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1. Intestinal Predictors of Whole Blood Serotonin Levels in Children with or without Autism

Author

Zuniga-Kennedy, Miranda, Davoren, Micah, Shuffrey, Lauren C., Luna, Ruth Ann, Savidge, Tor, Prasad, Vinay, Anderson, George M., Veenstra-VanderWeele, Jeremy, and Williams, Kent C.

Abstract

Hyperserotonemia, or elevated levels of whole blood serotonin (WB5-HT), was the first biomarker linked to autism spectrum disorder (ASD). Despite numerous studies investigating the etiology of hyperserotonemia, results have been inconsistent. Recent findings suggest a relationship between the immune system and hyperserotonemia. The current study investigated whether intestinal 5-HT levels, 5-HT gene expression, or intestinal cell types predict WB5-HT. Participants included thirty-one males aged 3-18 who were classified into one of three groups: ASD and functional GI issues, typically developing with GI issues, and typically developing without GI issues. Samples from a lower endoscopy were analyzed to examine the pathways in predicting WB-5HT. Results demonstrated an association between T-Lymphocytes and WB5-HT.

Published
2022
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2. Fusobacterium nucleatum Adheres to Clostridioides difficile via the RadD Adhesin to Enhance Biofilm Formation in Intestinal Mucus

Author

Engevik, Melinda A, Danhof, Heather A, Auchtung, Jennifer, Endres, Bradley T, Ruan, Wenly, Bassères, Eugénie, Engevik, Amy C, Wu, Qinglong, Nicholson, Maribeth, Luna, Ruth Ann, Garey, Kevin W, Crawford, Sue E, Estes, Mary K, Lux, Renate, Yacyshyn, Mary Beth, Yacyshyn, Bruce, Savidge, Tor, Britton, Robert A, and Versalovic, James

Subjects
Medical Microbiology, Biomedical and Clinical Sciences, Digestive Diseases, Infectious Diseases, Emerging Infectious Diseases, Oral and gastrointestinal, Infection, Good Health and Well Being, Adhesins, Bacterial, Bacterial Adhesion, Biofilms, Bioreactors, Clostridioides difficile, Clostridium Infections, Feces, Flagella, Fusobacterium nucleatum, Gastrointestinal Microbiome, HT29 Cells, Humans, Intestinal Mucosa, Mucin-2, MUC2, Mucus, Biofilm, Clinical Sciences, Neurosciences, Paediatrics and Reproductive Medicine, Gastroenterology & Hepatology, Clinical sciences, Nutrition and dietetics
Abstract

Background & aimsAlthough Clostridioides difficile infection (CDI) is known to involve the disruption of the gut microbiota, little is understood regarding how mucus-associated microbes interact with C difficile. We hypothesized that select mucus-associated bacteria would promote C difficile colonization and biofilm formation.MethodsTo create a model of the human intestinal mucus layer and gut microbiota, we used bioreactors inoculated with healthy human feces, treated with clindamycin and infected with C difficile with the addition of human MUC2-coated coverslips.ResultsC difficile was found to colonize and form biofilms on MUC2-coated coverslips, and 16S rRNA sequencing showed a unique biofilm profile with substantial cocolonization with Fusobacterium species. Consistent with our bioreactor data, publicly available data sets and patient stool samples showed that a subset of patients with C difficile infection harbored high levels of Fusobacterium species. We observed colocalization of C difficile and F nucleatum in an aggregation assay using adult patients and stool of pediatric patients with inflammatory bowel disease and in tissue sections of patients with CDI. C difficile strains were found to coaggregate with F nucleatum subspecies in vitro; an effect that was inhibited by blocking or mutating the adhesin RadD on Fusobacterium and removal of flagella on C difficile. Aggregation was shown to be unique between F nucleatum and C difficile, because other gut commensals did not aggregate with C difficile. Addition of F nucleatum also enhanced C difficile biofilm formation and extracellular polysaccharide production.ConclusionsCollectively, these data show a unique interaction of between pathogenic C difficile and F nucleatum in the intestinal mucus layer.

