Author: "Luigi Palumbo" - Searchworks@Jio Institute Digital Library Search Results

198 results on '"Luigi Palumbo"'

1. Dose increment in ultrashort particle irradiations via coherent stopping power

Author: Alessandro Curcio, Giancarlo Gatti, Luca Volpe, Enrica Chiadroni, Mauro Migliorati, Andrea Mostacci, Luigi Palumbo, and Massimo Petrarca
Subjects: Physics, QC1-999
Abstract: We present a relativistic self-consistent theory of the coherent stopping power (CSP) of ultradense charged particle beams propagating in a dense matter. CSP corresponds to a collective inelastic collision which adds to the ordinary stopping power of individual particles. Unlike the latter, which depends only on the particles' energy, CSP depends upon many more parameters such as the total charge of the ensemble and its charge density and shape. This paves the way for a broad variety of novel methods to tailor particle absorption and penetration in a dense matter. CSP losses can be explained both by collective excitations of single or multiple molecules and by the emission of coherent Cherenkov radiation. Here we demonstrate that the former mechanism is more relevant than the latter. We find that the coherent energy absorption of subpicosecond particle bunches in water occurs exciting a broad Debye process in the GHz range and an intermolecular stretching vibration mode in the THz region. We generalize the Bethe-Bloch stopping power formula to coherent effects including self-forces, dielectric screening, and absorption by the dense matter. For the sake of a self-consistent dynamical theory including phase space evolution, we have also generalized the Fermi-Eyges theory of particle diffusion to the presence of forces. Nonlinear dynamics is demonstrated, inducing nonlinear dose release, beam self-focusing, and self-enhancement of coherent losses. Given the advent of ultraintense particle sources and their use for biomedical and other relevant applications, our results may be of paramount importance for contemporary and future developments of science and technology.
Published: 2024
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2. A High-Flux Compact X-ray Free-Electron Laser for Next-Generation Chip Metrology Needs

Author: James B. Rosenzweig, Gerard Andonian, Ronald Agustsson, Petr M. Anisimov, Aurora Araujo, Fabio Bosco, Martina Carillo, Enrica Chiadroni, Luca Giannessi, Zhirong Huang, Atsushi Fukasawa, Dongsung Kim, Sergey Kutsaev, Gerard Lawler, Zenghai Li, Nathan Majernik, Pratik Manwani, Jared Maxson, Janwei Miao, Mauro Migliorati, Andrea Mostacci, Pietro Musumeci, Alex Murokh, Emilio Nanni, Sean O’Tool, Luigi Palumbo, River Robles, Yusuke Sakai, Evgenya I. Simakov, Madison Singleton, Bruno Spataro, Jingyi Tang, Sami Tantawi, Oliver Williams, Haoran Xu, and Monika Yadav
Subjects: metrology, semiconductor, ptychography, laminography, free-electron laser, photoinjector, Physics, QC1-999, Nuclear and particle physics. Atomic energy. Radioactivity, QC770-798
Abstract: Recently, considerable work has been directed at the development of an ultracompact X-ray free-electron laser (UCXFEL) based on emerging techniques in high-field cryogenic acceleration, with attendant dramatic improvements in electron beam brightness and state-of-the-art concepts in beam dynamics, magnetic undulators, and X-ray optics. A full conceptual design of a 1 nm (1.24 keV) UCXFEL with a length and cost over an order of magnitude below current X-ray free-electron lasers (XFELs) has resulted from this effort. This instrument has been developed with an emphasis on permitting exploratory scientific research in a wide variety of fields in a university setting. Concurrently, compact FELs are being vigorously developed for use as instruments to enable next-generation chip manufacturing through use as a high-flux, few nm lithography source. This new role suggests consideration of XFELs to urgently address emerging demands in the semiconductor device sector, as identified by recent national need studies, for new radiation sources aimed at chip manufacturing. Indeed, it has been shown that one may use coherent X-rays to perform 10–20 nm class resolution surveys of macroscopic, cm scale structures such as chips, using ptychographic laminography techniques. As the XFEL is a very promising candidate for realizing such methods, we present here an analysis of the issues and likely solutions associated with extending the UCXFEL to harder X-rays (above 7 keV), much higher fluxes, and increased levels of coherence, as well as methods of applying such a source for ptychographic laminography to microelectronic device measurements. We discuss the development path to move the concept to rapid realization of a transformative XFEL-based application, outlining both FEL and metrology system challenges.
Published: 2024
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3. Manipulation and Wakefield Effects on Multi-Pulse Driver Beams in PWFA Injector Stages

Author: Fabio Bosco, Gerard Andonian, Obed Camacho, Martina Carillo, Enrica Chiadroni, Anna Giribono, Gerard Lawler, Nathan Majernik, Pratik Manwani, Mauro Migliorati, Andrea Mostacci, Luigi Palumbo, Gilles Jacopo Silvi, Bruno Spataro, Cristina Vaccarezza, Monika Yadav, and James Rosenzweig
Subjects: linacs, beam dynamics, collective effects, tracking codes, beam manipulation, plasma acceleration, Physics, QC1-999, Nuclear and particle physics. Atomic energy. Radioactivity, QC770-798
Abstract: Particle-driven plasma wakefield acceleration (PWFA) exploits the intense wakefields excited in a plasma by a high-brightness driver beam in order to accelerate a trailing, properly delayed witness electron beam. Such a configuration offers notable advantages in achieving very large accelerating gradients that are suitable for applications in particle colliders and photon production. Moreover, the amplitude of the accelerating fields can be enhanced by resonantly exciting the plasma using a multi-pulse driver beam with a proper time structure. Before the injection into the plasma stage, the pulsed electron beam, conventionally termed the comb beam, is usually produced and pre-accelerated in a radio-frequency (RF) linear accelerator (linac). In this pape, we discuss challenging aspects of the dynamics that comb beams encounter in the RF injector stage preceding the plasma. In particular, the examples we analyze focus on the use of velocity bunching to manipulate the time structure of the beam and the impact of dipole short-range wakefields on the transverse emittances. Indeed, both processes crucially affect the phase space distribution and its quality, which are determinant features for an efficient acceleration in the plasma. In addition, the analyses we present are performed with the custom tracking code MILES, which utilizes semi-analytical models for a simplified evaluation of wakefield effects in the presence of space charge forces.
Published: 2024
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4. Evaluation of a multiparametric MRI radiomic-based approach for stratification of equivocal PI-RADS 3 and upgraded PI-RADS 4 prostatic lesions

Author: Valentina Brancato, Marco Aiello, Luca Basso, Serena Monti, Luigi Palumbo, Giuseppe Di Costanzo, Marco Salvatore, Alfonso Ragozzino, and Carlo Cavaliere
Subjects: Medicine, Science
Abstract: Abstract Despite the key-role of the Prostate Imaging and Reporting and Data System (PI-RADS) in the diagnosis and characterization of prostate cancer (PCa), this system remains to be affected by several limitations, primarily associated with the interpretation of equivocal PI-RADS 3 lesions and with the debated role of Dynamic Contrast Enhanced-Magnetic Resonance Imaging (DCE-MRI), which is only used to upgrade peripheral PI-RADS category 3 lesions to PI-RADS category 4 if enhancement is focal. We aimed at investigating the usefulness of radiomics for detection of PCa lesions (Gleason Score ≥ 6) in PI-RADS 3 lesions and in peripheral PI-RADS 3 upgraded to PI-RADS 4 lesions (upPI-RADS 4). Multiparametric MRI (mpMRI) data of patients who underwent prostatic mpMRI between April 2013 and September 2018 were retrospectively evaluated. Biopsy results were used as gold standard. PI-RADS 3 and PI-RADS 4 lesions were re-scored according to the PI-RADS v2.1 before and after DCE-MRI evaluation. Radiomic features were extracted from T2-weighted MRI (T2), Apparent diffusion Coefficient (ADC) map and DCE-MRI subtracted images using PyRadiomics. Feature selection was performed using Wilcoxon-ranksum test and Minimum Redundancy Maximum Relevance (mRMR). Predictive models were constructed for PCa detection in PI-RADS 3 and upPI-RADS 4 lesions using at each step an imbalance-adjusted bootstrap resampling (IABR) on 1000 samples. 41 PI-RADS 3 and 32 upPI-RADS 4 lesions were analyzed. Among 293 radiomic features, the top selected features derived from T2 and ADC. For PI-RADS 3 stratification, second order model showed higher performances (Area Under the Receiver Operating Characteristic Curve—AUC— = 80%), while for upPI-RADS 4 stratification, first order model showed higher performances respect to superior order models (AUC = 89%). Our results support the significant role of T2 and ADC radiomic features for PCa detection in lesions scored as PI-RADS 3 and upPI-RADS 4. Radiomics models showed high diagnostic efficacy in classify PI-RADS 3 and upPI-RADS 4 lesions, outperforming PI-RADS v2.1 performance.
Published: 2021
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5. RF Design and Measurements of a C-Band Prototype Structure for an Ultra-High Dose-Rate Medical Linac

Author: Lucia Giuliano, Fabio Bosco, Martina Carillo, Giuseppe Felici, Luca Ficcadenti, Andrea Mostacci, Mauro Migliorati, Luigi Palumbo, Bruno Spataro, and Luigi Faillace
Subjects: C-band, linear accelerator, RF design, RF measurements, Physics, QC1-999, Nuclear and particle physics. Atomic energy. Radioactivity, QC770-798
Abstract: In this paper, we illustrate the RF design and measurements of a C-band prototype structure for an Ultra High Dose Rate medical linac. (1) Background: FLASH Radiotherapy (RT) is a revolutionary new technique for cancer cure. It releases ultra-high radiation dose rates (above 100 Gy/s) in microsecond short pulses. In order to obtain a high dose in a very short time, accelerators with high-intensity currents (the order of 100 mA peak currents) have to be developed. In this contest, Sapienza University, in collaboration with SIT-Sordina IORT Technology spa, is developing a new C-band linac to achieve the FLASH regime. (2) Methods: We performed the RF electromagnetic design of the prototype of the C band linac using CST STUDIO Suite Code and the RF low power RF test at Sapienza University of Rome. The measurements of the field in the cavity have been done with the bead-pull technique. (3) Results: This device is a nine-cell structure operating on the π/2 mode at 5.712 GHz (C-band). We report and discuss the test measurement results on a full-scale copper prototype, showing good agreement with CST RF simulations. A tuning procedure has been implemented in order to ensure proper operating frequency and to reach a field profile flatness of the order of a few percent. (4) Conclusions: The prototype of a C-band linac for FLASH applications was successfully tested with low RF power at Sapienza University. The fabrication and ad hoc tuning procedures have been optimized and discussed in the paper.
Published: 2023
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6. Characterization of Ultra-High-Dose Rate Electron Beams with ElectronFlash Linac

Author: Lucia Giuliano, Gaia Franciosini, Luigi Palumbo, Lilia Aggar, Marie Dutreix, Luigi Faillace, Vincent Favaudon, Giuseppe Felici, Federica Galante, Andrea Mostacci, Mauro Migliorati, Matteo Pacitti, Annalisa Patriarca, and Sophie Heinrich
Subjects: FLASH-RT, FLASH electron linac, dosimetry, Technology, Engineering (General). Civil engineering (General), TA1-2040, Biology (General), QH301-705.5, Physics, QC1-999, Chemistry, QD1-999
Abstract: Purpose: The electron linac ElectronFlash installed at Institut Curie (Orsay, France) is entirely dedicated to FLASH irradiation for radiobiological and pre-clinical studies. The system was designed to deliver an ultra-high-dose rate per pulse (UHDR) (above 106 Gy/s) and a very high average dose rate at different energies and pulse durations. A campaign of tests and measurements was performed to obtain a full reliable characterizations of the electron beam and of the delivered dose, which are necessary to the radiobiological experiments. Methods: A Faraday cup was used to measure the electron charges in a single RF pulse. The percentage depth dose (PDD) and the transverse dose profiles, at the energies of 5 MeV and 7 MeV, were evaluated employing Gafchromic films EBT-XD for two Poly-methylmethacrylate (PMMA) applicators with irradiation sizes of 30 mm and 120 mm, normally used for in vivo and in vitro experiments, respectively. The results were compared with Monte Carlo (MC) simulations. Results: The measurements were performed during a period of a few months in which the experimental set up was adapted and tuned in order to characterize the electron beam parameters and the values of delivered doses before the radiobiological experiments. The measurements showed that the dose parameters, obtained at the energy of 5 MeV and 7 MeV with different applicators, fulfill the FLASH regime, with a maximum value of an average dose rate of 4750 Gy/s, a maximum dose per pulse of 19 Gy and an instantaneous dose rate up to 4.75 ×106 Gy/s. By means of the PMMA applicators, a very good flatness of the dose profiles was obtained at the cost of a reduced total current. The flatness of the large field is reliable and reproducible in radiobiological experiments. The measured PDD and dose profiles are in good agreement with Monte Carlo simulations with more than 95% of the gamma-index under the thresholds of 3 mm/3%. Conclusions: The results show that the system can provide UHDR pulses totally satisfying the FLASH requirements with very good performances in terms of beam profile flatness for any size of the fields. The monitoring of electron beams and the measurement of the dose parameters played an important role in the in vivo and in vitro irradiation experiments performed at the Institut Curie laboratory.
Published: 2023
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7. Deep Seated Tumour Treatments With Electrons of High Energy Delivered at FLASH Rates: The Example of Prostate Cancer

Author: Alessio Sarti, Patrizia De Maria, Giuseppe Battistoni, Micol De Simoni, Cinzia Di Felice, Yunsheng Dong, Marta Fischetti, Gaia Franciosini, Michela Marafini, Francesco Marampon, Ilaria Mattei, Riccardo Mirabelli, Silvia Muraro, Massimiliano Pacilio, Luigi Palumbo, Loredana Rocca, Damiana Rubeca, Angelo Schiavi, Adalberto Sciubba, Vincenzo Tombolini, Marco Toppi, Giacomo Traini, Antonio Trigilio, and Vincenzo Patera
Subjects: external beam radio therapy, prostate cancer, FLASH effect, very high energy electrons, deep seated tumours, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282
Abstract: Different therapies are adopted for the treatment of deep seated tumours in combination or as an alternative to surgical removal or chemotherapy: radiotherapy with photons (RT), particle therapy (PT) with protons or even heavier ions like 12C, are now available in clinical centres. In addition to these irradiation modalities, the use of Very High Energy Electron (VHEE) beams (100–200 MeV) has been suggested in the past, but the diffusion of that technique was delayed due to the needed space and budget, with respect to standard photon devices. These disadvantages were not paired by an increased therapeutic efficacy, at least when comparing to proton or carbon ion beams. In this contribution we investigate how recent developments in electron beam therapy could reshape the treatments of deep seated tumours. In this respect we carefully explored the application of VHEE beams to the prostate cancer, a well-known and studied example of deep seated tumour currently treated with high efficacy both using RT and PT. The VHEE Treatment Planning System was obtained by means of an accurate Monte Carlo (MC) simulation of the electrons interactions with the patient body. A simple model of the FLASH effect (healthy tissues sparing at ultra-high dose rates), has been introduced and the results have been compared with conventional RT. The study demonstrates that VHEE beams, even in absence of a significant FLASH effect and with a reduced energy range (70–130 MeV) with respect to implementations already explored in literature, could be a good alternative to standard RT, even in the framework of technological developments that are nowadays affordable.
Published: 2021
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8. Corrigendum: FLASH Radiotherapy With Electrons: Issues Related to the Production, Monitoring, and Dosimetric Characterization of the Beam

Author: Fabio Di Martino, Patrizio Barca, Salvatore Barone, Eleonora Bortoli, Rita Borgheresi, Silvia De Stefano, Massimo Di Francesco, Luigi Faillace, Lucia Giuliano, Luigi Grasso, Stefania Linsalata, Daniela Marfisi, Mauro Migliorati, Matteo Pacitti, Luigi Palumbo, and Giuseppe Felici
Subjects: radiotherapy, FLASH effect, FLASH electron linac, beam monitoring system, saturation problems, Physics, QC1-999
Published: 2021
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9. Computation of High-Frequency Sub-National Spatial Consumer Price Indexes Using Web Scraping Techniques

