linnemann, D., Lau, S., Laune, D., Le, L. T., Li, J., Lieberman, P., Lipworth, B., Lodrup Carlsen, K. C., Louis, R., Lund, V. J., Lupinek, C., Macnee, W., Magar, Y., Magnan, A., Mahboub, B., Maier, D., Majer, I., Malva, J., Manning, P., Marshall, G. D., Masjedi, M. R., Mathieu-Dupas, E., Maurer, M., Mavale-Manuel, S., Melen, E., Melo-Gomes, E., Meltzer, E. O., Mercier, J., Merk, H., Miculinic, N., Mihaltan, F., Milenkovic, B., Millot-Keurinck, J., Mohammad, Y., Momas, I., Morais-Almeida, M., Mosges, R., Mullol, J., Murray, R., Naclerio, R., Nadif, R., Namazova-Baranova, L., Neffen, H., Nekam, K., Nieto, A., Nogues, M., Nyembue, T. D., O'Hehir, R. E., Ohta, K., Okamoto, Y., Okubo, K., Olive-Elias, M., Ouedraogo, S., Paggiaro, P., Pali-Scholl, I., Palkonen, S., Panzner, P., Papadopoulos, N. G., Papi, A., Park, H. S., Passalacqua, G., Niggemann, B., Nogueira-Silva, L., Pereira, A. M., Pfaar, O., Picard, R., Pigearias, B., Pin, I., Plavec, D., Pohl, W., Popov, T. A., Portejoie, F., Postma, D., Potter, P., Poulsen, L. K., Price, D., Rabe, K. F., Raciborski, F., Riechelmann, H., Robalo-Cordeiro, C., Roberts, G., Rodenas, F., Rodriguez-Manas, L., Rolland, C., Roman Rodriguez, M., Romano, A., Rosado-Pinto, J., Rosario, N., Rottem, M., Ryan, D., Samolinski, B., Sanchez-Borges, M., Sastre-Dominguez, J., Scadding, G. K., Schlosser, R., Schmid-Grendelmeier, P., Schunemann, H. J., Scichilone, N., Senior, B., Serrano, E., Sheikh, A., Shields, M., Simons, F. E. R., Siroux, V., Sisul, J. C., Skrindo, I., Smit, H. A., Sole, D., Sooronbaev, T., Spranger, O., Stellato, C., Stelmach, R., Sterk, P. J., Strandberg, T., Sunyer, J., Thijs, C., Thomas, M., Todo-Bom, A., Tomazic, P. V., Toskala, E., Triggiani, M., Valenta, R., Valero, A., Valiulis, A., Valovirta, E., van Eerd, M., van Ganse, E., van Hage, M., van Wick, R. G., Vandenplas, O., Varona, L. L., Vazankari, T., Vellas, B., Ventura, M. T., Vezzani, G., Viegi, G., Voegels, R., Vontetsianos, T., Wagenmann, M., Wahn, U., Walker, S., Wang, D. Y., Wang, Y., Werfel, T., Whalley, B., Wickman, M., Williams, D. M., Williams, S., Wilson, N., Wormald, P. J., Wright, J., Yawn, B. P., Yiallouros, P. K., Yorgancioglu, A., Young, I., Yusuf, O. M., Zaidi, A., Zar, H. J., Zernotti, M. E., Zhang, L., Zhong, N., Zidarn, M., Asthma UK, Department of Dermatology, Allergology and Venereology, Clinicum, HUS Inflammation Center, RS: CAPHRI - R5 - Optimising Patient Care, Epidemiologie, Yiallouros, Panayiotis K. [0000-0002-8339-9285], Custovic, Adnan [0000-0001-5218-7071], Hellings, P.W., Fokkens, W.J., Akdis, C.A., Canonica, G.W., Seys, S.F., Ansotegui, I.J., Anto, J.M., Bateman, E.D., Beghé, B., Bel, E.H., Bennoor, K.S., Bergmann, K.C., Bialoszewski, A.Z., Boner, A.L., Boulet, L.P., Bousquet, P.J., Briggs, A.H., Brightling, C.E., Caimmi, D.P., Calderon, M.A., Camargos, P.A., Carlsen, K.H., Carriazo, A.M., Cepeda Sarabia, A.M., Chavannes, N.H., Chuchalin, A.G., Chung, K.F., Conzález Diaz, S., Cruz, A.A., Dahlen, S.E., de Sousa, J.C., Denburg, J.A., Dinh-Xuan, A.T., Durham, S.R., Dykewicz, M.S., Gemicioğlu, B., Gereda, J.E., Guldemond, N.A., Guzmán, M.A., Hourihane, J.O., Jares, E.J., Johnston, S.L., Jung, K.S., Kaidashev, I., Kalyoncu, A.F., Keith, P.K., Kerstjens, H.A., Koppelman, G.H., Kowalski, M.L., Le, L.T., Lodrup Carlsen, K.C., Lund, V.J., MacNee, W., Marshall, G.D., Masjedi, M.R., Melén, E., Meltzer, E.O., Mösges, R., Nyembue, T.D., O'Hehir, R.E., Pali-Schöll, I., Papadopoulos, N.G., Park, H.S., Pawankar, R., Pedersen, S., Pereira, A.M., Popov, T.A., Poulsen, L.K., Rabe, K.F., Rodriguez-Mañas, L., Scadding, G.K., Schunemann, H.J., Simons, F.E.R., Sisul, J.C., Smit, H.A., Solé, D., Sterk, P.J., Tomazic, P.V., van Wick, R.G., Varona, L.L., Ventura, M.T., Wang, D.Y., Williams, D.M., Wormald, P.J., Yawn, B.P., Yiallouros, P.K., Yusuf, O.M., Zar, H.J., and Zernotti, M.E.