Published
2021

6. Differences in gut microbial composition correlate with regional brain volumes in irritable bowel syndrome.

Author

Labus, Jennifer S, Hollister, Emily B, Jacobs, Jonathan, Kirbach, Kyleigh, Oezguen, Numan, Gupta, Arpana, Acosta, Jonathan, Luna, Ruth Ann, Aagaard, Kjersti, Versalovic, James, Savidge, Tor, Hsiao, Elaine, Tillisch, Kirsten, and Mayer, Emeran A

Subjects
Brain, Feces, Humans, Bacteria, Irritable Bowel Syndrome, DNA, Bacterial, DNA, Ribosomal, RNA, Ribosomal, 16S, Sequence Analysis, DNA, Phylogeny, Adult, Female, Male, Young Adult, Gastrointestinal Microbiome, Bacteroidetes, Brain-gut-microbiome axis, Firmicutes, Irritable bowel syndrome, Metagenome, Ecology, Microbiology, Medical Microbiology
Abstract

BackgroundPreclinical and clinical evidence supports the concept of bidirectional brain-gut microbiome interactions. We aimed to determine if subgroups of irritable bowel syndrome (IBS) subjects can be identified based on differences in gut microbial composition, and if there are correlations between gut microbial measures and structural brain signatures in IBS.MethodsBehavioral measures, stool samples, and structural brain images were collected from 29 adult IBS and 23 healthy control subjects (HCs). 16S ribosomal RNA (rRNA) gene sequencing was used to profile stool microbial communities, and various multivariate analysis approaches were used to quantitate microbial composition, abundance, and diversity. The metagenomic content of samples was inferred from 16S rRNA gene sequence data using Phylogenetic Investigation of Communities by Reconstruction of Unobserved States (PICRUSt). T1-weighted brain images were acquired on a Siemens Allegra 3T scanner, and morphological measures were computed for 165 brain regions.ResultsUsing unweighted Unifrac distances with hierarchical clustering on microbial data, samples were clustered into two IBS subgroups within the IBS population (IBS1 (n = 13) and HC-like IBS (n = 16)) and HCs (n = 23) (AUROC = 0.96, sensitivity 0.95, specificity 0.67). A Random Forest classifier provided further support for the differentiation of IBS1 and HC groups. Microbes belonging to the genera Faecalibacterium, Blautia, and Bacteroides contributed to this subclassification. Clinical features distinguishing the groups included a history of early life trauma and duration of symptoms (greater in IBS1), but not self-reported bowel habits, anxiety, depression, or medication use. Gut microbial composition correlated with structural measures of brain regions including sensory- and salience-related regions, and with a history of early life trauma.ConclusionsThe results confirm previous reports of gut microbiome-based IBS subgroups and identify for the first time brain structural alterations associated with these subgroups. They provide preliminary evidence for the involvement of specific microbes and their predicted metabolites in these correlations.

Published
2017

7. Fusobacteriumnucleatum Adheres to Clostridioides difficile via the RadD Adhesin to Enhance Biofilm Formation in Intestinal Mucus

Author

Engevik, Melinda A., Danhof, Heather A., Auchtung, Jennifer, Endres, Bradley T., Ruan, Wenly, Bassères, Eugénie, Engevik, Amy C., Wu, Qinglong, Nicholson, Maribeth, Luna, Ruth Ann, Garey, Kevin W., Crawford, Sue E., Estes, Mary K., Lux, Renate, Yacyshyn, Mary Beth, Yacyshyn, Bruce, Savidge, Tor, Britton, Robert A., and Versalovic, James

Published
2021
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9. Leveraging Human Microbiome Features to Diagnose and Stratify Children with Irritable Bowel Syndrome

Author

Hollister, Emily B., Oezguen, Numan, Chumpitazi, Bruno P., Luna, Ruth Ann, Weidler, Erica M., Rubio-Gonzales, Michelle, Dahdouli, Mahmoud, Cope, Julia L., Mistretta, Toni-Ann, Raza, Sabeen, Metcalf, Ginger A., Muzny, Donna M., Gibbs, Richard A., Petrosino, Joseph F., Heitkemper, Margaret, Savidge, Tor C., Shulman, Robert J., and Versalovic, James

Published
2019
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24. Towards standards for human fecal sample processing in metagenomic studies