Author: Ilaria Benedetti, Tiziana Laureti, Luigi Palumbo, and Brandon M. Rose
Subjects: consumer spatial price indexes, data scraping, spatial index, time comparison, big data, Economics as a science, HB71-74
Abstract: The development of Information and Communications Technology and digital economies has contributed to changes in the consumption of goods and services in various areas of life, affecting the growing expectations of users in relation to price statistics. Therefore, it is important to provide information on differences in consumer prices across space and over time in a timely manner. Web-scraped data, which is the process of collecting large amounts of data from the web, offer the potential to improve greatly the quality and efficiency of consumer price indices. In this paper, we explore the use of web-scraped data for compiling high-frequency price indexes for groups of products by using the time-interaction-region product model. We computed monthly average prices for five entry-level items according to the Consumer Price Index for All Urban Consumers (CPI-U) classification and tracked their evolution over time in 11 USA cities reported in our dataset. Even if our dataset covers a small percentage of the CPI-U index, results show how web scraping data may provide timely estimates of sub-national SPI evolution and unveil seasonal trends for specific categories.
Published: 2022
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10. FLASH Radiotherapy With Electrons: Issues Related to the Production, Monitoring, and Dosimetric Characterization of the Beam

Author: Fabio Di Martino, Patrizio Barca, Salvatore Barone, Eleonora Bortoli, Rita Borgheresi, Silvia De Stefano, Massimo Di Francesco, Luigi Faillace, Lucia Giuliano, Luigi Grasso, Stefania Linsalata, Daniela Marfisi, Mauro Migliorati, Matteo Pacitti, Luigi Palumbo, and Giuseppe Felici
Subjects: radiotherapy, FLASH effect, FLASH electron linac, beam monitoring system, saturation problems, Physics, QC1-999
Abstract: Various in vivo experimental works carried out on different animals and organs have shown that it is possible to reduce the damage caused to healthy tissue still preserving the therapeutic efficacy on the tumor tissue, by drastically reducing the total time of dose delivery (
Published: 2020
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11. A Hard Copper Open X-Band RF Accelerating Structure Made by Two Halves

Author: Bruno Spataro, Mostafa Behtouei, Fabio Cardelli, Martina Carillo, Valery Dolgashev, Luigi Faillace, Mauro Migliorati, and Luigi Palumbo
Subjects: n/a, Physics, QC1-999, Nuclear and particle physics. Atomic energy. Radioactivity, QC770-798
Abstract: This communication focuses on the technological developments aiming to show the viability of novel welding techniques [...]
Published: 2022
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12. Relativistic versus Nonrelativistic Approaches to a Low Perveance High Quality Matched Beam for a High Efficiency Ka-Band Klystron

Author: Mostafa Behtouei, Bruno Spataro, Luigi Faillace, Martina Carillo, Alberto Leggieri, Luigi Palumbo, and Mauro Migliorati
Subjects: high power klystron, electron gun, particle acceleration, linear accelerators, free electron laser, accelerator applications, Physics, QC1-999, Nuclear and particle physics. Atomic energy. Radioactivity, QC770-798
Abstract: Advanced technical solution for the design of a low perveance electron gun with a high quality beam dedicated to high power Ka-band klystrons is presented in this paper. The proposed electron gun can be used to feed linear accelerating structures at 36 GHz with an estimated input power of 20 MW, thus achieving an effective accelerating electric field in the (100–150) MV/m range. Additionally, in the framework of the Compact Light XLS project, a short Ka-band accelerating structure providing an integrated voltage of at least 15 MV, has been proposed for bunch-phase linearization. For the klystron, a very small beam dimension is needed and the presented electron gun responds to this requirement. An estimate of the rotational velocity at beam edge indicates that the diamagnetic field due to rotational currents are small compared to the longitudinal volume. A detailed analysis of how this has been achieved, including compression of the beam, rotation in the magnetic field, and analysis of the subsequently generated diamagnetic field has been discussed.
Published: 2021
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13. Performance Evaluation of a THz Pulsed Imaging System: Point Spread Function, Broadband THz Beam Visualization and Image Reconstruction

Author: Marta Di Fabrizio, Annalisa D’Arco, Sen Mou, Luigi Palumbo, Massimo Petrarca, and Stefano Lupi
Subjects: THz radiation, THz pulsed imaging, point spread function, spatial resolution, THz 3D beam, Technology, Engineering (General). Civil engineering (General), TA1-2040, Biology (General), QH301-705.5, Physics, QC1-999, Chemistry, QD1-999
Abstract: Terahertz (THz) technology is a promising research field for various applications in basic science and technology. In particular, THz imaging is a new field in imaging science, where theories, mathematical models and techniques for describing and assessing THz images have not completely matured yet. In this work, we investigate the performances of a broadband pulsed THz imaging system (0.2–2.5 THz). We characterize our broadband THz beam, emitted from a photoconductive antenna (PCA), and estimate its point spread function (PSF) and the corresponding spatial resolution. We provide the first, to our knowledge, 3D beam profile of THz radiation emitted from a PCA, along its propagation axis, without the using of THz cameras or profilers, showing the beam spatial intensity distribution. Finally, we evaluate the THz image formation on a test-sample composed by a regular linen natural pattern.
Published: 2021
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14. Design, realization, and high power test of high gradient, high repetition rate brazing-free S-band photogun

Author: David Alesini, Antonio Battisti, Marco Bellaveglia, Fabio Cardelli, Antonio Falone, Alessandro Gallo, Valerio Lollo, Dennis Thomas Palmer, Luigi Pellegrino, Luca Piersanti, Stefano Pioli, Alessandro Variola, Valerio Pettinacci, and Luigi Palumbo
Subjects: Nuclear and particle physics. Atomic energy. Radioactivity, QC770-798
Abstract: rf photoguns find several types of applications as high brightness electron sources for free-electron lasers, energy recovery linacs, Compton and Thomson sources, and high-energy linear colliders. The high peak current and low transverse emittance of the generated beam are obtained with the combination of a high peak electric field (>100 MV/m) at the cathode surface, a proper choice of the solenoid field around, or immediately after, the gun, and special fabrication and treatments of the cathode itself. On the other hand, to increase the average electron current, a high repetition rate (>100 Hz) and/or a multibunch rf gun have to be developed. These types of devices are, in general, fabricated by brazing processes of copper machined parts. The brazing processes require a large vacuum furnace, are very expensive, and pose a not negligible risk of failure. A new fabrication technique for this type of structure has been recently developed and implemented at the Laboratories of Frascati of the National Institute of Nuclear Physics (INFN-LNF, Italy) and already applied to an rf gun now operating at a relatively low cathode peak field and low repetition rate [D. Alesini et al., Phys. Rev. Accel. Beams 18, 092001 (2015)]. It is based on the use of special rf-vacuum gaskets that allow a brazing-free realization process. The S-band gun of the Extreme Light Infrastructure-Nuclear Physics Gamma Beam System, under construction in Magurele (Bucharest, Romania), has been realized with this new technique and represents a further and fundamental step toward the consolidation of this technology for high gradient particle accelerator fabrication. It operates at 100 Hz with a 120 MV/m cathode peak field and 1.5-μs-long rf pulses to house the 32 bunches necessary to reach the target gamma flux. High gradient tests, performed at full power and a full repetition rate, have shown the extremely good performances of the structure in terms of the breakdown rate and conditioning time and definitively demonstrated the reliability and suitability of such fabrication process for high gradient structure realization. In this paper, we report and discuss the electromagnetic and thermomechanical design, the realization process, and all the experimental results at low and high power at a full repetition rate.
Published: 2018
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15. Design of high gradient, high repetition rate damped C-band rf structures

Author: David Alesini, Marco Bellaveglia, Simone Bini, Alessandro Gallo, Valerio Lollo, Luigi Pellegrino, Luca Piersanti, Fabio Cardelli, Mauro Migliorati, Andrea Mostacci, Luigi Palumbo, Simone Tocci, Luca Ficcadenti, and Valerio Pettinacci
Subjects: Nuclear and particle physics. Atomic energy. Radioactivity, QC770-798
Abstract: The gamma beam system of the European Extreme Light Infrastructure–Nuclear Physics project foresees the use of a multibunch train colliding with a high intensity recirculated laser pulse. The linac energy booster is composed of 12 traveling wave C-band structures, 1.8 m long with a field phase advance per cell of 2π/3 and a repetition rate of 100 Hz. Because of the multibunch operation, the structures have been designed with a dipole higher order mode (HOM) damping system to avoid beam breakup (BBU). They are quasiconstant gradient structures with symmetric input couplers and a very effective damping of the HOMs in each cell based on silicon carbide (SiC) rf absorbers coupled to each cell through waveguides. An optimization of the electromagnetic and mechanical design has been done to simplify the fabrication and to reduce the cost of the structures. In the paper, after a review of the beam dynamics issues related to the BBU effects, we discuss the electromagnetic and thermomechanic design criteria of the structures. We also illustrate the criteria to compensate the beam loading and the rf measurements that show the effectiveness of the HOM damping.
Published: 2017
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16. Telomere length variation in juvenile acute myocardial infarction.

Author: Alessia Russo, Luigi Palumbo, Cristina Fornengo, Cornelia Di Gaetano, Fulvio Ricceri, Simonetta Guarrera, Rossana Critelli, Matteo Anselmino, Alberto Piazza, Fiorenzo Gaita, Serena Bergerone, and Giuseppe Matullo
Subjects: Medicine, Science
Abstract: Leukocyte telomere length (LTL) provides a potential marker of biological age, closely related to the endothelial dysfunction and consequently to the atherosclerotic process. To investigate the relationship between the LTL and the risk of premature acute myocardial infarction and to evaluate the predictive value of LTL on the onset of major cardiovascular events, 199 patients from 18 to 48 years old with first diagnosis of acute myocardial infarction were enrolled and were matched with 190 controls for sex and age (± 1 year). Clinical data and coronary artery disease were evaluated at enrollment and at follow up. LTL was measured at enrollment using a quantitative PCR-based method. No significant differences were observed in LTL between cases and controls (p = 0.20) and with the presence of coronary artery disease in patients (p = 0.47). Hypercholesterolemic cases presented LTL significantly longer than cases without hypercholesterolemia (t/s: 0.82 ± 0.16 p = 0.79 and t/s norm: 0.79 ± 0.19 p = 0.01), as confirmed in multivariate regression analysis (p = 0.005, β = 0.09). Furthermore, multivariate regression analysis showed LTL significantly shorter in hypertensive cases than in normotensive cases (p = 0.04, β = -0.07). One hundred seventy-one cases (86%) ended the average follow up of 9 ± 5 years, 92 (54%) presented a major cardiovascular event. At multivariate regression analysis the LTL detected at enrollment did not represent a predictive factor of major cardiovascular events nor it significantly impacted with cumulative events. Based on present cohort of young Italian patients, the LTL did not represent a marker of acute myocardial infarction nor had a predictive role at medium term follow up.
Published: 2012
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17. New technology based on clamping for high gradient radio frequency photogun

Author: David Alesini, Antonio Battisti, Massimo Ferrario, Luca Foggetta, Valerio Lollo, Luca Ficcadenti, Valerio Pettinacci, Sean Custodio, Eylene Pirez, Pietro Musumeci, and Luigi Palumbo
Subjects: Nuclear and particle physics. Atomic energy. Radioactivity, QC770-798
Abstract: High gradient rf photoguns have been a key development to enable several applications of high quality electron beams. They allow the generation of beams with very high peak current and low transverse emittance, satisfying the tight demands for free-electron lasers, energy recovery linacs, Compton/Thomson sources and high-energy linear colliders. In the present paper we present the design of a new rf photogun recently developed in the framework of the SPARC_LAB photoinjector activities at the laboratories of the National Institute of Nuclear Physics in Frascati (LNF-INFN, Italy). This design implements several new features from the electromagnetic point of view and, more important, a novel technology for its realization that does not involve any brazing process. From the electromagnetic point of view the gun presents high mode separation, low peak surface electric field at the iris and minimized pulsed heating on the coupler. For the realization, we have implemented a novel fabrication design that, avoiding brazing, strongly reduces the cost, the realization time and the risk of failure. Details on the electromagnetic design, low power rf measurements and high power radiofrequency and beam tests performed at the University of California in Los Angeles (UCLA) are discussed in the paper.
Published: 2015
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18. Third harmonic cavity design and RF measurements for the Frascati DAΦNE collider

Author: David Alesini, Roberto Boni, Alessandro Gallo, Fabio Marcellini, Mikhail Zobov, Mauro Migliorati, and Luigi Palumbo
Subjects: Nuclear and particle physics. Atomic energy. Radioactivity, QC770-798
Abstract: Third harmonic passive RF cavities have been proposed for installation in both rings of the DAΦNE factory collider to improve the Touschek lifetime and to increase the Landau damping. This paper illustrates the design of the harmonic cavities. The main requirements were to obtain a relatively low R/Q factor and a quality factor Q as high as possible to satisfy beam dynamics requirements and to damp all the higher order mode (HOM) to a harmless level in order to avoid multibunch instabilities. A spherical shape of the cavity central body has been chosen as an optimum compromise between a high Q resonator and a low R/Q factor. HOM suppression has been provided by a ferrite ring damper designed for the superconducting cavities of the high energy ring of the KEK-B factory. The design and electromagnetic properties of the resonant modes have been studied with MAFIA and HFSS codes. Cavities have been made of aluminum and the RF measurements have been performed to characterize them. The measurements are in a good agreement with numerical simulations results, demonstrating a satisfactory HOM damping.
Published: 2004
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19. Longitudinal beam dynamics in the Frascati DAΦNE e^{+}e^{-} collider with a passive third harmonic cavity in the lengthening regime

Author: David Alesini, Alessandro Gallo, Susanna Guiducci, Fabio Marcellini, Mikhail Zobov, Mauro Migliorati, and Luigi Palumbo
Subjects: Nuclear and particle physics. Atomic energy. Radioactivity, QC770-798
Abstract: A high-harmonic rf system is going to be installed in both rings of the DAΦNE Φ-Factory collider to improve the Touschek lifetime. The main goal of this paper is to study the impact of the 3rd harmonic cavity on beam dynamics making a special emphasis on the dynamics of a bunch train with a gap. The shift of the coherent synchrotron frequencies of the coupled-bunch modes has been estimated. In the following we investigated the effect of magnification of the synchrotron phase spread and beam spectrum variation due to the gap. Besides we simulated the bunch lengthening for different bunches along the unevenly filled train and evaluated the Touschek lifetime enhancement taking into account the obtained bunch distributions. Finally, the “cavity parking” option is discussed. It can be considered as a reliable backup procedure consisting of tuning the cavity away from the 3rd harmonic frequency and in between two revolution harmonics. It allows recovering, approximately, the same operating conditions as were before the harmonic cavity installation.
Published: 2003
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20. Web-based mini-games for language learning that support spoken interaction.

