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171 results on '"Luján Barroso, Leila"'

1. Should workers be physically active after work? Associations of leisure-time physical activity with cardiovascular and all-cause mortality across occupational physical activity levels—An individual participant data meta-analysis

Author

Cillekens, Bart, Coenen, Pieter, Huysmans, Maaike A., Holtermann, Andreas, Troiano, Richard P., Mork, Paul Jarle, Krokstad, Steinar, Clays, Els, De Bacquer, Dirk, Aadahl, Mette, Kårhus, Line Lund, Sjøl, Anette, Bo Andersen, Lars, Kauhanen, Jussi, Voutilainen, Ari, Pulsford, Richard, Stamatakis, Emmanuel, Goldbourt, Uri, Peters, Annette, Thorand, Barbara, Rosengren, Annika, Björck, Lena, Sprow, Kyle, Franzon, Kristin, Rodriguez-Barranco, Miguel, Luján-Barroso, Leila, Alfredsson, Lars, Bahls, Martin, Ittermann, Till, Wanner, Miriam, Bopp, Matthias, Marott, Jacob Louis, Schnohr, Peter, Nordestgaarda, Børge G., Dalene, Knut Eirik, Ekelund, Ulf, Clausen, Johan, Jensen, Magnus T., Petersen, Christina Bjørk, Krause, Niklas, Twisk, Jos, van Mechelen, Willem, and van der Beek, Allard J.

Published
2024
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3. Chrono-Nutrition, Chrono-Type, and the Prevalence of Type 2 Diabetes Mellitus in a Cross-Sectional Study from the EuroPean Prospective Investigation into Cancer and Nutrition (EPIC) Study.

Author

Luján-Barroso, Leila, Margara-Escudero, Hernando J., Crous-Bou, Marta, Huerta, José María, Chirlaque, María-Dolores, Molina-Montes, Esther, Sánchez, María José, Guevara, Marcela, Moreno-Iribas, Conchi, Amiano, Pilar, Mokoroa, Olatz, González, Sonia, Agudo, Antonio, Quirós, José Ramón, and Jakszyn, Paula

Abstract

Background: Previous studies have shown that meal timing, poor sleep quality, and chronotype may play a relevant role in the development of type 2 diabetes mellitus (T2DM). However, its relationship with macronutrients by eating occasions has not been explored deeply. Objective: Our aim was to estimate the association between chrono-nutrition, sleep quality, chronotype, and the prevalence of T2DM. Methods: This cross-sectional study included a subset of 3465 middle-aged Caucasian adults (2068 women) from the European Prospective Investigation into Cancer and Nutrition (EPIC) Spain cohort study. In the 2017–18 follow-up, we assessed chronotype, sleep quality, diet, and sociodemographic data using validated questionnaires. Further, we used blood samples to determine serum levels of glucose. We defined a case of T2DM when serum glucose concentration was ≥126 mg/dL or when participants self-reported diabetes. Results: A higher prevalence of T2DM was associated with poor sleep quality (ORpoorvsgood = 2.90, 95% CI = 1.30, 6.28). Carbohydrate intake at breakfast was inversely associated with the prevalence of T2DM (OR = 0.75, 95% CI = 0.66, 0.85). Finally, lipid intake at breakfast was associated with a 13% higher prevalence of T2DM (OR = 1.13, 95% CI = 1.01, 1.26) for each 1 standard deviation (1-SD) increase. Conclusions: This study concludes that a higher content of carbohydrates at breakfast is correlated with a reduced prevalence of T2DM, while higher lipids intake at breakfast is associated with a higher prevalence of T2DM. Furthermore, poor sleep quality is a potential factor associated with an elevated prevalence of T2DM. Our results emphasize the need for prospective studies to validate and strengthen these observed associations. [ABSTRACT FROM AUTHOR]

Published
2024
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4. Nitrosyl-Heme and Heme Iron Intake from Processed Meats in Subjects from the EPIC-Spain Cohort

Author

Rizzolo-Brime, Lucía, primary, Farran-Codina, Andreu, additional, Bou, Ricard, additional, Luján-Barroso, Leila, additional, Quirós, Jose Ramón, additional, Amiano, Pilar, additional, Sánchez, María José, additional, Rodríguez-Barranco, Miguel, additional, Guevara, Marcela, additional, Moreno-Iribas, Conchi, additional, Gasque, Alba, additional, Chirlaque, María-Dolores, additional, Colorado-Yohar, Sandra M., additional, Castaño, José María Huerta, additional, Agudo, Antonio, additional, and Jakszyn, Paula, additional

Published
2024
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5. Associations between Fatty Acid Intakes and Plasma Phospholipid Fatty Acid Concentrations in the European Prospective Investigation into Cancer and Nutrition

Author

Huybrechts, Inge, primary, Jacobs, Inarie, additional, Aglago, Elom K., additional, Yammine, Sahar, additional, Matta, Michèle, additional, Schmidt, Julie A., additional, Casagrande, Corinne, additional, Nicolas, Geneviève, additional, Biessy, Carine, additional, Van Puyvelde, Heleen, additional, Scalbert, Augustin, additional, Derksen, Jeroen W. G., additional, van der Schouw, Yvonne T., additional, Grioni, Sara, additional, Amiano, Pilar, additional, Halkjær, Jytte, additional, Tjønneland, Anne, additional, Huerta, José M., additional, Luján-Barroso, Leila, additional, Palli, Domenico, additional, Gunter, Marc J., additional, Perez-Cornago, Aurora, additional, and Chajès, Véronique, additional

Published
2023
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6. Reproductive and hormonal factors and risk of renal cell carcinoma among women in the European Prospective Investigation into Cancer and Nutrition

Author

Clasen, Joanna L., primary, Mabunda, Rita, additional, Heath, Alicia K., additional, Kaaks, Rudolf, additional, Katzke, Verena, additional, Schulze, Matthias B., additional, Birukov, Anna, additional, Tagliabue, Giovanna, additional, Chiodini, Paolo, additional, Tumino, Rosario, additional, Milani, Lorenzo, additional, Braaten, Tonje, additional, Gram, Inger, additional, Lukic, Marko, additional, Luján‐Barroso, Leila, additional, Rodriguez‐Barranco, Miguel, additional, Chirlaque, María‐Dolores, additional, Ardanaz, Eva, additional, Amiano, Pilar, additional, Manjer, Jonas, additional, Huss, Linnea, additional, Ljungberg, Börje, additional, Travis, Ruth, additional, Smith‐Byrne, Karl, additional, Gunter, Marc, additional, Johansson, Matthias, additional, Rinaldi, Sabina, additional, Weiderpass, Elisabete, additional, Riboli, Elio, additional, Cross, Amanda J., additional, and Muller, David C., additional

Published
2023
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7. Reproductive and hormonal factors and risk of renal cell carcinoma among women in the european prospective investigation into cancer and nutrition

Author

Clasen, Joanna L., Mabunda, Rita, Heath, Alicia K., Kaaks, Rudolf, Katzke, Verena, Schulze, Matthias B., Birukov, Anna, Tagliabue, Giovanna, Chiodini, Paolo, Tumino, Rosario, Milani, Lorenzo, Braaten, Tonje, Gram, Inger, Lukic, Marko, Luján-Barroso, Leila, Rodriguez-Barranco, Miguel, Chirlaque, María-Dolores, Ardanaz, Eva, Amiano, Pilar, Manjer, Jonas, Huss, Linnea, Ljungberg, Börje, Travis, Ruth, Smith-Byrne, Karl, Gunter, Marc, Johansson, Matthias, Rinaldi, Sabina, Weiderpass, Elisabete, Riboli, Elio, Cross, Amanda J., Muller, David C., Clasen, Joanna L., Mabunda, Rita, Heath, Alicia K., Kaaks, Rudolf, Katzke, Verena, Schulze, Matthias B., Birukov, Anna, Tagliabue, Giovanna, Chiodini, Paolo, Tumino, Rosario, Milani, Lorenzo, Braaten, Tonje, Gram, Inger, Lukic, Marko, Luján-Barroso, Leila, Rodriguez-Barranco, Miguel, Chirlaque, María-Dolores, Ardanaz, Eva, Amiano, Pilar, Manjer, Jonas, Huss, Linnea, Ljungberg, Börje, Travis, Ruth, Smith-Byrne, Karl, Gunter, Marc, Johansson, Matthias, Rinaldi, Sabina, Weiderpass, Elisabete, Riboli, Elio, Cross, Amanda J., and Muller, David C.

Abstract

Background: Renal cell carcinoma (RCC) is twice as common among men compared with women, and hormonal factors have been suggested to partially explain this difference. There is currently little evidence on the roles of reproductive and hormonal risk factors in RCC aetiology. Materials & Methods: We investigated associations of age at menarche and age at menopause, pregnancy-related factors, hysterectomy and ovariectomy and exogenous hormone use with RCC risk among 298,042 women in the European Prospective Investigation into Cancer and Nutrition (EPIC) study. Results: During 15 years of follow-up, 438 RCC cases were identified. Parous women had higher rates of RCC compared with nulliparous women (HR = 1.71, 95% CI 1.18, 2.46), and women who were older at age of first pregnancy had lower rates of RCC (30 years + vs. <20 years HR = 0.53, 95% CI 0.34, 0.82). Additionally, we identified a positive association for hysterectomy (HR = 1.43 95% CI 1.09, 1.86) and bilateral ovariectomy (HR = 1.67, 95% CI 1.13, 2.47), but not unilateral ovariectomy (HR = 0.99, 95% CI 0.61, 1.62) with RCC risk. No clear associations were found for age at menarche, age at menopause or exogenous hormone use. Conclusion: Our results suggest that parity and reproductive organ surgeries may play a role in RCC aetiology.

