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Your search keyword '"Luciana Risoléo"' showing total 2 results
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2 results on '"Luciana Risoléo"'

1. [Untitled]

Author

Luciana Risoléo, Vera Ferreira, Denise S. P. Q. Horton, Isaias Raw, Noemi Furuyama, Waldely O. Dias, and Vera C.B. Cainelli Gebara

Subjects
Vitamin, biology, Tetanus, business.industry, medicine.medical_treatment, Diphtheria, Bioengineering, General Medicine, Booster dose, medicine.disease, complex mixtures, Applied Microbiology and Biotechnology, Virology, chemistry.chemical_compound, Immune system, chemistry, Immunization, Immunology, medicine, biology.protein, Antibody, business, Adjuvant, Biotechnology
Abstract

Vitamin A was used as adjuvant, comparatively with Al(OH)3, in pertussis, tetanus and diphtheria vaccines. Both groups induced a primary immune response in mice, and one single booster dose elevated the antibodies titers in average 554 times to vitamin A groups and 104 times to Al(OH)3. These antibodies titers correlate with sera IL-4 in immunized animals, suggesting a Th2 response. Other cytokines detected in the sera and/or lymphocytes culture supernatants (IL-2 and IFN-□) indicated that vitamin A could also modulate a Th1 response in DPT and acellular pertussis vaccines.

Published
2002
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2. Adjuvant and immunogenic activities of the 73kDa N-terminal alpha-domain of BrkA autotransporter and Cpn60/60kDa chaperonin of Bordetella pertussis

Author

Wilmar Dias da Silva, Vera C.B. Cainelli Gebara, Alexandre P. Y. Lopes, Vera Ferreira, Wagner Quintilio, Isaias Raw, Luciana Risoléo, François Lépine, Centro de Biotecnologia [Sao Paulo], Instituto Butantan [São Paulo], Serviço de Controle de Qualidade, Instituto Butantan, Institut Armand Frappier (INRS-IAF), Institut National de la Recherche Scientifique [Québec] (INRS)-Réseau International des Instituts Pasteur (RIIP), Centro de Biociencias e Biotecnologia, Universidade Estadual do Norte Fluminense Darcy Ribeiro (UENF), and This work was supported by FAPESP, grant 00/08708-2, and FUNDACAO BUTANTAN

Subjects
Bordetella pertussis, [SDV.BIO]Life Sciences [q-bio]/Biotechnology, Whooping Cough, medicine.medical_treatment, Molecular Sequence Data, MESH: Mice, Inbred BALB C, MESH: Adjuvants, Immunologic, MESH: Amino Acid Sequence, complex mixtures, Microbiology, MESH: Bordetella pertussis, Mice, MESH: Protein Structure, Tertiary, Immune system, Adjuvants, Immunologic, medicine, Animals, MESH: Animals, Amino Acid Sequence, [INFO.INFO-BT]Computer Science [cs]/Biotechnology, MESH: Mice, Pertussis Vaccine, Mice, Inbred BALB C, MESH: Molecular Sequence Data, General Veterinary, General Immunology and Microbiology, biology, Immunogenicity, MESH: Bacterial Outer Membrane Proteins, Public Health, Environmental and Occupational Health, Chaperonin 60, MESH: Whooping Cough, biology.organism_classification, Protein Structure, Tertiary, Infectious Diseases, MESH: Pertussis Vaccine, biology.protein, Autotransporter domain, Molecular Medicine, MESH: Chaperonin 60, Female, Antibody, Pertactin, Adjuvant, MESH: Female, Bacteria, Bacterial Outer Membrane Proteins
Abstract

International audience; A soluble fraction obtained from Bordetella pertussis was evaluated as adjuvant for the pertussis component of the Diphtheria-Pertussis-Tetanus (DPT) vaccine. High levels of antibodies were induced, and a 78% protection rate of mice challenged with live B. pertussis was observed. Two proteins were identified as the 73 kDa N-terminal alpha-domain of BrkA autotransporter protein and the Cpn60/60 kDa chaperonin. Both stimulated antibodies against pertussis and induced a 42% protection rate against the challenge. IgG1 and IgG2a were stimulated suggesting that the immune response could be modulated to produce Th1 or Th2.

Published
2007
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