Author

Costea, Paul I, Zeller, Georg, Sunagawa, Shinichi, Pelletier, Eric, Alberti, Adriana, Levenez, Florence, Tramontano, Melanie, Driessen, Marja, Hercog, Rajna, Jung, Ferris-Elias, Kultima, Jens Roat, Hayward, Matthew R, Coelho, Luis Pedro, Allen-Vercoe, Emma, Bertrand, Laurie, Blaut, Michael, Brown, Jillian R M, Carton, Thomas, Cools-Portier, Stéphanie, Daigneault, Michelle, Derrien, Muriel, Druesne, Anne, de Vos, Willem M, Finlay, B Brett, Flint, Harry J, Guarner, Francisco, Hattori, Masahira, Heilig, Hans, Luna, Ruth Ann, van Hylckama Vlieg, Johan, Junick, Jana, Klymiuk, Ingeborg, Langella, Philippe, Le Chatelier, Emmanuelle, Mai, Volker, Manichanh, Chaysavanh, Martin, Jennifer C, Mery, Clémentine, Morita, Hidetoshi, O'Toole, Paul W, Orvain, Céline, Patil, Kiran Raosaheb, Penders, John, Persson, Søren, Pons, Nicolas, Popova, Milena, Salonen, Anne, Saulnier, Delphine, Scott, Karen P, Singh, Bhagirath, Slezak, Kathleen, Veiga, Patrick, Versalovic, James, Zhao, Liping, Zoetendal, Erwin G, Ehrlich, S Dusko, Dore, Joel, and Bork, Peer

Published
2017
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26. Bacterial Pathogens

Author

Luna, Ruth Ann, Versalovic, James, Leonard, Debra G. B., editor, Bagg, Adam, editor, Caliendo, Angela M., editor, Kaul, Karen L., editor, and Van Deerlin, Vivianna M., editor

Published
2007
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31. Bacteroides ovatus colonization influences the abundance of intestinal short chain fatty acids and neurotransmitters

Author

Horvath, Thomas D., primary, Ihekweazu, Faith D., additional, Haidacher, Sigmund J., additional, Ruan, Wenly, additional, Engevik, Kristen A., additional, Fultz, Robert, additional, Hoch, Kathleen M., additional, Luna, Ruth Ann, additional, Oezguen, Numan, additional, Spinler, Jennifer K., additional, Haag, Anthony M., additional, Versalovic, James, additional, and Engevik, Melinda A., additional

Published
2022
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32. Su1914 DO GASTROINTESTINAL SYMPTOMS CORRELATE WITH GI INFLAMMATION OR GUT PERMEABILITY IN CHILDREN WITH AUTISM SPECTRUM DISORDER?

Author

Harne, Vaishali, Fatheree, Nicole Y., Okeugo, Beanna, Alvarez, Ana B. Fadhel, Hessabi, Manouchehr, Tahanan, Amirali, Mansour, Rosleen, Navarro, Fernando, imseis, Essam, Nair, Supriya, Gleason, Wallace A., Van Arsdall, Melissa, Armbrister, Shabba A., Scott, Rebecca, Rahbar, Mohammad H., Pearson, Deborah A., Luna, Ruth Ann, Liu, Yuying, and Rhoads, J. Marc

Published
2024
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35. Contributors