Published
2023
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8. Associations between Fatty Acid Intakes and Plasma Phospholipid Fatty Acid Concentrations in the European Prospective Investigation into Cancer and Nutrition

Author

Epi Kanker Team B, Cancer, Cardiovasculaire Epi Team 1, Circulatory Health, JC onderzoeksprogramma Cardiovasculaire Epidemiologie, Huybrechts, Inge, Jacobs, Inarie, Aglago, Elom K., Yammine, Sahar, Matta, Michèle, Schmidt, Julie A., Casagrande, Corinne, Nicolas, Geneviève, Biessy, Carine, Van Puyvelde, Heleen, Scalbert, Augustin, Derksen, Jeroen W.G., van der Schouw, Yvonne T., Grioni, Sara, Amiano, Pilar, Halkjær, Jytte, Tjønneland, Anne, Huerta, José M., Luján-Barroso, Leila, Palli, Domenico, Gunter, Marc J., Perez-Cornago, Aurora, Chajès, Véronique, Epi Kanker Team B, Cancer, Cardiovasculaire Epi Team 1, Circulatory Health, JC onderzoeksprogramma Cardiovasculaire Epidemiologie, Huybrechts, Inge, Jacobs, Inarie, Aglago, Elom K., Yammine, Sahar, Matta, Michèle, Schmidt, Julie A., Casagrande, Corinne, Nicolas, Geneviève, Biessy, Carine, Van Puyvelde, Heleen, Scalbert, Augustin, Derksen, Jeroen W.G., van der Schouw, Yvonne T., Grioni, Sara, Amiano, Pilar, Halkjær, Jytte, Tjønneland, Anne, Huerta, José M., Luján-Barroso, Leila, Palli, Domenico, Gunter, Marc J., Perez-Cornago, Aurora, and Chajès, Véronique

Published
2023

9. The association of coffee intake with liver cancer risk is mediated by biomarkers of inflammation and hepatocellular injury: data from the European Prospective Investigation into Cancer and Nutrition

Author

Aleksandrova, Krasimira, Bamia, Christina, Drogan, Dagmar, Lagiou, Pagona, Trichopoulou, Antonia, Jenab, Mazda, Fedirko, Veronika, Romieu, Isabelle, Bueno-de-Mesquita, H Bas, Pischon, Tobias, Tsilidis, Kostas, Overvad, Kim, Tjønneland, Anne, Bouton-Ruault, Marie-Christine, Dossus, Laure, Racine, Antoine, Kaaks, Rudolf, Kühn, Tilman, Tsironis, Christos, Papatesta, Eleni-Maria, Saitakis, George, Palli, Domenico, Panico, Salvatore, Grioni, Sara, Tumino, Rosario, Vineis, Paolo, Peeters, Petra H, Weiderpass, Elisabete, Lukic, Marko, Braaten, Tonje, Quirós, J Ramón, Luján-Barroso, Leila, Sánchez, María-José, Chilarque, Maria-Dolores, Ardanas, Eva, Dorronsoro, Miren, Nilsson, Lena Maria, Sund, Malin, Wallström, Peter, Ohlsson, Bodil, Bradbury, Kathryn E, Khaw, Kay-Tee, Wareham, Nick, Stepien, Magdalena, Duarte-Salles, Talita, Assi, Nada, Murphy, Neil, Gunter, Marc J, Riboli, Elio, Boeing, Heiner, and Trichopoulos, Dimitrios

Published
2015
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11. Dietary intake of acrylamide and esophageal cancer risk in the European Prospective Investigation into Cancer and Nutrition cohort

Author

Lujan-Barroso, Leila, González, Carlos Alberto, Slimani, Nadia, Obón-Santacana, Mireia, Ferrari, Pietro, Freisling, Heinz, Overvad, Kim, Clavel-Chapelon, Françoise, Boutron-Ruault, Marie-Christine, Racine, Antoine, Katzke, Verena, Kühn, Tilman, Tjønneland, Anne, Olsen, Anja, Quirós, J. Ramón, Sánchez-Cantalejo, Emilio, Amiano, Pilar, Navarro, Carmen, Barricarte, Aurelio, Khaw, Kay-Tee, Wareham, Nick, Travis, Ruth C., Trichopoulou, Antonia, Bamia, Christina, Benetou, Vassiliki, Saieva, Calogero, Grioni, Sara, Tumino, Rosario, Vineis, Paolo, Mattiello, Amalia, Bueno-de-Mesquita, H. Bas, Siersema, Peter D., Numans, Mattijs E., Peeters, Petra H., Ericson, Ulrika, Wirfält, Elisabet, Sund, Malin, Johansson, Mattias, Weiderpass, Elisabete, Skeie, Guri, Riboli, Elio, Boeing, Heiner, and Duell, Eric J.

Published
2014

12. Circadian clock gene variants and their link with chronotype, chrononutrition, sleeping patterns and obesity in the European prospective investigation into cancer and nutrition (EPIC) study

Author

Molina-Montes, Esther, primary, Rodríguez-Barranco, Miguel, additional, Ching-López, Ana, additional, Artacho, Reyes, additional, Huerta, José María, additional, Amiano, Pilar, additional, Lasheras, Cristina, additional, Moreno-Iribas, Conchi, additional, Jimenez-Zabala, Ana, additional, Chirlaque, María-Dolores, additional, Barricarte, Aurelio, additional, Luján-Barroso, Leila, additional, Agudo, Antonio, additional, Jakszyn, Paula, additional, Quirós, José Ramón, additional, and Sánchez, María José, additional

Published
2022
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13. Mycotoxin Exposure and Renal Cell Carcinoma Risk: An Association Study in the EPIC European Cohort

Author

Claeys, Liesel, primary, De Saeger, Sarah, additional, Scelo, Ghislaine, additional, Biessy, Carine, additional, Casagrande, Corinne, additional, Nicolas, Genevieve, additional, Korenjak, Michael, additional, Fervers, Beatrice, additional, Heath, Alicia K., additional, Krogh, Vittorio, additional, Luján-Barroso, Leila, additional, Castilla, Jesús, additional, Ljungberg, Börje, additional, Rodriguez-Barranco, Miguel, additional, Ericson, Ulrika, additional, Santiuste, Carmen, additional, Catalano, Alberto, additional, Overvad, Kim, additional, Brustad, Magritt, additional, Gunter, Marc J., additional, Zavadil, Jiri, additional, De Boevre, Marthe, additional, and Huybrechts, Inge, additional

Published
2022
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14. Occupation and risk of lymphoid and myeloid leukaemia in the European Prospective Investigation into Cancer and Nutrition (EPIC)

Author

Hosnijeh, Fatemeh Saberi, Christopher, Yvette, Peeters, Petra, Romieu, Isabelle, Xun, Wei, Riboli, Elio, Raaschou-Nielsen, Ole, Tjønneland, Anne, Becker, Nikolaus, Nieters, Alexandra, Trichopoulou, Antonia, Bamia, Christina, Orfanos, Philip, Oddone, Enrico, Luján-Barroso, Leila, Dorronsoro, Miren, Navarro, Carmen, Barricarte, Aurelio, Molina-Montes, Esther, Wareham, Nick, Vineis, Paolo, and Vermeulen, Roel

Published
2013
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16. Mycotoxin Exposure and Renal Cell Carcinoma Risk: An Association Study in the EPIC European Cohort

Author

Claeys, Liesel, De Saeger, Sarah, Scelo, Ghislaine, Biessy, Carine, Casagrande, Corinne, Nicolas, Genevieve, Korenjak, Michael, Fervers, Beatrice, Heath, Alicia K., Krogh, Vittorio, Luján-Barroso, Leila, Castilla, Jesús, Ljungberg, Börje, Rodriguez-Barranco, Miguel, Ericson, Ulrika, Santiuste, Carmen, Catalano, Alberto, Overvad, Kim, Brustad, Magritt, Gunter, Marc J., Zavadil, Jiri, De Boevre, Marthe, Huybrechts, Inge, Claeys, Liesel, De Saeger, Sarah, Scelo, Ghislaine, Biessy, Carine, Casagrande, Corinne, Nicolas, Genevieve, Korenjak, Michael, Fervers, Beatrice, Heath, Alicia K., Krogh, Vittorio, Luján-Barroso, Leila, Castilla, Jesús, Ljungberg, Börje, Rodriguez-Barranco, Miguel, Ericson, Ulrika, Santiuste, Carmen, Catalano, Alberto, Overvad, Kim, Brustad, Magritt, Gunter, Marc J., Zavadil, Jiri, De Boevre, Marthe, and Huybrechts, Inge

