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1. mut-7 of C. elegans, required for transposon silencing and RNA interference is a homolog of Werner syndrome helicase and RNaseD

Author

Ketting, Rene F., Haverkamp, Thomas H.A., Luenen, Henri G.A.M.van, and Plasterk, Ronald H.A.

Subjects
Cytochemistry -- Research, Transposons -- Physiological aspects, Caenorhabditis elegans -- Physiological aspects, RNA -- Physiological aspects, Homology (Biology) -- Physiological aspects, Biological sciences
Abstract

A model in which MUT-7, guided by transposon-derived dsRNA, represses transposition by degrading transposon-specific messengers and prevents thereby transposase production and transposition, is proposed. It appears that NRAi may work by dsRNA-directed enzymatic RNA degradation. One Tc1 silenced strain of C. elegans has been has been mutagenized. Mutants in which Tc1 was activated in the germline were isolated.

Published
1999

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