Author: Helmer Strik, Luigi Palumbo, Febe de Wet, and Catia Cucchiarini
Published: 2015
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21. Saving Food from Waste or Advance Selling? An Empirical Analysis of Too Good To Go Offering in Rome

Author: Mengting Yu, Luigi Palumbo, and Luca Secondi
Subjects: econometrics_statistics
Abstract: Food waste is one of the greatest challenge to sustainability in developed and developing countries. In the former, food waste is concentrated in the final part of the chain. Too Good To Go is a digital platform aimed to prevent food waste, where consumers can buy magic boxes from different outlets containing food products that are approaching their end-of-life. However, the mechanism of the platform enable the outlets to publish their offering much in advance of the pick-up time, raising the question whether the food sold on the platform is effectively a leftover or a planned production. Our empirical study gathers data from over 1200 outlets in Rome on the Too Good To Go platform.
Published: 2022

22. Impact of laser chirp on the polarization of terahertz from two-color plasma

Author: Sen Mou, Luca Tomarchio, Annalisa D’Arco, Marta Di Fabrizio, Salvatore Macis, Alessandro Curcio, Luigi Palumbo, Stefano Lupi, and Massimo Petrarca
Subjects: Atomic and Molecular Physics, and Optics, Electronic, Optical and Magnetic Materials
Abstract: Two-color plasma, induced by two lasers of different colors, can radiate ultra-broadband and intense terahertz (THz) pulses, which is desirable in many technological and scientific applications. It was found that the polarization of the emitted THz depends on the phase difference between the fundamental laser wave and its second harmonic. Recent investigation suggests that chirp-induced change of pulse overlap plays an important role in the THz yield from two-color plasma. However, the effect of laser chirp on THz polarization remains unexplored. Hereby, we investigate the impact of laser chirp on THz polarization. It is unveiled that the chirp-induced phase difference affects THz polarization. Besides, positive and negative chirps have opposite effects on the variation of the THz polarization versus the phase difference. The polarization of THz generated by a positively chirped pump laser rotates clockwise with an increasing phase difference, while it rotates anticlockwise when generated by a negatively chirped pump laser.
Published: 2023

23. A Measurement Method Based on RF Deflector for Particle Bunch Longitudinal Parameters in Linear Accelerators

Author: Luigi Palumbo, Luca Sabato, Antonio Gilardi, Alessandro Variola, Pasquale Arpaia, Andrea Mostacci, Sabato, L., Arpaia, P., Gilardi, A., Mostacci, A., Palumbo, L., and Variola, A.
Subjects: Electron accelerators, Phase (waves), Electron accelerator, high energy physics instrumentation computing, 02 engineering and technology, Electron, linear particle accelerator, particle beam measurements, Linear particle accelerator, law.invention, Length measurement, Optics, law, 0202 electrical engineering, electronic engineering, information engineering, Chirp, Calibration, instrument, Electrical and Electronic Engineering, Instrumentation, Physics, business.industry, 020208 electrical & electronic engineering, Particle accelerator, Electron accelerators, high energy physics instrumentation computing, instruments, linear particle accelerator, particle beam measurements, instruments, Physics::Accelerator Physics, Radio frequency, business
Abstract: In high-brightness electron linear accelerators (LINACs), the particle bunch length is measured by a radio frequency deflector (RFD). The electron bunch is deflected vertically toward a screen and its length can be obtained using vertical spot size measurements after a proper calibration, e.g., measuring the vertical bunch centroid while varying the deflecting voltage phase. The energy parameters of the bunch (the energy chirp and the energy spread) and the correlation between particle positions, divergences, and energies contribute to the bunch vertical dimension at the screen position after the RFD and so far were considered as a source of systematic errors in a bunch length measurement. The measurement theory and production model for bunch length, energy spread and chirp, as well as correlations are described. As usual in particle accelerators physics, the method is validated using numerical simulations of state-of-the-art LINACs with a reference simulation code showing a typical accuracy in the few percent levels.
Published: 2021

24. Online Wine Ratings Determinants: The Case of Red Wines From Apulia

Author: Luigi Palumbo, Enrico Mazzoli, and Mengting Yu
Subjects: History, Polymers and Plastics, Business and International Management, Industrial and Manufacturing Engineering
Published: 2022

25. A novel method to calculate the magnetic field of a solenoid generated by a surface current element

Author: Mostafa Behtouei, Bruno Spataro, Luigi Faillace, Martina Carillo, Moreno Comelli, Luigi Palumbo, Alessandro Variola, and Mauro Migliorati
Subjects: linear accelerators, mathematical physics, accelerator subsystems and technologies, Particle acceleration, General Engineering, General Physics and Astronomy, accelerator applications
Published: 2022

26. Relativistic versus Nonrelativistic Approaches to a Low Perveance High Quality Matched Beam for a High Efficiency Ka-Band Klystron

Author: A Leggieri, Bruno Spataro, Luigi Palumbo, Martina Carillo, Mauro Migliorati, Mostafa Behtouei, and L. Faillace
Subjects: particle acceleration, Accelerator subsystems and technologies, QC1-999, high power klystron, free electron laser, QC770-798, Linear particle accelerator, law.invention, Optics, law, Electric field, Nuclear and particle physics. Atomic energy. Radioactivity, Instrumentation, Electron gun, Perveance, Physics, electron gun, linear accelerators, Klystron, business.industry, Free-electron laser, accelerator applications, Accelerator applications, Free electron laser, High power klystron, Linear accelerators, Particle acceleration, Physics::Accelerator Physics, business, Beam (structure), Voltage
Abstract: Advanced technical solution for the design of a low perveance electron gun with a high quality beam dedicated to high power Ka-band klystrons is presented in this paper. The proposed electron gun can be used to feed linear accelerating structures at 36 GHz with an estimated input power of 20 MW, thus achieving an effective accelerating electric field in the (100–150) MV/m range. Additionally, in the framework of the Compact Light XLS project, a short Ka-band accelerating structure providing an integrated voltage of at least 15 MV, has been proposed for bunch-phase linearization. For the klystron, a very small beam dimension is needed and the presented electron gun responds to this requirement. An estimate of the rotational velocity at beam edge indicates that the diamagnetic field due to rotational currents are small compared to the longitudinal volume. A detailed analysis of how this has been achieved, including compression of the beam, rotation in the magnetic field, and analysis of the subsequently generated diamagnetic field has been discussed.
Published: 2021

27. Coronary arteries pseudoaneurysms after drug-eluting stent implantation: role of coronary CT angiography

Author: Bianca Cusati, Gerolamo Sibilio, Vito Di Palma, Marco Boccalatte, Fabio Acanfora, Giovanna Gernone, Ilaria Ferrara, Puglia Marta, Luigi Palumbo, Giuseppe Di Costanzo, and Serena Dell'Aversana
Published: 2021

28. Compact S -band linear accelerator system for ultrafast, ultrahigh dose-rate radiotherapy

Author: Giuseppe Felici, Mauro Migliorati, Silvia Muraro, M. Di Francesco, Vincenzo Patera, Luigi Palumbo, Lucia Giuliano, F. Galante, Luca Ficcadenti, Gaia Franciosini, M. Pacitti, Salvatore Barone, Luigi Faillace, L. Grasso, G. Battistoni, and Andrea Mostacci
Subjects: Physics, Nuclear and High Energy Physics, Physics and Astronomy (miscellaneous), 010308 nuclear & particles physics, business.industry, Gamma ray, Bremsstrahlung, QC770-798, Surfaces and Interfaces, Electron, 01 natural sciences, Linear particle accelerator, Ionizing radiation, Flash (photography), Optics, Nuclear and particle physics. Atomic energy. Radioactivity, Beam diagnostics, Radio frequency calculations, Room temperature RF, 0103 physical sciences, Cathode ray, 010306 general physics, business, Beam (structure)
Abstract: Radiation therapy is currently the most utilized technique for the treatment of tumors by means of ionizing radiation, such as electrons, protons and x/gamma rays, depending on the type, size and depth of the cancer mass. Radiation therapy has in general fulfilled the main requirement of targeting thus damaging the malignant cells and sparing the healthy tissues as best as possible. In this scenario, electron linear accelerators have been operated as viable tools for the delivery of both high-energetic electrons and x-ray beams, which are obtained via the bremsstrahlung process of the electrons hitting on a high-Z material. Recently, it has been experimentally demonstrated that ultrahigh dose-rate bursts of electrons and x-ray beams increase the differential response between healthy and tumor tissues. This beneficial response is referred to as the FLASH effect. For this purpose, we have developed the first dedicated compact $S$-band linear accelerator for FLASH radiotherapy. This linac is optimized for a nominal energy of 7 MeV and a pulsed electron beam current of 100 mA and above. The accelerator is mounted on a remote-controlled system for preclinical research studies in the FLASH regime. We will show the rf and beam dynamics design of the $S$-band linac as well as the commissioning and high-power rf tests. Furthermore, the results of the dosimetric measurements will be illustrated.
Published: 2021

29. Selection rules for the orbital angular momentum of optically produced THz radiation

Author: Stefano Lupi, Massimo Petrarca, S Mou, Alessandro Curcio, and Luigi Palumbo
Subjects: Diffraction, Physics, Angular momentum, Infrared, business.industry, Terahertz radiation, non linear optic, Thz, structured light, laser, Physics::Optics, 02 engineering and technology, 021001 nanoscience & nanotechnology, Laser, Polarization (waves), 01 natural sciences, Atomic and Molecular Physics, and Optics, law.invention, 010309 optics, Optical rectification, Optics, law, 0103 physical sciences, Atomic physics, 0210 nano-technology, business, Circular polarization
Abstract: In this work, we theoretically study the transduction of orbital angular momentum (OAM) l for infrared pump lasers into the THz domain. In the case of optical rectification, the transduction of OAM occurs only through a spin–orbit interaction, with the selection rule on the OAM l = 0 valid for any kind of polarization of the pump, which means that there is no transfer of OAM along the propagation axis. In difference frequency generation, the selection rule for the difference Δ l between the OAM of the pump fields with linear or circular polarization is l = Δ l , whereas l ranges from Δ l − 2 to Δ l + 2 in cases of both radial and azimuthal polarization. Moreover, for THz generation in the latter case, the high diffraction obtained with tightly focused pumps yields l tending to Δ l ± 2 , while l tends to zero in the opposite case of large pump beams.
Published: 2021

30. A Multi-dimensional Clustering on Fuzzy Metrics to Classify CPG Pricing and Price Promotion Strategies

Author: Tiziana Laureti, Ilaria Benedetti, and Luigi Palumbo
Subjects: CpG site, Computer science, Multi dimensional, Data mining, Price promotion, Cluster analysis, computer.software_genre, computer, Fuzzy logic
Published: 2021

31. Feasibility Study of a Prostate Cancer FLASH Therapy Treatment With Electrons of High Energy

Author: Francesco Marampon, Luigi Palumbo, M. Marafini, Battistoni Giuseppe, Vincenzo Tombolini, Cinzia Di Felice, Ilaria Mattei, R. Mirabelli, Vincenzo Patera, M. Toppi, Adalberto Sciubba, M. Fischetti, Antonio Trigilio, Micol De Simoni, Giacomo Traini, Loredana Rocca, Silvia Muraro, Massimiliano Pacilio, Alessio Sarti, Damiana Rubeca, Patrizia De Maria, Y. Dong, Gaia Franciosini, and Angelo Schiavi
Subjects: Flash (photography), Prostate cancer, High energy, business.industry, Medicine, Optoelectronics, Electron, business, medicine.disease
Abstract: Prostate cancer is among the most common cancers in men and one of the leading causes of death worldwide. Different therapies are adopted for its treatment and generally radiotherapy with photons (RT) is the preferred solution in almost all cases. Up to now, in addition to photons, only protons have been implemented as alternative radiotherapy. The use of Very High Energy Electron (VHEE) beams (100-200 MeV) has been suggested in literature but the needed accelerators are more demanding, as far as space and cost are concerned, with respect to standard photon devices, with only limited advantages when compared to protons or other heavy ions. In this contribution we investigate how recent developments in electron beam therapy could reshape the landscape of prostate treatments. The VHEE Treatment Planning System obtained combining an accurate Monte Carlo (MC) simulation with a simple modelling of the FLASH effect (healthy tissues sparing at very high dose rates) is compared with conventional RT. The results demonstrate that FLASH therapy with VHEE beams of 70-130 MeV could represent a valid alternative to standard RT allowing a better sparing of the healthy tissues surrounding the tumour, in the framework of an affordable technological development.
Published: 2021

32. A hard open X-band RF accelerating structure made by two halves

Author: Bruno Spataro, MOSTAFA BEHTOUEI, Fabio Cardelli, Martina Carillo, Valery Dolgashev, Luigi Faillace, Mauro Migliorati, and Luigi Palumbo
Subjects: Accelerator Physics (physics.acc-ph), Physics::Accelerator Physics, FOS: Physical sciences, Physics - Accelerator Physics
Abstract: High-gradient linacs of next generation require novel accelerating structures which are compact, robust and cost-effective. Dedicated research and development have been launched in the linear-collider community. This paper focuses on the technological developments directed to show the viability of novel welding techniques and related applications, in order to benefit from the superior high-gradient performance of accelerating structures made of hard-copper alloys. The structure geometry that we propose allows getting a high longitudinal shunt impedance of the accelerating mode and increasing the mode separation frequencies.
Published: 2021
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33. Terahertz continuous wave spectroscopy: a portable advanced method for atmospheric gas sensing

Author: Annalisa D’Arco, Daniele Rocco, Fernando Piamonte Magboo, Candida Moffa, Giancarlo Della Ventura, Augusto Marcelli, Luigi Palumbo, Leonardo Mattiello, Stefano Lupi, Massimo Petrarca, D'Arco, A., Rocco, D., Magboo, F. P., Moffa, C., Della Ventura, G., Marcelli, A., Palumbo, L., Mattiello, L., Lupi, S., and Petrarca, M.
Subjects: gas sensing, Terahertz spectroscopy, Terahertz, VOCs, Terahertz, Terahertz spectroscopy, VOCs, gas sensing, Atomic and Molecular Physics, and Optics
Abstract: Motivated by the increasing demand to monitor the air-quality, our study proved the feasibility of a new compact and portable experimental approach based on Terahertz (THz) continuous wave high resolution spectroscopy, to detect the presence of the air's contaminants as greenhouse gases (GHG) and volatile organic compounds (VOCs). In this specific work, we first characterized, determining their molar absorption coefficient in the spectral region (0.06-1.2) THz, the pure optical response of the vapor of five VOCs: methanol, ethanol, isopropanol, 1-butanol and 2-butanol. In particular, 1-butanol and 2-butanol are characterized for the first time in literature at THz frequencies. Then we studied the optical response of their mixtures achieved with ambient air and ethanol. The results show that it is possible for a differentiation of single components by describing their spectral absorption in terms of the linear combination of pure compounds absorption. This proof of concept for this apparatus study and set-up paves the way to the use of THz Continuous wave high resolution spectroscopy for the environmental tracking of air pollutants. (C) 2022 Optica Publishing Group under the terms of the Optica Open Access Publishing Agreement
Published: 2022

34. FLASH Radiotherapy With Electrons: Issues Related to the Production, Monitoring, and Dosimetric Characterization of the Beam

Author: Lucia Giuliano, Massimo Di Francesco, L. Grasso, M. Pacitti, Rita Borgheresi, Luigi Faillace, Daniela Marfisi, Patrizio Barca, Luigi Palumbo, Salvatore Barone, Stefania Linsalata, Eleonora Bortoli, Fabio Di Martino, Giuseppe Felici, Mauro Migliorati, and Silvia De Stefano
Subjects: Computer science, Materials Science (miscellaneous), medicine.medical_treatment, saturation problems, Biophysics, General Physics and Astronomy, Healthy tissue, FLASH effect, 030218 nuclear medicine & medical imaging, 03 medical and health sciences, 0302 clinical medicine, beam monitoring system, medicine, Physical and Theoretical Chemistry, Mathematical Physics, radiotherapy, Therapeutic window, Dose delivery, Tumor tissue, FLASH electron linac, lcsh:QC1-999, Reliability engineering, Radiation therapy, 030220 oncology & carcinogenesis, lcsh:Physics
Abstract: Various in vivo experimental works carried out on different animals and organs have shown that it is possible to reduce the damage caused to healthy tissue still preserving the therapeutic efficacy on the tumor tissue, by drastically reducing the total time of dose delivery (in vivo experiments. Moreover, the work discusses the saturation problems of the most common radiotherapy dosimeters when used in the very high dose-per-pulse FLASH conditions and provides some preliminary experimental data on their behavior.
Published: 2020

35. Dual Energy Computed Tomography (DECT) for cardiac imaging: clinical potential applications

Author: Alfonso Ragozzino, Giuseppe Di Costanzo, Rossi Claudia, Luigi Palumbo, Gelsomina Gervasio, and Serena Dell'Aversana
Published: 2020

36. Evaluation of a multiparametric MRI radiomic-based approach for stratification of equivocal PI-RADS 3 and upgraded PI-RADS 4 prostatic lesions