Author

Aagaard, Kjersti, primary, Abrahamian, Fredrick M., additional, Allos, Ban Mishu, additional, Andes, David R., additional, Aoki, Fred Y., additional, Apicella, Michael A., additional, Ard, Kevin L., additional, Arias, Cesar A., additional, Aronoff, David M., additional, Augenbraun, Michael H., additional, Averhoff, Francisco, additional, Azar, Dimitri T., additional, Baddour, Larry M., additional, Baden, Lindsey R., additional, Baker, Carol J., additional, Ballard, Ronald C., additional, Barber, Gerard R., additional, Barnes, Scott D., additional, Barouch, Dan H., additional, Barrett, Alan D., additional, Barshak, Miriam Baron, additional, Basavaraju, Sridhar V., additional, Batteiger, Byron E., additional, Baum, Stephen G., additional, Bayer, Arnold S., additional, Beckham, J. David, additional, Beekmann, Susan E., additional, Bell, Beth P., additional, Bennett, John E., additional, Bente, Dennis A., additional, Berbari, Elie F., additional, Berman, Jonathan, additional, Bertino, Joseph S., additional, Bhimraj, Adarsh, additional, Birdsall, Holly H., additional, Bisno, Alan L., additional, Blackburn, Brian G., additional, Blanton, Lucas S., additional, Blaser, Martin J., additional, Bleck, Thomas P., additional, Blijlevens, Nicole M.A., additional, Bobak, David A., additional, Bonnez, William, additional, Boothroyd, John C., additional, Borio, Luciana L., additional, Bosque, Patrick J., additional, Bower, John, additional, Bradsher, Robert W., additional, Brook, Itzhak, additional, Brown, Kevin E., additional, Brown, Patricia D., additional, Brown-Elliott, Barbara A., additional, Bruhn, Roberta L., additional, Bryant, Amy E., additional, Burd, Eileen M., additional, Burns, Jane C., additional, Bush, Larry M., additional, Calderwood, Stephen B., additional, Cano, Luz Elena, additional, Carpenter, Charles C.J., additional, Caserta, Mary T., additional, Castagnola, Elio, additional, Chaisson, Richard E., additional, Chambers, Henry F., additional, Chapman, Stephen J., additional, Chappell, James D., additional, Chen, Lea Ann, additional, Chen, Sharon C-A, additional, Chow, Anthony W., additional, Clark, Rebecca A., additional, Cohen, Jeffrey I., additional, Cohen, Myron S., additional, Cohen-Poradosu, Ronit, additional, Cohn, Susan E., additional, Connors, Mark, additional, Corey, Lawrence, additional, Cottrell, Mackenzie L., additional, Cover, Timothy L., additional, Cox, Heather L., additional, Craig, William A., additional, Crossley, Kent B., additional, Crumpacker, Clyde S., additional, Curran, James W., additional, Currie, Bart J., additional, D'Agata, Erika, additional, Damon, Inger K., additional, Darouiche, Rabih O., additional, DeBiasi, Roberta L., additional, Deepe, George S., additional, del Rio, Carlos, additional, Delemos, Andrew S., additional, DeLeo, Frank R., additional, DeMuri, Gregory P., additional, Densen, Peter, additional, Dermody, Terence S., additional, Dewar, Robin, additional, Diaz, James H., additional, Dieffenbach, Carl W., additional, Dienstag, Jules L., additional, Doi, Yohei, additional, Dolin, Raphael, additional, Donnelly, J. Peter, additional, Donnenberg, Michael S., additional, Donowitz, Gerald R., additional, Dormitzer, Philip R., additional, Drake, James M., additional, Dumler, J. Stephen, additional, Dummer, J. Stephen, additional, DuPont, Herbert L., additional, Durack, David T., additional, Durand, Marlene L., additional, Edelstein, Paul H., additional, Edmond, Michael B., additional, Edwards, John E., additional, Edwards, Morven S., additional, Eliopoulos, George M., additional, Ellison, Richard T., additional, Endy, Timothy P., additional, Engleberg, N. Cary, additional, Erdem, Hakan, additional, Ernst, Joel D., additional, Ernst, Peter B., additional, Fairhurst, Rick M., additional, Fairley, Jessica K., additional, Falkow, Stanley, additional, Falsey, Ann R., additional, Fauci, Anthony S., additional, Fekete, Thomas, additional, Fey, Paul D., additional, Fine, Steven M., additional, Fitzgerald, Daniel W., additional, Flores, Anthony R., additional, Forster, Derek, additional, Fowler, Vance G., additional, Freedman, David O., additional, Friedlander, Arthur M., additional, Galgiani, John N., additional, Gallin, John I., additional, Gallo, Robert C., additional, Gandhi, Tejal N., additional, Garrett, Wendy S., additional, Gaydos, Charlotte A., additional, Geisbert, Thomas W., additional, Gelfand, Jeffrey A., additional, Gelone, Steven P., additional, Gerding, Dale N., additional, Gershon, Anne A., additional, Gilsdorf, Janet R., additional, Goldstein, Ellie J.C., additional, Gordin, Fred M., additional, Graman, Paul S., additional, Grayson, M. Lindsay, additional, Greene, Jeffrey