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386 results on '"Luedde, Mark"'

7. Sublethal necroptosis signaling promotes inflammation and liver cancer

Author

Vucur, Mihael, Ghallab, Ahmed, Schneider, Anne T., Adili, Arlind, Cheng, Mingbo, Castoldi, Mirco, Singer, Michael T., Büttner, Veronika, Keysberg, Leonie S., Küsgens, Lena, Kohlhepp, Marlene, Görg, Boris, Gallage, Suchira, Barragan Avila, Jose Efren, Unger, Kristian, Kordes, Claus, Leblond, Anne-Laure, Albrecht, Wiebke, Loosen, Sven H., Lohr, Carolin, Jördens, Markus S., Babler, Anne, Hayat, Sikander, Schumacher, David, Koenen, Maria T., Govaere, Olivier, Boekschoten, Mark V., Jörs, Simone, Villacorta-Martin, Carlos, Mazzaferro, Vincenzo, Llovet, Josep M., Weiskirchen, Ralf, Kather, Jakob N., Starlinger, Patrick, Trauner, Michael, Luedde, Mark, Heij, Lara R., Neumann, Ulf P., Keitel, Verena, Bode, Johannes G., Schneider, Rebekka K., Tacke, Frank, Levkau, Bodo, Lammers, Twan, Fluegen, Georg, Alexandrov, Theodore, Collins, Amy L., Nelson, Glyn, Oakley, Fiona, Mann, Derek A., Roderburg, Christoph, Longerich, Thomas, Weber, Achim, Villanueva, Augusto, Samson, Andre L., Murphy, James M., Kramann, Rafael, Geisler, Fabian, Costa, Ivan G., Hengstler, Jan G., Heikenwalder, Mathias, and Luedde, Tom

Published
2023
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12. The Association between Aortic Valve Stenosis and a Subsequent Diagnosis of Depression in Germany.

Author

Niepmann, Sven Thomas, Roderburg, Christoph, Luedde, Mark, Nickenig, Georg, Loosen, Sven H., and Kostev, Karel

Subjects
AORTIC stenosis, PROPENSITY score matching, AFFECTIVE disorders, WESTERN countries, CARDIOVASCULAR diseases
Abstract

Background/Objectives: Aortic valve stenosis (AS) represents one of the most common valve diseases in the western world. It often leads to severe symptoms that can lead to a restriction of everyday life and thus to psychological stress. Therefore, we aimed to investigate the association between AS and depression in outpatients in Germany. Methods: The IQVIATM Disease Analyzer database was used to identify 14,681 individuals with non-rheumatic AS (ICD-10: I35.0 or I35.2). They were propensity score matched (1:1) based on age, sex, average yearly consultation frequency during the follow-up, and co-diagnoses to 14,681 patients without AS. Cox regression models were used to analyze the association between aortic stenosis and depression. Results: Within the follow-up period of up to 10 years, depression was diagnosed in 20.6% of AS patients compared to 20.0% in the matched cohort (p = 0.351). In the regression analysis, we were not able to discover an association between AS and a subsequent diagnosis of depression (HR: 1.03; 95% CI: 0.96–1.11). This effect was consistent among different age and sex groups. Conclusions: In the broad population of patients treated outside of hospital settings in Germany, AS was not associated with a higher incidence of depression. [ABSTRACT FROM AUTHOR]

Published
2024
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17. microRNA 193a-5p Regulates Levels of Nucleolar- and Spindle-Associated Protein 1 to Suppress Hepatocarcinogenesis

Author

Roy, Sanchari, Hooiveld, Guido J., Seehawer, Marco, Caruso, Stefano, Heinzmann, Florian, Schneider, Anne T., Frank, Anna K., Cardenas, David Vargas, Sonntag, Roland, Luedde, Mark, Trautwein, Christian, Stein, Ilan, Pikarsky, Eli, Loosen, Sven, Tacke, Frank, Ringelhan, Marc, Avsaroglu, Seda Kilinc, Goga, Andrei, Buendia, Marie-Annick, Vucur, Mihael, Heikenwalder, Mathias, Zucman-Rossi, Jessica, Zender, Lars, Roderburg, Christoph, and Luedde, Tom

