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213 results on '"Lukacs-Kornek, Veronika"'

1. Chinese hospital staff in anxiety and depression: Not only comfort patients but also should be comforted - A nationwide cross-sectional study

Author

Mei, Qi, Li, Wanling, Feng, Huijing, Zhang, Junyan, Li, Jian, Yin, Junping, Lukacs-Kornek, Veronika, Kurts, Christian, Dai, Shujuan, Zhao, Xiaoxiao, Ai, Qinglong, Yu, Chunlei, Xu, Fan, Xi, Xiaoting, Liu, Fang, Song, DaoYuan, Wang, Yaochang, Zhong, Lianmei, Ashford, John. Wesson, Ashford, Curtis, Liu, Xiaolei, and Wang, Hongxing

Published
2024
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3. Multidisciplinary recommendations for the management of CAR-T recipients in the post-COVID-19 pandemic era

Author

Zhang, Tingting, Tian, Weiwei, Wei, Shuang, Lu, Xinyi, An, Jing, He, Shaolong, Zhao, Jie, Gao, Zhilin, Li, Li, Lian, Ke, Zhou, Qiang, Zhang, Huilai, Wang, Liang, Su, Liping, Kang, Huicong, Niu, Ting, Zhao, Ailin, Pan, Jing, Cai, Qingqing, Xu, Zhenshu, Chen, Wenming, Jing, Hongmei, Li, Peng, Zhao, Wanhong, Cao, Yang, Mi, Jianqing, Chen, Tao, Chen, Yuan, Zou, Ping, Lukacs-Kornek, Veronika, Kurts, Christian, Li, Jian, Liu, Xiansheng, Mei, Qi, Zhang, Yicheng, and Wei, Jia

Published
2023
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7. Artificial intelligence identifies spatial fingerprints of kidney-resident macrophages and brain microglia

Author

Kurts, Christian, primary, Yin, Junping, additional, Klaus, Daniela, additional, Eichler, Melanie, additional, Lukacs-Kornek, Veronika, additional, Ludwig-Portugall, Isis, additional, Li, Jian, additional, Mei, Qi, additional, Paust, Hans-Joachim, additional, Song, Ning, additional, Zhao, Yu, additional, Krebs, Christian, additional, Panzer, Ulf, additional, Hua, Yijun, additional, Qin, Jie, additional, Cheng, Weiting, additional, Weisheit, Christina, additional, von Vietinghoff, Sibylle, additional, and Klughammer, Johanna, additional

Published
2024
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8. Monocyte derived large extracellular vesicles in polytrauma.

Author

Wöhler, Aliona, Gries, Sabine K., Salzmann, Rebekka J. S., Krötz, Christina, Wang, Bingduo, Müller, Paula, Klein, Angelina, Schmidt‐Wolf, Ingo G. H., Schaaf, Sebastian, Schwab, Robert, Lukacs‐Kornek, Veronika, Willms, Arnulf G., and Kornek, Miroslaw T.

Subjects
TUMOR markers, EXTRACELLULAR vesicles, BIOMARKERS, TRAUMATOLOGY, SPLEEN
Abstract

Despite significant progress in the medical field, there is still a pressing need for minimal‐invasive tools to assist with decision‐making, especially in cases of polytrauma. Our team explored the potential of serum‐derived large extracellular vesicles, so called microparticles/microvesicles/ectosomes, to serve as a supportive tool in decision‐making in polytrauma situations. We focused on whether monocyte derived large EVs may differentiate between polytrauma patients with internal organ injury (ISS > 15) and those without. Thus, we compared our EV data to soluble biomarkers such as tumour necrosis factor alpha (TNF alpha) and Interleukin‐8 (IL‐8). From the blood of 25 healthy and 26 patients with polytrauma large EVs were isolated, purified, and characterized. TNF alpha and IL‐8 levels were quantified. We found that levels of these monocyte derived large EVs were significantly higher in polytrauma patients with internal organ damage and correlated with the ISS. Interestingly, we also observed a decline in AnnV+CD14+ large EVs during normal recovery after trauma. Thus, inflammatory serological markers as TNF alpha and as IL‐8 demonstrated an inability to discriminate between polytrauma patients with or without internal organ damage, such as spleen, kidney, or liver lacerations/ruptures. However, TNF and IL‐8 levels were elevated in polytrauma cases overall when contrasted with healthy non‐traumatic controls. These findings suggest that delving deeper into the potential of AnnV+ large EVs derived from monocytes could highly beneficial in the managment of polytrauma, potentially surpassing the efficacy of commonly used serum markers. [ABSTRACT FROM AUTHOR]