- Subjects
allergic rhinitis ,integrated care pathway ,precision medicine ,rhinosinusitis ,Allergy ,Rhinosinusitis ,Disease ,Allergic rhinitis ,0302 clinical medicine ,QUALITY-OF-LIFE ,Medicine ,Immunology and Allergy ,030223 otorhinolaryngology ,Sinusitis ,NASAL POLYPOSIS ,Rhinitis ,Precision medicine ,3. Good health ,Algorithm ,REAL-LIFE ,IMPACT OUTCOMES ,ARIA and EPOS working groups ,1107 Immunology ,DISEASES ,GA(2)LEN ,Disease Progression ,allergic rhiniti ,Life Sciences & Biomedicine ,ENDOSCOPIC SINUS SURGERY ,Algorithms ,Human ,Integrated care pathway ,Adult ,Chronic Disease ,Humans ,Precision Medicine ,Rhinitis, Allergic ,Young Adult ,Immunology ,medicine.medical_specialty ,rhinosinusiti ,PHENOTYPES ,VALIDATION ,03 medical and health sciences ,Therapeutic approach ,Allergic ,Patient satisfaction ,Quality of life (healthcare) ,Patient participation ,IMMUNOTHERAPY ,Intensive care medicine ,Asthma ,Science & Technology ,business.industry ,medicine.disease ,Sinusiti ,SEVERITY ,030228 respiratory system ,3121 General medicine, internal medicine and other clinical medicine ,Physical therapy ,ASTHMA ,business - Abstract
Precision medicine (PM) is increasingly recognized as the way forward for optimizing patient care. Introduced in the field of oncology, it is now considered of major interest in other medical domains like allergy and chronic airway diseases, which face an urgent need to improve the level of disease control, enhance patient satisfaction and increase effectiveness of preventive interventions. The combination of personalized care, prediction of treatment success, prevention of disease and patient participation in the elaboration of the treatment plan is expected to substantially improve the therapeutic approach for individuals suffering from chronic disabling conditions. Given the emerging data on the impact of patient stratification on treatment outcomes, European and American regulatory bodies support the principles of PM and its potential advantage over current treatment strategies. The aim of the current document was to propose a consensus on the position and gradual implementation of the principles of PM within existing adult treatment algorithms for allergic rhinitis (AR) and chronic rhinosinusitis (CRS). At the time of diagnosis, prediction of success of the initiated treatment and patient participation in the decision of the treatment plan can be implemented. The second-level approach ideally involves strategies to prevent progression of disease, in addition to prediction of success of therapy, and patient participation in the long-term therapeutic strategy. Endotype-driven treatment is part of a personalized approach and should be positioned at the tertiary level of care, given the efforts needed for its implementation and the high cost of molecular diagnosis and biological treatment. © 2017 EAACI and John Wiley and Sons A/S. Published by John Wiley and Sons Ltd. 72 9 1297 1305
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- 2017
30. Tactical EMS revisited – analysing the benefits needs a wider perspective
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Lund, V., Valli, J., Hallikainen, J., Sainio, A., and Niskanen, T.
