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La insuficiencia cardiaca crónica sigue siendo unas de las principales causas de afectación en el funcionamiento y en la calidad de vida de las personas que la presentan, así como una de las primeras causas de mortalidad en nuestro país y en todo el mundo. México tiene una alta prevalencia de factores de riesgo para desarrollar insuficiencia cardiaca, tales como hipertensión arterial, diabetes y obesidad, lo que hace imprescindible contar con un documento basado en la evidencia que brinde recomendaciones a los profesionales de la salud involucrados en el diagnóstico y el tratamiento de estos pacientes. Este documento establece la guía de práctica clínica (GPC) elaborada por iniciativa de la Sociedad Mexicana de Cardiología (SMC) en colaboración con la Agencia Iberoamericana de Desarrollo y Evaluación de Tecnologías en Salud, con la finalidad de establecer recomendaciones basadas en la mejor evidencia disponible y consensuadas por un grupo interdisciplinario y multicolaborativo de expertos. Cumple con estándares internacionales de calidad, como los descritos por el Institute of Medicine de los Estados Unidos de América (IOM), el National Institute of Clinical Excellence (NICE) del Reino Unido, la Intercollegiate Network for Scottish Guideline Development (SIGN) de Escocia y la Guidelines International Network (G-I-N). El grupo de desarrollo de la guía se integró de manera interdisciplinaria con el apoyo de metodólogos con experiencia en revisiones sistemáticas de la literatura y en el desarrollo de GPC. Se llevó a cabo y se condujo metodología de panel Delphi modificado para lograr un nivel de consenso adecuado en cada una de las recomendaciones contenidas en esta GPC. Esperamos que este documento contribuya para la mejor toma de decisiones clínicas y se convierta en un punto de referencia para los clínicos que manejan pacientes con insuficiencia cardiaca crónica en todas sus etapas clínicas, y de esta manera logremos mejorar la calidad en la atención clínica, aumentar la calidad de vida de los pacientes y disminuir las complicaciones de la enfermedad.

AbstractThe COVID-19 pandemic has brought about a profound transformation in the educational landscape in recent months. Educators worldwide have been challenged to tackle academic issues they could never have imagined. Among the most stressful situations faced by students and teachers is implementing online assessments. This paper proposes a system that includes exam prototypes for computer architecture modules at the higher education level. This system generates a wide range of questions and variations on the server side, supported by a set of simulators, resulting in many unique examination proposals. This system streamlines the monitoring process for the teacher, as it eliminates the possibility of two students receiving similar exams and reduces student stress by allowing them to practice with a limitless number of exam samples. This paper also highlights several indicators that demonstrate the advantages of this framework.

The use of unmanned aerial vehicles with multiple onboard sensors has grown significantly in tasks involving terrain coverage such as environmental and civil monitoring, disaster management, and forest fire fighting. Many of these tasks require a quick and early response, which makes maximizing the land covered from the flight path a challenging objective, especially when the area to be monitored is irregular, large and includes many blind spots. Accordingly, state-of-the-art total viewshed algorithms can be of great help to analyze large areas and find new paths providing maximum visibility. This article shows how the total viewshed computation is a valuable tool for generating paths that provide maximum visibility during a flight. We introduce a new heuristic called visibility-based path planning (VPP) that offers a different solution to the path planning problem. VPP identifies the hidden areas of the target territory to generate a path that provides the highest visual coverage. Simulation results show that VPP can cover up to 98.7% of the Montes de Malaga Natural Park and 94.5% of the Sierra de las Nieves National Park, both located within the province of Malaga (Spain) and chosen as regions of interest. In addition, a real flight test confirmed the high visibility achieved using VPP. Our methodology and analysis can be easily applied to enhance monitoring in other large outdoor areas.