Abstract

BACKGROUND: Mycotoxins have been suggested to contribute to a spectrum of adverse health effects in humans, including at low concentrations. The recognition of these food contaminants being carcinogenic, as co-occurring rather than as singularly present, has emerged from recent research. The aim of this study was to assess the potential associations of single and multiple mycotoxin exposures with renal cell carcinoma risk in the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort. METHODS: Food questionnaire data from the EPIC cohort were matched to mycotoxin food occurrence data compiled by the European Food Safety Authority (EFSA) from European Member States to assess long-term dietary mycotoxin exposures, and to associate these with the risk of renal cell carcinoma (RCC, n = 911 cases) in 450,112 EPIC participants. Potential confounding factors were taken into account. Analyses were conducted using Cox's proportional hazards regression models to compute hazard ratios (HRs) and 95% confidence intervals (95% CIs) with mycotoxin exposures expressed as µg/kg body weight/day. RESULTS: Demographic characteristics differed between the RCC cases and non-cases for body mass index, age, alcohol intake at recruitment, and other dietary factors. In addition, the mycotoxin exposure distributions showed that a large proportion of the EPIC population was exposed to some of the main mycotoxins present in European foods such as deoxynivalenol (DON) and derivatives, fumonisins, Fusarium toxins, Alternaria toxins, and total mycotoxins. Nevertheless, no statistically significant associations were observed between the studied mycotoxins and mycotoxin groups, and the risk of RCC development. CONCLUSIONS: These results show an absence of statistically significant associations between long-term dietary mycotoxin exposures and RCC risk. However, these results need to be validated in other cohorts and preferably using repeated dietary exposure measurements. In addit

Published
2022
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17. Dietary flavonoid and lignan intake and gastric adenocarcinoma risk in the European Prospective Investigation into Cancer and Nutrition (EPIC) study

Author

Zamora-Ros, Raul, Agudo, Antonio, Luján-Barroso, Leila, Romieu, Isabelle, Ferrari, Pietro, Knaze, Viktoria, Bueno-de-Mesquita, H Bas, Leenders, Max, Travis, Ruth C, Navarro, Carmen, Sánchez-Cantalejo, Emilio, Slimani, Nadia, Scalbert, Augustin, Fedirko, Veronika, Hjartåker, Anette, Engeset, Dagrun, Skeie, Guri, Boeing, Heiner, Förster, Jana, Li, Kuanrong, Teucher, Birgit, Agnoli, Claudia, Tumino, Rosario, Mattiello, Amalia, Saieva, Calogero, Johansson, Ingegerd, Stenling, Roger, Redondo, Maria Luisa, Wallström, Peter, Ericson, Ulrika, Khaw, Kay-Tee, Mulligan, Angela A, Trichopoulou, Antonia, Dilis, Vardis, Katsoulis, Michael, Peeters, Petra HM, Igali, Lazslo, Tjønneland, Anne, Halkjær, Jytte, Touillaud, Marina, Perquier, Florence, Fagherazzi, Guy, Amiano, Pilar, Ardanaz, Eva, Bredsdorff, Lea, Overvad, Kim, Ricceri, Fulvio, Riboli, Elio, and González, Carlos A

Published
2012
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18. Fatty acid patterns and risk of prostate cancer in a case-control study nested within the European Prospective Investigation into Cancer and Nutrition

Author

Dahm, Christina C, Gorst-Rasmussen, Anders, Crowe, Francesca L, Roswall, Nina, Tjønneland, Anne, Drogan, Dagmar, Boeing, Heiner, Teucher, Birgit, Kaaks, Rudolf, Adarakis, George, Zylis, Dimosthenes, Trichopoulou, Antonia, Fedirko, Veronika, Chajes, Veronique, Jenab, Mazda, Palli, Domenico, Pala, Valeria, Tumino, Rosario, Ricceri, Fulvio, van Kranen, Henk, Bueno-de-Mesquita, H Bas, Quirós, Jose R, Sánchez, María-José, Luján-Barroso, Leila, Larrañaga, Nerea, Chirlaque, María-Dolores, Ardanaz, Eva, Johansson, Mattias, Stattin, Pär, Khaw, Kay-Tee, Wareham, Nick, Wark, Petra A, Norat, Teresa, Riboli, Elio, Key, Tim J, and Overvad, Kim

Published
2012
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20. Alcohol consumption and gastric cancer risk in the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort

Author

Duell, Eric J, Travier, Noémie, Lujan-Barroso, Leila, Clavel-Chapelon, Françoise, Boutron-Ruault, Marie-Christine, Morois, Sophie, Palli, Domenico, Krogh, Vittorio, Panico, Salvatore, Tumino, Rosario, Sacerdote, Carlotta, Quirós, J Ramón, Sánchez-Cantalejo, Emilio, Navarro, Carmen, Gurrea, Aurelio Barricarte, Dorronsoro, Miren, Khaw, Kay-Tee, Allen, Naomi E, Key, Timothy J, Bueno-de-Mesquita, H Bas, Ros, Martine M, Numans, Mattijs E, Peeters, Petra HM, Trichopoulou, Antonia, Naska, Androniki, Dilis, Vardis, Teucher, Birgit, Kaaks, Rudolf, Boeing, Heiner, Schütze, Madlen, Regner, Sara, Lindkvist, Björn, Johansson, Ingegerd, Hallmans, Göran, Overvad, Kim, Egeberg, Rikke, Tjønneland, Anne, Lund, Eiliv, Weiderpass, Elisabete, Braaten, Tonje, Romieu, Isabelle, Ferrari, Pietro, Jenab, Mazda, Stenling, Roger, Aune, Dagfinn, Norat, Teresa, Riboli, Elio, and González, Carlos A

Published
2011
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22. A prospective study of one-carbon metabolism biomarkers and cancer of the head and neck and esophagus

Author

Fanidi, Anouar, Relton, Caroline, Ueland, Per Magne, Midttun, ivind, Vollset, Stein Emil, Travis, Ruth C., Trichopoulou, Antonia, Lagiou, Pagona, Trichopoulos, Dimitrios, Bueno-de-Mesquita, B(as) H, Ros, Martine, Boeing, Heiner, Tumino, Rosario, Panico, Salvatore, Palli, Domenico, Sieri, Sabina, Vineis, Paolo, Sánchez, María-José, Huerta, José María, Gurrea, Aurelio Barricarte, Luján-Barroso, Leila, Quirós, Ramón J, Tjnneland, Anne, Halkjær, Jytte, Boutron-Ruault, Marie-Christine, Clavel-Chapelon, Françoise, Cadeau, Claire, Weiderpass, Elisabete, Johansson, Mikael, Riboli, Elio, Brennan, Paul, and Johansson, Mattias

Published
2015
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23. Dietary Advanced Glycation End-Products and Colorectal Cancer Risk in the European Prospective Investigation into Cancer and Nutrition (EPIC) Study

Author

Aglago, Elom K., primary, Mayén, Ana-Lucia, additional, Knaze, Viktoria, additional, Freisling, Heinz, additional, Fedirko, Veronika, additional, Hughes, David J., additional, Jiao, Li, additional, Eriksen, Anne Kirstine, additional, Tjønneland, Anne, additional, Boutron-Ruault, Marie-Christine, additional, Rothwell, Joseph A., additional, Severi, Gianluca, additional, Kaaks, Rudolf, additional, Katzke, Verena, additional, Schulze, Matthias B., additional, Birukov, Anna, additional, Palli, Domenico, additional, Sieri, Sabina, additional, Santucci de Magistris, Maria, additional, Tumino, Rosario, additional, Ricceri, Fulvio, additional, Bueno-de-Mesquita, Bas, additional, Derksen, Jeroen W. G., additional, Skeie, Guri, additional, Gram, Inger Torhild, additional, Sandanger, Torkjel, additional, Quirós, J. Ramón, additional, Luján-Barroso, Leila, additional, Sánchez, Maria-Jose, additional, Amiano, Pilar, additional, Chirlaque, María-Dolores, additional, Gurrea, Aurelio Barricarte, additional, Johansson, Ingegerd, additional, Manjer, Jonas, additional, Perez-Cornago, Aurora, additional, Weiderpass, Elisabete, additional, Gunter, Marc J., additional, Heath, Alicia K., additional, Schalkwijk, Casper G., additional, and Jenab, Mazda, additional

Published
2021
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24. A comparison of complementary measures of vitamin B6 status, function, and metabolism in the European Prospective Investigation into Cancer and Nutrition (EPIC) study

Author

Clasen, Joanna L, primary, Heath, Alicia K, additional, Van Puyvelde, Heleen, additional, Huybrechts, Inge, additional, Park, Jin Young, additional, Ferrari, Pietro, additional, Johansson, Mattias, additional, Scelo, Ghislaine, additional, Ulvik, Arve, additional, Midttun, Øivind, additional, Ueland, Per Magne, additional, Dahm, Christina C, additional, Halkjær, Jytte, additional, Olsen, Anja, additional, Johnson, Theron, additional, Katzke, Verena, additional, Schulze, Matthias B, additional, Masala, Giovanna, additional, Segrado, Francesco, additional, de Magistris, Maria Santucci, additional, Sacerdote, Carlotta, additional, Ocké, Marga C, additional, Luján-Barroso, Leila, additional, Ching-López, Ana, additional, Huerta, José María, additional, Ardanaz, Eva, additional, Amiano, Pilar, additional, Ericson, Ulrika, additional, Manjer, Jonas, additional, Gylling, Björn, additional, Johansson, Ingegerd, additional, Schmidt, Julie, additional, Weiderpass, Elisabete, additional, Riboli, Elio, additional, Cross, Amanda J, additional, and Muller, David C, additional