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- 2012
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31. Lack of efficacy of long-term, low-dose azithromycin in chronic rhinosinusitis: a randomized controlled trial
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Videler, W. J., Badia, L., Harvey, R. J., Gane, S., Georgalas, C., van der Meulen, F. W., Menger, D. J., Lehtonen, M. T., Toppila-Salmi, S. K., Vento, S. I., Hytönen, M., Hellings, P. W., Kalogjera, L., Lund, V. J., Scadding, G., Mullol, J., and Fokkens, W. J.
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- 2011
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32. Serum zinc in critically ill adult patients with acute respiratory failure
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LINKO, R., KARLSSON, S., PETTILä, V., VARPULA, T., OKKONEN, M., LUND, V., ALA-KOKKO, T., and RUOKONEN, E.
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- 2011
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33. Outcomes may have been no better after trauma care in university-level intensive care units
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Reinikainen, M., Laru-Sompa, R., Loisa, P., Lund, V., and Kairi, P.
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- 2010
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34. Scandinavian clinical practice guidelines on general anaesthesia for emergency situations
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JENSEN, A. G., CALLESEN, T., HAGEMO, J. S., HREINSSON, K., LUND, V., and NORDMARK, J.
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- 2010
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35. Head and neck / ear, nose, and throat
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Lund, V J, primary, Powles, J, additional, and Howard, D J, additional
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- 2006
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36. Animal welfare and ethics in organic agriculture.
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Lund, V., primary
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- 2006
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37. Psychometric validity of the 22-item Sinonasal Outcome Test
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Hopkins, C., Gillett, S., Slack, R., Lund, V. J., and Browne, J. P.
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- 2009
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38. Is there a role for surgery in allergic rhinitis?
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Lund, V. J.
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- 2009
39. Important research questions in allergy and related diseases: 3-chronic rhinosinusitis and nasal polyposis - a GA2LEN study
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Bachert, C., Van Bruaene, N., Toskala, E., Zhang, N., Olze, H., Scadding, G., Van Drunen, C. M., Mullol, J., Cardell, L., Gevaert, P., Van Zele, T., Claeys, S., Halldén, C., Kostamo, K., Foerster, U., Kowalski, M., Bieniek, K., Olszewska-Ziaber, A., Nizankowska-Mogilnicka, E., Szczeklik, A., Swierczynska, M., Arcimowicz, M., Lund, V., Fokkens, W., Zuberbier, T., Akdis, C., Canonica, G., Van Cauwenberge, P., Burney, P., and Bousquet, J.
