1. Acetogenins in Annona muricata L. (annonaceae) leaves are potent molluscicides.
- Author
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Luna Jde S, De Carvalho JM, De Lima MR, Bieber LW, Bento Ede S, Franck X, and Sant'ana AE
- Subjects
- Acetogenins, Animals, Chromatography, High Pressure Liquid, Fatty Alcohols chemistry, Fatty Alcohols isolation & purification, Lactones chemistry, Lactones isolation & purification, Magnetic Resonance Spectroscopy, Mass Spectrometry, Annona chemistry, Fatty Alcohols pharmacology, Lactones pharmacology, Mollusca drug effects, Plant Leaves chemistry
- Abstract
An ethanolic extract of the leaves of Annona muricata was shown to be toxic to adult forms of the snail Biomphalaria glabrata (LC50 9.32 microg mL(-1)) and to larvae of the brine shrimp Artemia salina (LC50 0.49 microg mL(-1)). Activity-guided fractionation of the extract gave rise to a sample with high molluscicidal activity that contained the acetogenins, annonacin (90%), isoannonacin (6%) and goniothalamicin (4%).
- Published
- 2006
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