1. Immune System, Cell Senescence, Aging and Longevity - Inflamm-Aging Reappraised
- Author
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Elena Bellavista, Laura Lomartire, Morena Martucci, Daniela Monti, Paolo Garagnani, Rita Ostan, Vincenzo Borelli, Maria Giulia Bacalini, Federica Sevini, Maria Conte, Stella Lukas Yani, Miriam Capri, Laura Bucci, Aurelia Santoro, Dario Vianello, Maria Scurti, Cristina Giuliani, Elisa Pini, Stefano Salvioli, Claudio Franceschi, Catia Lanzarini, Elisa Fontanesi, Annalaura Barbieri, Fiammetta Biondi, Chiara Pirazzini, Elisa Cevenini, Salvioli S., Monti D., Lanzarini C., Conte M., Pirazzini C., Bacalini M.G., Garagnani P., Giuliani C., Fontanesi E., Ostan R., Bucci L., Sevini F., Lukas Yani S., Barbieri A., Lomartire L., Borelli V., Vianello D., Bellavista E., Martucci M., Cevenini E., Pini E., Scurti M., Biondi F., Santoro A., Capri M., and Franceschi C.
- Subjects
Senescence ,Inflamm aging ,CELL SENESCENCE ,media_common.quotation_subject ,Cell ,Inflammation ,Biology ,centenarian ,03 medical and health sciences ,Immune system ,0302 clinical medicine ,INFLAMMATION ,Drug Discovery ,medicine ,Pathological ,media_common ,030304 developmental biology ,immunosenescence ,Pharmacology ,0303 health sciences ,aging ,Longevity ,Immunosenescence ,medicine.anatomical_structure ,Immunology ,medicine.symptom ,030217 neurology & neurosurgery - Abstract
Inflamm-aging, that is the age-associated inflammatory status, is considered one of the most striking consequences of immunosenescence, as it is believed to be linked to the majority of age-associated diseases sharing an inflammatory basis. Nevertheless, evidence is emerging that inflamm-aging is at least in part independent from immunological stimuli. Moreover, centenarians who avoided or delayed major inflammatory diseases display markers of inflammation. In this paper we proposed a reappraisal of the concept of inflamm- aging, suggesting that its pathological effects can be independent from the total amount of pro-inflammatory mediators, but they would be rather associated with the anatomical district and type of cells where they are produced and where they primarily act.
- Published
- 2013