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7. GLP-1R and IL-6 expression in the gastrointestinal tract of a murine model of metabolic syndrome.

Author

Costa, José, Oliveira, Sofia, Cláudia Pereira, Ana, Soares, Raquel, Baylina, Pilar, Guerreiro, Susana G., Fernandes, Rúben, and Luis, Carla

Subjects
METABOLIC syndrome, GASTROINTESTINAL system, INTERLEUKIN-6, METABOLIC models, HIGH-fat diet, GLUCOSE metabolism, INSULIN
Abstract

Background and aims: Glucose homeostasis is a critical cornerstone in both health and disease. It is described to be regulated by the balance of insulin and glucagon secretion but, this bi-hormonal perspective is long overdue since glucose homeostasis is now known to be a multi-hormonal process. Metabolic syndrome (MetS) is a cluster of metabolic features that includes impaired glucose metabolism and obesity. Obesity promotes a low chronic inflammation state due to the release of bioactive molecules like cytokines, ultimately contributing to cardiovascular disease, diabetes, and cancer. The gastrointestinal tract (GIT), namely the stomach and intestine, has a vital role not only in the food uptake and absorption but also in the production of incretin hormones, such as GLP-1. We aim to evaluate the GLP-1 receptor (GLP-1R) in the GIT of a MetS animal model and to assess whether it correlates with inflammatory levels. Material and method: The expression of GLP-1R and interleukin-6 (IL-6) was evaluated in the stomach and intestine of mice subjected to normal diet (ND) and high fat diet (HFD) by immunohistochemistry. Results: We observed that HFD fed animals presented lower levels of GLP-1R in the stomach and intestine when compared with animals fed with ND. Concomitantly, these mice expressed increased levels of IL-6. Conclusions: GLP-1R expression is inversely correlated with the expression of the pro-inflammatory cytokine IL-6. [ABSTRACT FROM AUTHOR]

Published
2022
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8. Pathways of estrogen metabolism underlying the association between Schistosoma haematobium and bladder cancer

Author

Gonçalves, Ana Rita, Luis, Carla, Soares, Raquel, Fernandes, Ruben, and Botelho, Monica C.

Subjects
Estrogen Metabolism, parasitic diseases, urologic and male genital diseases, Schistosoma Haematobium, Bladder Cancer, female genital diseases and pregnancy complications, hormones, hormone substitutes, and hormone antagonists, Cancer
Abstract

Communication on pathways of estrogen metabolism underlying the association between Schistosoma haematobium and bladder cancer. N/A

Published
2018
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10. Permanent Genetic Resources added to Molecular Ecology Resources Database 1 April 2013–31 May 2013