Published
2021
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25. Pre-pregnancy overweight and obesity prevalence and relation to maternal and perinatal outcomes Prevalencia de sobrepeso y obesidad preconcepcional en mujeres gestantes y relación con los resultados maternos y perinatales

Author

González Plaza, Elena, Bellart, Jordi, Martínez Verdú, Maria Ángels, Arranz Betegón, Ángela, Luján Barroso, Leila, and Seguranyes Guillot, Glòria

Subjects
Pregnancy, Complications of pregnancy, Embaràs, Obesitat, Obesity, Complicacions en l'embaràs
Abstract

Objective: To identify the prevalence of pre-pregnancy overweight/obesity in pregnant women and its relationship with socio-demographic factors and to describe the maternal and perinatal outcomes in a Barcelona hospital (Spain). Method: A descriptive cross-association study, with retrospective data collection, was performed Barcelona Hospital. The data of 5447 pregnant women who delivered at >=23 weeks of gestation were included. Body Mass Index (BMI) data were categorised into World Health Organization classifications. p values

Published
2021

26. A comparison of complementary measures of vitamin B6 status, function, and metabolism in the European Prospective Investigation into Cancer and Nutrition (EPIC) study

Author

Clasen, Joanna L., Heath, Alicia K., Van Puyvelde, Heleen, Huybrechts, Inge, Park, Jin Young, Ferrari, Pietro, Johansson, Mattias, Scelo, Ghislaine, Ulvik, Arve, Midttun, Øivind, Ueland, Per Magne, Dahm, Christina C., Halkjær, Jytte, Olsen, Anja, Johnson, Theron, Katzke, Verena, Schulze, Matthias B., Masala, Giovanna, Segrado, Francesco, de Magistris, Maria Santucci, Sacerdote, Carlotta, Ocké, Marga C., Luján-Barroso, Leila, Ching-López, Ana, Huerta, José María, Ardanaz, Eva, Amiano, Pilar, Ericson, Ulrika, Manjer, Jonas, Gylling, Björn, Johansson, Ingegerd, Schmidt, Julie, Weiderpass, Elisabete, Riboli, Elio, Cross, Amanda J., Muller, David C., Clasen, Joanna L., Heath, Alicia K., Van Puyvelde, Heleen, Huybrechts, Inge, Park, Jin Young, Ferrari, Pietro, Johansson, Mattias, Scelo, Ghislaine, Ulvik, Arve, Midttun, Øivind, Ueland, Per Magne, Dahm, Christina C., Halkjær, Jytte, Olsen, Anja, Johnson, Theron, Katzke, Verena, Schulze, Matthias B., Masala, Giovanna, Segrado, Francesco, de Magistris, Maria Santucci, Sacerdote, Carlotta, Ocké, Marga C., Luján-Barroso, Leila, Ching-López, Ana, Huerta, José María, Ardanaz, Eva, Amiano, Pilar, Ericson, Ulrika, Manjer, Jonas, Gylling, Björn, Johansson, Ingegerd, Schmidt, Julie, Weiderpass, Elisabete, Riboli, Elio, Cross, Amanda J., and Muller, David C.

Abstract

BACKGROUND: Vitamin B6 insufficiency has been linked to increased risk of cancer and other chronic diseases. The circulating concentration of pyridoxal 5'-phosphate (PLP) is a commonly used measure of vitamin B6 status. Ratios of substrates indicating PLP coenzymatic function and metabolism may be useful complementary measures to further explore the role of vitamin B6 in health. OBJECTIVES: We explored the sensitivity of 5 outcomes, namely PLP concentration, homocysteine:cysteine (Hcy:Cys), cystathionine:cysteine (Cysta:Cys), the 3´-hydroxykynurenine ratio (HKr), and the 4-pyridoxic acid ratio (PAr) to vitamin B6 intake as well as personal and lifestyle characteristics. MEDTHODS: Dietary intake and biomarker data were collected from participants from 3 nested case-control studies within the European Prospective Investigation into Cancer and Nutrition (EPIC). Bayesian regression models assessed the associations of the 5 biomarker outcomes with vitamin B6 intake and personal and lifestyle covariates. Analogous models examined the relations of Hcy:Cys, Cysta:Cys, and HKr with PLP. RESULTS: In total, 4608 participants were included in the analyses. Vitamin B6 intake was most strongly associated with PLP, moderately associated with Hcy:Cys, Cysta:Cys, and HKr, and not associated with PAr (fold change in marker given a doubling of vitamin B6 intake: PLP 1.60 [95% credible interval (CrI): 1.50, 1.71]; Hcy:Cys 0.87 [95% CrI: 0.84, 0.90]; Cysta:Cys 0.89 [95% CrI: 0.84, 0.94]; HKr 0.88 [95% CrI: 0.85, 0.91]; PAr 1.00 [95% CrI: 0.95, 1.05]). PAr was most sensitive to age, and HKr was least sensitive to BMI and alcohol intake. Sex and menopause status were strongly associated with all 5 markers. CONCLUSIONS: We found that 5 different markers, capturing different aspects of vitamin B6-related biological processes, varied in their associations with vitamin B6 intake and personal and lifestyle predictors.

Published
2021
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27. Dietary Advanced Glycation End-Products and Colorectal Cancer Risk in the European Prospective Investigation into Cancer and Nutrition (EPIC) Study

Author

Epi Kanker Team B, Cancer, Aglago, Elom K, Mayén, Ana-Lucia, Knaze, Viktoria, Freisling, Heinz, Fedirko, Veronika, Hughes, David J, Jiao, Li, Eriksen, Anne Kirstine, Tjønneland, Anne, Boutron-Ruault, Marie-Christine, Rothwell, Joseph A, Severi, Gianluca, Kaaks, Rudolf, Katzke, Verena, Schulze, Matthias B, Birukov, Anna, Palli, Domenico, Sieri, Sabina, Santucci de Magistris, Maria, Tumino, Rosario, Ricceri, Fulvio, Bueno-de-Mesquita, Bas, Derksen, Jeroen W G, Skeie, Guri, Gram, Inger Torhild, Sandanger, Torkjel, Quirós, J Ramón, Luján-Barroso, Leila, Sánchez, Maria-Jose, Amiano, Pilar, Chirlaque, María-Dolores, Gurrea, Aurelio Barricarte, Johansson, Ingegerd, Manjer, Jonas, Perez-Cornago, Aurora, Weiderpass, Elisabete, Gunter, Marc J, Heath, Alicia K, Schalkwijk, Casper G, Jenab, Mazda, Epi Kanker Team B, Cancer, Aglago, Elom K, Mayén, Ana-Lucia, Knaze, Viktoria, Freisling, Heinz, Fedirko, Veronika, Hughes, David J, Jiao, Li, Eriksen, Anne Kirstine, Tjønneland, Anne, Boutron-Ruault, Marie-Christine, Rothwell, Joseph A, Severi, Gianluca, Kaaks, Rudolf, Katzke, Verena, Schulze, Matthias B, Birukov, Anna, Palli, Domenico, Sieri, Sabina, Santucci de Magistris, Maria, Tumino, Rosario, Ricceri, Fulvio, Bueno-de-Mesquita, Bas, Derksen, Jeroen W G, Skeie, Guri, Gram, Inger Torhild, Sandanger, Torkjel, Quirós, J Ramón, Luján-Barroso, Leila, Sánchez, Maria-Jose, Amiano, Pilar, Chirlaque, María-Dolores, Gurrea, Aurelio Barricarte, Johansson, Ingegerd, Manjer, Jonas, Perez-Cornago, Aurora, Weiderpass, Elisabete, Gunter, Marc J, Heath, Alicia K, Schalkwijk, Casper G, and Jenab, Mazda

Published
2021

28. Tea and coffee consumption and risk of esophageal cancer: The European prospective investigation into cancer and nutrition study

Author

Zamora-Ros, Raul, Luján-Barroso, Leila, Bueno-de-Mesquita, H. B(as), Dik, Vincent K., Boeing, Heiner, Steffen, Annika, Tjnneland, Anne, Olsen, Anja, Bech, Bodil Hammer, Overvad, Kim, Boutron-Ruault, Marie-Christine, Racine, Antoine, Fagherazzi, Guy, Kuhn, Tilman, Katzke, Verena, Trichopoulou, Antonia, Lagiou, Pagona, Trichopoulos, Dimitrios, Tumino, Rosario, Panico, Salvatore, Vineis, Paolo, Grioni, Sara, Palli, Domenico, Weiderpass, Elisabete, Skeie, Guri, Huerta, José María, Sánchez, María-José, Argüelles, Marcial, Amiano, Pilar, Ardanaz, Eva, Nilsson, Lena, Wallner, Bengt, Lindkvist, Björn, Wallström, Peter, Peeters, Petra H.M., Key, Timothy J., Khaw, Kay-Thee, Wareham, Nicholas J., Freisling, Heinz, Stepien, Magdalena, Ferrari, Pietro, Gunter, Marc J., Murphy, Neil, Riboli, Elio, and González, Carlos A.