Author: Marco Aiello, Serena Monti, Luigi Palumbo, Marco Salvatore, Luca Basso, Giuseppe Di Costanzo, Alfonso Ragozzino, Carlo Cavaliere, and Valentina Brancato
Subjects: Male, medicine.medical_specialty, Science, Urological cancer, Predictive markers, Article, 030218 nuclear medicine & medical imaging, 03 medical and health sciences, Prostate cancer, 0302 clinical medicine, Medical research, Prostate, Predictive Value of Tests, Biopsy, medicine, Effective diffusion coefficient, Humans, Multiparametric Magnetic Resonance Imaging, Aged, Retrospective Studies, Cancer, Aged, 80 and over, Prostatectomy, Multidisciplinary, medicine.diagnostic_test, Receiver operating characteristic, business.industry, Multiparametric MRI, Prostatic Neoplasms, Diagnostic markers, Gold standard (test), Middle Aged, medicine.disease, eye diseases, PI-RADS, medicine.anatomical_structure, ROC Curve, 030220 oncology & carcinogenesis, Medicine, Radiology, Neoplasm Grading, business, Follow-Up Studies
Abstract: Despite the key-role of the Prostate Imaging and Reporting and Data System (PI-RADS) in the diagnosis and characterization of prostate cancer (PCa), this system remains to be affected by several limitations, primarily associated with the interpretation of equivocal PI-RADS 3 lesions and with the debated role of Dynamic Contrast Enhanced-Magnetic Resonance Imaging (DCE-MRI), which is only used to upgrade peripheral PI-RADS category 3 lesions to PI-RADS category 4 if enhancement is focal. We aimed at investigating the usefulness of radiomics for detection of PCa lesions (Gleason Score ≥ 6) in PI-RADS 3 lesions and in peripheral PI-RADS 3 upgraded to PI-RADS 4 lesions (upPI-RADS 4). Multiparametric MRI (mpMRI) data of patients who underwent prostatic mpMRI between April 2013 and September 2018 were retrospectively evaluated. Biopsy results were used as gold standard. PI-RADS 3 and PI-RADS 4 lesions were re-scored according to the PI-RADS v2.1 before and after DCE-MRI evaluation. Radiomic features were extracted from T2-weighted MRI (T2), Apparent diffusion Coefficient (ADC) map and DCE-MRI subtracted images using PyRadiomics. Feature selection was performed using Wilcoxon-ranksum test and Minimum Redundancy Maximum Relevance (mRMR). Predictive models were constructed for PCa detection in PI-RADS 3 and upPI-RADS 4 lesions using at each step an imbalance-adjusted bootstrap resampling (IABR) on 1000 samples. 41 PI-RADS 3 and 32 upPI-RADS 4 lesions were analyzed. Among 293 radiomic features, the top selected features derived from T2 and ADC. For PI-RADS 3 stratification, second order model showed higher performances (Area Under the Receiver Operating Characteristic Curve—AUC— = 80%), while for upPI-RADS 4 stratification, first order model showed higher performances respect to superior order models (AUC = 89%). Our results support the significant role of T2 and ADC radiomic features for PCa detection in lesions scored as PI-RADS 3 and upPI-RADS 4. Radiomics models showed high diagnostic efficacy in classify PI-RADS 3 and upPI-RADS 4 lesions, outperforming PI-RADS v2.1 performance.
Published: 2020

37. Realization and high power test of damped C-band accelerating structures

Author: Luigi Palumbo, Fabio Cardelli, R. Di Raddo, Alessandro Variola, Marco Bellaveglia, F. Poletto, D. Alesini, V. Lollo, Alessandro Gallo, P. Favaron, and Luca Piersanti
Subjects: Physics, Nuclear and High Energy Physics, Physics and Astronomy (miscellaneous), Field (physics), 010308 nuclear & particles physics, C band, business.industry, Pulse duration, Surfaces and Interfaces, 01 natural sciences, Linear particle accelerator, Dipole, chemistry.chemical_compound, Optics, chemistry, 0103 physical sciences, C-band accelerating, Silicon carbide, lcsh:QC770-798, lcsh:Nuclear and particle physics. Atomic energy. Radioactivity, 010306 general physics, business, Realization (systems), Beam (structure)
Abstract: The linac of the European project Extreme Light Infrastructure-Nuclear Physics (ELI-NP) foresees the use of 12 traveling wave $C$-band accelerating structures. The cavities are 1.8 m long, quasiconstant gradient, and have a field phase advance per cell of $2\ensuremath{\pi}/3$. They operate at 100 Hz repetition rate, and, because of the multibunch operation, they have been designed with a dipole higher-order mode (HOM) damping system to avoid beam breakup. The structures have symmetric input and output couplers and integrate, in each cell, a damping system based on silicon carbide (SiC) rf absorbers coupled to each cell through waveguides. An optimization of the electromagnetic and mechanical design has been done to simplify the fabrication and to reduce the costs. The cavities have been fabricated, and the first full-scale prototype has been also successfully tested at the nominal gradient of $33\text{ }\text{ }\mathrm{MV}\mathrm{/m}$, repetition rate of 100 Hz, and pulse length of 820 ns. It represents, to our knowledge, the first full-scale linac structure with HOM damping waveguides and SiC absorbers tested at this high gradient. In the paper, we illustrate the realization process of such a complicated device together with the low and high power test results.
Published: 2020