Author

Agostini, Cecilia, Albaladejo, R. G., Aparicio, A., Arthofer, Wolfgang, Berrebi, P., Boag, Peter T., Carbone, Ignazio, Conroy, Gabriel C., Cortesero, Anne-Marie, Goncalves, Evonnildo Costa, Costa, Diogo, Couto, Alvarina, De Girolamo, Mirko, Du, Hao, Fu, Shi-Jian, Garrido-Garduño, T., Gettova, L., Gilles, A., Hamoy, Igor Guerreiro, Herrera, C. M., Heussler, Carina, Isidro, Eduardo, Josso, Céline, Krapf, Patrick, Lamont, Robert W., Le Ralec, Anne, Lopes, Susana, Luis, Carla, Luo, Hui, Maheo, Frédérique, Marino, Ilaria A. M., Mieuzet, Lucie, Murray, Brent W., Ogbourne, Steven M., Pallavicini, Alberto, Parejo-Farnés, C., Patarnello, Tomaso, Paty, Chrystelle, Pereira, Carolina, Pinho, Catarina, Pinto, Pablo, Poinsot, Denis, Powell, Adrienne, Putman, Alexander I., Santoro, André, Santos, Sidney, Schlick-Steiner, Birgit C., Scott, Candace, Barbosa, Maria Silvanira, Simkova, A., Simon, Jean-Christophe, Solé-Cava, Antonio, Steiner, Florian M., Sun, Zhengxin, Torboli, Valentina, Tredway, Lane P., de Groot, Peter J. Van Coeverden, Vasconcellos, Anderson, Vázquez-Domínguez, E., Wang, Deng-Qiang, Wang, Yu-Xiang, Wei, Qi-Wei, Zane, Lorenzo, Zhang, Shu-Huan, Department of Biology, Universita degli Studi di Padova, Departamento Biología Vegetal y Ecología, Institute of Ecology, Molecular Ecology Group, University of Innsbruck, Institut des Sciences de l'Evolution de Montpellier (UMR ISEM), Centre de Coopération Internationale en Recherche Agronomique pour le Développement (Cirad)-École pratique des hautes études (EPHE)-Université de Montpellier (UM)-Institut de recherche pour le développement [IRD] : UR226-Centre National de la Recherche Scientifique (CNRS), Queen's University [Kingston], Department of Plant Pathology, North Carolina State University [Raleigh] (NC State), University of North Carolina System (UNC)-University of North Carolina System (UNC), GeneCology Research Centre, University of the Sunshine Coast, Institut de Génétique, Environnement et Protection des Plantes (IGEPP), AGROCAMPUS OUEST-Université de Rennes 1 (UR1), Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES)-Institut National de la Recherche Agronomique (INRA), Université européenne de Bretagne - European University of Brittany (UEB), Instituto de Ciências Biológicas, Laboratório de Tecnologia Biomolecular, Federal University of Para - Universidade Federal do Para [Belem - Brésil], CIBIO/UP, Centro de Investigação em Biodiversidade e Recursos Genéticos, Universidade do Porto [Porto], Instituto do Mar (IMAR), Department of Oceanography and Fisheries, University of the Azores, Key Laboratory of Freshwater Biodiversity Conservation, Ministry of Agriculture of China, Yangtze River Fisheries Research Institute, Chinese Academy of Fishery Sciences, Laboratory of Evolutionary Physiology and Behaviour, Chongqing Key Laboratory of Animal Biology, Chongqing University, Instituto de Ecología, Departamento de Ecología de la Biodiversidad / Posgrado en Ciencias Biológicas, Universidad National Autonoma de Mexico, Faculty of Science, Department of Botany and Zoology, Masaryk University, Institut méditerranéen de biodiversité et d'écologie marine et continentale (IMBE), Avignon Université (AU)-Aix Marseille Université (AMU)-Institut de recherche pour le développement [IRD] : UMR237-Centre National de la Recherche Scientifique (CNRS), Universidade Federal Rural da Amazônia (UFRA), Instituto de Ciências Biológicas, Laboratório de Genética Humana e Médica, Estación Biológica de Doñana, Spanish National Research Council (CSIC), Fisheries College, Huazhong Agricultural University, Natural Resources and Environmental Studies Institute, University of Northern British Columbia (UNBC), Dipartimento di Scienze della Vita, Laboratorio di Genetica, University of Trieste, Department of Comparative Biomedicine and Food Science, Instituto de Biologia, Laboratório de Biodiversidade Molecular, Universidade Federal Rural do Rio de Janeiro (UFRRJ), Instituto de Ciências Biológicas, Laboratório de Polimorfismo de DNA, Instituto de Ecología, Departamento de Ecología de la Biodiversidad, Università degli Studi di Padova = University of Padua (Unipd), Leopold Franzens Universität Innsbruck - University of Innsbruck, Centre de Coopération Internationale en Recherche Agronomique pour le Développement (Cirad)-École Pratique des Hautes Études (EPHE), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Université de Montpellier (UM)-Institut de recherche pour le développement [IRD] : UR226-Centre National de la Recherche Scientifique (CNRS), Queen's University [Kingston, Canada], Institut National de la Recherche Agronomique (INRA)-Université de Rennes (UR)-AGROCAMPUS OUEST, Federal University of Para - Universidade Federal do Pará - UFPA [Belém, Brazil] (UFPA), Universidade do Porto = University of Porto, Masaryk University [Brno] (MUNI), Estación Biológica de Doñana (EBD), Consejo Superior de Investigaciones Científicas [Madrid] (CSIC), Huazhong Agricultural University [Wuhan] (HZAU), University of Northern British Columbia [Prince George] (UNBC), Università degli studi di Trieste = University of Trieste, Centre de Coopération Internationale en Recherche Agronomique pour le Développement (Cirad)-École pratique des hautes études (EPHE), Institut National de la Recherche Agronomique (INRA)-Université de Rennes 1 (UR1), Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES)-AGROCAMPUS OUEST, Institut national d'enseignement supérieur pour l'agriculture, l'alimentation et l'environnement (Institut Agro)-Institut national d'enseignement supérieur pour l'agriculture, l'alimentation et l'environnement (Institut Agro), Universidade do Porto, Centre National de la Recherche Scientifique (CNRS)-Institut de recherche pour le développement [IRD] : UMR237-Aix Marseille Université (AMU)-Avignon Université (AU), Cecilia, Agostini, R. G., Albaladejo, A., Aparicio, Wolfgang, Arthofer, P., Berrebi, Peter T., Boag, Ignazio, Carbone, Gabriel C., Conroy, A. M., Cortesero, Evonnildo Costa, Gonçalve, Diogo, Costa, Alvarina, Couto, MIrko De, Girolamo, Hao, Du, Shi Jian, Fu, T., Garrido Garduño, L., Gettová, A., Gille, Igor Guerreiro, Hamoy, C. M., Herrera, Carina, Heussler, Eduardo, Isidro, C., Josso, Patrick, Krapf, Robert W., Lamont, A., Le Ralec, Susana, Lope, Carla, Luí, Hui, Luo, F., Mahéo, Ilaria A. M., Marino, L., Mieuzet, Brent W., Murray, Steven M., Ogbourne, Pallavicini, Alberto, C., Parejo Farné, Tomaso, Patarnello, C., Paty, Carolina, Pereira, Catarina, Pinho, Pablo, Pinto, D., Poinsot, Adrienne, Powell, Alexander I., Putman, André, Santoro, Sidney, Santo, Birgit C., Schlick Steiner, Candace, Scott, Maria Silvanira, Barbosa, A., Šimková, J. C., Simon, Antonio Solé, Cava, Florian M., Steiner, Zhengxin, Sun, Torboli, Valentina, Lane P., Tredway, Peter J., Van Coeverden de Groot, Anderson, Vasconcello, E., Vázquez Domínguez, Deng Qiang, Wang, Yu Xiang, Wang, Qi Wei, Wei, Lorenzo, Zane, and Shu Huan, Zhang