Bruce, additional, Griffin, Patricia M., additional, Griffith, David E., additional, Guerrant, Richard L., additional, Gul, H. Cem, additional, Haake, David A., additional, Haas, David W., additional, Haines, Charles, additional, Hall, Caroline Breese, additional, Hallak, Joelle, additional, Halperin, Scott A., additional, Hammerschlag, Margaret R., additional, Haque, Rashidul, additional, Harris, Jason B., additional, Hawkins, Claudia, additional, Hay, Roderick J., additional, Hedberg, Craig W., additional, Henderson, David K., additional, Henderson, Donald A., additional, High, Kevin P., additional, Hill, Adrian V.S., additional, Hill, David R., additional, Hinman, Alan R., additional, Hirsch, Martin S., additional, Hodowanec, Aimee, additional, Hohl, Tobias M., additional, Holland, Steven M., additional, Holzman, Robert S., additional, Hook, Edward W., additional, Hooper, David C., additional, Hooton, Thomas M., additional, Horowitz, Harold W., additional, Horsburgh, C. Robert, additional, Horton, James M., additional, Hospenthal, Duane R., additional, Hsueh, Kevin, additional, Hughes, James M., additional, Hynes, Noreen A., additional, Iovine, Nicole M., additional, Iredell, Jonathan R., additional, Ison, Michael G., additional, Janda, J. Michael, additional, Janoff, Edward N., additional, Johannsen, Eric C., additional, Kashuba, Angela D.M., additional, Kasper, Dennis L., additional, Kaye, Donald, additional, Kaye, Keith S., additional, Kaye, Kenneth M., additional, Kazura, James W., additional, Keystone, Jay S., additional, Khabbaz, Rima, additional, Khan, David A., additional, Khudyakov, Yury, additional, Kim, Rose, additional, King, Charles H., additional, Kirchhoff, Louis V., additional, Klein, Jerome O., additional, Klompas, Michael, additional, Knoll, Bettina M., additional, Knowlton, Kirk U., additional, Koehler, Jane E., additional, Kohlhoff, Stephan A., additional, Könönen, Eija, additional, Kontoyiannis, Dimitrios P., additional, Koralnik, Igor J., additional, Korpe, Poonum S., additional, Koshy, Anita A., additional, Kovacs, Joseph A., additional, Kozarsky, Phyllis, additional, Krieger, John, additional, Kroger, Andrew T., additional, Kuehnert, Matthew J., additional, Kumar, Nalin M., additional, Kuruvilla, Merin Elizabeth, additional, LaRocque, Regina C., additional, Leggett, James E., additional, Legido-Quigley, Helena, additional, Levett, Paul N., additional, Levine, Donald P., additional, Levison, Matthew E., additional, Levitt, Alexandra, additional, Lewis, Russell E., additional, Liles, W. Conrad, additional, Lima, Aldo A.M., additional, Limaye, Ajit P., additional, Lipkin, W. Ian, additional, Litman, Nathan, additional, Lorber, Bennett, additional, Luna, Ruth Ann, additional, MacDougall, Conan, additional, Roy, Rob, additional, Mackowiak, Philip A., additional, Madoff, Lawrence C., additional, Magill, Alan J., additional, Maguire, James H., additional, Maldarelli, Frank, additional, Markoff, Lewis, additional, Marrazzo, Jeanne M., additional, Marrie, Thomas J., additional, Marth, Thomas, additional, Martin, David H., additional, Martin, Gregory J., additional, Marty, Francisco M., additional, Maslow, Melanie Jane, additional, Masur, Henry, additional, Mawle, Alison, additional, Mayer, Kenneth H., additional, McBride, John T., additional, McCarthy, James S., additional, McCormack, William M., additional, McGowan, Catherine C., additional, McIntosh, Kenneth, additional, Mead, Paul S., additional, Mikulska, Malgorzata, additional, Miller, Robert F., additional, Miller, Samuel I., additional, Mitchell, David H., additional, Modlin, John F., additional, Mody, Rajal K., additional, Moellering, Robert C., additional, Moffa, Matthew, additional, Moir, Susan, additional, Montoya, José G., additional, Moore, Thomas A., additional, Moreillon, Philippe, additional, Morris, J. Glenn, additional, Morse, Caryn Gee, additional, Moseley, Robin, additional, Munford, Robert S., additional, Murphy, Edward L., additional, Murphy, Timothy F., additional, Murray, Barbara E., additional, Murray, Clinton K., additional, Murray, Patrick R., additional, Musher, Daniel M., additional, Nagel, Jerod L., additional, Nannini, Esteban C., additional, Narezkina, Anna, additional, Nash, Theodore E., additional, Nauseef, William M., additional, Nayak, Jennifer L., additional, Neill, Marguerite A., additional, O'Donnell, Judith A., additional, Ohl, Christopher A., additional, Okhuysen, Pablo C., additional, Onderdonk, Andrew B., additional, Opal, Steven M., additional, Orenstein, Walter A., additional, Osmon, Douglas R., additional, Osterholm, Michael T., additional, Ostroff, Stephen M., additional, Oxman, Michael