Published
2024
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9. Increased type-I interferon level is associated with liver damage and fibrosis in primary sclerosing cholangitis

Author

Salzmann, Rebekka J.S., primary, Krötz, Christina, additional, Mocan, Tudor, additional, Mocan, Lavinia P., additional, Grapa, Cristiana, additional, Rottmann, Sophia, additional, Reichelt, Ramona, additional, Keller, Cindy M., additional, Langhans, Bettina, additional, Schünemann, Frederik, additional, Pohl, Alexander, additional, Böhler, Thomas, additional, Bersiner, Käthe, additional, Krawczyk, Marcin, additional, Milkiewicz, Piotr, additional, Sparchez, Zeno, additional, Lammert, Frank, additional, Gehlert, Sebastian, additional, Gonzalez-Carmona, Maria A., additional, Willms, Arnulf, additional, Strassburg, Christian P., additional, Kornek, Miroslaw T., additional, Dold, Leona, additional, and Lukacs-Kornek, Veronika, additional

Published
2024
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10. Editorial: Inflammatory responses on the road from NASH to HCC: pathogenic mechanisms and possible therapeutic strategies.

Author

Lukacs-Kornek, Veronika, Hendrikx, Tim, and Sutti, Salvatore

Subjects
NON-alcoholic fatty liver disease, CELL transformation, KILLER cells, LIVER cells, PROTEASE-activated receptors
Abstract

The editorial discusses the transition from metabolic dysfunction-associated liver disease (MASLD) to metabolic dysfunction-associated steatohepatitis (MASH) and its potential progression to hepatocellular carcinoma (HCC). Chronic inflammation is identified as a key factor in this process, with various molecules and receptors playing crucial roles in mediating inflammatory responses. The article highlights the importance of understanding these mechanisms to develop therapeutic strategies for MASH and its complications, emphasizing the need for further research in this area. [Extracted from the article]

Published
2024
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11. The role of dendritic cells in MASH: friends or foes?

Author

Pinto, Antonio T. and Lukacs-Kornek, Veronika

Subjects
DENDRITIC cells, NATURAL immunity
Abstract

Dendritic cells (DCs) are major antigen-presenting cells that connect innate and adaptive immunity. Hepatic DCs are less activated and contribute to maintain the tolerogenic environment of the liver under steady state. Several studies indicated DCs in metabolic dysfunction-associated steatohepatitis (MASH), representing a substantial burden on healthcare systems due to its association with liver-related morbidity and mortality. Studies highlighted the potential disease-promoting role of liver DCs in the development of MASH while other experimental systems suggested their protective role. This review discusses this controversy and the current understanding of how DCs affect the pathogenesis of MASH. [ABSTRACT FROM AUTHOR]

Published
2024
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13. Regulatory T Cell Inhibition by P60 Combined with Adenoviral AFP Transduced Dendritic Cells for Immunotherapy of Hepatocellular Carcinoma

Author

Sadeghlar, Farsaneh, primary, Seelemann, Julia, additional, Vogt, Annabelle, additional, Möhring, Christian, additional, Zhou, Taotao, additional, Mahn, Robert, additional, Kornek, Miroslaw, additional, Lukacs-Kornek, Veronika, additional, Casares, Noelia, additional, Lasarte, Juan José, additional, Sarobe, Pablo, additional, van Beekum, Cornelius, additional, Matthaei, Hanno, additional, Manekeller, Steffen, additional, Kalff, Jörg, additional, Schmidt-Wolf, Ingo G.H., additional, Strassburg, Christian P., additional, and Gonzalez-Carmona, Maria A., additional

Published
2023
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14. Fibroblastic reticular cells enhance T cell metabolism and survival via epigenetic remodeling

Author

Brown, Flavian D., Sen, Debattama R., LaFleur, Martin W., Godec, Jernej, Lukacs-Kornek, Veronika, Schildberg, Frank A., Kim, Hye-Jung, Yates, Kathleen B., Ricoult, Stéphane J. H., Bi, Kevin, Trombley, Justin D., Kapoor, Varun N., Stanley, Illana A., Cremasco, Viviana, Danial, Nika N., Manning, Brendan D., Sharpe, Arlene H., Haining, W. Nicholas, and Turley, Shannon J.

Published
2019
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15. Liquid Biopsy in Organ Damage: small extracellular vesicle chipbased assessment of polytrauma.

