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Introduction Mental disorders represent the second cause of years lived with disability worldwide. Suicide mortality has been targeted as a key public health concern by the WHO. Smartphone technology provides a huge potential to develop massive and fast surveys. Given the vast cultural diversity of Mexico and its abrupt orography, smartphone-based resources are invaluable in order to adequately manage resources, services and preventive measures in the population. The objective of this study is to conduct a universal suicide risk screening in a rural area of Mexico, measuring also other mental health outcomes such as depression, anxiety and alcohol and substance use disorders. Methods and analysis A population-based cross-sectional study with a temporary sampling space of 9 months will be performed between September 2019 and June 2020. We expect to recruit a large percentage of the target population (at least 70%) in a short-term survey of Milpa Alta Delegation, which accounts for 137 927 inhabitants in a territorial extension of 288 km² . They will be recruited via an institutional call and a massive public campaign to fill in an online questionnaire through mobile-assisted or computer-assisted web app. This questionnaire will include data on general health, validated questionnaires including Well-being Index 5, Patient Health Questionnaire-9, Generalized Anxiety Disorder Scale 2, Alcohol Use Disorders Identification Test, selected questions of the Drug Abuse Screening Test and Columbia-Suicide Severity Rating Scales and Diagnostic and statistical manual of mental disorders (DSM-5) questions about self-harm. We will take into account information regarding time to mobile app response and geo-spatial location, and aggregated data on social, demographical and environmental variables. Traditional regression modelling, multilevel mixed methods and data-driven machine learning approaches will be used to test hypotheses regarding suicide risk factors at the individual and the population level. [ABSTRACT FROM AUTHOR]

Background: The individual Metacognitive Training (MCT+) is useful to reduce positive symptoms in people with schizophrenia, however less is known in people with first-episode psychosis (FEP). The aim of the study is to assess the effectiveness of MCT+ in FEP regarding symptoms and cognitive insight. Methods: A random clinical trial was performed with people with FEP from 10 clinical centers of Spain. One group received ten sessions of MCT+ and the other group received TAU. A total of 75 patients were included in the study, however only 40 finished the final assessment. Patients were assessed before treatment, post-treatment and 6 month follow-up. The assessment includes a battery of instruments for the main aims the Positive and Negative Syndrome Scale (PANSS) and the Beck Cognitive Insight (BCIS) will be analyzed. Repeated measures statistical test were used in order to assess differences between groups. Results: Both groups improved in Positive symptoms, in the MCT+ group the difference was 5.18 (SD=6.8) with a significance of p=0.002, while in the TAU group the difference was 3.38 (SD=4.9) with a significance of p=0.005. Regarding cognitive insight, in the MCT+ group patients improved in Self-reflectiveness, obtaining a score in baseline of 15.21 (SD=5.52) and 18 (SD=5.28) in post-treatment (p=0.017). The TAU group did not improve in any subscale of the BCIS. Discussion: The MCT+ seems to improve more in positive symptoms than TAU, although both interventions diminished the presence of these symptoms. The MCT+ improved the self-reflectiveness, being one of the important areas for the understanding of the daily social functioning in relation to other. Further analysis should be explored. [ABSTRACT FROM AUTHOR]

Background: Previous studies have found that the best predictor of individual risk when developing one or several mental and neurocognitive disorders is family history of mental disorder, more specifically, first degree relatives. The estimated risk of developing schizophrenia is of approximately 10% in individuals that present a paternal or maternal risk of psychosis, increasing to a 50% if both parents are affected; in comparison to a 1% risk in general population (Hall, 1994; Hannon et al., 2016). Having a first-degree family member with psychosis is the best individual risk predictor in developing mental or neurocognitive disorders (Bhatia et al., 2016; Thorup et al., 2018). However, literature exploring the role of family history of psychosis on symptoms, cognition, social cognition and metacognition in first-episode of psychosis (FEP) is scarce, and there is a dearth of studies examining the influence of the maternal and paternal history of psychosis independently. Methods: The main aim of the present study is to assess the clinical, cognitive, social cognitive and metacognitive variables in people with FEP with family risk, considering the maternal and paternal history of mental disorder separately. As secondary aims, we will assess the clinical, cognitive, social cognition and metacognition variables considering the presence of a maternal and paternal history of psychosis. Methods: A transversal, descriptive, observational design was chosen for this study. The sample was composed of people with a recent onset of psychosis, recruited from 10 public centers in Spain. We recruited 186 individuals with FEP between 18 and 45 years of age. We collected information about the diagnosis of mother and father with mental disorders. Symptoms were assed with the PANSS. A battery of questionnaires on metacognition and social cognition variables was included. Neurocognitive functioning was measured. The statistical analysis was done using SPSS. Results: Individuals with a maternal history of a mental disorder showed higher scores in delusional experiences (p=0.004) and scored lower in general functioning as measured by the GAF (p=0.029). The individuals with the presence of a maternal history of psychosis scored significantly higher in the positive subscale of the PANSS (p=0.030). Individuals with a paternal history of psychotic disorder scored worse in high expectations and the need for adapting to the others and they had a greater presence of externalizing bias than those without a paternal history (p=0.026). Discussion: Results yield that there is a higher prevalence of a maternal history of psychosis than the paternal history of psychosis, and furthermore, these individuals exhibit a specific clinical, cognitive, social and metacognitive profile. This study raises awareness on the different profiles of persons with first-episode psychosis and the influence of the family history on clinical, cognitive, social and metacognitive variables, which should be taken into account when offering individualized early treatment. [ABSTRACT FROM AUTHOR]