Published
2014
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29. Aromatic adducts and lung cancer risk in the European Prospective Investigation into Cancer and Nutrition (EPIC) Spanish cohort

Author

Gilberson, Tamra, Peluso, Marco E.M., Munia, Armelle, Luján-Barroso, Leila, Sánchez, María-José, Navarro, Carmen, Amiano, Pilar, Barricarte, Aurelio, Quirós, Ramón J., Molina-Montes, Esther, Sánchez-Cantalejo, Emilio, Tormo, María-José, Chirlaque, María-Dolores, Ardanaz, Eva, Dorronsoro, Miren, Confortini, Massimo, Bonet, Catalina, Sala, Núria, González, Carlos A., and Agudo, Antonio

Published
2014
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30. Efectividad de una intervención digital compleja en los hábitos alimentarios de gestantes con obesidad preconcepcional.

Author

González-Plaza, Elena, Bellart, Jordi, Luján-Barroso, Leila, Crespo-Mirasol, Esther, Viñas, Helena, and Seguranyes, Gloria

Subjects
DIGITAL technology, SCALE analysis (Psychology), MEDICAL informatics, STATISTICAL sampling, QUESTIONNAIRES, PREGNANT women, RANDOMIZED controlled trials, DESCRIPTIVE statistics, WORLD health, TELEMEDICINE, PRENATAL care, FOOD habits, SOCIAL support, PATIENT satisfaction, DATA analysis software, OBESITY
Abstract

Objective: To assess the effectiveness of a complex digital health intervention, in pregnant women with obesity, by means of an app for advice eating habits and a virtual midwife's support, regarding their eating habits, and also to analyze the global satisfaction with digital intervention. Methods: A parallel randomized clinical trial with two arms 1:1 with intervention group (IG) and control group (CG) was conducted. 150 pregnant women with pre-pregnancy obesity were included. Both groups received usual prenatal care. The intervention, in the IG, was delivered with smartband and an app providing advice about eating habits and with a virtual midwife to support women. The validated «Questionnaire of eating habits for patients with overweight and obesity» was administrated and measured using a 1-to-5-point Likert scale. Statistical tests were two-sided and evaluated at an a level of 0.05. Analyzes were performed with SPSS v. 25 and SAS v. 9.4. Results: 110 (73.3% of the total) women were analyzed. In the IG, the mean score for eating habits was higher than in the CG (3.49 ± 0.36 versus 3.35 ± 0.41; p=0.056), but no statistically significant differences were observed. In the IG, the mean score for the intake of the type of food was higher than in the CG (3.49 ± 0.78 versus 3.18 ± 0.71; p=0.019). The mean of global satisfaction was 4.76 ± 0.6 points. Conclusions: The use of a complex digital intervention was effective in improving the intake of the type of food compared to pregnant women who only received usual prenatal care. [ABSTRACT FROM AUTHOR]

Published
2022

32. Soft Drink and Juice Consumption and Renal Cell Carcinoma Incidence and Mortality in the European Prospective Investigation into Cancer and Nutrition

Author

Heath, Alicia K., primary, Clasen, Joanna L., additional, Jayanth, Nick P., additional, Jenab, Mazda, additional, Tjønneland, Anne, additional, Petersen, Kristina Elin Nielsen, additional, Overvad, Kim, additional, Srour, Bernard, additional, Katzke, Verena, additional, Bergmann, Manuela M., additional, Schulze, Matthias B., additional, Masala, Giovanna, additional, Krogh, Vittorio, additional, Tumino, Rosario, additional, Catalano, Alberto, additional, Pasanisi, Fabrizio, additional, Brustad, Magritt, additional, Olsen, Karina Standahl, additional, Skeie, Guri, additional, Luján-Barroso, Leila, additional, Rodríguez-Barranco, Miguel, additional, Amiano, Pilar, additional, Santiuste, Carmen, additional, Barricarte Gurrea, Aurelio, additional, Axelson, Håkan, additional, Ramne, Stina, additional, Ljungberg, Börje, additional, Watts, Eleanor L., additional, Huybrechts, Inge, additional, Weiderpass, Elisabete, additional, Riboli, Elio, additional, and Muller, David C., additional

Published
2021
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33. Meat and heme iron intake and esophageal adenocarcinoma in the European Prospective Investigation into Cancer and Nutrition study

Author

Jakszyn, Paula, Luján-Barroso, Leila, Agudo, Antonio, Bueno-de-Mesquita, Bas H., Molina, Esther, Sánchez, M José, Fonseca-Nunes, Ana, Siersema, Peter D, Matiello, Amalia, Tumino, Rosario, Saieva, Calogero, Pala, Valeria, Vineis, Paolo, Boutron-Ruault, Marie-Christine, Racine, Antoine, Bastide, Nadie, Travis, Ruth C., Khaw, Kay-Tee, Riboli, Elio, Murphy, Neil, Vergnaud, Anne-Claire, Trichopoulou, Antonia, Valanou, Elissavet, Oikonomidou, Despina E, Weiderpass, Elisabete, Skeie, Guri, Johansen, Dorthe, Lindkvist, Björn, Johansson, Mattias, Duarte-Salles, Talita, Freisling, Heinz, Barricarte, Aurelio, M Huerta, Jose, Amiano, Pilar, Tjonneland, Anne, Overvad, Kim, Kuehn, Tilman, Grote, Verena, Boeing, Heiner, Peeters, Petra HM, and González, Carlos A

Published
2013
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34. Dietary Flavonoid Intake and Esophageal Cancer Risk in the European Prospective Investigation into Cancer and Nutrition Cohort

Author

Vermeulen, Esther, Zamora-Ros, Raul, Duell, Eric J., Luján-Barroso, Leila, Boeing, Heiner, Aleksandrova, Krasimira, Bueno-de-Mesquita, H. Bas, Scalbert, Augustin, Romieu, Isabelle, Fedirko, Veronika, Touillaud, Marina, Fagherazzi, Guy, Perquier, Florence, Molina-Montes, Esther, Chirlaque, Maria-Dolores, Vicente Argüelles, Marcial, Amiano, Pilar, Barricarte, Aurelio, Pala, Valeria, Mattiello, Amalia, Saieva, Calogero, Tumino, Rosario, Ricceri, Fulvio, Trichopoulou, Antonia, Vasilopoulou, Effie, Ziara, Gianna, Crowe, Francesca L., Khaw, Kay-Thee, Wareham, Nicholas J., Lukanova, Annekatrin, Grote, Verena A., Tjønneland, Anne, Halkjær, Jytte, Bredsdorff, Lea, Overvad, Kim, Siersema, Peter D., Peeters, Petra H. M., May, Anne M., Weiderpass, Elisabete, Skeie, Guri, Hjartåker, Anette, Landberg, Rikard, Johansson, Ingegerd, Sonestedt, Emily, Ericson, Ulrika, Riboli, Elio, and González, Carlos A.

Published
2013
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35. Occupation and risk of lymphoid and myeloid leukaemia in the European Prospective Investigation into Cancer and Nutrition (EPIC)

Author

Saberi Hosnijeh, Fatemeh, Christopher, Yvette, Peeters, Petra, Romieu, Isabelle, Xun, Wei, Riboli, Elio, Raaschou-Nielsen, Ole, Tjønneland, Anne, Becker, Nikolaus, Nieters, Alexandra, Trichopoulou, Antonia, Bamia, Christina, Orfanos, Philip, Oddone, Enrico, Luján-Barroso, Leila, Dorronsoro, Miren, Navarro, Carmen, Barricarte, Aurelio, Molina-Montes, Esther, Wareham, Nick, Vineis, Paolo, and Vermeulen, Roel

Published
2013
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36. Dietary intake of iron, heme-iron and magnesium and pancreatic cancer risk in the European prospective investigation into cancer and nutrition cohort

Author

Molina-Montes, Esther, Wark, Petra A., Sánchez, María-José, Norat, Teresa, Jakszyn, Paula, Luján-Barroso, Leila, Michaud, Dominique S., Crowe, Francesca, Allen, Naomi, Khaw, Kay-Tee, Wareham, Nicholas, Trichopoulou, Antonia, Adarakis, George, Katarachia, Helen, Skeie, Guri, Henningsen, Maria, Broderstad, Ann Ragnhild, Berrino, Franco, Tumino, Rosario, Palli, Domenico, Mattiello, Amalia, Vineis, Paolo, Amiano, Pilar, Barricarte, Aurelio, Huerta, José-María, Duell, Eric J., Quirós, José-Ramón, Ye, Weimin, Sund, Malin, Lindkvist, Björn, Johansen, Dorthe, Overvad, Kim, Tjnneland, Anne, Roswall, Nina, Li, Kuanrong, Grote, Verena A., Steffen, Annika, Boeing, Heiner, Racine, Antoine, Boutron-Ruault, Marie-Christine, Carbonnel, Franck, Peeters, Petra HM, Siersema, Peter D., Fedirko, Veronika, Jenab, Mazda, Riboli, Elio, and Bueno-de-Mesquita, Bas

Published
2012
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37. Dietary total antioxidant capacity and gastric cancer risk in the European prospective investigation into cancer and nutrition study

Author

Serafini, Mauro, Jakszyn, Paula, Luján-Barroso, Leila, Agudo, Antonio, Bas Bueno-de-Mesquita, H., van Duijnhoven, Fränzel J.B., Jenab, Mazda, Navarro, Carmen, Palli, Domenico, Boeing, Heiner, Wallström, Peter, Regnér, Sara, Numans, Mattijs E., Carneiro, Fatima, Boutron-Ruault, Marie-Christine, Clavel-Chapelon, Françoise, Morois, Sophie, Grioni, Sara, Panico, Salvatore, Tumino, Rosario, Sacerdote, Carlotta, Ramon Quirós, José, Molina-Montes, Esther, Huerta Castaño, Jose M., Barricarte, Aurelio, Amiano, Pilar, Khaw, Kay-Tee, Wareham, Nicholas, Allen, Naomi E., Key, Timothy J., Jeurnink, Suzanne M., Peeters, Petra H.M., Bamia, Christina, Valanou, Elisabeth, Trichopoulou, Antonia, Kaaks, Rudolf, Lukanova, Annekatrin, Bergmann, Manuela M., Lindkvist, Björn, Stenling, Roger, Johansson, Ingegerd, Dahm, Christina C., Overvad, Kim, Jensen, Majken, Olsen, Anja, Tjonneland, Anne, Lund, Eiliv, Rinaldi, Sabina, Michaud, Dominique, Mouw, Traci, Riboli, Elio, and González, Carlos A.

