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3 results on '"Ludmilla Hedlund"'

1. The Drosophila midkine/pleiotrophin homologues Miple1 and Miple2 affect adult lifespan but are dispensable for alk signaling during embryonic gut formation.

Author

Fredrik Hugosson, Camilla Sjögren, Anna Birve, Ludmilla Hedlund, Therese Eriksson, and Ruth H Palmer

Subjects
Medicine, Science
Abstract

Midkine (MDK) and Pleiotrophin (PTN) are small heparin-binding cytokines with closely related structures. The Drosophila genome harbours two genes encoding members of the MDK/PTN family of proteins, known as miple1 and miple2. We have investigated the role of Miple proteins in vivo, in particular with regard to their proposed role as ligands for the Alk receptor tyrosine kinase (RTK). Here we show that Miple proteins are neither required to drive Alk signaling during Drosophila embryogenesis, nor are they essential for development in the fruit fly. Additionally we show that neither MDK nor PTN can activate hALK in vivo when ectopically co-expressed in the fly. In conclusion, our data suggest that Alk is not activated by MDK/PTN related growth factors Miple1 and Miple 2 in vivo.

Published
2014
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2. Health-related quality of life of children and adolescents with functional disabilities in a northern Swedish county

Author

Ludmilla Hedlund, Erik Domellöf, and Pia Ödman

Subjects
Male, Gerontology, medicine.medical_specialty, Adolescent, Health Status, Population, MEDLINE, Social class, Statistics, Nonparametric, Quality of life (healthcare), Intellectual Disability, Surveys and Questionnaires, Intellectual disability, medicine, Humans, Child, education, Hearing Disorders, Quality of Life Research, Sweden, Health related quality of life, education.field_of_study, Movement Disorders, business.industry, Public health, Public Health, Environmental and Occupational Health, medicine.disease, Disabled Children, Social Class, Child Development Disorders, Pervasive, Quality of Life, Female, business
Abstract

Health-related quality of life (HRQoL) studies in children and adolescents with disabilities tend to report lower self-reported health than in the typical population. However, reports are not always consistent and HRQoL appears to vary depending on diagnosis, cultural setting and clinical context. The aim of this study was to explore HRQoL in children and adolescents with various disabilities in Västerbotten County, Sweden.A total of 175 children and adolescents [57 girls, 118 boys; mean age 11.7 years (range 7-17 years)] divided into four different diagnostic groups (intellectual disabilities, autism spectrum disorders, movement disorders and hearing disabilities) participated in the study. The EuroQol Five Dimensions Health Questionnaire, Youth version (EQ-5D-Y) was used as HRQoL measure.Significant differences in various EQ-5D-Y dimensions between the different diagnostic groups were found, but no differences in overall health status. HRQoL in children and adolescents with hearing disabilities was found similar to the typical child population in Sweden whereas children and adolescents with other diagnoses reported evidently more problems.Findings suggest that there is an increased risk for children with functional disabilities other than hearing disabilities in northern Sweden to experience difficulties in various health domains and lowered general health.

Published
2013

3. The Drosophila midkine/pleiotrophin homologues Miple1 and Miple2 affect adult lifespan but are dispensable for alk signaling during embryonic gut formation

Author

Ludmilla Hedlund, Anna Birve, Camilla Sjögren, Fredrik Hugosson, Ruth H. Palmer, and Therese Eriksson

Subjects
Male, Mesoderm, lcsh:Medicine, Pleiotrophin, Biochemistry, Genetics, medicine, Animals, Drosophila Proteins, Humans, Anaplastic Lymphoma Kinase, lcsh:Science, Molecular Biology, Midkine, Multidisciplinary, biology, fungi, lcsh:R, Biochemistry and Molecular Biology, Organisms, Gene Expression Regulation, Developmental, Receptor Protein-Tyrosine Kinases, Biology and Life Sciences, Drosophila embryogenesis, Cell Biology, biology.organism_classification, Molecular biology, Phenotype, Cell biology, medicine.anatomical_structure, biology.protein, Cytokines, Drosophila, Female, lcsh:Q, Drosophila melanogaster, Signal transduction, Carrier Proteins, Biokemi och molekylärbiologi, Gene Deletion, Drosophila Protein, Signal Transduction, Research Article, Developmental Biology
Abstract

Midkine (MDK) and Pleiotrophin (PTN) are small heparin-binding cytokines with closely related structures. The Drosophila genome harbours two genes encoding members of the MDK/PTN family of proteins, known as miple1 and miple2. We have investigated the role of Miple proteins in vivo, in particular with regard to their proposed role as ligands for the Alk receptor tyrosine kinase (RTK). Here we show that Miple proteins are neither required to drive Alk signaling during Drosophila embryogenesis, nor are they essential for development in the fruit fly. Additionally we show that neither MDK nor PTN can activate hALK in vivo when ectopically co-expressed in the fly. In conclusion, our data suggest that Alk is not activated by MDK/PTN related growth factors Miple1 and Miple 2 in vivo.

Published
2014

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