N., additional, Paessler, Slobodan, additional, Page, Andrea V., additional, Pai, Manjunath P., additional, Palmore, Tara N., additional, Palraj, Raj, additional, Pappas, Peter G., additional, Pasternack, Mark S., additional, Patterson, Thomas F., additional, Pavan-Langston, Deborah, additional, Pegues, David A., additional, Penn, Robert L., additional, Perfect, John R., additional, Perlman, Stanley, additional, Petersen, Brett W., additional, Peterson, Phillip K., additional, Petri, William A., additional, Petti, Cathy A., additional, Philips, Jennifer A., additional, Philley, Julie V., additional, Phillips, Michael, additional, Pickering, Larry K., additional, Piot, Peter, additional, Pogue, Jason M., additional, Pop-Vicas, Aurora, additional, Portal-Celhay, Cynthia, additional, Powers, John H., additional, Price, Richard N., additional, Que, Yok-Ai, additional, Radolf, Justin D., additional, Ram, Sanjay, additional, Raoult, Didier, additional, Ravdin, Jonathan I., additional, Ray, Stuart C., additional, Reboli, Annette C., additional, Reitz, Marvin S., additional, Relman, David A., additional, Renault, Cybèle A., additional, Restrepo, Angela, additional, Rex, John H., additional, Rhee, Elizabeth G., additional, Roberts, Norbert J., additional, Romero, José R., additional, Rothman, Alan L., additional, Roy, Craig R., additional, Ruoff, Kathryn L., additional, Rupp, Mark E., additional, Rupprecht, Charles E., additional, Russo, Thomas A., additional, Rutala, William A., additional, Ryan, Edward T., additional, Safdar, Amar, additional, Sajadi, Mohammad M., additional, Salazar, Juan C., additional, Sarria, Juan Carlos, additional, Savoia, Maria C., additional, Sax, Paul E., additional, Scheld, W. Michael, additional, Schiffer, Joshua T., additional, Schlossberg, David, additional, Schneider, Thomas, additional, Schuchat, Anne, additional, Schwebke, Jane R., additional, Sears, Cynthia L., additional, Segal, Leopoldo N., additional, Sendi, Parham, additional, Sepkowitz, Kent A., additional, Septimus, Edward J., additional, Seregin, Alexey, additional, Shulman, Stanford T., additional, Siberry, George K., additional, Siddiqi, Omar K., additional, Sifri, Costi D., additional, Simberkoff, Michael S., additional, Simonetti, Francesco R., additional, Singh, Kamaljit, additional, Singh, Nina, additional, Singh, Upinder, additional, Sinner, Scott W., additional, Sivapalasingam, Sumathi, additional, Slater, Leonard N., additional, Smulian, A. George, additional, Sobel, Jack D., additional, Sohail, M. Rizwan, additional, Soper, David E., additional, Sorrell, Tania C., additional, Steckelberg, James M., additional, Steere, Allen C., additional, Steigbigel, Neal H., additional, Steinberg, James P., additional, Stephens, David S., additional, Sterling, Timothy R., additional, Stevens, David A., additional, Stevens, Dennis L., additional, Strahilevitz, Jacob, additional, Stratton, Charles W., additional, Suffredini, Anthony F., additional, Suh, Kathryn N., additional, Sulkowski, Mark S., additional, Swartz, Morton N., additional, Talbot, Thomas R., additional, Tan, C. Sabrina, additional, Tan, Ming, additional, Thio, Chloe Lynne, additional, Thomas, David L., additional, Thomas, Lora D., additional, Thomas, Stephen J., additional, Thorner, Anna R., additional, María Tobón, Angela, additional, Tramont, Edmund C., additional, Treanor, John J., additional, Trubiano, Jason, additional, Tsibris, Athe M.N., additional, Tunkel, Allan R., additional, Turner, Ronald B., additional, Tyler, Kenneth L., additional, Uluer, Ahmet, additional, van de Beek, Diederik, additional, van der Velden, Walter J.F.M., additional, Vannier, Edouard G., additional, Van, Trevor C., additional, Versalovic, James, additional, Viscoli, Claudio, additional, Wald, Ellen R., additional, Waldor, Matthew K., additional, Walker, David H., additional, Wallace, Richard J., additional, Walsh, Edward E., additional, Walsh, Stephen R., additional, Walzer, Peter D., additional, Wanke, Christine A., additional, Warren, Cirle A., additional, Washburn, Ronald G., additional, Waters, Valerie, additional, Weber, David J., additional, Weiden, Michael D., additional, Weinberg, Geoffrey A., additional, Weisdorf, Daniel J., additional, Weiss, Louis M., additional, Welch, David F., additional, Wellems, Thomas E., additional, Wenzel, Richard P., additional, Wharton, Melinda, additional, White, A. Clinton, additional, Whitley, Richard J., additional, Wilson, Walter R., additional, Wortmann, Glenn W., additional, Wright, William F., additional, Young, Jo-Anne H., additional, Young, Vincent B., additional, Yun, Nadezhda, additional, Zimmerli, Werner, additional, Zinner, Stephen H., additional, and Zurlo, John J., additional