Currently, specific nutrient concentration, metabolizable energy (ME) and digestible amino acids are used as feed formulation criteria. A balanced nutrient density (BND) concept based on 2 criteria of nutrient density and balanced amino acids-to-ME ratio may offer more flexibility in optimisation of profit in formulation of diets compared with current formulation based on set values per unit of feed mass. A total of 672 one-d-old off-sex male Ross 308 broiler chickens were used across two 42-d performance trials in a 3 × 2 factorial arrangement of treatments with each diet replicated 8 times (14 birds per replicate). The experimental factors were 2 nutrient density levels (low [LD] and high [HD]) and 3 digestible lysine-to-ME ratios (DLYS:ME; low, medium, and high). Low density diets had ME of 2,876 and 3,023 kcal/kg for starter and finisher, respectively, while values for HD diets were 3,169 and 3,315 kcal/kg with proportionally higher non-nitrogenated nutrients. Separate digestibility and apparent metabolizable energy (AME) assays were conducted at d 21 and 42. Digestibility assays at d 7 were conducted on birds used for performance trials. Regardless of the diet density, birds fed low DLYS:ME had a lower (P

ABSTRACT: High ambient temperature is one of the most common stressors in modern poultry production, resulting in reduced feed intake, weight gain, and increased mortality. This study evaluated the effects of vitamin E (Vit E) and organic selenium (Se) supplementation on performance, body composition, core body temperatures, and mRNA abundance of nutrient transporters in the jejunum of broilers exposed to daily 4-h elevated temperature during d 28 to 35. A total of 640 Cobb male birds were randomly allocated to 32 floor pens in a 2 × 2 factorial arrangement that included ambient temperature (thermoneutral, [TN]; or heat stress, [HS]) and dietary treatments (basal diet or Vit E + Se). Four rooms were used (2 TN and 2 HS) each housing half of the 8 replicate pens per group. Vit E and organic Se were added to the basal diet at the rate of 250 mg/kg and 1 mg/kg diet, respectively. Data were subjected to a 2-way ANOVA using the GLM procedure of JMP (SAS). During the HS period, birds fed the Vit E/Se diet had significantly lower mortality compared to nonsupplemented group (1.92% vs. 7.01%). Moreover, dietary Vit E/Se supplementation had a significant effect on performance by increasing BWG, FI, and European production efficiency factor (EPEF) during the entire experimental period (d 0–35). Dietary Vit E and Se supplementation significantly increased carcass, tissue, lean, and fat weights as well as bone mineral content (BMC) and bone mineral density (BMD) on d 35. Birds fed Vit E/Se supplemented diet had significantly lower (P = 0.010) core body temperature compared to birds fed the basal diet on d 30. Dietary treatment did not influence mRNA abundance of PepT1, SGLT1, or NaPi-IIb on d 28 or d 35. However, HS significantly upregulated levels of PepT1 and NaPi-IIb (P < 0.001) and downregulated that of SGLT1 (P = 0.017) on d 28. In conclusion, dietary Vit E and Se supplementation significantly improved broiler growth performance and carcass composition, and reduced heat-related mortality and core body temperature (on d 30) without influencing the mRNA abundance of intestinal nutrient transporters.

ABSTRACT: This study evaluated the effects of vitamin E (Vit E) and selenium (Se) supplementation on mRNA abundance of antioxidant, immune response, and tight junction genes, as well as taxonomic and functional profiles of ileal microbiota of broilers exposed to daily 4-h elevated temperature during d 28 to 35. A total of 640-day-old Cobb male broiler chicks were randomly allocated to 32 floor pens in a 2 × 2 factorial arrangement that included ambient temperature (thermoneutral [TN] or heat stress [HS]) and dietary treatments (basal diet or Vit E + Se). Vit E and organic Se were added to the basal diet at the rate of 250 mg/kg and 1 mg/kg, respectively. Liver and jejunum tissue samples were taken on d 27 (1 bird/pen), d 28 and d 35 (2 birds/pen) from birds for qPCR analysis. Data were subjected to a 2-way ANOVA using the GLM procedure of JMP. Ileal contents were taken on d 27 and d 35 for microbial profiling. Microbiota data were analyzed in QIIME 2 and significance between treatments identified linear discriminant analysis effect size (LEfSe, P < 0.05). Dietary Vit E/Se significantly downregulated the mRNA levels of HSPs in liver and jejunal tissues of the HS-challenged birds both on d 28 and d 35. Moreover, mRNA abundance of TLR2, TNFα, IFNγ, IL-1β, IL-10, and iNOS in the liver were significantly downregulated in birds fed the Vit E/Se diet on d 35. However, dietary treatment had no significant impact on oxidative stress, immunity, and gut integrity related genes analyzed in jejunal tissues on d 28 and d 35, except downregulation of IFNγ on d 35 (P = 0.052). LEfSe analysis revealed that Lachnospiraceae FE2018 and Ruminococcaceae NK4A214 groups was enriched in the Vit E/Se birds on d 35. Moreover, PICRUSt analysis predicted significant functional differences among the treatment groups. In conclusion, dietary supplementation of Vit E/Se mitigated the negative effects of HS potentially via improving antioxidant status, regulating cytokine responses and modifying ileal microbiota and its function.