38. HE-LHC: The High-Energy Large Hadron Collider Future Circular Collider Conceptual Design Report Volume 4

Author: Pushpalatha C Bhat, B. Seeber, C. Pagliarone, Marco Statera, Victor P. Goncalves, Daria Astapovych, W. Bartmann, S. Iwamoto, M. Mentink, Alessandro Tricoli, E. R. Bielert, Laurent Chevalier, Patrick Koppenburg, Marco Calviani, C. Montag, P. Spiller, Jan Uythoven, P. Di Nezza, G. Guillermo Canton, B. Sailer, Markus Elsing, Sara Khatibi, Luca Vecchi, Luigi Palumbo, J. P. Penttinen, T. Podzorny, Maneesh Kumar, J. M. Rifflet, C. Kotnig, Jean Zinn-Justin, Christopher B. Verhaaren, A. Chernoded, Alessandro Bertarelli, L. M. Tkachenko, C. Koeberl, P. J. Mallon, M. Takeuchi, W. Venturini Delsolaro, G. Lamanna, S. Weinzierl, J. Gao, W. Kaabi, David D'Enterria, D. Barna, Paolo Castelnovo, Rajat Gupta, Oliver Boine-Frankenheim, Adarsh Pyarelal, Andreas Salzburger, Tessa Charles, M.E. Biagini, O. Panella, M. Stuart, A. Kollegger, V. Garcia Diaz, Olcay Bolukbasi, Maurizio Pierini, H. Aksakal, Tord Riemann, Abhishek M. Iyer, V. Shiltsev, D. Buttazzo, J. Blümlein, Prateek Agrawal, L. Sestini, Martin Bauer, Felicitas Pauss, S. Fiorendi, F. Bossu, Marco Nardecchia, C. Leonidopoulos, Wojciech Kotlarski, A. Saba, I. Bautista-Guzmán, W. Hillert, Giorgio Ambrosio, T. Lehtinen, Michael Andrew Parker, Silvia Taroni, Gian F. Giudice, Ph. Lebrun, Johann A. Briffa, T. Risselada, Giuseppe Lerner, A. Lechner, L. S. Miralles, M. Kuze, J. M. Valet, P. S. B. Dev, S. Holleis, Ph. Schwemling, M. Biglietti, S. Banerjee, Thomas Schörner-Sadenius, A. Sanz Ull, V. Tikhomirov, S. Savelyeva, Jiayin Gu, D. Zhou, Federico Ravotti, S. A. Bogacz, Daniele Mirarchi, R. Tomás García, Yann Coadou, F. Yu, Y. Cai, T. Lari, F. Holdener, D. Shwartz, C. Bhat, Ramesh Gupta, Markus Klute, E. Palmieri, P. Collier, Branislav Sitar, Yves Sirois, Livio Fanò, S. Rojas-Torres, E. Locci, Ruben Garcia Alia, I. Božović Jelisavić, R. Chehab, J. A. Aguilar-Saavedra, M. Pasquali, A. Di Cicco, Bernhard Auchmann, Klaus Heinemann, Alessia Tricomi, D. Lucchesi, B. Haerer, M. Morrone, Paolo Giacomelli, Sonia Carra, A. Senol, Ivan Koop, Luca Silvestrini, Anna Stakia, Heather Gray, E. Skordis, A. D. Kovalenko, Paul Langacker, R. Li, Bernardo Bordini, R. Rata, Arjan Verweij, Shehu S. AbdusSalam, Andrey Karyukhin, U. van Rienen, Gianluigi Arduini, Bernhard Holzer, S. A. Nikitin, S. S. Kozub, Satoshi Mishima, B. Di Micco, S. Izquierdo Bermudez, N. Pukhaeva, Nigel Watson, F. Prino, Jean-Michel Sallese, Sotirios Vlachos, Alessandro Vicini, A. Valassi, Daniel Treille, F. Dordei, A. M. Fernandez Navarro, B. Dziewit, Marcello Abbrescia, J. M. Hauptman, I. Chaikovska, Paolo Giubellino, Michael J. Baker, V.V. Kashikhin, Friedrich Lackner, Filippo Sala, A. Langner, D. Pulikowski, H. Eriksson, Matteo Turri, Andrea Wulzer, M. Aiba, Lisa Borgonovi, I. Morozov, V. Haurylavets, J. F. Croteau, S. Boselli, L. A. Gonzalez Gomez, Claudia Tambasco, F. Mahmoudi, Sébastien Descotes-Genon, A. Luciani, Pavel Piminov, M. Varasteh, T. Herzig, Sandra Aumon, Cristina Bernini, Joseph Bramante, Roberta Arnaldi, G. Zick, Daniel Schulte, R. Santoro, Anna Kulesza, I. Turk Cakir, M. Nonis, Silvia Posada Arias, Livia Soffi, T. Wojtoń, E. Cennini, Florian Bauer, B. Rousset, J.-L. Grenard, C. Neubüser, Frederic Derue, Loukas Gouskos, Rainer Wallny, G. Calderini, M. Merk, M. Mühlegger, Roberto Cimino, M. Ramsey-Musolf, P. Rebello Teles, Mario Galanti, Mikhail Shaposhnikov, A. Andreazza, Maria Vittoria Garzelli, Masaya Ishino, José W. F. Valle, Colin Bernet, G. Velev, Cristina Botta, E. Fischer, J. Malclés, Giuseppe Montenero, Tripurari Srivastava, E. Renner, Shahnam Gorgi Zadeh, D. Cantore-Cavalli, Paul Laycock, J. Komppula, Simon C. Hopkins, Helmut Burkhardt, Eric Lancon, I. Aichinger, Andre Sznajder, F. Bordry, Massimo Giovannozzi, Aidan Robson, Anna Giunta, A. Carvalho, S. Farinon, Daniel Wollmann, M. Fouaidy, Martti Raidal, R. Gerard, Giovanni Volpini, U. Niedermayer, A. Alekou, Alexander J.G. Lunt, Vincenzo Cavasinni, Andrzej Siodmok, U. Kaya, Matthias Schott, Marumi Kado, S. A. Arsenyev, José Zurita, John Osborne, Patrick Meade, Gianmarco Bovone, G. Li, Klaus Schlenga, Antti Stenvall, D. Duellmann, Werner Riegler, I. Garzia, Yasuyuki Okumura, G. Pikurs, F. Maltoni, Massimo Sorbi, M. Arzeo, B. Strauss, Y. W. Baek, Mauro Chiesa, K. Ilyina-Brunner, Javier L. Albacete, R. Farinelli, C. Pes, Nicolas Morange, S. M. Zernov, U. Wagner, Emmanuelle Perez, G. G. Da Silveira, J. Neundorf, Néstor Armesto, T. Hahn, Roman N. Lee, Roderik Bruce, B. Y. Sharkov, T. du Pree, G. Cibinetto, Evelin Meoni, R. Rinaldesi, James A. Ellison, Radim Slovak, Silvia Franchino, Mikko Laine, T. Pugnat, S. P. Das, Yuji Enari, Emanuela Barzi, Cihan Bayindir, R. Boels, Jana Faltova, M. Moreno Llácer, Scott A. Yost, Michael Spannowsky, Florian Burkart, Marcin Chrzaszcz, K. Suzuki, Luca Trentadue, S. Masciocchi, Gilad Perez, Steve Peggs, K. Sugita, Eleonora Belli, Carmine Senatore, K. Y. Oyulmaz, Aldo Deandrea, Irakli Minashvili, Desmond P. Barber, M. I. Martínez-Hernández, A. Apyan, S. Petracca, Mikael Chala, Urs Achim Wiedemann, T. Sian, Olivier Deschamps, R. Monge, G. Avrillaud, Jan Kieseler, Hubert Spiesberger, J. Maitre, G. D. Shirkov, M. Hofer, Emanuela Sirtori, Sinan Kuday, Kirill Skovpen, Sara Casalbuoni, Johann Usovitsch, N. Chen, G. Tejeda-Muñoz, F. Bellini, E. Chyhyrynets, Michael Stöger-Pollach, M. Vogel, J. G. Mendes Saraiva, A. Rivetti, M. Podeur, Luc Poggioli, V. A. Gromov, R. Sirvinskaite, S. B. Leith, Giancarlo D'Ambrosio, Tony Price, Philippe Mermod, Rabindra N. Mohapatra, T. Mitshuhashi, Koji Terashi, Leonel Ferreira, L. Vale Silva, N. Muchnoi, J. L. Stanyard, Thomas Marriott-Dodington, A. Andriatis, Oleg Solovyanov, A. Daljevec, A. Butterworth, S. Myers, D. Chanal, Tatiana Pieloni, M. Rodríguez-Cahuantzi, G. Nardini, D. Boscherini, Kazuhito Ohmi, James Molson, S. Kowalski, Christoph Haberstroh, Martin Aleksa, K. Kershaw, M. Mulder, Leonid Rivkin, G. Vorotnikov, Luigi Salvatore Esposito, J. 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Karpov, Valentina Morretta, Saverio D'Auria, Patrick Draper, B. Hacışahinoğlu, E. Gorini, Andrew J. Long, S. La Mendola, G. Zevi Dell Porta, I. Abdyukhanov, M. Cobal, Luca Marzola, E. Rochepault, A. Kusina, German Rodrigo, R. Schmidt, Jan Steggemann, E. Premat, P. Slavich, F. Gianotti, P. Jarry, Ram Krishna Dewanjee, L. Felsberger, T. Martinez, A. Niemi, Jürgen Reuter, P. A. Bruckman de Renstrom, Ryu Sawada, J. T. Childers, Gelsomina Catalano, P. Barjhoux, O. R. Blanco-García, Pilar Hernández, H. Correia-Rodrigues, V. Ippolito, S. De Curtis, Juan Rojo, Ayberk Yilmaz, S. Baird, Morteza Khatiri Yanehsari, Enrico Scomparin, Daniel Appelö, J. Kozaczuk, Matthew Jones, B. Caiffi, C. Del Bo, Susanna Guiducci, Giuliano Panico, M. Knecht, J. Coupard, M. Ciuchini, H. Kritscher, Claire Gwenlan, P. Costa Pinto, Thibaut Lefèvre, N. Bellegarde, Christian Scheuerlein, P. Ferreira da Silva, M. Verducci, X. Ruan, H. Pikhartova, Juan M. O'Callaghan, Kazuro Furukawa, D. 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Zurita, J, Işık Üniversitesi, Mühendislik Fakültesi, İnşaat Mühendisliği Bölümü, Işık University, Faculty of Engineering, Department of Civil Engineering, Bayındır, Cihan, Universitat Politècnica de Catalunya. Departament de Teoria del Senyal i Comunicacions, Universitat Politècnica de Catalunya. RF&MW - Grup de Recerca de sistemes, dispositius i materials de RF i microones, Abada A., Abbrescia M., AbdusSalam S.S., Abdyukhanov I., Abelleira Fernandez J., Abramov A., Aburaia M., Acar A.O., Adzic P.R., Agrawal P., Aguilar-Saavedra J.A., Aguilera-Verdugo J.J., Aiba M., Aichinger I., Aielli G., Akay A., Akhundov A., Aksakal H., Albacete J.L., Albergo S., Alekou A., Aleksa M., Aleksan R., Alemany Fernandez R.M., Alexahin Y., Alia R.G., Alioli S., Alipour Tehrani N., Allanach B.C., Allport P.P., Altinli M., Altmannshofer W., Ambrosio G., Amorim D., Amstutz O., Anderlini L., Andreazza A., Andreini M., Andriatis A., Andris C., Andronic A., Angelucci M., Antinori F., Antipov S.A., Antonelli M., Antonello M., Antonioli P., Antusch S., Anulli F., Apolinario L., Apollinari G., Apollonio A., Appelo D., Appleby R.B., Apyan A., Arbey A., Arbuzov A., Arduini G., Ari V., Arias S., Armesto N., Arnaldi R., Arsenyev S.A., Arzeo M., Asai S., Aslanides E., Assmann R.W., Astapovych D., Atanasov M., 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E.R., Biglietti M., Bilei G.M., Bilki B., Biscari C., Bishara F., Blanco-Garcia O.R., Blanquez F.R., Blekman F., Blondel A., Blumlein J., Boccali T., Boels R., Bogacz S.A., Bogomyagkov A., Boine-Frankenheim O., Boland M.J., Bologna S., Bolukbasi O., Bomben M., Bondarenko S., Bonvini M., Boos E., Bordini B., Bordry F., Borghello G., Borgonovi L., Borowka S., Bortoletto D., Boscherini D., Boscolo M., Boselli S., Bosley R.R., Bossu F., Botta C., Bottura L., Boughezal R., Boutin D., Bovone G., Bozovic Jelisavic I., Bozbey A., Bozzi C., Bozzini D., Braccini V., Braibant-Giacomelli S., Bramante J., Braun-Munzinger P., Briffa J.A., Britzger D., Brodsky S.J., Brooke J.J., Bruce R., Bruckman De Renstrom P., Bruna E., Bruning O., Brunner O., Brunner K., Bruzzone P., Buffat X., Bulyak E., Burkart F., Burkhardt H., Burnet J.-P., Butin F., Buttazzo D., Butterworth A., Caccia M., Cai Y., Caiffi B., Cairo V., Cakir O., Calaga R., Calatroni S., Calderini G., Calderola G., Caliskan A., Calvet D., Calviani M., Camalich J.M., Camarri P., Campanelli M., Camporesi T., Canbay A.C., Canepa A., Cantergiani E., Cantore-Cavalli D., Capeans M., Cardarelli R., Cardella U., Cardini A., Carloni Calame C.M., Carra F., Carra S., Carvalho A., Casalbuoni S., Casas J., Cascella M., Castelnovo P., Castorina G., Catalano G., Cavasinni V., Cazzato E., Cennini E., Cerri A., Cerutti F., Cervantes J., Chaikovska I., Chakrabortty J., Chala M., Chamizo-Llatas M., Chanal H., Chanal D., Chance S., Chance A., Charitos P., Charles J., Charles T.K., Chattopadhyay S., Chehab R., Chekanov S.V., Chen N., Chernoded A., Chetvertkova V., Chevalier L., Chiarelli G., Chiarello G., Chiesa M., Chiggiato P., Childers J.T., Chmielinska A., Cholakian A., Chomaz P., Chorowski M., Chou W., Chrzaszcz M., Chyhyrynets E., Cibinetto G., Ciftci A.K., Ciftci R., Cimino R., Ciuchini M., Clark P.J., Coadou Y., Cobal M., Coccaro A., Cogan J., Cogneras E., Collamati F., Colldelram C., Collier P., Collot J., Contino R., Conventi F., Cook C.T.A., Cooley L., Corcella G., Cornell A.S., Corral G.H., Correia-Rodrigues H., Costanza F., Costa Pinto P., Couderc F., Coupard J., Craig N., Crespo Garrido I., Crivellin A., Croteau J.F., Crouch M., Cruz Alaniz E., Cure B., Curti J., Curtin D., Czech M., Dachauer C., D'Agnolo R.T., Daibo M., Dainese A., Dalena B., Daljevec A., Dallapiazza W., D'Aloia Schwartzentruber L., Dam M., D'Ambrosio G., Das S.P., DasBakshi S., da Silva W., da Silveira G.G., D'Auria V., D'Auria S., David A., Davidek T., Deandrea A., de Blas J., Debono C.J., De Curtis S., De Filippis N., de Florian D., Deghaye S., de Jong S.J., Del Bo C., Del Duca V., Delikaris D., Deliot F., Dell'Acqua A., Delle Rose L., Delmastro M., De Lucia E., Demarteau M., Denegri D., Deniau L., Denisov D., Denizli H., Denner A., d'Enterria D., de Rijk G., De Roeck A., Derue F., Deschamps O., Descotes-Genon S., Dev P.S.B., de Vivie de Regie J.B., Dewanjee R.K., Di Ciaccio A., Di Cicco A., Dillon B.M., Di Micco B., Di Nezza P., Di Vita S., Doblhammer A., Dominjon A., D'Onofrio M., Dordei F., Drago A., Draper P., Drasal Z., Drewes M., Duarte L., Dubovyk I., Duda P., Dudarev A., Dudko L., Duellmann D., Dunser M., du Pree T., Durante M., Duran Yildiz H., Dutta S., Duval F., Duval J.M., Dydyshka Y., Dziewit B., Eisenhardt S., Eisterer M., Ekelof T., El Khechen D., Ellis S.A., Ellis J., Ellison J.A., Elsener K., Elsing M., Enari Y., Englert C., Eriksson H., Eskola K.J., Esposito L.S., Etisken O., Etzion E., Fabbricatore P., Falkowski A., Falou A., Faltova J., Fan J., Fano L., Farilla A., Farinelli R., Farinon S., Faroughy D.A., Fartoukh S.D., Faus-Golfe A., Fawcett W.J., Felici G., Felsberger L., Ferdeghini C., Fernandez Navarro A.M., Fernandez-Tellez A., Ferradas Troitino J., Ferrara G., Ferrari R., Ferreira L., Ferreira da Silva P., Ferrera G., Ferro F., Fiascaris M., Fiorendi S., Fiorio C., Fischer O., Fischer E., Flieger W., Florio M., Fonnesu D., Fontanesi E., Foppiani N., Foraz K., Forkel-Wirth D., Forte S., Fouaidy M., Fournier D., Fowler T., Fox J., Francavilla P., Franceschini R., Franchino S., Franco E., Freitas A., Fuks B., Furukawa K., Furuseth S.V., Gabrielli E., Gaddi A., Galanti M., Gallo E., Ganjour S., Gao J., Garcia Diaz V., Garcia Perez M., Garcia Tabares L., Garion C., Garzelli M.V., Garzia I., Gascon-Shotkin S.M., Gaudio G., Gay P., Ge S.-F., Gehrmann T., Genest M.H., Gerard R., Gerigk F., Gerwig H., Giacomelli P., Giagu S., Gianfelice-Wendt E., Gianotti F., Giffoni F., Gilardoni S.S., Gil Costa M., Giovannetti M., Giovannozzi M., Giubellino P., Giudice G.F., Giunta A., Gladilin L.K., Glukhov S., Gluza J., Gobbi G., Goddard B., Goertz F., Golling T., Goncalves V.P., Goncalo R., Gonzalez Gomez L.A., Gorgi Zadeh S., Gorine G., Gorini E., Gourlay S.A., Gouskos L., Grancagnolo F., Grassellino A., Grau A., Graverini E., Gray H.M., Greco M., Grenard J.-L., Grimm O., Grojean C., Gromov V.A., Grosse-Oetringhaus J.F., Grudiev A., Grzanka K., Gu J., Guadagnoli D., Guidi V., Guiducci S., Guillermo Canton G., Gunaydin Y.O., Gupta R., Gupta R.S., Gutierrez J., Gutleber J., Guyot C., Guzey V., Gwenlan C., Haberstroh C., Hacisahinoglu B., Haerer B., Hahn K., Hahn T., Hammad A., Han C., Hance M., Hannah A., Harris P.C., Hati C., Haug S., Hauptman J., Haurylavets V., He H.-J., Hegglin A., Hegner B., Heinemann K., Heinemeyer S., Helsens C., Henriques A., Hernandez P., Hernandez-Pinto R.J., Hernandez-Sanchez J., Herzig T., Hiekkanen I., Hillert W., Hoehn T., Hofer M., Hofle W., Holdener F., Holleis S., Holzer B., Hong D.K., Honorato C.G., Hopkins S.C., Hrdinka J., Hug F., Humann B., Humer H., Hurth T., Hutton A., Iacobucci G., Ibarrola N., Iconomidou-Fayard L., Ilyina-Brunner K., Incandela J., Infantino A., Ippolito V., Ishino M., Islam R., Ita H., Ivanovs A., Iwamoto S., Iyer A., Izquierdo Bermudez S., Jadach S., Jamin D.O., Janot P., Jarry P., Jeff A., Jenny P., Jensen E., Jensen M., Jiang X., Jimenez J.M., Jones M.A., Jones O.R., Jowett J.M., Jung S., Kaabi W., Kado M., Kahle K., Kalinovskaya L., Kalinowski J., Kamenik J.F., Kannike K., Kara S.O., Karadeniz H., Karaventzas V., Karpov I., Kartal S., Karyukhin A., Kashikhin V., Katharina Behr J., Kaya U., Keintzel J., Keinz P.A., Keppel K., Kersevan R., Kershaw K., Khanpour H., Khatibi S., Khatiri Yanehsari M., Khoze V.V., Kieseler J., Kilic A., Kilpinen A., Kim Y.-K., Kim D.W., Klein U., Klein M., Kling F., Klinkenberg N., Kloppel S., Klute M., Klyukhin V.I., Knecht M., Kniehl B., Kocak F., Koeberl C., Kolano A.M., Kollegger A., Kolodziej K., Kolomiets A.A., Komppula J., Koop I., Koppenburg P., Koratzinos M., Kordiaczynska M., Korjik M., Kortner O., Kostka P., Kotlarski W., Kotnig C., Kottig T., Kotwal A.V., Kovalenko A.D., Kowalski S., Kozaczuk J., Kozlov G.A., Kozub S.S., Krainer A.M., Kramer T., Kramer M., Krammer M., Krasnov A.A., Krauss F., Kravalis K., Kretzschmar L., Kriske R.M., Kritscher H., Krkotic P., Kroha H., Kucharczyk M., Kuday S., Kuendig A., Kuhlmann G., Kulesza A., Kumar M., Kusina A., Kuttimalai S., Kuze M., Kwon T., Lackner F., Lackner M., La Francesca E., Laine M., Lamanna G., La Mendola S., Lancon E., Landsberg G., Langacker P., Lange C., Langner A., Lankford A.J., Lansberg J.P., Lari T., Laycock P.J., Lebrun P., Lechner A., Lee K., Lee S., Lee R., Lefevre T., Le Guen P., Lehtinen T., Leith S.B., Lenzi P., Leogrande E., Leonidopoulos C., Leon-Monzon I., Lerner G., Leroy O., Lesiak T., Levai P., Leveratto A., Levichev E., Li G., Li S., Li R., Liberati D., Liepe M., Lissauer D.A., Liu Z., Lobko A., Locci E., Logothetis Agaliotis E., Lombardo M.P., Long A.J., Lorin C., Losito R., Louzguiti A., Low I., Lucchesi D., Lucchini M.T., Luciani A., Lueckhof M., Lunt A.J.G., Luzum M., Lyubimtsev D.A., Maggiora M., Magnin N., Mahmoud M.A., Mahmoudi F., Maitre J., Makarenko V., Malagoli A., Malcles J., Malgeri L., Mallon P.J., Maltoni F., Malvezzi S., Malyshev O.B., Mancinelli G., Mandrik P., Manfrinetti P., Mangano M., Manil P., Mannelli M., Marchiori G., Marhauser F., Mariani V., Marinozzi V., Mariotto S., Marquard P., Marquet C., Marriott-Dodington T., Martin R., Martin O., Martin Camalich J., Martinez T., Martinez Bruzual H., Martinez-Hernandez M.I., Martins D.E., Marzani S., Marzocca D., Marzola L., Masciocchi S., Masina I., Massimiliano A., Massironi A., Masubuchi T., Matveev V.A., Mazzoni M.A., McCullough M., McIntosh P.A., Meade P., Medina L., Meier A., Meignan J., Mele B., Mendes Saraiva J.G., Menez F., Mentink M., Meoni E., Meridiani P., Merk M., Mermod P., Mertens V., Mether L., Metral E., Migliorati M., Milanese A., Milardi C., Milhano G., Militsyn B.L., Millet F., Minashvili I., Minervini J.V., Miralles L.S., Mirarchi D., Mishima S., Missiaen D.P., Mitselmakher G., Mitshuhashi T., Mnich J., Mohammadi Najafabadi M., Mohapatra R.N., Mokhov N., Molson J.G., Monge R., Montag C., Montagna G., Monteil S., Montenero G., Montesinos E., Moortgat F., Morange N., Morello G., Moreno Llacer M., Moretti M., Moretti S., Morley A.K., Moros A., Morozov I., Morretta V., Morrone M., Mostacci A., Muanza S., Muchnoi N., Muhlegger M., Mulder M., Mulders M., Muller B., Muller F., Muller A.-S., Munilla J., Murray M.J., Muttoni Y., Myers S., Mylona M., Nachtman J., Nakamoto T., Nardecchia M., Nardini G., Nason P., Nergiz Z., Nesterenko A.V., Netto J.A., Nettstrater A., Neubuser C., Neundorf J., Niccoli F., Nicrosini O., Nie Y., Niedermayer U., Niedziela J., Niemi A., Nikitin S.A., Nisati A., No J.M., Nonis M., Nosochkov Y., Novak M., Novokhatski A., O'Callaghan J.M., Ochando C., Ogur S., Ohmi K., Oide K., Okorokov V.A., Okumura Y., Oleari C., Olness F.I., Onel Y., Ortino M., Osborne J., Osland P., Otto T., Oyulmaz K.Y., Ozansoy A., Ozcan V., Ozdemir K., Pagliarone C.E., Pais da Silva H.F., Palmieri E., Palumbo L., Pampaloni A., Pan R.-Q., Panareo M., Panella O., Panico G., Panizzo G., Pankov A.A., Pantsyrny V., Papadopoulos C.G., Papaefstathiou A., Papaphilippou Y., Parker M.A., Parma V., Pasquali M., Patra S.K., Patterson R., Paukkunen H., Pauss F., Peggs S., Penttinen J.-P., Peon G., Perepelkin E.E., Perez E., Perez J.C., Perez G., Perez F., Perez Codina E., Perez Morales J., Perfilov M., Pernegger H., Peruzzi M., Pes C., Peters K., Petracca S., Petriello F., Pezzotti L., Pfeiffer S., Piccinini F., Pieloni T., Pierini M., Pikhartova H., Pikurs G., Pilicer E., Piminov P., Pira C., Pittau R., Placzek W., Plagge M., Plehn T., Pleier M.