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- 2009
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40. EPOS2020: development strategy and goals for the latest European Position Paper on Rhinosinusitis
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Fokkens, W., Desrosiers, M., Harvey, R., Hopkins, C., Mullol, J., Philpott, C., Alobid, I., Anselmo-Lima, W. T., Bachert, C., Baroody, F., Bernal-Sprekelsen, M., von Buchwald, C., Cervin, A., Cohen, N., Constantinidis, J., de Gabory, L., Douglas, R., Gevaert, P., Hafner, A., Hellings, P., Joos, G., Kalogjera, L., Kern, R., Knill, A., Kocks, J., Landis, B. N., Limpens, J., Lebeer, S., Lourenco, O., Matricardi, P. M., Meco, C., O Mahony, L., Reitsma, S., Ryan, D., Schlosser, R., Senior, B., Smith, T., Teeling, T., Tomazic, P. V., Toppila-Salmi, S., Wang, D. Y., Wang, D., Zhang, L., Lund, V., van Drunen, Cornelis, Ear, Nose and Throat, and AII - Inflammatory diseases
- Abstract
BACKGROUND: The European Position Papers on Rhinosinusitis from 2005, 2007 and 2012 have had a measurable impact on the way this common condition with high impact on quality of life is managed around the world. EPOS2020 will be the latest iteration of the guideline, addressing new stakeholders and target users, presenting a summary of the latest literature and evolving treatment modalities, and formulating clear recommendations based on all available evidence. METHODOLOGY: Based on the AGREE II framework, this article demonstrates how the EPOS2020 steering group will address six key areas to ensure consistency in quality and presentation of information in the latest rhinosinusitis clinical practice guideline: scope and purpose; stakeholder involvement; rigour of development; clarity of presentation; recommendations and applicability; editorial independence. RESULTS: By analysing the guidance from AGREE II, we formulated a detailed development strategy for EPOS2020. We identify new stakeholders and target users and ratify the importance of patient involvement in the latest EPOS guideline. New and expanded areas of research to be addressed are highlighted. We confirm our intention to use mixed methodologies, combining evidence-based medicine with real life studies; when no evidence can be found, use Delphi rounds to achieve clear, inclusive recommendations. We also introduce new concepts for dissemination of the guideline, using Internet and social media to improve accessibility. CONCLUSION: This article is an introduction to the EPOS2020 project, and presents the key goals, core stakeholders, planned methodology and dissemination strategies for the latest version of this influential guideline.
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- 2019
41. Research activity and capability in the European reference network MetabERN
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Heard, J. -M., Bellettato, C, Van, Lingen, Scarpa, M, Debray, F. -G., Nassogne, M. -C., Van, Coster, Meirleir, De, Eyskens, L., Morava, F., Baric, E., Kozich, I., Lund, V., Germain, A. M., Belmatoug, D., Guffon, N., Labrune, N., Gouya, P., Lonlay, De, Schiff, P., Dobbelaere, M., Chabrol, D., Das, B., Spiekerkoetter, A. M., Rutsch, U., Ploeckinger, F., Mohnike, U., Hahn, K., Kölker, A., Ullrich, S., Balogh, K., Bembi, I., Donati, B., Gasperini, M. A., Parenti, S., Salviati, G., Vici, A., C. -D., Rocco, Di, Cefalo, M., Burlina, G., Ceccarini, G., Federico, A., Van Der Ploeg, Rubio-Gozalbo, A., M. -E., Van, Spronsen, Visser, F., Bosch, G., Tangeraas, A., Sanderberg, T., Kieć-Wilk, S., Gaspar, B., A. -M. S. M., Martins, E., Silva, E. -M. F. R., De Abreu Freire Diogo Matos, L. -M., Azevedo, O., Tansek, M. -Z., Couce-Pico, M. -L., Cazorla, A. G., Azuara, L. A. -E., Del, Toro-Riera, Lajic, M., Darin, S., Deegan, N., Vijaym, P., Chronopoulou, S., Jones, E., Chakrapani, S., Hiwot, A., Pediatrics, MetabERN Collaboration Grp, RS: GROW - R4 - Reproductive and Perinatal Medicine, Kindergeneeskunde, MUMC+: MA Medische Staf Kindergeneeskunde (9), VU University medical center, Amsterdam Reproduction & Development (AR&D), Paediatric Metabolic Diseases, and AGEM - Inborn errors of metabolism