Published
2018
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21. Prediction of heart transplant rejection from routine pathology slides with self-supervised deep learning

Author

Seraphin, Tobias Paul, primary, Luedde, Mark, additional, Roderburg, Christoph, additional, van Treeck, Marko, additional, Scheider, Pascal, additional, Buelow, Roman D, additional, Boor, Peter, additional, Loosen, Sven H, additional, Provaznik, Zdenek, additional, Mendelsohn, Daniel, additional, Berisha, Filip, additional, Magnussen, Christina, additional, Westermann, Dirk, additional, Luedde, Tom, additional, Brochhausen, Christoph, additional, Sossalla, Samuel, additional, and Kather, Jakob Nikolas, additional

Published
2023
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26. Effects of percutaneous coronary intervention on dyspnea in stable coronary artery disease

Author

Wester, Michael, Koll, Franziska, Luedde, Mark, Langer, Christoph, Resch, Markus, Luchner, Andreas, Müller, Karolina, Zeman, Florian, Koller, Michael, Maier, Lars S., and Sossalla, Samuel

Subjects
ddc:610, 610 Medizin, PCI, Stable CAD, QoL, PLA-pCi-EBO, Dyspnea, General Medicine, Cardiology and Cardiovascular Medicine
Abstract

Background Dyspnea is a frequent symptom in patients with stable coronary artery disease (CAD) and is recognized as a possible angina equivalent. Objectives This study was to assess the impact of percutaneous coronary intervention (PCI) on dyspnea, quality of life, and angina pectoris in patients with stable CAD. Methods The prospective, multi-center PLA-pCi-EBO-pilot trial included 144 patients with symptomatic stable CAD and successful PCI. The prespecified endpoints angina pectoris (Seattle Angina Questionnaire–SAQ) and dyspnea (NYHA scale) were assessed 6 months after PCI. Predictors for symptomatic improvement were assessed with uni- and multivariable logistic regression analyses. Results Patients with concomitant dyspnea had worse SAQ physical limitation scores at baseline (49.5 ± 21.0 vs 58.9 ± 22.0, p = 0.013) but showed no difference for angina frequency or quality of life. Overall, symptomatic burden of angina pectoris and dyspnea was alleviated by PCI. However, patients with concomitant dyspnea had markedly worse scores for physical limitation (78.9 ± 25.0 vs 94.3 ± 10.6, p 0.001), angina frequency (77.9 ± 22.8 vs 91.1 ± 12.4, p 0.001), and quality of life (69.4 ± 24.1 vs 82.5 ± 14.4, p 0.001) after PCI. The prevalence of dyspnea (NYHA class ≥ 2) declined from 73% before PCI to 54%. Of 95 initially dyspneic patients, 57 (60%) improved at least one NYHA class 6 months after PCI. In a multivariable logistic regression analysis, “atypical angina pectoris” was associated with improved NYHA class, whereas “diabetes mellitus” had a negative association. Conclusion PCI effectively reduced dyspnea, which is a frequent and demanding symptom in patients with CAD. The German Clinical Trials Register registration number is DRKS0001752 (www.drks.de). Graphical abstract

Published
2022

28. Antihypertensive Therapy and Incidence of Cancer

Author

Loosen, Sven H., primary, Schöler, David, additional, Luedde, Mark, additional, Eschrich, Johannes, additional, Luedde, Tom, additional, Gremke, Niklas, additional, Kalder, Matthias, additional, Kostev, Karel, additional, and Roderburg, Christoph, additional

Published
2022
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29. Prediction of heart transplant rejection from routine pathology slides with self-supervised Deep Learning