-A., Ploskon M., Podeur M., Podlech H., Podzorny T., Poggioli L., Poiron A., Polesello G., Poli Lener M., Polini A., Polinski J., Polozov S.M., Ponce L., Pont M., Pontecorvo L., Portaluri T., Potamianos K., Prasse C., Prausa M., Preinerstorfer A., Premat E., Price T., Primavera M., Prino F., Prioli M., Proudfoot J., Provino A., Pugnat T., Pukhaeva N., Pulawski S., Pulikowski D., Punzi G., Putti M., Pyarelal A., Quack H., Quispe M., Racioppi A., Rafique H., Raginel V., Raidal M., Ramirez-Uribe N.S., Ramsey-Musolf M.J., Rata R., Ratoff P., Ravotti F., Rebello Teles P., Reboud M., Redaelli S., Renner E., Renteria-Olivo A.E., Rescigno M., Reuter J., Ribon A., Ricci A.M., Riegler W., Riemann S., Riemann B., Riemann T., Rifflet J.M., Rimmer R.A., Rinaldesi R., Rinolfi L., Rios Rubiras O., Risselada T., Rivetti A., Rivkin L., Rizzo T., Robens T., Robert F., Robson A.J., Rochepault E., Roda C., Rodrigo G., Rodriguez-Cahuantzi M., Rogan C., Roig M., Rojas-Torres S., Rojo J., Rolandi G., Rolando G., Roloff P., Romanenko A., Romanov A., Roncarolo F., Rosado Sanchez A., Rosaz G., Rossi L., Rossi A., Rossmanith R., Rousset B., Royon C., Ruan X., Ruehl I., Ruhlmann-Kleider V., Ruiz R., Rumyantsev L., Ruprecht R., Ryazanov A.I., Saba A., Sadykov R., Saez de Jauregui D., Sahin M., Sailer B., Saito M., Sala F., Salam G.P., Salfeld-Nebgen J., Salgado C.A., Salini S., Sallese J.M., Salmi T., Salzburger A., Sampayo O.A., Sanfilippo S., Santiago J., Santopinto E., Santoro R., Sanz Ull A., Sarasola X., Sarpun I.H., Sauvain M., Savelyeva S., Sawada R., Sborlini G.F.R., Schaffer A., Schaumann M., Schenk M., Scheuerlein C., Schienbein I., Schlenga K., Schmickler H., Schmidt R., Schoerling D., Schoning A., Schorner-Sadenius T., Schott M., Schulte D., Schwaller P., Schwanenberger C., Schwemling P., Schwerg N., Scibile L., Sciuto A., Scomparin E., Sebastiani C., Seeber B., Segreti M., Selva P., Selvaggi M., Senatore C., Senol A., Serin L., Serluca M., Serra N., Seryi A., Sestini L., Sfyrla A., Shaposhnikov M., Shaposhnikova E., Sharkov B.Y., Shatilov D., Shelton J., Shiltsev V., Shipsey I.P., Shirkov G.D., Shivaji A., Shwartz D., Sian T., Sidorov S., Siemko A., Silvestrini L., Simand N., Simon F., Singh B.K., Siodmok A., Sirois Y., Sirtori E., Sirvinskaite R., Sitar B., Sjostrand T., Skands P., Skordis E., Skovpen K., Skrzypek M., Slade E., Slavich P., Slovak R., Smaluk V., Smirnov V., Snoeys W., Soffi L., Sollander P., Solovyanov O., Soltveit H.K., Song H., Sopicki P., Sorbi M., Spallino L., Spannowsky M., Spataro B., Sphicas P., Spiesberger H., Spiller P., Spira M., Srivastava T., Stachel J., Stakia A., Stanyard J.L., Starchenko E., Starikov A.Y., Stasto A.M., Statera M., Steerenberg R., Steggemann J., Stenvall A., Stivanello F., Stockinger D., Stoel L.S., Stoger-Pollach M., Strauss B., Stuart M., Stupakov G., Su S., Sublet A., Sugita K., Sulak L., Sullivan M.K., Sultansoy S., Sumida T., Suzuki K., Sylva G., Syphers M.J., Sznajder A., Taborelli M., Tahir N.A., Takeuchi M., Tal Hod E., Tambasco C., Tanaka J., Tang K., Tapan I., Taroni S., Tartarelli G.F., Tassielli G., Tavian L., Taylor T.M., Taylor G.N., Teixeira A.M., Tejeda-Munoz G., Telnov V.I., Tenchini R., ten Kate H.H.J., Terashi K., Tesi A., Testa M., Tetrel C., Teytelman D., Thaler J., Thamm A., Thomas S., Tiirakari M.T., Tikhomirov V., Tikhonov D., Timko H., Tisserand V., Tkachenko L.M., Tkaczuk J., Tock J.P., Todd B., Todesco E., Tomas Garcia R., Tommasini D., Tonelli G., Toral F., Torims T., Torre R., Townsend Z., Trant R., Treille D., Trentadue L., Tricoli A., Tricomi A., Trischuk W., Tropin I.S., Tuchming B., Tudora A.A., Turbiarz B., Turk Cakir I., Turri M., Tydecks T., Usovitsch J., Uythoven J., Vaglio R., Valassi A., Valchkova F., Valdivia Garcia M.A., Valente P., Valente R.U., Valente-Feliciano A.-M., Valentino G., Vale Silva L., Valet J.M., Valizadeh R., Valle J.W.F., Vallecorsa S., Vallone G., van Leeuwen M., van Rienen U.H., van Riesen-Haupt L., Varasteh M., Vecchi L., Vedrine P., Velev G., Veness R., Ventura A., Venturini Delsolaro W., Verducci M., Verhaaren C.B., Vernieri C., Verweij A.P., Verwilligen O., Viazlo O., Vicini A., Viehhauser G., Vignaroli N., Vignolo M., Vitrano A., Vivarelli I., Vlachos S., Vogel M., Vogt D.M., Volkl V., Volkov P., Volpini G., von Ahnen J., Vorotnikov G., Voutsinas G.G., Vysotsky V., Wagner U., Wallny R., Wang L.-T., Wang R., Wang K., Ward B.F.L., Watson T.P., Watson N.K., Ws Z., Weiland C., Weinzierl S., Welsch C.P., Wenninger J., Widorski M., Wiedemann U.A., Wienands H.-U., Wilkinson G., Williams P.H., Winter A., Wohlfahrt A., Wojton T., Wollmann D., Womersley J., Woog D., Wu X., Wulzer A., Yanehsari M.K., Yang G., Yang H.J., Yao W.-M., Yazgan E., Yermolchik V., Yilmaz A., Yoo H.-D., Yost S.A., You T., Young C., Yu T.-T., Yu F., Zaborowska A., Zadeh S.G., Zahnd M., Zanetti M., Zanotto L., Zawiejski L., Zeiler P., Zerlauth M., Zernov S.M., Zevi Dell Porta G., Zhang Z., Zhang Y., Zhang C., Zhang H., Zhao Z., Zhong Y.-M., Zhou J., Zhou D., Zhuang P., Zick G., Zimmermann F., Zinn-Justin J., Zivkovic L., Zlobin A.V., Zobov M., Zupan J., Zurita J., BAİBÜ, Fen Edebiyat Fakültesi, Fizik Bölümü, Denizli, Haluk, TOBB ETU, Faculty of Engineering, Department of Electrical & Electronics Engineering, TOBB ETU, Faculty of Engineering, Department of Material Science & Nanotechnology Engineering, TOBB ETÜ, Mühendislik Fakültesi, Elektrik ve Elektronik Mühendisliği Bölümü, TOBB ETÜ, Mühendislik Fakültesi, Malzeme Bilimi ve Nanoteknoloji Mühendisliği Bölümü, Bozbey, Ali, Sultansoy, Saleh, Özdemir, Kadri, Giresun Üniversitesi, UCL - SST/IRMP - Institut de recherche en mathématique et physique, and Ege Üniversitesi
Subjects: Beam losses, IMPACT, Physics::Instrumentation and Detectors, Physics beyond the Standard Model, EVENT BUILDER, hadron collider, General Physics and Astronomy, Mathematics and natural science: 400::Physics: 430::Nuclear and elementary particle physics: 431 [VDP], 01 natural sciences, 7. Clean energy, law.invention, Subatomär fysik, chemistry.chemical_compound, Conceptual design, Colliding beam accelerators, law, HE-LHC, Subatomic Physics, General Materials Science, Hadron colliders, Física::Física de partícules::Hadrons [Àrees temàtiques de la UPC], Large Hadron Collider, Acceleradors de partícules, Physics, Settore FIS/01 - Fisica Sperimentale, Beams (radiation), Settore FIS/02 - Fisica Teorica, Modelli e Metodi Matematici, Upgrade, Impact, collimators, partikkelfysikk, Future Circular Collider, High-Energy, Systems engineering, HE-LHC: The High-Energy Large Hadron Collider, Col·lisionadors d'hadrons, Applied physics, Collimators, Socio-culturale, Fizik, Hadrons, Accelerator Physics and Instrumentation, HE-LHC physics, Condensed Matter::Materials Science, 0103 physical sciences, Physics::Atomic and Molecular Clusters, beam losses, ddc:530, High Energy Physics, partikkelakselerator, Physical and Theoretical Chemistry, Niobium-tin, 010306 general physics, Collider, Particle Physics, Beams (radiation) | Collimators | Beam losses, Energies::Energia nuclear [Àrees temàtiques de la UPC], Large Hadron Collider HE-LHC, 010308 nuclear & particles physics, High Energy Physics::Phenomenology, Colliders (Nuclear physics), Acceleratorfysik och instrumentering, Event builder, Accelerators and Storage Rings, Particle accelerators, chemistry, Experimental High Energy Physics, Physics::Accelerator Physics, High Energy Physics::Experiment, Future Colliders
Abstract: Authors: A. AbadaM. AbbresciaS. S. AbdusSalamI. AbdyukhanovJ. Abelleira FernandezA. AbramovM. AburaiaA. O. AcarP. R. AdzicP. AgrawalJ. A. Aguilar-SaavedraJ. J. Aguilera-VerdugoM. AibaI. AichingerG. AielliA. AkayA. AkhundovH. AksakalJ. L. AlbaceteS. AlbergoA. AlekouM. AleksaR. AleksanR. M. Alemany FernandezY. AlexahinR. G. AlíaS. AlioliN. Alipour TehraniB. C. AllanachP. P. AllportM. AltınlıW. AltmannshoferG. AmbrosioD. AmorimO. AmstutzL. AnderliniA. AndreazzaM. AndreiniA. AndriatisC. AndrisA. AndronicM. AngelucciF. AntinoriS. A. AntipovM. AntonelliM. AntonelloP. AntonioliS. AntuschF. AnulliL. ApolinárioG. ApollinariA. ApollonioD. AppelöR. B. ApplebyA. ApyanA. ApyanA. ArbeyA. ArbuzovG. ArduiniV. ArıS. AriasN. ArmestoR. ArnaldiS. A. ArsenyevM. ArzeoS. AsaiE. AslanidesR. W. AßmannD. AstapovychM. AtanasovS. AtiehD. AttiéB. AuchmannA. AudurierS. AullS. AumonS. AuneF. AvinoG. AvrillaudG. AydınA. AzatovG. AzuelosP. AzziO. AzzoliniP. AzzurriN. BacchettaE. BacchiocchiH. BachacouY. W. BaekV. BaglinY. BaiS. BairdM. J. BakerM. J. BaldwinA. H. BallA. BallarinoS. BanerjeeD. P. BarberD. BarducciP. BarjhouxD. BarnaG. G. BarnaföldiM. J. BarnesA. BarrJ. Barranco GarcíaJ. Barreiro Guimarães da CostaW. BartmannV. BaryshevskyE. BarziS. A. BassA. BastianinB. BaudouyF. BauerM. BauerT. BaumgartnerI. Bautista-GuzmánC. BayındırF. BeaudetteF. BedeschiM. BéguinI. BellafontL. BellagambaN. BellegardeE. BelliE. BellingeriF. BelliniG. BellomoS. BelomestnykhG. BencivenniM. BenediktG. BernardiJ. BernardiC. BernetJ. M. BernhardtC. BerniniC. BerriaudA. BertarelliS. BertolucciM. I. BesanaM. BesançonO. BeznosovP. BhatC. BhatM. E. BiaginiJ. -L. BiarrotteA. Bibet ChevalierE. R. BielertM. BigliettiG. M. BileiB. BilkiC. BiscariF. BisharaO. R. Blanco-GarcíaF. R. BlánquezF. BlekmanA. BlondelJ. BlümleinT. BoccaliR. BoelsS. A. BogaczA. BogomyagkovO. Boine-FrankenheimM. J. BolandS. BolognaO. BolukbasiM. BombenS. BondarenkoM. BonviniE. BoosB. BordiniF. BordryG. BorghelloL. BorgonoviS. BorowkaD. 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ChattopadhyayR. ChehabS. V. ChekanovN. ChenA. ChernodedV. ChetvertkovaL. ChevalierG. ChiarelliG. ChiarelloM. ChiesaP. ChiggiatoJ. T. ChildersA. ChmielińskaA. CholakianP. ChomazM. ChorowskiW. ChouM. ChrzaszczE. ChyhyrynetsG. CibinettoA. K. CiftciR. CiftciR. CiminoM. CiuchiniP. J. ClarkY. CoadouM. CobalA. CoccaroJ. CoganE. CognerasF. CollamatiC. ColldelramP. CollierJ. CollotR. ContinoF. ConventiC. T. A. CookL. CooleyG. CorcellaA. S. CornellG. H. CorralH. Correia-RodriguesF. CostanzaP. Costa PintoF. CoudercJ. CoupardN. CraigI. Crespo GarridoA. CrivellinJ. F. CroteauM. CrouchE. Cruz AlanizB. CuréJ. CurtiD. CurtinM. CzechC. DachauerR. T. D’AgnoloM. DaiboA. DaineseB. DalenaA. DaljevecW. DallapiazzaL. D’Aloia SchwartzentruberM. DamG. D’AmbrosioS. P. DasS. DasBakshiW. da SilvaG. G. da SilveiraV. D’AuriaS. D’AuriaA. DavidT. DavidekA. DeandreaJ. de BlasC. J. DebonoS. De CurtisN. De FilippisD. de FlorianS. DeghayeS. J. de JongC. Del BoV. Del DucaD. DelikarisF. DeliotA. Dell’AcquaL. Delle RoseM. DelmastroE. De LuciaM. DemarteauD. DenegriL. DeniauD. DenisovH. DenizliA. DennerD. d’EnterriaG. de RijkA. De RoeckF. DerueO. DeschampsS. Descotes-GenonP. S. B. DevJ. B. de Vivie de RégieR. K. DewanjeeA. Di CiaccioA. Di CiccoB. M. DillonB. Di MiccoP. Di NezzaS. Di VitaA. DoblhammerA. DominjonM. D’OnofrioF. DordeiA. DragoP. DraperZ. DrasalM. DrewesL. DuarteI. DubovykP. DudaA. DudarevL. DudkoD. DuellmannM. DünserT. du PreeM. DuranteH. Duran YildizS. DuttaF. DuvalJ. M. DuvalY. DydyshkaB. DziewitS. EisenhardtM. EistererT. EkelofD. El KhechenS. A. EllisJ. EllisJ. A. EllisonK. ElsenerM. ElsingY. EnariC. EnglertH. ErikssonK. J. EskolaL. S. EspositoO. EtiskenE. EtzionP. FabbricatoreA. FalkowskiA. FalouJ. FaltovaJ. FanL. FanòA. FarillaR. FarinelliS. FarinonD. A. FaroughyS. D. FartoukhA. Faus-GolfeW. J. FawcettG. FeliciL. FelsbergerC. FerdeghiniA. M. Fernandez NavarroA. Fernández-TéllezJ. Ferradas TroitinoG. FerraraR. FerrariL. FerreiraP. Ferreira da SilvaG. FerreraF. FerroM. FiascarisS. 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GuiducciG. Guillermo CantonY. O. GünaydinR. GuptaR. S. GuptaJ. GutierrezJ. GutleberC. GuyotV. GuzeyC. GwenlanC. HaberstrohB. HacışahinoğluB. HaererK. HahnT. HahnA. HammadC. HanM. HanceA. HannahP. C. HarrisC. HatiS. HaugJ. HauptmanV. HaurylavetsH. -J. HeA. HegglinB. HegnerK. HeinemannS. HeinemeyerC. HelsensA. HenriquesA. HenriquesP. HernandezR. J. Hernández-PintoJ. Hernandez-SanchezT. HerzigI. HiekkanenW. HillertT. HoehnM. HoferW. HöfleF. HoldenerS. HolleisB. HolzerD. K. HongC. G. HonoratoS. C. HopkinsJ. HrdinkaF. HugB. HumannH. HumerT. HurthA. HuttonG. IacobucciN. IbarrolaL. Iconomidou-FayardK. Ilyina-BrunnerJ. IncandelaA. InfantinoV. IppolitoM. IshinoR. IslamH. ItaA. IvanovsS. IwamotoA. IyerS. Izquierdo BermudezS. JadachD. O. JaminP. JanotP. JarryA. JeffP. JennyE. JensenM. JensenX. JiangJ. M. JiménezM. A. JonesO. R. JonesJ. M. JowettS. JungW. KaabiM. KadoK. KahleL. KalinovskayaJ. KalinowskiJ. F. KamenikK. KannikeS. O. KaraH. KaradenizV. KaraventzasI. KarpovS. KartalA. KaryukhinV. 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LehtinenS. B. LeithP. LenziE. LeograndeC. LeonidopoulosI. Leon-MonzonG. LernerO. LeroyT. LesiakP. LévaiA. LeverattoE. LevichevG. LiS. LiR. LiD. LiberatiM. LiepeD. A. LissauerZ. LiuA. LobkoE. LocciE. Logothetis AgaliotisM. P. LombardoA. J. LongC. LorinR. LositoA. LouzguitiI. LowD. LucchesiM. T. LucchiniA. LucianiM. LueckhofA. J. G. LuntM. LuzumD. A. LyubimtsevM. MaggioraN. MagninM. A. MahmoudF. MahmoudiJ. MaitreV. MakarenkoA. MalagoliJ. MalclésL. MalgeriP. J. MallonF. MaltoniS. MalvezziO. B. MalyshevG. MancinelliP. MandrikP. ManfrinettiM. ManganoP. ManilM. MannelliG. MarchioriF. MarhauserV. MarianiV. MarinozziS. MariottoP. MarquardC. MarquetT. Marriott-DodingtonR. MartinO. MartinJ. Martin CamalichT. MartinezH. Martinez BruzualM. I. Martínez-HernándezD. E. MartinsS. MarzaniD. MarzoccaL. MarzolaS. MasciocchiI. MasinaA. MassimilianoA. MassironiT. MasubuchiV. A. MatveevM. A. MazzoniM. McCulloughP. A. McIntoshP. MeadeL. MedinaA. MeierJ. MeignanB. MeleJ. G. Mendes SaraivaF. MenezM. MentinkE. 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OsborneP. OslandT. OttoK. Y. OyulmazA. OzansoyV. ÖzcanK. ÖzdemirC. E. PagliaroneH. F. Pais da SilvaE. PalmieriL. PalumboA. PampaloniR. -Q. PanM. PanareoO. PanellaG. PanicoG. PanizzoA. A. PankovV. PantsyrnyC. G. PapadopoulosA. PapaefstathiouY. PapaphilippouM. A. ParkerV. ParmaM. PasqualiS. K. PatraR. PattersonH. PaukkunenF. PaussS. PeggsJ. -P. PenttinenG. PeónE. E. PerepelkinE. PerezJ. C. PerezG. PerezF. PérezE. Perez CodinaJ. Perez MoralesM. PerfilovH. PerneggerM. PeruzziC. PesK. PetersS. PetraccaF. PetrielloL. PezzottiS. PfeifferF. PiccininiT. PieloniM. PieriniH. PikhartovaG. PikursE. PilicerP. PiminovC. PiraR. PittauW. PłaczekM. PlaggeT. PlehnM. -A. PleierM. PłoskońM. PodeurH. PodlechT. PodzornyL. PoggioliA. PoironG. PoleselloM. Poli LenerA. PoliniJ. PolinskiS. M. PolozovL. PonceM. PontL. PontecorvoT. PortaluriK. PotamianosC. PrasseM. PrausaA. PreinerstorferE. PrematT. PriceM. PrimaveraF. PrinoM. PrioliJ. ProudfootA. ProvinoT. PugnatN. PukhaevaS. PuławskiD. PulikowskiG. PunziM. PuttiA. PyarelalH. QuackM. QuispeA. RacioppiH. RafiqueV. RaginelM. RaidalN. S. Ramírez-UribeM. J. Ramsey-MusolfR. RataP. RatoffF. RavottiP. Rebello TelesM. ReboudS. RedaelliE. RennerA. E. Rentería-OlivoM. RescignoJ. ReuterA. RibonA. M. RicciW. RieglerS. RiemannB. RiemannT. RiemannJ. M. RiffletR. A. RimmerR. RinaldesiL. RinolfiO. Rios RubirasT. RisseladaA. RivettiL. RivkinT. RizzoT. RobensF. RobertA. J. RobsonE. RochepaultC. RodaG. RodrigoM. Rodríguez-CahuantziC. RoganM. RoigS. Rojas-TorresJ. RojoG. RolandiG. RolandoP. RoloffA. RomanenkoA. RomanovF. RoncaroloA. Rosado SanchezG. RosazL. RossiA. RossiR. RossmanithB. RoussetC. RoyonX. RuanI. RuehlV. Ruhlmann-KleiderR. RuizL. RumyantsevR. RuprechtA. I. RyazanovA. SabaR. SadykovD. Saez de JaureguiM. SahinB. SailerM. SaitoF. SalaG. P. SalamJ. Salfeld-NebgenC. A. SalgadoS. SaliniJ. M. SalleseT. SalmiA. SalzburgerO. A. SampayoS. SanfilippoJ. SantiagoE. SantopintoR. SantoroA. Sanz UllX. SarasolaI. H. SarpünM. SauvainS. SavelyevaR. SawadaG. F. R. SborliniA. SchafferM. SchaumannM. SchenkC. ScheuerleinI. SchienbeinK. SchlengaH. SchmicklerR. SchmidtD. SchoerlingA. SchoningT. Schörner-SadeniusM. SchottD. SchulteP. SchwallerC. SchwanenbergerP. SchwemlingN. SchwergL. ScibileA. SciutoE. ScomparinC. SebastianiB. SeeberM. SegretiP. SelvaM. SelvaggiC. SenatoreA. SenolL. SerinM. SerlucaN. SerraA. SeryiL. SestiniA. SfyrlaM. ShaposhnikovE. ShaposhnikovaB. Y. SharkovD. ShatilovJ. SheltonV. ShiltsevI. P. ShipseyG. D. ShirkovA. ShivajiD. ShwartzT. SianS. SidorovA. SiemkoL. SilvestriniN. SimandF. SimonB. K. SinghA. SiódmokY. SiroisE. SirtoriR. SirvinskaiteB. SitarT. SjöstrandP. SkandsE. SkordisK. SkovpenM. SkrzypekE. SladeP. SlavichR. SlovakV. SmalukV. SmirnovW. SnoeysL. SoffiP. SollanderO. SolovyanovH. K. SoltveitH. SongP. SopickiM. SorbiL. SpallinoM. SpannowskyB. SpataroP. SphicasH. SpiesbergerP. SpillerM. SpiraT. SrivastavaJ. StachelA. StakiaJ. L. StanyardE. StarchenkoA. Y. StarikovA. M. StaśtoM. StateraR. SteerenbergJ. SteggemannA. StenvallF. StivanelloD. StöckingerL. S. StoelM. Stöger-PollachB. StraussM. StuartG. StupakovS. SuA. SubletK. SugitaL. SulakM. K. SullivanS. SultansoyT. SumidaK. SuzukiG. SylvaM. J. SyphersA. SznajderM. TaborelliN. A. TahirM. TakeuchiE. Tal HodC. TambascoJ. TanakaK. TangI. TapanS. TaroniG. F. TartarelliG. TassielliL. TavianT. M. TaylorG. N. TaylorA. M. TeixeiraG. Tejeda-MuñozV. I. TelnovR. TenchiniH. H. J. ten KateK. TerashiA. TesiM. TestaC. TetrelD. TeytelmanJ. ThalerA. ThammS. ThomasM. T. TiirakariV. TikhomirovD. TikhonovH. TimkoV. TisserandL. M. TkachenkoJ. TkaczukJ. P. TockB. ToddE. TodescoR. Tomás GarciaD. TommasiniG. TonelliF. ToralT. TorimsR. TorreZ. TownsendR. TrantD. TreilleL. TrentadueA. TricoliA. TricomiW. TrischukI. S. TropinB. TuchmingA. A. TudoraB. TurbiarzI. Turk CakirM. TurriT. TydecksJ. UsovitschJ. UythovenR. VaglioA. ValassiF. ValchkovaM. A. Valdivia GarciaP. ValenteR. U. ValenteA. -M. Valente-FelicianoG. ValentinoL. Vale SilvaJ. M. ValetR. ValizadehJ. W. F. ValleS. VallecorsaG. ValloneM. van LeeuwenU. H. van RienenL. van Riesen-HauptM. VarastehL. VecchiP. VedrineG. VelevR. VenessA. VenturaW. Venturini DelsolaroM. VerducciC. B. VerhaarenC. VernieriA. P. VerweijO. VerwilligenO. ViazloA. ViciniG. ViehhauserN. VignaroliM. VignoloA. VitranoI. VivarelliS. VlachosM. VogelD. M. VogtV. VölklP. VolkovG. VolpiniJ. von AhnenG. VorotnikovG. G. VoutsinasV. VysotskyU. WagnerR. WallnyL. -T. WangR. WangK. WangB. F. L. WardT. P. WatsonN. K. WatsonZ. WsC. WeilandS. WeinzierlC. P. WelschJ. WenningerM. WidorskiU. A. WiedemannH. -U. WienandsG. WilkinsonP. H. WilliamsA. WinterA. WohlfahrtT. WojtońD. WollmannJ. WomersleyD. WoogX. WuA. WulzerM. K. YanehsariG. YangH. J. YangW. -M. YaoE. YazganV. YermolchikA. YilmazA. YilmazH. -D. YooS. A. YostT. YouC. YoungT. -T. YuF. YuA. ZaborowskaS. G. ZadehM. ZahndM. ZanettiL. ZanottoL. ZawiejskiP. ZeilerM. ZerlauthS. M. ZernovG. Zevi Dell PortaZ. ZhangY. ZhangC. ZhangH. ZhangZ. ZhaoY. -M. ZhongJ. ZhouD. ZhouP. ZhuangG. ZickF. ZimmermannEmail authorJ. Zinn-JustinL. ZivkovicA. V. ZlobinM. ZobovJ. ZupanJ. Zuritathe FCC Collaboration, In response to the 2013 Update of the European Strategy for Particle Physics (EPPSU), the Future Circular Collider (FCC) study was launched as a world-wide international collaboration hosted by CERN. The FCC study covered an energy-frontier hadron collider (FCC-hh), a highest-luminosity high-energy lepton collider (FCC-ee), the corresponding 100km tunnel infrastructure, as well as the physics opportunities of these two colliders, and a high-energy LHC, based on FCC-hh technology. This document constitutes the fourth volume of the FCC Conceptual Design Report, devoted to the High-Energy Large Hadron Collider HE-LHC. It summarizes the HE-LHC physics discovery opportunities, presents the HE-LHC accelerator design, performance reach, and operation plan, discusses the underlying technologies, the civil engineering and technical infrastructure, and also sketches a possible implementation. Combining ingredients from the Large Hadron Collider (LHC), the high-luminosity LHC upgrade and adding novel technologies and approaches, the HE-LHC design aims at a hadron collider with about twice the centre-of-mass collision energy that the LHC can reach. Its performance aims at exploring physics beyond the Standard Model, signi cantly extending the LHC's direct and indirect sensitivity to new physics and discoveries.
Published: 2020