Published
2012
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38. Dietary factors and in situ and invasive cervical cancer risk in the European prospective investigation into cancer and nutrition study

Author

González, Carlos A., Travier, Noemie, Luján-Barroso, Leila, Castellsagué, Xavier, Bosch, Xavier F., Roura, Esther, Bueno-de-Mesquita, Bas H., Palli, Domenico, Boeing, Heiner, Pala, Valeria, Sacerdote, Carlotta, Tumino, Rosario, Panico, Salvatore, Manjer, Jonas, Dillner, Joakim, Hallmans, Göran, Kjellberg, Lennart, Sanchez, María-José, Altzibar, Jone M., Barricarte, Aurelio, Navarro, Carmen, Rodriguez, Laudina, Allen, Naomi, Key, Timothy J., Kaaks, Rudolf, Rohrmann, Sabine, Overvad, Kim, Olsen, Anja, Tjnneland, Anne, Munk, Christian, Kjaer, Susanne Krüger, Peeters, Petra H.M., van Duijnhoven, Fränzel J.B., Clavel-Chapelon, Françoise, Boutron-Ruault, Marie-Christine, Trichopoulou, Antonia, Benetou, Vasiliki, Naska, Androniki, Lund, Eiliv, Engeset, Dagrun, Skeie, Guri, Franceschi, Silvia, Slimani, Nadia, Rinaldi, Sabina, and Riboli, Elio

Published
2011
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39. Consumption of nuts and seeds and pancreatic ductal adenocarcinoma risk in the European Prospective Investigation into Cancer and Nutrition

Author

Obón‐Santacana, Mireia, primary, Luján‐Barroso, Leila, additional, Freisling, Heinz, additional, Naudin, Sabine, additional, Boutron‐Ruault, Marie‐Christine, additional, Mancini, Francesca Romana, additional, Rebours, Vinciane, additional, Kühn, Tilman, additional, Katzke, Verena, additional, Boeing, Heiner, additional, Tjønneland, Anne, additional, Olsen, Anja, additional, Overvad, Kim, additional, Lasheras, Cristina, additional, Rodríguez‐Barranco, Miguel, additional, Amiano, Pilar, additional, Santiuste, Carmen, additional, Ardanaz, Eva, additional, Khaw, Kay‐Thee, additional, Wareham, Nicholas J., additional, Schmidt, Julie A., additional, Aune, Dagfinn, additional, Trichopoulou, Antonia, additional, Thriskos, Paschalis, additional, Peppa, Eleni, additional, Masala, Giovanna, additional, Grioni, Sara, additional, Tumino, Rosario, additional, Panico, Salvatore, additional, Bueno‐de‐Mesquita, Bas, additional, Sciannameo, Veronica, additional, Vermeulen, Roel, additional, Sonestedt, Emily, additional, Sund, Malin, additional, Weiderpass, Elisabete, additional, Skeie, Guri, additional, González, Carlos A., additional, Riboli, Elio, additional, and Duell, Eric J., additional

Published
2019
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40. Pre-diagnostic circulating insulin-like growth factor-I and bladder cancer risk in the European Prospective Investigation into Cancer and Nutrition

Author

Lin, Crystal, Travis, Ruth C., Appleby, Paul N., Tipper, Sarah, Weiderpass, Elisabete, Chang-Claude, Jenny, Gram, Inger T., Kaaks, Rudolf, Kiemeney, Lambertus A., Ljungberg, Börje, Tumino, Rosario, Tjønneland, Anne, Roswall, Nina, Overvad, Kim, Boutron-Ruault, Marie Christine, Manciniveri, Francesca Romana, Severi, Gianluca, Trichopoulou, Antonia, Masala, Giovanna, Sacerdote, Carlotta, Agnoli, Claudia, Panico, Salvatore, Bueno-de-Mesquita, Bas, Peeters, Petra H., Salamanca-Fernández, Elena, Chirlaque, Maria Dolores, Ardanaz, Eva, Dorronsoro, Miren, Menéndez, Virginia, Luján-Barroso, Leila, Liedberg, Fredrik, Freisling, Heinz, Gunter, Marc, Aune, Dagfinn, Cross, Amanda J., Riboli, Elio, Key, Timothy J., Perez-Cornago, Aurora, Lin, Crystal, Travis, Ruth C., Appleby, Paul N., Tipper, Sarah, Weiderpass, Elisabete, Chang-Claude, Jenny, Gram, Inger T., Kaaks, Rudolf, Kiemeney, Lambertus A., Ljungberg, Börje, Tumino, Rosario, Tjønneland, Anne, Roswall, Nina, Overvad, Kim, Boutron-Ruault, Marie Christine, Manciniveri, Francesca Romana, Severi, Gianluca, Trichopoulou, Antonia, Masala, Giovanna, Sacerdote, Carlotta, Agnoli, Claudia, Panico, Salvatore, Bueno-de-Mesquita, Bas, Peeters, Petra H., Salamanca-Fernández, Elena, Chirlaque, Maria Dolores, Ardanaz, Eva, Dorronsoro, Miren, Menéndez, Virginia, Luján-Barroso, Leila, Liedberg, Fredrik, Freisling, Heinz, Gunter, Marc, Aune, Dagfinn, Cross, Amanda J., Riboli, Elio, Key, Timothy J., and Perez-Cornago, Aurora

Published
2018

41. Pre-diagnostic circulating insulin-like growth factor-I and bladder cancer risk in the European Prospective Investigation into Cancer and Nutrition

Author

MS MDL 1, JC onderzoeksprogramma Kanker, Cancer, Epi Kanker Team 1, Speerpunt Cancer, UMC Utrecht, Lin, Crystal, Travis, Ruth C., Appleby, Paul N., Tipper, Sarah, Weiderpass, Elisabete, Chang-Claude, Jenny, Gram, Inger T., Kaaks, Rudolf, Kiemeney, Lambertus A., Ljungberg, Börje, Tumino, Rosario, Tjønneland, Anne, Roswall, Nina, Overvad, Kim, Boutron-Ruault, Marie Christine, Manciniveri, Francesca Romana, Severi, Gianluca, Trichopoulou, Antonia, Masala, Giovanna, Sacerdote, Carlotta, Agnoli, Claudia, Panico, Salvatore, Bueno-de-Mesquita, Bas, Peeters, Petra H., Salamanca-Fernández, Elena, Chirlaque, Maria Dolores, Ardanaz, Eva, Dorronsoro, Miren, Menéndez, Virginia, Luján-Barroso, Leila, Liedberg, Fredrik, Freisling, Heinz, Gunter, Marc, Aune, Dagfinn, Cross, Amanda J., Riboli, Elio, Key, Timothy J., Perez-Cornago, Aurora, MS MDL 1, JC onderzoeksprogramma Kanker, Cancer, Epi Kanker Team 1, Speerpunt Cancer, UMC Utrecht, Lin, Crystal, Travis, Ruth C., Appleby, Paul N., Tipper, Sarah, Weiderpass, Elisabete, Chang-Claude, Jenny, Gram, Inger T., Kaaks, Rudolf, Kiemeney, Lambertus A., Ljungberg, Börje, Tumino, Rosario, Tjønneland, Anne, Roswall, Nina, Overvad, Kim, Boutron-Ruault, Marie Christine, Manciniveri, Francesca Romana, Severi, Gianluca, Trichopoulou, Antonia, Masala, Giovanna, Sacerdote, Carlotta, Agnoli, Claudia, Panico, Salvatore, Bueno-de-Mesquita, Bas, Peeters, Petra H., Salamanca-Fernández, Elena, Chirlaque, Maria Dolores, Ardanaz, Eva, Dorronsoro, Miren, Menéndez, Virginia, Luján-Barroso, Leila, Liedberg, Fredrik, Freisling, Heinz, Gunter, Marc, Aune, Dagfinn, Cross, Amanda J., Riboli, Elio, Key, Timothy J., and Perez-Cornago, Aurora

Published
2018

42. The influence of lifestyle, diet, and reproductive history on age at natural menopause in Spain: analysis from the EPIC-Spain sub-cohort