Author

Seraphin, Tobias Paul, primary, Luedde, Mark, additional, Roderburg, Christoph, additional, van Treeck, Marko, additional, Scheider, Pascal, additional, Buelow, Roman D., additional, Boor, Peter, additional, Loosen, Sven H., additional, Provaznik, Zdenek, additional, Mendelsohn, Daniel, additional, Berisha, Filip, additional, Magnussen, Christina, additional, Westermann, Dirk, additional, Luedde, Tom, additional, Brochhausen, Christoph, additional, Sossalla, Samuel, additional, and Kather, Jakob Nikolas, additional

Published
2022
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41. Comparative Analysis of Circulating Biomarkers for Patients Undergoing Resection of Colorectal Liver Metastases

Author

Loosen, Sven H., Roderburg, Christoph, Alizai, Patrick H., Roeth, Anjali A., Schmitz, Sophia M., Vucur, Mihael, Luedde, Mark, Schöler, David, Paffenholz, Pia, Tacke, Frank, Trautwein, Christian, Luedde, Tom, Neumann, Ulf P., and Ulmer, Tom F.

Subjects
Medicine (General), R5-920, CEA, endocrine system diseases, liver resection, CRLM, cancer, CA19-9, CRP, survival, digestive system diseases, Article, CRC
Abstract

Diagnostics : open access journal 11(11), 1999 (2021). doi:10.3390/diagnostics11111999 special issue: "Special issue "Novel approaches in the diagnosis of primary and secondary disease within colorectal cancer" / special issue editors: Lucía Inglada-Pérez, guest editor; José Perea, guest editor", Published by MDPI, Basel

Published
2021

44. Circulating Osteopontin Levels and Outcomes in Patients Hospitalized for COVID-19

Author

Hayek, Salim S., Roderburg, Christoph, Blakely, Pennelope, Launius, Christopher, Eugen-Olsen, Jesper, Tacke, Frank, Ktena, Sofia, Keitel, Verena, Luedde, Mark, Giamarellos-Bourboulis, Evangelos J., Luedde, Tom, and Loosen, Sven H.

Subjects
OPN, Coronavirus disease 2019, Renal replacement therapy, SARS-CoV-2, Outcomes, mechanical ventilation, outcomes, Risk prediction, Article, Death, coronavirus disease 2019, risk prediction, Mechanical ventilation, stomatognathic system, death, Medicine, CRP, PCT, Procalcitonin, renal replacement therapy, procalcitonin
Abstract

Background: Severe coronavirus disease 2019 (COVID-19) is the result of a hyper-inflam matory reaction to the severe acute respiratory syndrome coronavirus 2. The biomarkers of inflammation have been used to risk-stratify patients with COVID-19. Osteopontin (OPN) is an integrin-binding glyco-phosphoprotein involved in the modulation of leukocyte activation; its levels are associated with worse outcomes in patients with sepsis. Whether OPN levels predict outcomes in COVID-19 is unknown. Methods: We measured OPN levels in serum of 341 hospitalized COVID-19 patients collected within 48 h from admission. We characterized the determinants of OPN levels and examined their association with in-hospital outcomes; notably death, need for mechanical ventilation, and need for renal replacement therapy (RRT) and as a composite outcome. The risk discrimination ability of OPN was compared with other inflammatory biomarkers. Results: Patients with COVID-19 (mean age 60, 61.9% male, 27.0% blacks) had significantly higher levels of serum OPN compared to healthy volunteers (96.63 vs. 16.56 ng/mL, p < 0.001). Overall, 104 patients required mechanical ventilation, 35 needed dialysis, and 53 died during their hospitalization. In multivariable analyses, OPN levels ≥140.66 ng/mL (third tertile) were associated with a 3.5 × (95%CI 1.44–8.27) increase in the odds of death, and 4.9 × (95%CI 2.48–9.80) increase in the odds of requiring mechanical ventilation. There was no association between OPN and need for RRT. Finally, OPN levels in the upper tertile turned out as an independent prognostic factor of event-free survival with respect to the composite endpoint. Conclusion: Higher OPN levels are associated with increased odds of death and mechanical ventilation in patients with COVID-19, however, their utility in triage is questionable.

Published
2021

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