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Interdisciplinary Research/methods ,0301 basic medicine ,media_common.quotation_subject ,Interdisciplinary Research ,Medical research activity ,lcsh:Medicine ,030105 genetics & heredity ,Research Support ,BIOBANKS ,03 medical and health sciences ,Social support ,Hereditary metabolic diseases ,REGISTRIES ,0302 clinical medicine ,Quality of life (healthcare) ,Excellence ,Surveys and Questionnaires ,Medicine and Health Sciences ,Journal Article ,Humans ,media_common.cataloged_instance ,Pharmacology (medical) ,European union ,Non-U.S. Gov't ,Empowerment ,Genetics (clinical) ,media_common ,European reference Centres ,Multidisciplinary research ,Medical education ,Descriptive statistics ,Research Support, Non-U.S. Gov't ,Research ,lcsh:R ,General Medicine ,Biobank ,Europe ,Respondent ,Quality of Life ,Human medicine ,Business ,RARE DISEASES ,030217 neurology & neurosurgery - Abstract
Background MetabERN is one of the 24 European Reference Networks created according to the European Union directive 2011/24/EU on patient’s rights in cross border healthcare. MetabERN associates 69 centres in 18 countries, which provide care for patients with Hereditary Metabolic Diseases, and have the mission to reinforce research and provide training for health professionals in this field. MetabERN performed a survey in December 2017 with the aim to produce an overview documenting research activities and potentials within the network. As the centres are multidisciplinary, separated questionnaires were sent to the clinical, university and laboratory teams. Answers were received from 52 out of the 69 centres of the network, covering 16 countries. A descriptive analysis of the information collected is presented. Results The answers indicate a marked interest of the respondents for research, who expressed high motivation and commitment, and estimated that the conditions to do research in their institution were mostly satisfactory. They are active in research, which according to several indicators, is competitive and satisfies standards of excellence, as well as the education programs offered in the respondent’s universities. Research in the centres is primarily performed in genetics, pathophysiology, and epidemiology, and focuses on issues related to diagnosis. Few respondents declared having activity in human and social sciences, including research on patient’s quality of life, patient’s awareness, or methods for social support. Infrastructures offering services for medical research were rarely known and used by respondents, including national and international biobanking platforms. In contrast, respondents often participate to patient registries, even beyond their specific field of interest. Conclusions Taken as a whole, these results provide an encouraging picture of the research capacities and activities in the MetabERN network, which, with respect to the number and representativeness of the investigated centres, gives a comprehensive picture of research on Hereditary Metabolic Diseases in Europe, as well as the priorities for future actions. Marginal activity in human and social sciences points out the limited multidisciplinary constitution of the responding teams with possible consequences on their current capability to participate to patient’s empowerment programs and efficiently collaborate with patient’s advocacy groups. Electronic supplementary material The online version of this article (10.1186/s13023-019-1091-8) contains supplementary material, which is available to authorized users.
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- 2019
42. Heme oxygenase-1 repeat polymorphism in septic acute kidney injury
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Vilander, L. M. (Laura M.), Vaara, S. T. (Suvi T.), Donner, K. M. (Kati M.), Lakkisto, P. (Paivi), Kaunisto, M. A. (Mari A.), Pettila, V. (Ville), Laru-Sompa, R. (Raili), Pulkkinen, A. (Anni), Saarelainen, M. (Minna), Reilama, M. (Mikko), Tolmunen, S. (Sinikka), Rantalainen, U. (Ulla), Miettinen, M. (Marja), Suvela, M. (Markku), Pesola, K. (Katrine), Saastamoinen, P. (Pekka), Kauppinen, S. (Sirpa), Kaukonen, K.-M. (Kirsi-Maija), Korhonen, A.