39. Resistive wall impedance in elliptical multilayer vacuum chambers

Author: Luigi Palumbo, Vittorio Vaccaro, Carlo Zannini, Mauro Migliorati, and Nicolo Biancacci
Subjects: Physics, Nuclear and High Energy Physics, Resistive touchscreen, Physics and Astronomy (miscellaneous), 010308 nuclear & particles physics, Point particle, Particle accelerators, electromagnetic fields, coupling impedance, Surfaces and Interfaces, Mechanics, 01 natural sciences, Accelerators and Storage Rings, symbols.namesake, Mathieu function, Transmission line, 0103 physical sciences, symbols, Equivalent circuit, Physics::Accelerator Physics, lcsh:QC770-798, Vacuum chamber, lcsh:Nuclear and particle physics. Atomic energy. Radioactivity, 010306 general physics, Electrical impedance, Beam (structure)
Abstract: The resistive wall impedance of a vacuum chamber with elliptic cross section is of particular interest for circular particle accelerators as well as for undulators in free electron lasers. By using the electric field of a point charge and of a small dipole moving at arbitrary speed in an elliptical vacuum chamber, expressed in terms of Mathieu functions, in this paper we take into account the finite conductivity of the beam pipe walls by means of the surface impedance, and evaluate the longitudinal and transverse driving and detuning impedances for any beam velocity. We also extend the definition of the Yokoya form factors, valid in the thick wall regime, at any beam energy, and show that, in the ultra-relativistic limit, they coincide with the ones that are found in literature. The method is also extended to the multilayer vacuum chamber case. Under conditions generally satisfied with particle accelerator beam pipes, the classical transmission line theory can be used to modelling the impedance seen by a bunch in a vacuum chamber with several layers as an equivalent circuit with the same number of load impedances, giving, as result, a surface impedance that can be used in combination with the fields of the elliptic geometry to obtain the resistive wall impedance in an elliptical multilayer vacuum chamber. The results are also compared with a more time consuming 3D electromagnetic code and with solutions for known cases of circular and flat beam pipe.
Published: 2019

40. A gamma beam profile imager for ELI-NP Gamma Beam System

Author: Luigi Palumbo, M. Andreotti, E. Consoli, O. Adriani, P. Cardarelli, S. Squerzanti, Gianfranco Paternò, G. Passaleva, Alessia Tricomi, F. Evangelisti, Michele Marziani, A. Serban, G. Graziani, O. Starodubtsev, Gigi Cappello, G. Di Domenico, Sebastiano Albergo, M. Veltri, Mauro Gambaccini, Alessandro Variola, and R. Borgheresi
Subjects: Nuclear and High Energy Physics, Photon, Monte Carlo method, Scintillator, 01 natural sciences, NO, law.invention, 010309 optics, Optics, law, 0103 physical sciences, Gamma beam diagnostics, Instrumentation, Physics, 010308 nuclear & particles physics, business.industry, Inverse Compton, Monochromatic radiation, X and gamma sources, Imager, Detector, Compton scattering, Laser, Cathode ray, Physics::Accelerator Physics, Monochromatic color, business
Abstract: The Gamma Beam System of ELI-Nuclear Physics is a high brilliance monochromatic gamma source based on the inverse Compton interaction between an intense high power laser and a bright electron beam with tunable energy. The source, currently being assembled in Magurele (Romania), is designed to provide a beam with tunable average energy ranging from 0.2 to 19.5 MeV, rms energy bandwidth down to 0.5 % and flux of about 1 0 8 photons/s. The system includes a set of detectors for the diagnostic and complete characterization of the gamma beam. To evaluate the spatial distribution of the beam a gamma beam profile imager is required. For this purpose, a detector based on a scintillator target coupled to a CCD camera was designed and a prototype was tested at INFN-Ferrara laboratories. A set of analytical calculations and Monte Carlo simulations were carried out to optimize the imager design and evaluate the performance expected with ELI-NP gamma beam. In this work the design of the imager is described in detail, as well as the simulation tools used and the results obtained. The simulation parameters were tuned and cross-checked with the experimental measurements carried out on the assembled prototype using the beam from an x-ray tube.
Published: 2018

41. Optical transition radiation screens: A numerical procedure to choose the most performing material

Author: D. Alesini, Massimo Ciambrella, Alessandro Variola, Luigi Palumbo, Valerio Pettinacci, Marco Marongiu, Andrea Mostacci, Fara Cioeta, D. Cortis, and V. Lollo
Subjects: Physics, Nuclear and High Energy Physics, Field (physics), Matter-radiation interaction, Finite element analysis, Mechanical engineering, Particle accelerator, Optical transition radiation screen, Electron, Radiation, ANSYS ®APDL, law.invention, Gamma beam source, Bunches, Material selection, law, Thermal, Instrumentation, Beam (structure)
Abstract: In the field of diagnostics applied to particle accelerators, and more specifically when it comes to linear electron accelerators, OTR screens represent one of the most widespread and used techniques for beam monitoring. These devices must be able to withstand the thermal stress that the several bunches induce by hitting the surface at high frequency, without compromising the optical performance following the possible induced deformations. This paper presents a complete methodology to predict the behaviour of the OTR screens – thermal, mechanical and optical – for a given beam and screen material with the aim to define guidelines for the optimal target material selection.
Published: 2021

42. Electromagnetic characterization of the crystal primary collimators for the HL-LHC

Author: Stefano Redaelli, I. Lamas Garcia, D. Quartullo, Luigi Palumbo, Nicolo Biancacci, L. Teofili, B. Salvant, Pasquale Arpaia, Andrea Mostacci, Mauro Migliorati, and F. Giordano
Subjects: Nuclear and High Energy Physics, Physics::Instrumentation and Detectors, Context (language use), 01 natural sciences, Collimated light, law.invention, Optics, law, 0103 physical sciences, lhc, 010306 general physics, Collider, Instrumentation, Electrical impedance, Physics, Large Hadron Collider, 010308 nuclear & particles physics, business.industry, Collimator, Upgrade, electromagnetic simulations, beam-coupling impedance, Physics::Accelerator Physics, business, Beam (structure)
Abstract: The crystal-based primary collimators installed in the Large Hadron Collider (LHC) at CERN use the channelling process in bent crystals to steer halo particles efficiently onto downstream collimators. This scheme, called crystal collimation , is also considered for applications of fixed-target implementations in the context of the Physics Beyond Collider at the LHC. Crystal collimation uses 4 mm-long silicon crystals that need to be approached very close to the high-intensity circulating beams, posing obvious concerns for machine impedance. A complex mechanical assembly was developed for this purpose. The setup includes also a system to control with sub- μ rad accuracy the angular orientation of the crystal, which is done with a high-precision interferometric system. In order to prevent possible beam-induced instabilities and/or damage of the device components from excessive RF-heating, the electromagnetic (EM) characterization of this device is essential prior to its usage with high-intensity beams. In this article, the longitudinal impedance of the crystal primary collimator is studied extensively and estimations of power loss inside the device are provided for the different beam types planned at the LHC and at its High-Luminosity upgrade (HL-LHC). Electromagnetic simulations are performed on a realistic model that includes all the relevant components. The model is described in detail and computational challenges coming from its complexity are discussed. Care is taken to characterize the materials of each relevant sub-component. In particular, the lossy properties of silicon, whose complex permittivity is also evaluated through RF rectangular-cavity perturbation measurements, are taken into account. Numerical results are then compared with dedicated RF measurements performed on a prototype built for the LHC.
Published: 2021