Author

Universitat Politècnica de Catalunya. Departament d'Estadística i Investigació Operativa, Universitat Politècnica de Catalunya. KEMLG - Grup d'Enginyeria del Coneixement i Aprenentatge Automàtic, Luján-Barroso, Leila, Gibert, Karina, Obón-Santacana, Mireia, Chirlaque, Maria Dolores, Sánchez, Maria-José, Larrañaga, Nerea, Barricarte, Aurelio, Quirós, Jose-Ramón, Salamanca-Fernandez, Elena, Colorado-Yohar, Sandra, Gomez-Pozo, Basilio, Agudo, Antonio, Duell, Eric J, Universitat Politècnica de Catalunya. Departament d'Estadística i Investigació Operativa, Universitat Politècnica de Catalunya. KEMLG - Grup d'Enginyeria del Coneixement i Aprenentatge Automàtic, Luján-Barroso, Leila, Gibert, Karina, Obón-Santacana, Mireia, Chirlaque, Maria Dolores, Sánchez, Maria-José, Larrañaga, Nerea, Barricarte, Aurelio, Quirós, Jose-Ramón, Salamanca-Fernandez, Elena, Colorado-Yohar, Sandra, Gomez-Pozo, Basilio, Agudo, Antonio, and Duell, Eric J

Abstract

This is the peer reviewed version of the following article: Luján-Barroso, L. [et al.]. The influence of lifestyle, diet, and reproductive history on age at natural menopause in Spain: analysis from the EPIC-Spain sub-cohort. "American Journal of Human Biology", Novembre 2018, vol. 30, núm. 6, article e23181., which has been published in final form at https://onlinelibrary.wiley.com/doi/abs/10.1002/ajhb.23181. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions. This article may not be enhanced, enriched or otherwise transformed into a derivative work, without express permission from Wiley or by statutory rights under applicable legislation. Copyright notices must not be removed, obscured or modified. The article must be linked to Wiley’s version of record on Wiley Online Library and any embedding, framing or otherwise making available the article or pages thereof by third parties from platforms, services and websites other than Wiley Online Library must be prohibited., Objective To determinate the role of lifestyle factors, recent diet, menstrual factors, and reproductive history in age at natural menopause in adult Spanish women. Methods In total, 12¿562 pre-menopausal women were available for analysis from the EPIC-Spain sub-cohort. Women were recruited between 1992 and 1996 in five regions of Spain (Asturias, Granada, Murcia, Navarra, and San Sebastian) and, for these analyses, were followed for 3 years. Questionnaires on diet, lifestyle, anthropometric measurements, and reproductive and exogenous hormones history were collected at baseline. Menopause status was updated at a median of 3 years of follow-up. Results After a median of 3 years of follow-up 1166 women became postmenopausal. An earlier age at menopause was observed in current smokers (HR: 1.29; 95%CI 1.08-1.55) and in non-users of oral contraceptives (HR: 1.32; 95%CI 1.01-1.57). A later age at menopause was observed in women with irregular menses (HR: 0.71; 95%CI 0.56-0.91) and in women with a higher number of pregnancies (HR: 0.74; 95%CI 0.56-0.94). Conclusions Our results confirm that women who smoked had an earlier age at natural menopause, while use of oral contraceptives, higher number of pregnancies, and irregularity of menses were associated with a prolonged reproductive lifespan. No associations were observed for dietary habits assessed after the age of 40¿years., Peer Reviewed, Objectius de Desenvolupament Sostenible::3 - Salut i Benestar, Postprint (author's final draft)

Published
2018

43. Endometrial cancer risk prediction including serum-based biomarkers: results from the EPIC cohort

Author

Fortner, Renée T., Hüsing, Anika, Kühn, Tilman, Konar, Meric, Overvad, Kim, Tjønneland, Anne, Hansen, Louise, Boutron-Ruault, Marie-Christine, Severi, Gianluca, Fournier, Agnès, Boeing, Heiner, Trichopoulou, Antonia, Benetou, Vassiliki, Orfanos, Philippos, Masala, Giovanna, Agnoli, Claudia, Mattiello, Amalia, Tumino, Rosario, Sacerdote, Carlotta, Bueno de Mesquita, H. Bas, Peeters, Petra H. M., Weiderpass, Elisabete, Gram, Inger T., Gavrilyuk, Oxana, Quirós, J. Ramón, Huerta Castaño, José María, Ardanaz, Eva, Larrañaga, Nerea, Luján Barroso, Leila, Sánchez-Cantalejo, Emilio, Tunå Butt, Salma, Borgquist, Signe, Idahl, Annika, Lundin, Eva, Khaw, Kay-Tee, Allen, Naomi E., Rinaldi, Sabina, Dossus, Laure, Gunter, Marc, Merritt, Melissa A., and Universitat de Barcelona

Subjects
Serum, Endometrial cancer, Càncer d'endometri, Marcadors bioquímics, Sèrum, Biochemical markers, Nutrició, Nutrition
Abstract

Endometrial cancer risk prediction models including lifestyle, anthropometric and reproductive factors have limited discrimination. Adding biomarker data to these models may improve predictive capacity; to our knowledge, this has not been investigated for endometrial cancer. Using a nested case-control study within the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort, we investigated the improvement in discrimination gained by adding serum biomarker concentrations to risk estimates derived from an existing risk prediction model based on epidemiologic factors. Serum concentrations of sex steroid hormones, metabolic markers, growth factors, adipokines and cytokines were evaluated in a step-wise backward selection process; biomarkers were retained at p < 0.157 indicating improvement in the Akaike information criterion (AIC). Improvement in discrimination was assessed using the C-statistic for all biomarkers alone, and change in C-statistic from addition of biomarkers to preexisting absolute risk estimates. We used internal validation with bootstrapping (1000-fold) to adjust for over-fitting. Adiponectin, estrone, interleukin-1 receptor antagonist, tumor necrosis factor-alpha and triglycerides were select-ed into the model. After accounting for over-fitting, discrimination was improved by 2.0 percentage points when all evaluated biomarkers were included and 1.7 percentage points in the model including the selected biomarkers. Models including etiologic markers on independent pathways and genetic markers may further improve discrimination.

Published
2017

44. Consumption of nuts and seeds and pancreatic ductal adenocarcinoma risk in the European Prospective Investigation into Cancer and Nutrition.

Author

Obón‐Santacana, Mireia, Luján‐Barroso, Leila, Freisling, Heinz, Naudin, Sabine, Boutron‐Ruault, Marie‐Christine, Mancini, Francesca Romana, Rebours, Vinciane, Kühn, Tilman, Katzke, Verena, Boeing, Heiner, Tjønneland, Anne, Olsen, Anja, Overvad, Kim, Lasheras, Cristina, Rodríguez‐Barranco, Miguel, Amiano, Pilar, Santiuste, Carmen, Ardanaz, Eva, Khaw, Kay‐Thee, and Wareham, Nicholas J.

Subjects
PANCREATIC intraepithelial neoplasia, PROPORTIONAL hazards models, NUTS, NUTRITION, SEEDS, REDUCING diets
Abstract

Four epidemiologic studies have assessed the association between nut intake and pancreatic cancer risk with contradictory results. The present study aims to investigate the relation between nut intake (including seeds) and pancreatic ductal adenocarcinoma (PDAC) risk in the European Prospective Investigation into Cancer and Nutrition (EPIC) study. Cox proportional hazards models were used to estimate hazards ratio (HR) and 95% confidence intervals (95% CI) for nut intake and PDAC risk. Information on intake of nuts was obtained from the EPIC country‐specific dietary questionnaires. After a mean follow‐up of 14 years, 476,160 participants were eligible for the present study and included 1,283 PDAC cases. No association was observed between consumption of nuts and PDAC risk (highest intake vs nonconsumers: HR, 0.89; 95% CI, 0.72–1.10; p‐trend = 0.70). Furthermore, no evidence for effect‐measure modification was observed when different subgroups were analyzed. Overall, in EPIC, the highest intake of nuts was not statistically significantly associated with PDAC risk. What's new? Environmental and lifestyle factors probably play a major role in the development—or prevention—of pancreatic cancer (PC). For example, might the inclusion of nuts in one's diet reduce the risk of PC? Results of previous studies have been contradictory. In this analysis of data from the large, prospective EPIC study, the authors found no significant protective role for nuts or seeds against PC. [ABSTRACT FROM AUTHOR]

Published
2020
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45. Pre‐diagnostic circulating insulin‐like growth factor‐I and bladder cancer risk in the European Prospective Investigation into Cancer and Nutrition

Author

Lin, Crystal, primary, Travis, Ruth C., additional, Appleby, Paul N., additional, Tipper, Sarah, additional, Weiderpass, Elisabete, additional, Chang‐Claude, Jenny, additional, Gram, Inger T., additional, Kaaks, Rudolf, additional, Kiemeney, Lambertus A., additional, Ljungberg, Börje, additional, Tumino, Rosario, additional, Tjønneland, Anne, additional, Roswall, Nina, additional, Overvad, Kim, additional, Boutron‐Ruault, Marie‐Christine, additional, Manciniveri, Francesca Romana, additional, Severi, Gianluca, additional, Trichopoulou, Antonia, additional, Masala, Giovanna, additional, Sacerdote, Carlotta, additional, Agnoli, Claudia, additional, Panico, Salvatore, additional, Bueno‐de‐Mesquita, Bas, additional, Peeters, Petra H., additional, Salamanca‐Fernández, Elena, additional, Chirlaque, Maria‐Dolores, additional, Ardanaz, Eva, additional, Dorronsoro, Miren, additional, Menéndez, Virginia, additional, Luján‐Barroso, Leila, additional, Liedberg, Fredrik, additional, Freisling, Heinz, additional, Gunter, Marc, additional, Aune, Dagfinn, additional, Cross, Amanda J., additional, Riboli, Elio, additional, Key, Timothy J., additional, and Perez‐Cornago, Aurora, additional

