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Your search keyword '"Lukowicz, Celine"' showing total 12 results
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12 results on '"Lukowicz, Celine"'

1. Obesity promotes fumonisin B1 hepatotoxicity

Author

Dopavogui, Léonie, Régnier, Marion, Polizzi, Arnaud, Ponchon, Quentin, Smati, Sarra, Klement, Wendy, Lasserre, Frédéric, Lukowicz, Céline, Lippi, Yannick, Fougerat, Anne, Bertrand-Michel, Justine, Naylies, Claire, Canlet, Cécile, Debrauwer, Laurent, Rousseau-Bacquié, Elodie, Gamet-Payrastre, Laurence, Dauriat, Charlène, Casas, Josefina, Croubels, Siska, De Baere, Siegrid, Burger, Hester M., Chassaing, Benoit, Ellero-Simatos, Sandrine, Guillou, Hervé, Oswald, Isabelle P., and Loiseau, Nicolas

Published
2023
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2. Perinatal exposure to a dietary pesticide cocktail does not increase susceptibility to high-fat diet-induced metabolic perturbations at adulthood but modifies urinary and fecal metabolic fingerprints in C57Bl6/J mice

Author

Smith, Lorraine, Klément, Wendy, Dopavogui, Léonie, de Bock, Frédéric, Lasserre, Frédéric, Barretto, Sharon, Lukowicz, Céline, Fougerat, Anne, Polizzi, Arnaud, Schaal, Benoist, Patris, Bruno, Denis, Colette, Feuillet, Guylène, Canlet, Cécile, Jamin, Emilien L, Debrauwer, Laurent, Mselli-Lakhal, Laila, Loiseau, Nicolas, Guillou, Hervé, Marchi, Nicola, Ellero-Simatos, Sandrine, and Gamet-Payrastre, Laurence

Published
2020
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4. Integrative study of diet-induced mouse models of NAFLD identifies PPARα as a sexually dimorphic drug target

Author

Smati, Sarra, primary, Polizzi, Arnaud, additional, Fougerat, Anne, additional, Ellero-Simatos, Sandrine, additional, Blum, Yuna, additional, Lippi, Yannick, additional, Régnier, Marion, additional, Laroyenne, Alexia, additional, Huillet, Marine, additional, Arif, Muhammad, additional, Zhang, Cheng, additional, Lasserre, Frederic, additional, Marrot, Alain, additional, Al Saati, Talal, additional, Wan, JingHong, additional, Sommer, Caroline, additional, Naylies, Claire, additional, Batut, Aurelie, additional, Lukowicz, Celine, additional, Fougeray, Tiffany, additional, Tramunt, Blandine, additional, Dubot, Patricia, additional, Smith, Lorraine, additional, Bertrand-Michel, Justine, additional, Hennuyer, Nathalie, additional, Pradere, Jean-Philippe, additional, Staels, Bart, additional, Burcelin, Remy, additional, Lenfant, Françoise, additional, Arnal, Jean-François, additional, Levade, Thierry, additional, Gamet-Payrastre, Laurence, additional, Lagarrigue, Sandrine, additional, Loiseau, Nicolas, additional, Lotersztajn, Sophie, additional, Postic, Catherine, additional, Wahli, Walter, additional, Bureau, Christophe, additional, Guillaume, Maeva, additional, Mardinoglu, Adil, additional, Montagner, Alexandra, additional, Gourdy, Pierre, additional, and Guillou, Hervé, additional

Published
2021
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5. Integrative study of diet-induced mouse models of NAFLD identifies PPARα as a sexually dimorphic drug target.

Author

Smati, Sarra, Polizzi, Arnaud, Fougerat, Anne, Ellero-Simatos, Sandrine, Blum, Yuna, Lippi, Yannick, Régnier, Marion, Laroyenne, Alexia, Huillet, Marine, Arif, Muhammad, Cheng Zhang, Lasserre, Frederic, Marrot, Alain, Al Saati, Talal, JingHong Wan, Sommer, Caroline, Naylies, Claire, Batut, Aurelie, Lukowicz, Celine, and Fougeray, Tiffany

Subjects
FATTY liver, CHOLESTEROL content of food, NON-alcoholic fatty liver disease, ELLAGIC acid, DRUG target, SEXUAL dimorphism, LABORATORY mice, NF-kappa B
Published
2022
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6. Gene Expression Profiling Reveals That PXR Activation Inhibits Hepatic PPARα Activity and Decreases FGF21 Secretion in Male C57Bl6/J Mice