Published
2015
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36. Fecal Microbiota Transplantation Commonly Failed in Children With Co-Morbidities

Author

Kellermayer, Richard, primary, Wu, Qinglong, additional, Nagy-Szakal, Dorottya, additional, Queliza, Karen, additional, Ihekweazu, Faith D., additional, Bocchini, Claire E., additional, Magee, Abria R., additional, Oezguen, Numan, additional, Spinler, Jennifer K., additional, Hollister, Emily B., additional, Shulman, Robert J., additional, Versalovic, James, additional, Luna, Ruth Ann, additional, and Savidge, Tor C., additional

Published
2021
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37. Editorial: Interactions of the Nervous System With Bacteria

Author

Hill-Yardin, Elisa L., Grabrucker, Andreas M., Franks, Ashley E., Luna, Ruth Ann, and Monif, Mastura

Subjects
Editorial, enteric nervous system, brain, neurological disorders, gastrointestinal tract, dysbiosis, microbes, diet, Neuroscience, neuroinflammation
Published
2021

38. Fusobacteriumnucleatum Adheres to Clostridioides difficile via the RadD Adhesin to Enhance Biofilm Formation in Intestinal Mucus

Author

Engevik, Melinda A, Danhof, Heather A, Auchtung, Jennifer, Endres, Bradley T, Ruan, Wenly, Bassères, Eugénie, Engevik, Amy C, Wu, Qinglong, Nicholson, Maribeth, Luna, Ruth Ann, Garey, Kevin W, Crawford, Sue E, Estes, Mary K, Lux, Renate, Yacyshyn, Mary Beth, Yacyshyn, Bruce, Savidge, Tor, Britton, Robert A, and Versalovic, James