Subjects
0106 biological sciences, 0303 health sciences, [SDV]Life Sciences [q-bio], Computational Biology, 010603 evolutionary biology, 01 natural sciences, 03 medical and health sciences, Databases, Genetic, micropsatellites, Genetics, Animals, Ecology, Evolution, Behavior and Systematics, Microsatellite Repeats, 030304 developmental biology, Biotechnology
Abstract

International audience; This article documents the addition of 234 microsatellite marker loci to the Molecular Ecology Resources Database. Loci were developed for the following species: Acipenser sinensis, Aleochara bilineata, Aleochara bipustulata, Barbus meridionalis, Colossoma macropomum, Delia radicum, Drosophila nigrosparsa, Fontainea picrosperma, Helianthemum cinereum, Liomys pictus, Megabalanus azoricus, Pelteobagrus vachelli, Pleuragramma antarcticum, Podarcis hispanica type 1A, Sardinella brasiliensis and Sclerotinia homoeocarpa. These loci were cross-tested on the following species: Acipenser dabryanus, Barbus balcanicus, Barbus barbus, Barbus cyclolepis, Drosophila hydei, Drosophila melanogaster, Drosophila obscura, Drosophila subobscura, Fontainea australis, Fontainea fugax, Fontainea oraria, Fontainea rostrata, Fontainea venosa, Podarcis bocagei, Podarcis carbonelli, Podarcis liolepis, Podarcis muralis and Podarcis vaucheri.

Published
2013

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