Author

Bingduo Wang, Wöhler, Aliona, Greven, Johannes, Salzmann, Rebekka J. S., Keller, Cindy M., Tertel, Tobias, Qun Zhao, Mert, Ümit, Horst, Klemens, Lupu, Ludmila, Huber-Lang, Markus, van Griensven, Martijn, Mollnes, Tom Erik, Schaaf, Sebastian, Schwab, Robert, Strassburg, Christian P., Schmidt-Wolf, Ingo G. H., Giebel, Bernd, Hildebrand, Frank, and Lukacs-Kornek, Veronika

Subjects
EXTRACELLULAR vesicles, FIBROSIS, BIOPSY, LIQUIDS, SENSITIVITY & specificity (Statistics), MONOCYTES
Abstract

Background: Despite major advances in medicine, blood-borne biomarkers are urgently needed to support decision-making, including polytrauma. Here, we assessed serum-derived extracellular vesicles (EVs) as potential markers of decision-making in polytrauma. Objective: Our Liquid Biopsy in Organ Damage (LiBOD) study aimed to differentiate polytrauma with organ injury from polytrauma without organ injury. We analysed of blood-borne small EVs at the individual level using a combination of immunocapture and high-resolution imaging. Methods: To this end, we isolated, purified, and characterized small EVs according to the latest Minimal Information for Studies of Extracellular Vesicles (MISEV) guidelines from human blood collected within 24 h post-trauma and validated our results using a porcine polytrauma model.Results: We found that small EVs derived from monocytes CD14+ and CD14+CD61+ were significantly elevated in polytrauma with organ damage. To be precise, our findings revealed that CD9+CD14+ and CD14+CD61+ small EVs exhibited superior performance compared to CD9+CD61+ small EVs in accurately indicating polytrauma with organ damage, reaching a sensitivity and a specificity of 0.81% and 0.97%, respectively. The results in humans were confirmed in an independent porcine model of polytrauma.Conclusion: These findings suggest that these specific types of small EVs may serve as valuable, non-invasive, and objective biomarkers for assessing and monitoring the severity of polytrauma and associated organ damage. [ABSTRACT FROM AUTHOR]

Published
2023
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17. NanoView EV Chip-based profiling in liver cancer differentiation-HCC from intrahepatic CCA-small EVs vs large EVs

Author

Wang, Bingduo, primary, Mocan, Tudor, additional, Urban, Sabine K., additional, Horhat, Adelina, additional, Zölzer, Dominik, additional, Sparchez, Zeno, additional, Shephard, Alex, additional, Owen, Ben, additional, Willms, Arnulf, additional, Schmidt-Wolf, Ingo G., additional, Gonzalez-Carmona, Maria Angeles, additional, Strassburg, Christian, additional, Lukacs-Kornek, Veronika, additional, and Kornek, Miroslaw, additional

Published
2022
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24. Podoplanin-Rich Stromal Networks Induce Dendritic Cell Motility via Activation of the C-type Lectin Receptor CLEC-2

Author

Acton, Sophie E., Astarita, Jillian L., Malhotra, Deepali, Lukacs-Kornek, Veronika, Franz, Bettina, Hess, Paul R., Jakus, Zoltan, Kuligowski, Michael, Fletcher, Anne L., Elpek, Kutlu G., Bellemare-Pelletier, Angelique, Sceats, Lindsay, Reynoso, Erika D., Gonzalez, Santiago F., Graham, Daniel B., Chang, Jonathan, Peters, Anneli, Woodruff, Matthew, Kim, Young- A., Swat, Wojciech, Morita, Takashi, Kuchroo, Vijay, Carroll, Michael C., Kahn, Mark L., Wucherpfennig, Kai W., and Turley, Shannon J.

Published
2012
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26. Synergistic effects of extracellular vesicle phenotyping and AFP in hepatobiliary cancer differentiation

Author

Urban, Sabine, primary, Sänger, Hanna, additional, Krawczyk, Marcin, additional, Willms, Arnulf, additional, Ligocka, Joanna, additional, Azkargorta, Mikel, additional, Mocan, Tudor, additional, Kahlert, Christoph, additional, Schwab, Robert, additional, Wöhler, Aliona, additional, Gonzalez-Carmona, Maria Angeles, additional, Sparchez, Zeno, additional, Banales, Jesus M., additional, Strassburg, Christian, additional, Milkiewicz, Piotr, additional, Lukacs-Kornek, Veronika, additional, and Kornek, Miroslaw, additional

Published
2020
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28. The tumour microenvironment and immune milieu of cholangiocarcinoma

Author

Fabris, Luca, Perugorria, María J, Mertens, Joachim, Björkström, Niklas K, Cramer, Thorsten, Lleo, Ana, Solinas, Antonio, Sänger, Hanna, Lukacs-Kornek, Veronika, Moncsek, Anja, Siebenhüner, Alexander, Strazzabosco, Mario, University of Zurich, and Fabris, Luca