Latent fingerprint identification is one of the most essential identification procedures in criminal investigations. Addressing this task is challenging as (i) it requires analyzing massive databases in reasonable periods and (ii) it is commonly solved by combining different methods with very complex data-dependencies, which make fully exploiting heterogeneous CPU-GPU systems very complex. Most efforts in this context focus on improving the accuracy of the approaches and neglect reducing the processing time. Indeed, the most accurate approach was designed for one single thread. This work introduces the fastest methodology for latent fingerprint identification maintaining high accuracy called Asynchronous processing for Latent Fingerprint Identification (ALFI). ALFI fully exploits all the resources of CPU-GPU systems using asynchronous processing and fine-coarse parallelism for analyzing massive databases. Our approach reduces idle times in processing and exploits the inherent parallelism of comparing latent fingerprints to fingerprint impressions. We analyzed the performance of ALFI on Linux and Windows operating systems using the well-known NIST/FVC databases. Experimental results reveal that ALFI is in average 22x faster than the state-of-the-art algorithm, reaching a value of 44.7x for the best-studied case.

En este trabajo se estudió la funcionalización de escualano y tetradecano al variar el efecto electrónico del sustituyente sobre los anillos aromáticos del núcleo porfirínico y el agente oxidante (KIO4, 2KHSO5 •KHSO4•K2SO4, NaClO y H2O2). Se sintetizaron y caracterizaron tres metaloporfirinas: cloruro de meso tetrakis-4-nitrofenilporfirinato manganeso(III), cloruro de meso-tetrakis-2,4,6-trimetoxifenilporfirinato manganeso(III) y cloruro de meso-tetrafenilporfirinato manganeso(III), con rendimientos del 40, 52 y 43%, respectivamente. Posteriormente se probaron 24 sistemas de funcionalización, que se cuantificaron empleando cromatografía de gases usando el método del patrón interno, y sus productos se identificaron por cromatografía de gases acoplada a espectrometría de masas e infrarrojo. Los resultados muestran que la adecuada selección del par porfirina- agente oxidante puede llevar a funcionalizaciones hasta del 42% para el tetradecano y del 80% para el escualano.

Con el fin de conocer el índice de infección por Chlamydia rachomatis, Gardnerella vaginalis y otros gérmenes sexualmente transmisibles en un grupo de gestantes. Se estudiaron 135 mujeres del primer, segundo y tercer trimestre de gestación atendidas en el Hospital de Maternidad Rafael Calvo. Mediante estudios combinados de laboratorio, que incluyeron exámenes directos, cultivos bacteriológicos y técnicas de inmunoensayo, se identificaron los microorganismos infectantes en flujo vaginal, secreción endocervical suero de 83% de los pacientes. Se encontró que el 15,5%, 9,6%, 8,5%, 40%, 8,8% y 0,7% de las gestantes tuvieron infección genital por C. trachomatis, G. vaginalis, T. vaginalis, Candida sp., Streptococcus By N. gonorrhoeae, respectivamente; ninguna paciente fue reactiva para marcador de infección activa por citomegalovirus. La cervicitis y el aborto, como antecedentes, fueron las patologías asociadas más frecuentemente halladas; la ruptura temprana de membranas, tambi6n se presentó en algunas de las pacientes. La significativa proporción de gestantes con infección por bacterias que causan complicaciones en el embarazo, amerita su estudio en el diagnóstico de rutina de la consulta prenatal del Hospital de Maternidad Rafael Calvo.