43. Thermal behavior of the optical transition radiation screens for the ELI-NP Compton Gamma source

Author: D. Alesini, Massimo Ciambrella, V. Lollo, Alessandro Variola, Luigi Palumbo, Fara Cioeta, Alessandro Cianchi, Valerio Pettinacci, Luigi Pellegrino, Enrica Chiadroni, Cristina Vaccarezza, Anna Giribono, Marco Marongiu, and Andrea Mostacci
Subjects: Nuclear and High Energy Physics, Brightness, Compton Gamma Source, Optical Transition Radiation, Thermal Issue, 02 engineering and technology, Compton Gamma Source, Radiation, 01 natural sciences, Optics, 0103 physical sciences, Thermal, Instrumentation, Physics, Luminosity (scattering theory), Interaction point, 010308 nuclear & particles physics, business.industry, Thermal Issue, Settore FIS/01 - Fisica Sperimentale, 021001 nanoscience & nanotechnology, Optical Transition Radiation, Settore FIS/07 - Fisica Applicata(Beni Culturali, Ambientali, Biol.e Medicin), Bunches, Physics::Accelerator Physics, Optical radiation, 0210 nano-technology, business, Beam (structure)
Abstract: A high brightness electron Linac is being built in the Compton Gamma Source at the ELI Nuclear Physics facility in Romania. To achieve the design luminosity, a train of 32, 16 ns spaced, bunches with a nominal charge of 250 pC will collide with the laser beam in the interaction point. Electron beam spot size is measured with optical transition radiation profile monitors. In order to measure the beam properties along the train, the screens must sustain the thermal stress due to the energy deposited by the bunches; moreover, the optical radiation detecting system must have the necessary accuracy and resolution. This paper deals with the analytical studies as well as numerical simulations to investigate the thermal behavior of the screens impinged by the nominal bunch; the design and the performance of the optical detection line is discussed as well. In particular with the numerical simulations the behavior of the aluminum and silicon under thermal stress can be studied. The simulations allow us to see how the heat spreads on the OTR screen and frame, and what are their deformations during the heating.
Published: 2017

44. A collimation system for ELI-NP Gamma Beam System – design and simulation of performance

Author: P. Cardarelli, Luigi Palumbo, Alessandro Variola, Cristina Vaccarezza, Vittoria Petrillo, M. Andreotti, Mauro Gambaccini, F. Evangelisti, Gianfranco Paternò, Michele Marziani, Enrico Bagli, Alberto Bacci, and Illya Drebot
Subjects: Nuclear and High Energy Physics, Astrophysics::High Energy Astrophysical Phenomena, Inverse, Radiation, 01 natural sciences, Collimated light, NO, 030218 nuclear medicine & medical imaging, law.invention, 03 medical and health sciences, 0302 clinical medicine, Optics, law, Collimator, 0103 physical sciences, Instrumentation, Inverse Compton, Monochromatic radiation, X-ray and gamma sources, 010302 applied physics, Physics, business.industry, Bandwidth (signal processing), Compton scattering, Beam system, Beamline, Physics::Accelerator Physics, business
Abstract: The purpose of this study was to evaluate the performance and refine the design of the collimation system for the gamma radiation source (GBS) currently being realised at ELI-NP facility. The gamma beam, produced by inverse Compton scattering, will provide a tunable average energy in the range between 0.2 and 20 MeV, an energy bandwidth 0.5% and a flux of about 108 photons/s. As a result of the inverse Compton interaction, the energy of the emitted radiation is related to the emission angle, it is maximum in the backscattering direction and decreases as the angle increase [1] , [2] . Therefore, the required energy bandwidth can be obtained only by developing a specific collimation system of the gamma beam, i.e. filtering out the radiation emitted at larger angles. The angular acceptance of the collimation for ELI-NP-GBS must be continuously adjustable in a range from about 700 to 60 μrad, to obtain the required parameters in the entire energy range. The solution identified is a stack of adjustable slits, arranged with a relative rotation around the beam axis to obtain an hole with an approximately circular shape. In this contribution, the final collimation design and its performance evaluated by carrying out a series of detailed Geant4 simulations both of the high-energy and the low-energy beamline are presented.
Published: 2017

45. New Analytical Derivation of Group Velocity in TW Accelerating Structures

Author: Bruno Spataro, Mauro Migliorati, Luigi Palumbo, Luigi Faillace, and Mostafa Behtouei
Subjects: Physics, History, longitudinal space phase, MC5: Beam Dynamics and EM Fields, Polarization (waves), Ka band accelerating structure, Computer Science Applications, Education, Accelerator Physics, Dipole, Quantum electrodynamics, high gradient accelerating structures, traveling wave, group velocity, longitudinal space phase, Ka band accelerating structure, Group velocity, Physics::Accelerator Physics, high gradient accelerating structures, traveling wave, group velocity
Abstract: Ultra high-gradient accelerating structures are needed for the next generation of compact light sources. In the framework of the Compact Light XLS project, we are studying a high harmonic traveling-wave accelerating structure operating at a frequency of 35.982 GHz, in order to linearize the longitudinal space phase. In this paper, we propose a new analytical approach for the estimation of the group velocity in the structure and we compare it with numerical electromagnetic simulations that are carried out by using the code HFSS in the frequency domain., Proceedings of the 10th Int. Particle Accelerator Conf., IPAC2019, Melbourne, Australia
Published: 2019
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46. Dual energy computed tomography evaluation of skeletal traumas

Author: Igino Simonetti, Francesco Verde, Francesco Di Pietto, Mariano Scaglione, Marta Puglia, Luigi Palumbo, Stefania Romano, and Alfonso Ragozzino
Subjects: medicine.medical_specialty, Appendicular skeleton, medicine.medical_treatment, 030218 nuclear medicine & medical imaging, Radiography, Dual-Energy Scanned Projection, 03 medical and health sciences, Metal Artifact, 0302 clinical medicine, medicine, Edema, Humans, Radiology, Nuclear Medicine and imaging, Bone Marrow Diseases, Reduction (orthopedic surgery), medicine.diagnostic_test, business.industry, Soft tissue, Magnetic resonance imaging, Dual-Energy Computed Tomography, General Medicine, Magnetic Resonance Imaging, Intervertebral disk, medicine.anatomical_structure, 030220 oncology & carcinogenesis, Ligament, Radiology, Tomography, X-Ray Computed, business, Algorithms
Abstract: Skeletal traumas are among the most common routine challenges faced by Emergency Radiologists, in particular in case of radiographically occult nondisplaced fractures or in case of soft tissue injuries. With the development of Dual Energy Computed Tomography (DECT) technology, new post-processing applications have gained a useful diagnostic role in many fields of musculoskeletal imaging including acute skeletal trauma imaging. In addition to conventional CT images, DECT allows for the generation of virtual calcium-suppressed images subtracting calcium from unenhanced CT images based on the fact that material attenuation varies at different energy levels. In this way, virtual-non-calcium (VNC) images can precisely characterize traumatic bone marrow edema in both axial and appendicular skeleton, facilitating prompt clinical decision, especially when magnetic resonance method is contraindicated or unavailable. Other DECT emerging applications in the trauma setting include metal artifact reduction and collagen mapping for the evaluation of injuries affecting ligament, tendon, and intervertebral disk. This review focuses on the basic principles of DECT and related post-processing algorithms, highlighting the current advantages and limitations of these new imaging advances in the Emergency Department related to skeletal traumas.
Published: 2021

47. Design, realization and test of C-band accelerating structures for the SPARC_LAB linac energy upgrade

Author: R. Clementi, Alessandro Gallo, Luigi Palumbo, Luca Ficcadenti, M.E. Biagini, D. Alesini, R. Boni, Massimo Ferrario, R. Di Raddo, T. Schilcher, P. Chimenti, Marco Bellaveglia, M. Brönnimann, V. Lollo, G. Di Pirro, Fabio Cardelli, Luca Piersanti, and Roger Kalt
Subjects: Physics, Nuclear and High Energy Physics, 010308 nuclear & particles physics, C band, business.industry, Free-electron laser, Constant impedance, Tuning, 01 natural sciences, Linear particle accelerator, Pulse (physics), Breakdown rate, High gradient, Upgrade, Optics, Rf breakdown, 0103 physical sciences, C-band, Instrumentation, 010306 general physics, business, Realization (systems), Energy (signal processing), Beam (structure)
Abstract: The energy upgrade of the SPARC_LAB photo-injector at LNF-INFN (Frascati, Italy) has been originally conceived replacing one low gradient (13 MV/m) 3 m long SLAC type S-band traveling wave (TW) section with two 1.4 m long C-band accelerating sections. Due to the higher gradients reached by such structures, a higher energy beam can be obtained within the same accelerator footprint length. The use of C-band structures for electron acceleration has been adopted in a few FEL linacs in the world, among others, the Japanese Free Electron Laser at SPring-8 and the SwissFEL at Paul Scherrer Institute (PSI). The C-band sections are traveling wave, constant impedance structures with symmetric input and output axial couplers. Their design has been optimized for the operation with a SLED RF pulse compressor. In this paper we briefly review their design criteria and we focus on the construction, tuning, low and high-power RF tests. We also illustrate the design and realization of the dedicated low level RF system that has been done in collaboration with PSI in the framework of the EU TIARA project. Preliminary experimental results appear to confirm the operation of such structures with accelerating gradients larger than 35 MV/m.
Published: 2016

48. The concept of coupling impedance in the self-consistent plasma wake field excitation

Author: Renato Fedele, Alberto Marocchino, T. Akhter, Luigi Palumbo, S. De Nicola, Mauro Migliorati, F. Massimo, Fedele, Renato, Akhter, Tahmina, De Nicola, S., Migliorati, M., Marocchino, A., Massimo, F., and Palumbo, L.
Subjects: Plasma wake field excitation, Physics, Coupling, Nuclear and High Energy Physics, Coupling impedance, 010308 nuclear & particles physics, Plasma wake field excitations, Stability analysis, Plasma, System of linear equations, 01 natural sciences, Stability (probability), Acceleration, Classical mechanics, Quantum electrodynamics, 0103 physical sciences, Vlasov–Maxell system of equation, Physics::Accelerator Physics, Coupling impedance, Plasma wake field excitations, Stability analysis, Vlasov-Maxell system of equations, Instrumentation, Nuclear and High Energy Physics, 010306 general physics, Vlasov-Maxell system of equations, Instrumentation, Electrical impedance, Excitation, Beam (structure)
Abstract: Within the framework of the Vlasov–Maxwell system of equations, we describe the self-consistent interaction of a relativistic charged-particle beam with the surroundings while propagating through a plasma-based acceleration device. This is done in terms of the concept of coupling (longitudinal) impedance in full analogy with the conventional accelerators. It is shown that also here the coupling impedance is a very useful tool for the Nyquist-type stability analysis. Examples of specific physical situations are finally illustrated.
Published: 2016

49. Mental Fitness for patients with acute coronary syndrome: A randomized clinical trial

Author: Erika Cavallero, Bruno G. Bara, Luigi Palumbo, Serena Bergerone, Fiorenzo Gaita, Daniela Rabellino, Claudia Bianchino, and Claudia Chiavarino
Subjects: Male, Health Knowledge, Attitudes, Practice, medicine.medical_specialty, media_common.quotation_subject, Psychological intervention, Physical exercise, 030204 cardiovascular system & hematology, law.invention, 03 medical and health sciences, 0302 clinical medicine, Quality of life (healthcare), Patient Education as Topic, Randomized controlled trial, law, Intervention (counseling), Adaptation, Psychological, Humans, Medicine, Single-Blind Method, Prospective Studies, 030212 general & internal medicine, Acute Coronary Syndrome, Exercise, Applied Psychology, Depression (differential diagnoses), media_common, business.industry, Standard treatment, General Medicine, Awareness, Middle Aged, Treatment Outcome, Feeling, Quality of Life, Physical therapy, Female, business, Follow-Up Studies, Clinical psychology
Abstract: Objectives The aim of this study was to verify the efficacy of a manualized, cognitively oriented psychological intervention, called Mental Fitness, in improving the mental and physical health of patients with acute coronary syndrome (ACS). Mental Fitness is a small-group four-session treatment aimed at increasing awareness of one's own bodily perceptions, emotions, and thoughts and is overall tailored on participants' perception of control over their health. Design Prospective randomized controlled single-blind trial. Methods Patients with ACS were recruited within a week from their acute cardiac event. Patients in the intervention group underwent one of two variants of Mental Fitness, depending on their perceived (internal or external) control over their health. Patients in the control group underwent standard treatment. All the patients were submitted to a clinical and psychological follow-up for 8 months. Results The patients who underwent the Mental Fitness intervention (N = 31) showed, compared to the control patients (N = 34), increased quality of life in its physical, psychological, social and environmental domains, more functional emotional and problem-centred coping strategies, and higher emotional awareness. They also showed improved high-density lipoprotein cholesterol, triglycerides, heart rate, and left ventricular ejection fraction compared to the controls. In addition, they were more successful in maintaining physical exercise. Conclusions This study demonstrates the efficacy of Mental Fitness in modifying specific psychological and physical variables conditioning cardiological patients' prognosis. It also confirms the importance of differentiating psychological interventions based on the psychological characteristics of the patients. Statement of contribution What is already known on this subject? Traditional symptom-based interventions in heart disease are aimed at diagnosing and reducing psychological symptomatology (e.g., depression), but recent work has shown the usefulness of orienting psychological interventions to patients' representations of themselves and of the world and to how such representations influence their thoughts, feelings, and behaviours (e.g., Chiavarino et al., 2012). What does this study add? Mental Fitness, by working on awareness of bodily perceptions, emotions, and thoughts, leads to positive changes in physical and psychological health. Mental Fitness is a cost-effective psychological intervention that adds significantly to the effectiveness of standard medical care.
Published: 2016

50. Design, realization, and high power test of high gradient, high repetition rate brazing-free S-band photogun

Author: Luigi Palumbo, Alessandro Gallo, Alessandro Variola, Marco Bellaveglia, Valerio Pettinacci, V. Lollo, Antonio Battisti, Dennis Palmer, Luigi Pellegrino, Antonio Falone, Fabio Cardelli, Stefano Pioli, Luca Piersanti, and David Alesini
Subjects: Physics, Nuclear and High Energy Physics, Physics and Astronomy (miscellaneous), 010308 nuclear & particles physics, business.industry, Particle accelerator, Solenoid, Surfaces and Interfaces, Electron, Type (model theory), 01 natural sciences, Cathode, law.invention, Radio frequency, Room temperature, RF Accelerators & Beams, Optics, law, 0103 physical sciences, Physics::Accelerator Physics, lcsh:QC770-798, Thermal emittance, lcsh:Nuclear and particle physics. Atomic energy. Radioactivity, 010306 general physics, business, Realization (systems), Electron gun
Abstract: rf photoguns find several types of applications as high brightness electron sources for free-electron lasers, energy recovery linacs, Compton and Thomson sources, and high-energy linear colliders. The high peak current and low transverse emittance of the generated beam are obtained with the combination of a high peak electric field ($g100\text{ }\text{ }\mathrm{MV}/\mathrm{m}$) at the cathode surface, a proper choice of the solenoid field around, or immediately after, the gun, and special fabrication and treatments of the cathode itself. On the other hand, to increase the average electron current, a high repetition rate ($g100\text{ }\text{ }\mathrm{Hz}$) and/or a multibunch rf gun have to be developed. These types of devices are, in general, fabricated by brazing processes of copper machined parts. The brazing processes require a large vacuum furnace, are very expensive, and pose a not negligible risk of failure. A new fabrication technique for this type of structure has been recently developed and implemented at the Laboratories of Frascati of the National Institute of Nuclear Physics (INFN-LNF, Italy) and already applied to an rf gun now operating at a relatively low cathode peak field and low repetition rate [D. Alesini et al., Phys. Rev. Accel. Beams 18, 092001 (2015)]. It is based on the use of special rf-vacuum gaskets that allow a brazing-free realization process. The $S$-band gun of the Extreme Light Infrastructure-Nuclear Physics Gamma Beam System, under construction in Magurele (Bucharest, Romania), has been realized with this new technique and represents a further and fundamental step toward the consolidation of this technology for high gradient particle accelerator fabrication. It operates at 100 Hz with a $120\text{ }\text{ }\mathrm{MV}/\mathrm{m}$ cathode peak field and $1.5\text{\ensuremath{-}}\ensuremath{\mu}\mathrm{s}$-long rf pulses to house the 32 bunches necessary to reach the target gamma flux. High gradient tests, performed at full power and a full repetition rate, have shown the extremely good performances of the structure in terms of the breakdown rate and conditioning time and definitively demonstrated the reliability and suitability of such fabrication process for high gradient structure realization. In this paper, we report and discuss the electromagnetic and thermomechanical design, the realization process, and all the experimental results at low and high power at a full repetition rate.
Published: 2018

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