Subjects
Clinical Sciences, Bacterial Adhesion, Oral and gastrointestinal, Paediatrics and Reproductive Medicine, Feces, Bioreactors, Humans, Intestinal Mucosa, Mucin-2, Fusobacterium nucleatum, Gastroenterology & Hepatology, Clostridioides difficile, Biofilm, Bacterial, Neurosciences, Adhesins, Gastrointestinal Microbiome, Mucus, Emerging Infectious Diseases, Infectious Diseases, Good Health and Well Being, Flagella, Biofilms, MUC2, Clostridium Infections, Digestive Diseases, Infection, HT29 Cells
Abstract

Background & aimsAlthough Clostridioides difficile infection (CDI) is known to involve the disruption of the gut microbiota, little is understood regarding how mucus-associated microbes interact with C difficile. We hypothesized that select mucus-associated bacteria would promote C difficile colonization and biofilm formation.MethodsTo create a model of the human intestinal mucus layer and gut microbiota, we used bioreactors inoculated with healthy human feces, treated with clindamycin and infected with C difficile with the addition of human MUC2-coated coverslips.ResultsC difficile was found to colonize and form biofilms on MUC2-coated coverslips, and 16S rRNA sequencing showed a unique biofilm profile with substantial cocolonization with Fusobacterium species. Consistent with our bioreactor data, publicly available data sets and patient stool samples showed that a subset of patients with C difficile infection harbored high levels of Fusobacterium species. We observed colocalization of C difficile and F nucleatum in an aggregation assay using adult patients and stool of pediatric patients with inflammatory bowel disease and in tissue sections of patients with CDI. C difficile strains were found to coaggregate with F nucleatum subspecies invitro; an effect that was inhibited by blocking or mutating the adhesin RadD on Fusobacterium and removal of flagella on C difficile. Aggregation was shown to be unique between F nucleatum and C difficile, because other gut commensals did not aggregate with C difficile. Addition of F nucleatum also enhanced C difficile biofilm formation and extracellular polysaccharide production.ConclusionsCollectively, these data show a unique interaction of between pathogenic C difficile and F nucleatum in the intestinal mucus layer.

Published
2021

39. Supplemental Material, sj-pdf-1-brn-10.1177_1099800420984543 - A Comprehensive Self-Management Program With Diet Education Does Not Alter Microbiome Characteristics in Women With Irritable Bowel Syndrome

Author

Kamp, Kendra J., Plantinga, Anna M., Cain, Kevin C., Burr, Robert L., Barney, Pamela, Jarrett, Monica, Luna, Ruth Ann, Savidge, Tor, Shulman, Robert, and Heitkemper, Margaret M.

Subjects
111099 Nursing not elsewhere classified, FOS: Health sciences
Abstract

Supplemental Material, sj-pdf-1-brn-10.1177_1099800420984543 for A Comprehensive Self-Management Program With Diet Education Does Not Alter Microbiome Characteristics in Women With Irritable Bowel Syndrome by Kendra J. Kamp, Anna M. Plantinga, Kevin C. Cain, Robert L. Burr, Pamela Barney, Monica Jarrett, Ruth Ann Luna, Tor Savidge, Robert Shulman and Margaret M. Heitkemper in Biological Research For Nursing

Published
2021
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40. Probiotic VSL#3 Treatment Reduces Colonic Permeability and Abdominal Pain Symptoms in Patients With Irritable Bowel Syndrome

Author

Boonma, Prapaporn, primary, Shapiro, Jordan M., additional, Hollister, Emily B., additional, Badu, Shyam, additional, Wu, Qinglong, additional, Weidler, Erica M., additional, Abraham, Bincy P., additional, Devaraj, Sridevi, additional, Luna, Ruth Ann, additional, Versalovic, James, additional, Heitkemper, Margaret M., additional, Savidge, Tor C., additional, and Shulman, Robert J., additional

Published
2021
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48. Mucin-Degrading Microbes Release Monosaccharides That Chemoattract Clostridioides difficile and Facilitate Colonization of the Human Intestinal Mucus Layer

Author

Engevik, Melinda A., primary, Engevik, Amy C., additional, Engevik, Kristen A., additional, Auchtung, Jennifer M., additional, Chang-Graham, Alexandra L., additional, Ruan, Wenly, additional, Luna, Ruth Ann, additional, Hyser, Joseph M., additional, Spinler, Jennifer K., additional, and Versalovic, James, additional

Published
2020
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