Author

Barretto, Sharon Ann, primary, Lasserre, Frederic, additional, Fougerat, Anne, additional, Smith, Lorraine, additional, Fougeray, Tiffany, additional, Lukowicz, Celine, additional, Polizzi, Arnaud, additional, Smati, Sarra, additional, Régnier, Marion, additional, Naylies, Claire, additional, Betoulieres, Colette, additional, Lippi, Yannick, additional, guillou, hervé, additional, Loiseau, Nicolas, additional, Payrastre, Laurence, additional, Lakhal, Laila, additional, and Ellero-Simatos, Sandrine, additional

Published
2019
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8. Metabolic Effects of a Chronic Dietary Exposure to a Low-Dose Pesticide Cocktail in Mice: Sexual Dimorphism and Role of the Constitutive Androstane Receptor

Author

Lukowicz, Celine, Ellero-Simatos, Sandrine, Regnier, Marion, Polizzi, Arnaud, Lasserre, Frederic, Montagner, Alexandra, Lippi, Yannick, Jamin, Emilien L., Martin, Jean- Francois, Naylies, Claire, Canle, Cecile, Debrauwer, Laurent, Bertrand-Michel, Justine, Saati, Talal Al, Theodorou, Vassilia, Loiseau, Nicolas, Mselli-Lakhal, Laila, Guillou, Herve, and Gamet-Payrastre, Laurence

Subjects
Metabolites -- Research, Metabolic diseases -- Genetic aspects -- Care and treatment -- Research, Liquid chromatography -- Usage, Body weight -- Physiological aspects -- Health aspects, Mass spectrometry -- Usage, Environmental issues, Health, European Union. European Food Safety Authority
Abstract

BACKGROUND: Epidemiological evidence suggests a link between pesticide exposure and the development of metabolic diseases. However, most experimental studies have evaluated the metabolic effects of pesticides using individual molecules, often at nonrelevant doses or in combination with other risk factors such as high-fat diets. OBJECTIVES: We aimed to evaluate, in mice, the metabolic consequences of chronic dietary exposure to a pesticide mixture at nontoxic doses, relevant to consumers' risk assessment. METHODS: A mixture of six pesticides commonly used in France, i.e., boscalid, captan, chlorpyrifos, thiofanate, thiacloprid, and ziram, was incorporated in a standard chow at doses exposing mice to the tolerable daily intake (TDI) of each pesticide. Wild-type (WT) and constitutive androstane receptor-deficient ([CAR.sup.-/-]) male and female mice were exposed for 52 wk. We assessed metabolic parameters [body weight (BW), food and water consumption, glucose tolerance, urinary metabolome] throughout the experiment. At the end of the experiment, we evaluated liver metabolism (histology, transcriptomics, metabolomics, lipidomics) and pesticide detoxification using liquid chromatography-mass spectrometry (LC-MS). RESULTS: Compared to those fed control chow, WT male mice fed pesticide chow had greater BW gain and more adiposity. Moreover, these WT males fed pesticide chow exhibited characteristics of hepatic steatosis and glucose intolerance, which were not observed in those fed control chow. WT exposed female mice exhibited fasting hyperglycemia, higher reduced glutathione (GSH):oxidized glutathione (GSSG) liver ratio and perturbations of gut microbiota-related urinary metabolites compared to WT mice fed control chow. When we performed these experiments on [CAR.sup.-/-] mice, pesticide-exposed [CAR.sup.-/-] males did not exhibit BW gain or changes in glucose metabolism compared to the [CAR.sup.-/-] males fed control chow. Moreover, [CAR.sup.-/-] females fed pesticide chow exhibited pesticide toxicity with higher BWs and mortality rate compared to the [CAR.sup.-/-] females fed control chow. CONCLUSIONS: To our knowledge, we are the first to demonstrate a sexually dimorphic obesogenic and diabetogenic effect of chronic dietary exposure to a common mixture of pesticides at TDI levels, and to provide evidence for a partial role for CAR in an in vivo mouse model. This raises questions about the relevance of TDI for individual pesticides when present in a mixture. https://doi.org/10.1289/EHP2877, Introduction The rates of metabolic disorders, including obesity and its complications, such as type 2 diabetes (T2D) and nonalcoholic fatty liver disease (NAFLD), have increased dramatically over the past three [...]

Published
2018
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12. CO-77 - L’hépatokine FGF21 est unique dans sa réponse nutrionnelle au glucose et au jeûne dans le foie : interdépendence des facteurs de transcription ChREBP et PPARα

Author

Iroz, Alison, Montagner, Alexandra, Benhamed, Fadila, Polizzi, Arnaud, Levavasseur, Françoise, Antony, Elodie, Régnier, Marion, Fouché, Edwin, Lukowicz, Céline, Lippi, Yannick, Daujat-Chavanieu, Martine, Gerbal-Chalouin, Sabine, Fauveau, Véronique, Burnol, Anne-Françoise, Walter Wahli, Sandra Guilmeau, Dentin, Renaud, Guillou, Hervé, and Postic, Catherine

Published
2017
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