-M. (Anna-Maija), Nisula, S. (Sara), Vaara, S. (Suvi), Suojaranta-Ylinen, R. (Raili), Mildh, L. (Leena), Haapio, M. (Mikko), Nurminen, L. (Laura), Sutinen, S. (Sari), Pettila, L. (Leena), Laitinen, H. (Helina), Syrja, H. (Heidi), Henttonen, K. (Kirsi), Lappi, E. (Elina), Boman, H. (Hillevi), Varpula, T. (Tero), Porkka, P. (Paivi), Sivula, M. (Mirka), Rahkonen, M. (Mira), Tsurkka, A. (Anne), Nieminen, T. (Taina), Prittinen, N. (Niina), Alaspaa, A. (Ari), Salanto, V. (Ville), Juntunen, H. (Hanna), Sanisalo, T. (Teija), Parviainen, I. (Ilkka), Uusaro, A. (Ari), Ruokonen, E. (Esko), Bendel, S. (Stepani), Rissanen, N. (Niina), Lang, M. (Maarit), Rahikainen, S. (Sari), Rissanen, S. (Saija), Ahonen, M. (Merja), Halonen, E. (Elina), Vaskelainen, E. (Eija), Poukkanen, M. (Meri), Lintula, E. (Esa), Suominen, S. (Sirpa), Heikkinen, J. (Jorma), Lavander, T. (Timo), Heinonen, K. (Kirsi), Juopperi, A.-M. (Anne-Mari), Kaminski, T. (Tadeusz), Gaddnas, F. (Fiia), Kuusela, T. (Tuija), Roiko, J. (Jane), Karlsson, S. (Sari), Reinikainen, M. (Matti), Surakka, T. (Tero), Jyrkonen, H. (Helena), Eiserbeck, T. (Tanja), Kallinen, J. (Jaana), Lund, V. (Vesa), Tuominen, P. (Paivi), Perkola, P. (Pauliina), Tuominen, R. (Riikka), Hietaranta, M. (Marika), Johansson, S. (Satu), Hovilehto, S. (Seppo), Kirsi, A. (Anne), Tiainen, P. (Pekka), Myllarinen, T. (Tuija), Leino, P. (Pirjo), Toropainen, A. (Anne), Kuitunen, A. (Anne), Leppanen, I. (Ilona), Levoranta, M. (Markus), Hoppu, S. (Sanna), Sauranen, J. (Jukka), Tenhunen, J. (Jyrki), Kukkurainen, A. (Atte), Kortelainen, S. (Samuli), Varila, S. (Simo), Inkinen, O. (Outi), Koivuviita, N. (Niina), Kotamaki, J. (Jutta), Laine, A. (Anu), Ala-Kokko, T. (Tero), Laurila, J. (Jouko), Salkio, S. (Sinikka), Koivisto, S.-P. (Simo-Pekka), Hautamaki, R. (Raku), and Skinnar, M. (Maria)
- Abstract
Acute kidney injury (AKI) is a syndrome that frequently affects the critically ill. Recently, an increased number of dinucleotide repeats in the HMOX1 gene were reported to associate with development of AKI in cardiac surgery. We aimed to test the replicability of this finding in a Finnish cohort of critically ill septic patients. This multicenter study was part of the national FINNAKI study. We genotyped 300 patients with severe AKI (KDIGO 2 or 3) and 353 controls without AKI (KDIGO 0) for the guanine–thymine (GTn) repeat in the promoter region of the HMOX1 gene. The allele calling was based on the number of repeats, the cut off being 27 repeats in the S–L (short to long) classification, and 27 and 34 repeats for the S–M–L₂ (short to medium to very long) classification. The plasma concentrations of heme oxygenase-1 (HO-1) enzyme were measured on admission. The allele distribution in our patients was similar to that published previously, with peaks at 23 and 30 repeats. The S-allele increases AKI risk. An adjusted OR was 1.30 for each S-allele in an additive genetic model (95% CI 1.01–1.66; p = 0.041). Alleles with a repeat number greater than 34 were significantly associated with lower HO-1 concentration (p
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- 2019
43. Organic livestock standards.
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Padel, S., primary, Schmid, O., additional, and Lund, V., additional
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- 2003
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44. Organic principles and values: the framework for organic animal husbandry.
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Vaarst, M., primary, Roderick, S., additional, Lund, V., additional, Lockeretz, W., additional, and Hovi, M., additional
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- 2003
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45. Organic animal husbandry: the future challenges.
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Vaarst, M., primary, Roderick, S., additional, Lund, V., additional, Lockeretz, W., additional, and Hovi, M., additional
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- 2003
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46. Understanding animal behaviour and its use in organic animal husbandry.
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Lund, V., primary and Weary, D., additional
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- 2003
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47. Animal welfare, ethics and organic farming.