Subjects
10219 Clinic for Gastroenterology and Hepatology, 10032 Clinic for Oncology and Hematology, 610 Medicine & health, 2721 Hepatology
Published
2019

29. Extracellular Vesicles in Liver Diseases: Meeting Report from the International Liver Congress 2018

Author

Medicina, Medikuntza, Bañales Asurmendi, Jesús María, Feldstein, Ariel E., Sänger, Hanna, Lukacs-Kornek, Veronika, Szabo, Gyongyi, Kornek, Miroslaw, Medicina, Medikuntza, Bañales Asurmendi, Jesús María, Feldstein, Ariel E., Sänger, Hanna, Lukacs-Kornek, Veronika, Szabo, Gyongyi, and Kornek, Miroslaw

Abstract

Extracellular vesicles (EVs) are small and heterogeneous membrane-bound structures released by cells and found in all biological fluids. They are effective intercellular communicators, acting on a number of close and/or distant target cells. EV cargo may reflect the cell of origin as well as the specific stress that induces their formation and release. They transport a variety of bioactive molecules, including messenger RNA, noncoding RNAs, proteins, lipids, and metabolites, that can be transferred among cells, regulating various cell responses. Alteration in the concentration and composition of EVs in biological fluids is a typical hallmark of pathologies in different liver diseases. Circulating EVs can serve as biomarkers or as messengers following uptake by other cells. This review is a meeting report from the International Liver Congress 2018 (European Association for the Study of the Liver) celebrated in Paris (Symposium: Extracellular vesicles and signal transmission) that discusses the role of EVs in several liver diseases, highlighting their potential value as disease biomarkers and therapeutic opportunities.

Published
2019

30. The tumour microenvironment and immune milieu of cholangiocarcinoma

Author

Fabris, Luca; https://orcid.org/0000-0001-8538-6317, Perugorria, María J; https://orcid.org/0000-0002-7636-0972, Mertens, Joachim; https://orcid.org/0000-0003-2007-0308, Björkström, Niklas K; https://orcid.org/0000-0002-0967-076X, Cramer, Thorsten; https://orcid.org/0000-0002-6462-239X, Lleo, Ana; https://orcid.org/0000-0002-0561-7902, Solinas, Antonio; https://orcid.org/0000-0002-5537-6692, Sänger, Hanna, Lukacs-Kornek, Veronika; https://orcid.org/0000-0002-6718-1219, Moncsek, Anja; https://orcid.org/0000-0002-1191-5842, Siebenhüner, Alexander; https://orcid.org/0000-0002-5404-2383, Strazzabosco, Mario; https://orcid.org/0000-0002-1995-6331, Fabris, Luca; https://orcid.org/0000-0001-8538-6317, Perugorria, María J; https://orcid.org/0000-0002-7636-0972, Mertens, Joachim; https://orcid.org/0000-0003-2007-0308, Björkström, Niklas K; https://orcid.org/0000-0002-0967-076X, Cramer, Thorsten; https://orcid.org/0000-0002-6462-239X, Lleo, Ana; https://orcid.org/0000-0002-0561-7902, Solinas, Antonio; https://orcid.org/0000-0002-5537-6692, Sänger, Hanna, Lukacs-Kornek, Veronika; https://orcid.org/0000-0002-6718-1219, Moncsek, Anja; https://orcid.org/0000-0002-1191-5842, Siebenhüner, Alexander; https://orcid.org/0000-0002-5404-2383, and Strazzabosco, Mario; https://orcid.org/0000-0002-1995-6331

Abstract

Tumour microenvironment is a complex, multicellular functional compartment that, particularly when assembled as an abundant desmoplastic reaction, may profoundly affect the proliferative and invasive abilities of epithelial cancer cells. Tumour microenvironment comprises not only stromal cells, mainly cancer-associated fibroblasts, but also immune cells of both the innate and adaptive system (tumour-associated macrophages, neutrophils, natural killer cells, and T and B lymphocytes), and endothelial cells. This results in an intricate web of mutual communications regulated by an extensively remodelled extracellular matrix, where the tumour cells are centrally engaged. In this regard, cholangiocarcinoma, in particular the intrahepatic variant, has become the focus of mounting interest in the last years, largely because of the lack of effective therapies despite its rising incidence and high mortality rates worldwide. On the other hand, recent studies in pancreatic cancer, which similarly to cholangiocarcinoma, is highly desmoplastic, have argued against a tumour-promoting function of the tumour microenvironment. In this review, we will discuss recent developments concerning the role of each cellular population and their multifaceted interplay with the malignant biliary epithelial counterpart. We ultimately hope to provide the working knowledge on how their manipulation may lead to a therapeutic gain in cholangiocarcinoma.

