Search

Fundamento y objetivo Evaluar la asociacion entre biomarcadores del metabolismo del colageno, indice de masa ventricular izquierda (IMVI) y funcion diastolica en pacientes con hipertension arterial (HTA) refractaria. Pacientes y metodo Se estudiaron 52 pacientes diagnosticados de HTA refractaria y se compararon con 24 individuos sanos. Se midio en suero el propeptido C-terminal de la molecula de procolageno tipo I (PICP) y el factor de crecimiento transformante beta 1 (TGFs1) por metodos de enzimoinmunoanalisis, y el telopeptido C-terminal del colageno tipo I (ICTP) por inmunoensayo electroquimioluminiscente. A los pacientes se les practico una ecocardiografia donde se calculo el IMVI por la formula de Devereux y se valoro la funcion diastolica a partir de la relacion entre las ondas E y A (E/A) y la velocidad de propagacion mitral. Tambien se les practico un registro de monitorizacion de la presion arterial (PA) de 24h. Resultados Los hipertensos mostraron valores (media ±DE) superiores de PICP e inferiores de ICPT que los controles: 83,7 (24,7) frente a 55,0 (8,7), p

Endothelial colony-forming cells (ECFCs) are a subset of circulating endothelial progenitor cells that are particularly abundant in umbilical cord blood. We sought to determine whether ECFC abundance in cord blood is associated with maternal body-mass index (BMI) in nonpathologic pregnancies.We measured the level of ECFCs in the cord blood of neonates (n = 27) born from non-obese healthy mothers with nonpathologic pregnancies and examined whether ECFC abundance correlated with maternal BMI. We also examined the effect of maternal BMI on ECFC phenotype and function using angiogenic and vasculogenic assays.We observed variation in ECFC abundance among subjects and found a positive correlation between prepregnancy maternal BMI and ECFC content (r = 0.51, P = .007), which was independent of other obstetric factors. Despite this variation, ECFC phenotype and functionality were deemed normal and highly similar between subjects with maternal BMI25 kg/m(2) and BMI between 25-30 kg/m(2), including the ability to form vascular networks in vivo.This study underlines the need to consider maternal BMI as a potential confounding factor for cord blood levels of ECFCs in future comparative studies between healthy and pathologic pregnancies.

BACKGROUND Olive oil polyphenols have been associated with several cardiovascular health benefits. This study aims to examine the influence of a polyphenol-rich olive oil on blood pressure (BP) and endothelial function in 24 young women with high-normal BP or stage 1 essential hypertension. METHODS We conducted a double-blind, randomized, crossover dietary-intervention study. After a run-in period of 4 months (baseline values), two diets were used, one with polyphenol-rich olive oil (∼30 mg/day), the other with polyphenol-free olive oil. Each dietary period lasted 2 months with a 4-week washout between diets. Systolic and diastolic BP, serum or plasma biomarkers of endothelial function, oxidative stress, and inflammation, and ischemia-induced hyperemia in the forearm were measured. RESULTS When compared to baseline values, only the polyphenol-rich olive oil diet led to a significant (P < 0.01) decrease of 7.91 mm Hg in systolic and 6.65 mm Hg of diastolic BP. A similar finding was found for serum asymmetric dimethylarginine (ADMA) (-0.09 ± 0.01 µmol/l, P < 0.01), oxidized low-density lipoprotein (ox-LDL) (-28.2 ± 28.5 µg/l, P < 0.01), and plasma C-reactive protein (CRP) (-1.9 ± 1.3 mg/l, P < 0.001). The polyphenol-rich olive oil diet also elicited an increase in plasma nitrites/nitrates (+4.7 ± 6.6 µmol/l, P < 0.001) and hyperemic area after ischemia (+345 ± 386 perfusion units (PU)/sec, P < 0.001). CONCLUSIONS We concluded that the consumption of a diet containing polyphenol-rich olive oil can decrease BP and improve endothelial function in young women with high-normal BP or stage 1 essential hypertension.