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Verhoog, H., primary, Lund, V., additional, and Alrøe, H. F., additional
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- 2003
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48. Food Standards Agency multidisciplinary workshop: childrenʼs food choice in the family setting
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Stockley, L., Lund, V., and Levy, L.
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- 2007
49. Irish college of ophthalmologists: Proceedings of annual meeting held in Slieve Russell Hotel, Ballyconnell, Co. Cavan on May 4th and 5th, 1995
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Abdulla, N., Lanigan, B., O’Keefe, M., Bowell, R., Abdulla, N., Lanigan, B., Bowell, R., O’Keefe, M., Aduriz-Lorenzo, P. M., Acheson, R. W., Aduriz-Lorenzo, P. M., Logan, P., Eustace, P., Toland, J., Beatty, S., Kheterpal, S., Eagling, E. M., O’Neill, E. C., Beatty, S., Aggarwal, R. K., David, D. B., Jones, H., Guarro, M., Pearce, J. L., Best, R. M., Bailie, J. R., Stitt, A. W., Hadden, D. R., Traub, A. I., Chakravarthy, U., Archer, D. B., Cahil, M., Acheson, R. W., Mooney, D., Peyton, K., Cassidy, L., Barry, P., Early, A., Blayney, A., Stack, S., Eustace, P., Fenton, S., Collum, A., Hurley, C., Collum, L. M. T., Foley-Nolan, A., Foley-Nolan, A., O’Keefe, M., Goggin, M., Algawi, K., Gregor, Z. J., Hedges, T. R., Hurley, C., Hillery, M., Hoh, H. B., Claoue, C., Easty, D. L., Kenna, P., Collum, L. M. T., Keenan, J. M., Kriss, A., Harris, C., Clayton, P. T., Russell-Eggitt, I. R., Kilmartin, D. J., Mooney, D., Acheson, R. W., Payne, S., Maher, E. R., Eustace, P., Kilmartin, D. J., Moore, J., Silvestri, G., Acheson, R. W., Knight-Nanan, D. M., Algawi, K., O’Keefe, M., Larkin, D. F. P., George, A. J. T., Larkin, G., Olver, J., Lund, V., Fells, P., Lee, J. P., Lewis, H., Minihan, M., Horgan, T., Cleary, P. E., Mulholland, D. A., Earley, O. T., Sharkey, J. A., Atkinson, G., Mullaney, P. B., Noble, B. A., James, T. E., O’Brannagain, D., Nelson, E. I., O’Regan, R., O’Regan, R., Power, W. J., Dutt, J. E., Foster, C. S., Saidléar, C., Gilligan, P., Robinson, E., Ennis, J., Eustace, P., Sharkey, J. A., Sinton, J. E., Jackson, J., Frazer, D. G., Stitt, A., Gardiner, W. T. A., Archer, D. B., Weiser, B., O’Brien, C., Butt, Z., Beatty, S., Murray, P. I., Beatty, S., Nischal, K., Cahill, M., O’Meara, N., Mooney, D., Acheson, R. W., Chuah, K., Lyness, R., Earley, O. T., Datta, K., Fulcher, T., O’Keefe, M., Lacey, B., Earley, O. T., Buchanan, T. A. S., Lacey, B., Best, R. M., Earley, O. T., Johnston, P. B., Archer, D. B., Moore, J., Mahon, G., Limb, G. A., Buchanan, T. A. S., Kervick, G. N., Earley, O. T., Mulholland, D. A., Sharkey, J. A., Johnston, P. B., O’Regan, R., Nelson, E., Brannagain, D. O, and Irish Diabetic Study Group
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- 1995
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50. Tissue remodelling in upper airways: where is the link with lower airway remodelling?
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Watelet, J.-B., Van Zele, T., Gjomarkaj, M., Canonica, G. W., Dahlen, S.-E., Fokkens, W., Lund, V. J., Scadding, G. K., Mullol, J., Papadopoulos, N., Bonini, S., Kowalski, M. L., Van Cauwenberge, P., and Bousquet, J.
- Published
- 2006
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