Published
2018
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46. Aromatic DNA adducts and breast cancer risk: a case-cohort study within the EPIC-Spain

Author

Agudo, Antonio, primary, Peluso, Marco, additional, Munnia, Armelle, additional, Luján-Barroso, Leila, additional, Barricarte, Aurelio, additional, Amiano, Pilar, additional, Navarro, Carmen, additional, Sánchez, María-José, additional, Quirós, J.Ramón, additional, Ardanaz, Eva, additional, Larrañaga, Nerea, additional, Tormo, María-José, additional, Chirlaque, María-Dolores, additional, Rodríguez-Barranco, Miguel, additional, Sánchez-Cantalejo, Emilio, additional, Cellai, Filippo, additional, Bonet, Catalina, additional, Sala, Núria, additional, and González, Carlos A., additional

Published
2017
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47. Tea and coffee consumption and risk of esophageal cancer:the European Prospective Investigation into Cancer and Nutrition (EPIC) study

Author

Zamora-Ros, Raul, Luján-Barroso, Leila, Bueno-de-Mesquita, H Bas, Dik, Vincent K, Boeing, Heiner, Steffen, Annika, Tjønneland, Anne, Olsen, Anja Viendahl, Bech, Bodil Hammer, Overvad, Kim, Boutron-Ruault, Marie-Christine, Racine, Antoine, Fagherazzi, Guy, Kuhn, Tilman, Katzke, Verena, Trichopoulou, Antonia, Lagiou, Pagona, Trichopoulos, Dimitrios, Tumino, Rosario, Panico, Salvatore, Vineis, Paolo, Grioni, Sara, Palli, Domenico, Weiderpass, Elisabete, Skeie, Guri, Huerta, José María, Sánchez, María-José, Argüelles, Marcial, Amiano, Pilar, Ardanaz, Eva, Nilsson, Lena, Wallner, Bengt, Lindkvist, Björn, Wallström, Peter, Peeters, Petra H M, Key, Timothy J, Khaw, Kay-Thee, Wareham, Nicholas J, Freisling, Heinz, Stepien, Magdalena, Ferrari, Pietro, Gunter, Marc J, Murphy, Neil, Riboli, Elio, and González, Carlos A

Abstract

Epidemiological data regarding tea and coffee consumption and risk of esophageal cancer (EC) is still inconclusive. We examined the association of tea and coffee consumption with EC risk among 442,143 men and women without cancer at baseline from 9 countries of the European Prospective Investigation into Cancer and Nutrition (EPIC). Tea and coffee intakes were recorded using country-specific validated dietary questionnaires. Cox regression models were used to analyze the relationships between tea and coffee intake and EC risk. During a mean follow-up of 11.1 years, 339 participants developed EC, of which 142 were esophageal adenocarcinoma (EAC) and 174 were esophageal squamous cell carcinoma (ESCC). In the multivariable models, no significant associations between tea (mostly black tea), and coffee intake and risk of EC, EAC and ESCC were observed. In stratified analyses, among men coffee consumption was inversely related to ESCC (HR for comparison of extreme tertiles 0.42, 95% CI 0.20-0.88; P-trend=0.022), but not among women. In current smokers, a significant and inverse association was observed between ESCC risk and tea (HR 0.46, 95% CI 0.23-0.93; P-trend=0.053) and coffee consumption (HR 0.37, 95% CI 0.19-0.73; P-trend=0.011). However, no statistically significant findings were observed using the continuous variable (per 100mL/d). These data did not show a significant association between tea and coffee consumption and EC, EAC and ESCC, although a decreased risk of ESCC among men and current smokers is suggested, but need to be confirmed in further prospective studies including more cases. © 2014 Wiley Periodicals, Inc.

Published
2014
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48. The association of coffee intake with liver cancer risk is mediated by biomarkers of inflammation and hepatocellular injury: Data from the European Prospective Investigation into Cancer and Nutrition

Author

Epi Kanker Team 1, JC onderzoeksprogramma Kanker, Cancer, Infection & Immunity, Aleksandrova, Krasimira, Bamia, Christina, Drogan, Dagmar, Lagiou, Pagona, Trichopoulou, Antonia, Jenab, Mazda, Fedirko, Veronika, Romieu, Isabelle, Bueno-De-Mesquita, H. Bas, Pischon, Tobias, Tsilidis, Kostas, Overvad, Kim, Tjønneland, Anne, Bouton-Ruault, Marie Christine, Dossus, Laure, Racine, Antoine, Kaaks, Rudolf, Kühn, Tilman, Tsironis, Christos, Papatesta, Eleni Maria, Saitakis, George, Palli, Domenico, Panico, Salvatore, Grioni, Sara, Tumino, Rosario, Vineis, Paolo, Peeters, Petra H., Weiderpass, Elisabete, Lukic, Marko, Braaten, Tonje, Quirós, J. Ramón, Luján-Barroso, Leila, Sánchez, María José, Chilarque, Maria Dolores, Ardanas, Eva, Dorronsoro, Miren, Maria Nilsson, Lena, Sund, Malin, Wallström, Peter, Ohlsson, Bodil, Bradbury, Kathryn E., Khaw, Kay Tee, Wareham, Nick, Stepien, Magdalena, Duarte-Salles, Talita, Assi, Nada, Murphy, Neil, Gunter, Marc J., Riboli, Elio, Boeing, Heiner, Trichopoulos, Dimitrios, Epi Kanker Team 1, JC onderzoeksprogramma Kanker, Cancer, Infection & Immunity, Aleksandrova, Krasimira, Bamia, Christina, Drogan, Dagmar, Lagiou, Pagona, Trichopoulou, Antonia, Jenab, Mazda, Fedirko, Veronika, Romieu, Isabelle, Bueno-De-Mesquita, H. Bas, Pischon, Tobias, Tsilidis, Kostas, Overvad, Kim, Tjønneland, Anne, Bouton-Ruault, Marie Christine, Dossus, Laure, Racine, Antoine, Kaaks, Rudolf, Kühn, Tilman, Tsironis, Christos, Papatesta, Eleni Maria, Saitakis, George, Palli, Domenico, Panico, Salvatore, Grioni, Sara, Tumino, Rosario, Vineis, Paolo, Peeters, Petra H., Weiderpass, Elisabete, Lukic, Marko, Braaten, Tonje, Quirós, J. Ramón, Luján-Barroso, Leila, Sánchez, María José, Chilarque, Maria Dolores, Ardanas, Eva, Dorronsoro, Miren, Maria Nilsson, Lena, Sund, Malin, Wallström, Peter, Ohlsson, Bodil, Bradbury, Kathryn E., Khaw, Kay Tee, Wareham, Nick, Stepien, Magdalena, Duarte-Salles, Talita, Assi, Nada, Murphy, Neil, Gunter, Marc J., Riboli, Elio, Boeing, Heiner, and Trichopoulos, Dimitrios

Published
2015

50. Meat and heme iron intake and esophageal adenocarcinoma the European Prospective investigation into Cancer and Nutrition study

Author

Jakszyn, Paula, Luján-Barroso, Leila, Agudo, Antonio, Bueno-de-Mesquita, H Bas, Molina, Esther, Sánchez, M José, Fonseca-Nunes, Ana, Siersema, Peter D, Matiello, Amalia, Tumino, Rosario, Saieva, Calogero, Pala, Valeria, Vineis, Paolo, Boutron-Ruault, Marie-Christine, Racine, Antoine, Bastide, Nadie, Travis, Ruth C, Khaw, Kay-Tee, Riboli, Elio, Murphy, Neil, Vergnaud, Anne-Claire, Trichopoulou, Antonia, Valanou, Elissavet, Oikonomidou, Despina, Weiderpass, Elisabete, Skeie, Guri, Johansen, Dorthe, Lindkvist, Björn, Johansson, Mattias, Duarte-Salles, Talita, Freisling, Heinz, Barricarte, Aurelio, Huerta, Jose M, Amiano, Pilar, Tjonneland, Anne, Overvad, Kim, Kuehn, Tilman, Grote, Verena, Boeing, Heiner, Peeters, Petra Hm, and González, Carlos A

Subjects
food and beverages
Abstract

Although recent studies suggest that high intakes of meat and heme iron are risk factors for several types of cancer, studies in relation to esophageal adenocarcinoma (EAC) are scarce. Previous results in the European Prospective Investigation into Cancer and Nutrition (EPIC) based on a relatively small number of cases suggested a positive association between processed meat and EAC. In this study we investigate the association between intake of different types of meats as well as heme iron intake, and EAC risk in a larger number of cases from EPIC. The study included 481,419 individuals and 137 incident cases of EAC that occurred during an average of 11 years of follow-up. Dietary intake of meat (unprocessed/processed red and white meat) was assessed by validated center-specific questionnaires. Heme iron was calculated as a type-specific percentage of the total iron content in meat. After adjusting for relevant confounders we observed a statistically significant positive association of EAC risk with heme iron and processed meat intake, with HR: 1.67, 95% CI: 1.05-2.68 and HR: 2.27, 95% CI:1.33-3.89 respectively for comparison of the highest vs. lowest tertile of intake Our results suggest a potential association between higher intakes of processed meat and heme iron and risk of EAC. © 2013 Wiley Periodicals, Inc.

Published
2013
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