Published
2019

32. The tumour microenvironment and immune milieu of cholangiocarcinoma

Author

Fabris, Luca, primary, Perugorria, María J., additional, Mertens, Joachim, additional, Björkström, Niklas K., additional, Cramer, Thorsten, additional, Lleo, Ana, additional, Solinas, Antonio, additional, Sänger, Hanna, additional, Lukacs‐Kornek, Veronika, additional, Moncsek, Anja, additional, Siebenhüner, Alexander, additional, and Strazzabosco, Mario, additional

Published
2019
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38. Cancer-associated circulating large extracellular vesicles in cholangiocarcinoma and hepatocellular carcinoma

Author

Julich-Haertel, Henrike, primary, Urban, Sabine K., additional, Krawczyk, Marcin, additional, Willms, Arnulf, additional, Jankowski, Krzysztof, additional, Patkowski, Waldemar, additional, Kruk, Beata, additional, Krasnodębski, Maciej, additional, Ligocka, Joanna, additional, Schwab, Robert, additional, Richardsen, Ines, additional, Schaaf, Sebastian, additional, Klein, Angelina, additional, Gehlert, Sebastian, additional, Sänger, Hanna, additional, Casper, Markus, additional, Banales, Jesus M., additional, Schuppan, Detlef, additional, Milkiewicz, Piotr, additional, Lammert, Frank, additional, Krawczyk, Marek, additional, Lukacs-Kornek, Veronika, additional, and Kornek, Miroslaw, additional

Published
2017
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41. Macrophage Death following Influenza Vaccination Initiates the Inflammatory Response that Promotes Dendritic Cell Function in the Draining Lymph Node

Author

Chatziandreou, Nikolaos, primary, Farsakoglu, Yagmur, additional, Palomino-Segura, Miguel, additional, D’Antuono, Rocco, additional, Pizzagalli, Diego Ulisse, additional, Sallusto, Federica, additional, Lukacs-Kornek, Veronika, additional, Uguccioni, Mariagrazia, additional, Corti, Davide, additional, Turley, Shannon J., additional, Lanzavecchia, Antonio, additional, Carroll, Michael C., additional, and Gonzalez, Santiago F., additional

Published
2017
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44. Tumour-associated circulating microparticles: A novel liquid biopsy tool for screening and therapy monitoring of colorectal carcinoma and other epithelial neoplasia

Author

Willms, Arnulf, primary, Müller, Clara, additional, Julich, Henrike, additional, Klein, Niklas, additional, Schwab, Robert, additional, Güsgen, Christoph, additional, Richardsen, Ines, additional, Schaaf, Sebastian, additional, Krawczyk, Marcin, additional, Krawczyk, Marek, additional, Lammert, Frank, additional, Schuppan, Detlef, additional, Lukacs-Kornek, Veronika, additional, and Kornek, Miroslaw, additional

Published
2016
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47. Complement-dependent transport of antigen into B cell follicles

Author

Gonzalez, Santiago F., Lukacs-Kornek, Veronika, Kuligowski, Michael P., Pitcher, Lisa A., Degn, Søren Egedal, Turley, Shannon J., and Carroll, Michael C.

Abstract

Since the original proposal by Fearon and Locksley (Fearon and Locksley. 1996. Science 272: 50-53) that the complement system linked innate and adaptive immunity, there has been a rapid expansion of studies on this topic. With the advance of intravital imaging, a number of recent papers revealed an additional novel pathway in which complement C3 and its receptors enhance humoral immunity through delivery of Ag to the B cell compartment. In this review, we discuss this pathway and highlight several novel exceptions recently found with a model influenza vaccine, such as mannose-binding lectin opsonization of influenza and uptake by macrophages, and the capture of virus by dendritic cells residing in the medullary compartment of peripheral lymph nodes.

Published
2010

48. Characterization of tetraspanin-2 expressing cells in the mouse

Author

Ruland, Christina, primary, Patzig, Julia, additional, Lahl, Katharina, additional, Lukacs-Kornek, Veronika, additional, Fattahi-Mehr, Arezoo, additional, Scheu, Stefanie, additional, Zimmer, Andreas, additional, Kuhlmann, Tanja, additional, Werner, Hauke, additional, Förster, Irmgard, additional, Sparwasser, Tim, additional, and Alferink, Judith, additional

Published
2014
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