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Background Primary pulmonary malignant melanoma (PPMM) is an extreme rarity in clinic practice, accounting for only 0.01% of all primary pulmonary tumors. And its diagnosis should meet clinical and pathological diagnosis criteria in addition to excluding the possibility of metastatic melanoma. The mainstay of treatment is surgery. The concurrence of primary pulmonary malignant melanoma and invasive pulmonary adenocarcinoma has not been reported before. Case presentation Herein we report the case of a 39-year-old woman who was asymptomatic and accidently found to have the concurrence of PPMM with invasive pulmonary adenocarcinoma. Before considering the diagnosis of primary pulmonary malignant melanoma, a systemic positron emission tomography-computed tomography (PET-CT) was done to excluding primary tumor metastasis from other sites. The pathological biopsy proved that two lesions in the right middle lobe were invasive pulmonary adenocarcinomas and the mass in the right lower lobe was malignant melanoma. She underwent right middle and lower lobectomy of the lung with mediastinal and hilar lymph dissection. She refused adjuvant chemotherapy, genetic molecular testing or immunotherapy. Fifteen months later she had brain metastasis. Then she received brain radiotherapy and underwent follow-up at the outpatient clinic regularly. Conclusions We experienced a case of concurrent PPMM and invasive pulmonary adenocarcinoma. The patient reported here is the first case of primary pulmonary malignant melanoma combined with invasive pulmonary adenocarcinoma. This patient remained disease-free 15 months after lung surgery.

Carbon cloth is regarded as a promising substrate for supercapacitors due to its good electrical conductivity, light weight and flexibility. However, its relatively hydrophobic property prevents the large-scale growth of active substances, restricting the potential practical applications. In this paper, by using NiCo LDH nanowall array as a hydrophilic substrate, a high mass-loading nanowall-supported-nanorod NiCo LDH arrays are formed via an alternate solvo/hydrothermal synthesis and subsequently alkali conversion process. The strong substrate adhesion of NiCo LDH nanoarrays ensures efficient electron transfer of the electrode. Moreover, the as-achieved open holey framework, integrated by free-standing nanorods and porous nanowalls, provides a hierarchical nanostructure for realizing the enhanced capacitive performance. Consequently, nanowall-supported-nanorod NiCo LDH electrode achieves a high capacitance of 7.73 F cm−2 at a current density of 5 mA cm−2 with excellent rate performance. When assembled into an all-solid-state hybrid supercapacitor, it delivers a maximum working voltage of 1.8 V, and an energy density of 0.46 mWh cm−2 (6.37 mWh cm−3) at a power density of 4.5 mW cm−2 (62.5 mW cm−2). Therefore, this work provides a proof-of-concept design for the high-performance supercapacitor electrode with carbon cloth substrate.

Highlights • The characteristics of 200 patients with COVID-19 in Yichang were analyzed. • COVID-19 was of clustering onset, and can cause severe respiratory disease and death. • The mortality of ICU patients confirmed with COVID-19 was considerably high. • The lymphocytes might be the main target of SARS-CoV-2 and this may be related to the severity and mortality of the disease. • The cytokine storm may be associated with the worsening of the disease., Background The recent outbreak of coronavirus disease 2019 (COVID-19) has spread worldwide, with especially severe epidemics occurring in cities across China. Objectives To report the epidemiological and clinical futures of the 200 patients infected with COVID-19 in Yichang, Hubei Province, China. Study design 200 patients confirmed with COVID-19 in a designated hospital in Yichang from Jan 30 to Feb 8, 2020 were investigated retrospectively. The epidemiological data and clinical characteristics were collected. The data between the ICU patients and non-ICU patients were compared. The patients were followed up till Feb 26, 2020. Results Of the 200 hospitalized patients with COVID-19, 98 (49.0%) were male, and the mean age was 55 years. Eighty-seven (43.5%) had no linkage to Wuhan or contact history. Familial clustering was found in 34 patients. Sixtyfive (32.5%) suffered from chronic diseases. The common symptoms included fever (171[85.5%]), cough (116[58.0%]), and fatigue (64[32%]). Most patients had lymphopenia. One hundred and seventy-two (86%) patients showed typical imaging findings of viral pneumonia. Most patients received antiviral, antibiotic, and corticosteroid treatment. Compared with the non-ICU patients, 29 (14.5%) patients in the ICU were older and more likely to show dyspnea and complications including ARDS. As of Feb 26, 15 (51.7%) patients in the ICU had died. Conclusions The COVID-19 infection was of clustering onset and can cause severe respiratory disease and even death. The mortality of ICU patients with COVID-19 was considerably high.