Search

Your search keyword '"Luciano de G. Santos"' showing total 2 results
Start Over Author "Luciano de G. Santos"
2 results on '"Luciano de G. Santos"'

1. Depressant effect of geraniol on the central nervous system of rats: Behavior and ECoG power spectra

Author

Katty Anne A.L. Medeiros, José R. dos Santos, Thaís Cristina de S. Melo, Marina F. de Souza, Luciano de G. Santos, Auderlan M. de Gois, Rachel R. Cintra, Lívia Cristina R.F. Lins, Alessandra M. Ribeiro, and Murilo Marchioro

Subjects
Medicine (General), R5-920, Biology (General), QH301-705.5
Abstract

Geraniol is a monoterpene alcohol that is derived from the essential oils of aromatic plants, with anti-inflammatory, antimicrobial, antioxidant and neuroprotective properties. This study characterized the effect of geraniol on behavior and brainwave patterns in rats. Male rats were submitted to administration of geraniol (25, 50 and 100 mg/kg). The hole board (HB) and open field (OF) tests were performed to evaluate anxiety and motor behavior, respectively. In addition, barbiturate-induced sleeping time (BIST) was used to analyze sedative effect. Finally, electrocorticogram (ECoG) recordings were used to characterize brain-wave patterns. The results showed that geraniol treatment in rats decreased the distance traveled, rearing numbers and lead to increase in immobility time in HB and OF tests. In BIST test, geraniol treatment increased sleep duration but not sleep latency in the animals. Furthermore, geraniol-treated animals demonstrated an increase in the percentage of delta waves in the total spectrum power. Taken together, our results suggested that geraniol exerted a depressant effect on the central nervous system of rats. Keywords: Sedation, Monoterpene, Brain waves, Hypnose, Natural product

Published
2018
Full Text
View/download PDF

2. Depressant effect of geraniol on the central nervous system of rats: Behavior and ECoG power spectra

Author

Marina F. Souza, Alessandra Mussi Ribeiro, Luciano de G. Santos, Auderlan M. Gois, Thais Cristina de Souza Melo, Katty A.A.L. Medeiros, José R. Santos, Murilo Marchioro, Rachel R. Cintra, and Lívia C.R.F. Lins

Subjects
0301 basic medicine, Central Nervous System, Male, Sedative effect, Antioxidant, medicine.drug_class, Monoterpene, medicine.medical_treatment, Acyclic Monoterpenes, Central nervous system, Brain waves, Pharmacology, Open field, Natural product, Antioxidants, 03 medical and health sciences, chemistry.chemical_compound, 0302 clinical medicine, medicine, Animals, Hypnotics and Sedatives, Rats, Wistar, lcsh:QH301-705.5, lcsh:R5-920, Hypnose, Behavior, Animal, Chemistry, Terpenes, General Medicine, Delta wave, 030104 developmental biology, medicine.anatomical_structure, lcsh:Biology (General), Sedation, Barbiturates, Depressant, Original Article, lcsh:Medicine (General), Sleep, 030217 neurology & neurosurgery, Geraniol
Abstract

Geraniol is a monoterpene alcohol that is derived from the essential oils of aromatic plants, with anti-inflammatory, antimicrobial, antioxidant and neuroprotective properties. This study characterized the effect of geraniol on behavior and brainwave patterns in rats. Male rats were submitted to administration of geraniol (25, 50 and 100 mg/kg). The hole board (HB) and open field (OF) tests were performed to evaluate anxiety and motor behavior, respectively. In addition, barbiturate-induced sleeping time (BIST) was used to analyze sedative effect. Finally, electrocorticogram (ECoG) recordings were used to characterize brain-wave patterns. The results showed that geraniol treatment in rats decreased the distance traveled, rearing numbers and lead to increase in immobility time in HB and OF tests. In BIST test, geraniol treatment increased sleep duration but not sleep latency in the animals. Furthermore, geraniol-treated animals demonstrated an increase in the percentage of delta waves in the total spectrum power. Taken together, our results suggested that geraniol exerted a depressant effect on the central nervous system of rats. Keywords: Sedation, Monoterpene, Brain waves, Hypnose, Natural product

Published
2018

Catalog

Books, media, physical & digital resources
See catalog results